human reproduction

401 Pages·2014·5.98 MB·English

WWW.HUMREP.OXFORDJOURNALS.ORG
VOLUME 29, SUPP 1 2014
ABSTRACT BOOK
ESHRE 2014 – MUNICH, GERMANY – 29 JUNE TO 2 JULY
human
reproduction
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Abstracts of the
30th Annual Meeting of the
European Society of
Human Reproduction and Embryology
Munich
Germany
29 June to 2 July 2014
Abstracts
30th Annual Meeting of the
European Society of
Human Reproduction and Embryology
Munich, Germany
29 June to 2 July 2014
Print copies of the meeting abstracts are provided for Conference Delegates only. However, the abstracts
are available on-line to all Human Reproduction/Update/Molecular Human Reproduction subscribers and
are also freely available to all visitors to the following website www.humrep.oxfordjournals.org, and on the
ESHRE website: www.eshre.eu
Copyright Notice: All abstracts together with the programme, for presentation during the 30th Annual
Meeting of ESHRE are copyright of ESHRE. These abstracts [or parts thereof] may not be reproduced,
stored, printed or transmitted in any form, or by any means, electronic, mechanical, photocopied, recording,
or otherwise without written permission of ESHRE and the author of the abstract.
Note to the media: all abstracts are strictly embargoed until the time and date of presentation at the
conference.
The opinions or views expressed in this abstracts supplement are those of the authors and do not necessarily
reflect the opinions or recommendations of ESHRE. The abstracts have been reviewed by the Congress
Scientific Committee and revised accordingly by the authors. The selection of abstracts is based on the
scores given by an international panel of peer reviewers.
Dosages, indications and methods of use for products that are referred to in the abstracts by the authors are
not necessarily appropriate for clinical use and may reflect the clinical experience of the authors or may be
derived from the professional literature of other clinical sources. Because of differences between in-vitro
and in-vivo systems and between laboratory animal models and clinical data in humans, in-vitro and animal
data may not necessarily correlate with clinical results.
The investigators of these abstracts have stated in their submission letter that prospective studies where
patients are involved have institutional Ethics Committee approval and informed patient consent, and
that the studies using experimental animals have institutional approval. The Publishers have endeavoured
to reproduce faithfully all of the abstracts as accepted by the Conference Organisers, but can accept no
responsibility for inaccuracies or omissions caused by the late receipt of abstracts.
EUROPEAN SOCIETY OF HUMAN REPRODUCTION AND EMBRYOLOGY (ESHRE)
COMMITTEES
Executive Committee Veerle De Rijbel Andreea Sandra Mustata (Romania)
(2013 – 2015) Veerle Goossens Lyubov Mykhaylyshyn (Ukraine)
Karen Maris Nan Brigitte Oldereid (Norway)
Chairman Catherine Plas Julia Paget (United Kingdom)
Juha Tapanainen (Finland) Erika Mar Rodriguez Raes Michael Pelekanos (Cyprus)
Heidi Roijemans Manuel Pensis (Switzerland)
Chairman Elect Bruno Van den Eede Zoranco Petanovski (Macedonia)
Kersti Lundin (Sweden) Titia Van Roy Ireneusz Polac (Poland)
Ine Van Wassenhove Nebojsa Radunovic (Serbia)
Members Nathalie Vermeulen Catherine Rongieres (France)
Carlos Calhaz-Jorge (Portugal) Pia Saldeen (Sweden)
Jacques De Mouzon (France) Committee of National Ertan Saridogan (United Kingdom)
Petra De Sutter (Belgium) Representatives Kirsten Louise Tryde Schmidt
Roy Farquharson (United Kingdom) (2011 – 2014) (Denmark)
Anis Feki (Switzerland) Jesper M.J. Smeenk (The Netherlands)
Georg Griesinger (Germany) Vasco Almeida (Portugal) Anna Smirnova (Russia C.I.S.)
Grigoris Grimbizis (Greece) Birol Aydin (Macedonia) Patrik Stanic (Croatia)
Cornelis Lambalk (The Netherlands) Basak Balaban (Turkey) Nada Tabs (Serbia)
Cristina Magli (Italy) Anette Bergh (Norway) Tania Nikolova Timeva (Bulgaria)
Tatjana Motrenko Simic (Montenegro) Zeev Blumenfeld (Israel) Krinos M. Trokoudes (Cyprus)
Andres Salumets (Estonia) Pierre Boyer (France) Bulent Urman (Turkey)
Giovanni Coticchio (Italy) Aafke Van Montfoort (The Netherlands)
Immediate Past Chairman
Gabriel De Candolle (Switzerland) Frank Vandekerckhove (Belgium)
Anna Veiga (Spain)
Alfonso L. De La Fuente (Spain) Peter H. Vogt (Germany)
José Joaquim Domingues Hrvoje Vrcic (Croatia)
Coordinator SIG’s
Nunes (Portugal) Eda Vrtacnik-Bokal (Slovenia)
Timur Gürgan (Turkey)
Jeremy Don (Israel) Anthony Walsh (Ireland (Rep.))
Bogdan Doroftei (Romania) Ludwig Wildt (Austria)
Paramedical Board
Thomas Ebner (Austria) Sergey Yakovenko (Russia C.I.S.)
Geraldine Emerson (Ireland)
Chairman
Gregoris Grimbizis (Greece) International Scientific Committee
Helle Bendtsen (Denmark)
Maurizio Guido (Italy)
Bjorn Heindryckx (Belgium) Chris Barratt (United Kingdom)
Past-Chairman
Christina Hnida (Denmark) Helle Bendtsen (Denmark)
Jolieneke Schoonenberg-Pomper (the
José Antonio Horcajadas Maria Jose De Los Santos (Spain)
Netherlands)
Almansa (Spain) Gerard A.J. Dunselman
Members Julius Hreinsson (Sweden) (The Netherlands)
Eline Dancet (Belgium) Katalin Kanyo (Hungary) Ursula Eichenlaub-Ritter (Germany)
Yves Guns (Belgium) Borut Kovacic (Slovenia) Johannes Evers (The Netherlands)
Inge Rose Jorgensen (Denmark) Péter Kovács (Hungary) Luca Gianaroli (Italy)
Helen Kendrew (United Kingdom) Markus S. Kupka (Germany) Mariette Goddijn (The Netherlands)
Uschi Van den Broeck (Belgium) Rafal Kurzawa (Poland) Timur Gürgan (Turkey)
Leonie Van Den Hoven Kalliopi Loutradi (Greece) Efstratios Kolibianakis (Greece)
(The Netherlands) Sirpa Makinen (Finland) Markus S. Kupka (Germany)
Cecilia Westin (Sweden) Alice Malenovska (Czech Republic) Tin-Chiu Li (United Kingdom)
Tania Milachich (Bulgaria) Kersti Lundin (Sweden)
Central Office Laure C. Morin - Papunen (Finland) Edgar Vasile Mocanu (Ireland)
Christine Bauquis Milan Mrazek (Czech Republic) Willianne Nelen (The Netherlands)
iii
Willem Ombelet (Belgium) Richardo Felberbaum Andreas Schmutzler
Guido Pennings (Belgium) Georg Griesinger Ulrich Schneider
Felice Petraglia (Italy) Jörg Gromoll Katarina Spanel-Borowski
Helen M. Picton (United Kingdom) Thomas Haaf Thomas Strowitski
Veerle Provoost (Belgium) U. Hilland Hans Tinneberg
Stefan Schlatt (Germany) Jens Hirchenhain Bettina Toth
Augusto Enrico Semprini (Italy) Bernhard Horsthemke Hans van der Ven
Johan E.J. Smitz (Belgium) Karin Hübner Peter H. Vogt
Juha S. Tapanainen (Finland) Evgenia Isachenko Victoria Von Schönfeld
Uschi Van den Broeck (Belgium) Heribert Kentenich Lisa Wiesmüller
Bruno Van den Eede (Belgium) Ludwig Kiesel Peter Wieacker
Rita Vassena (Spain) Susanne Kliesch Elke Winterhager
Anna Veiga (Spain) Frank M. Köhn Ulrich Zechner
Jan-S Krüssel
National Committee Michael Ludwig Local Committee
Artur Mayerhofer
Monika Bals-Pratsch Lilo Mettler Tina Bucholz
Hermann M. Behre Markus Montag Klaus Diedrich
Hennig Beier Verena Nordhoff Ursula Eichenlaub-Ritter
Verona Blumenauer Thomas Rabe Karl Friese (Chair)
Klaus Buehler Hans Schöler Markus Kupka
Ralf Dittrich Stefan Schlatt Christian Thaler
Every effort has been made to faithfully reproduce the abstracts as submitted. However, no responsibility is assumed by the organisers for any
injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any meth-
ods, products, instructions or ideas contained in the material herein. Because of the rapid advances in the medical sciences, we recommend that
independent verification of diagnoses and drug dosages should be made.
iv
human
human
hurhehmupumarmnoaadnnuction
reproduction
rerepprorodduucctitoionn
reproduction
Editor-in-Chief
J. L. H. Evers
Editor-in-Chief
A. VDaenp Sutteyir Etedghiteomrs
E. Somigliana
Editor-in-CEDhdeiietpofurEt-yidn Ei-tCodrhit-ioienrf-sChief
R. Sharpe
A.VEa.n SASo.tmVeiairgnteligSahtneeaimrteghem
A.Van Steirteghem
DeJAp. suLst.oy DHcieEa.p dtEueiv ttEyoerrdEssitdoirtsors
Deputy Editors
R. Sharpe
T Adriaenssens, Belgium A Ferlin, Italy P.G.CrPo.sGig.CnaLrno Pisailg, UnSaAni S Sunkara, UK
P.G.Crosignani
Chrisi Amorim, Belgium J Fuglsang, Denmark S Palomba, Italy J G Thompson, Australia
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C Y Andersen, Denmark S GaJm.Lei.rHo, .UEKvers A Palumbo, Spain A Tiitinen, Finland
A-M Andersson,R D. Aenbmir,a Irskrael M GauRst.eSr,h AaursGptr.e iHaaRrto.nS, hUaSrARpe.SCh Paertprye, UK A. Palumbo, Spain G Toft, Denmark
B Ata, Turkey C. Y. Andersen, DenmKa rGkemzell-DanEAi.e sHlssasorovcnii,la lAet,es UsEoSAcdiiaJtt oRerasEmdalihtoo-rSsaCn.t oPse,t rPyo, rUtuKgal K Toulis, Greece
M Bedaiwy, CanAa.d-Ma. Andersson, DeSnAwmeasdrskeonc iateEEd. Hitaourzsman, HungPa rRyay, FranceC. Plancha, PortugalK Tremellen, Australia
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EditorEmerEiEtdudistiotorDrEE .EHmdm.i etBoerarirrtilutEouswms eritus
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ManagingEMdMitaoManrnaaagngiMnainggaginEn Eadggdi tiEinotdorgritEodritor
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GVoocytGeVwiothocaynteonw-istuhraronuonnd-isnugrrnouucnldeoinlugsnsutcalienoeldufsosrta(Ain)edchfroorm(Aat)inch(DroAmPaIt;inbl(uDeA)aPnI;db(lBu)e)haisntdon(eBa)cheitsytolanteioance(atynltai-tHio4nK(a1n2tai-cH;r4eKd)1.2Naco;teretdh)e.rNegoitoenthseregions
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ofintensechromatinstaininginsomeareas,whereasothersshownoacetylation(C;overlay).Thelowerpanels,ofamoredevelopedoocytewitha
surroundisnugrrnouucnldeiunsgsntauicnleedusfosrtacihnreodmfaotrinch(rDo)maantidnh(iDst)onanedacheistytolanteioance(tEy)l,atsihoonw(Em),orsehocwonmdeonrseecdocnhdreonmseadtinchtrhoamnaintinthtehaenarilny-tshteageearoloyc-syttaege(aoboocvyet)e,(above),
surroundingnucleusstainedforchromatin(D)andhistoneacetylation(E),showmorecondensedchromatinthanintheearly-stageoocyte(above),
althoughathltehoouogchyttehestiollochyatsessotmillehaacsestyolmateedaccehtryolamteadtincharsomshaotwinnaisnsEhoawnndionveErlaanyd(Fo)v.eFrloarym(Fo)r.eFdoertamilosrseedeevtaainlsdseeneBvearngdeetnaBl.,erpgp.et11a8l.1,–pp1.19101.81–1190.
althoughtheoocytestillhassomeacetylatedchromatinasshowninEandoverlay(F).FormoredetailsseevandenBergetal.,pp.1181–1190.
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Contents
Oral Presentations
Monday 30 June 2014
O-001-O-002 Session 01 – Robert G. Edwards’ memorial keynote session .............................................i1
O-003-O-008 Session 02 – Revisiting embryo culture .............................................................i1
O-009-O-014 Session 03 – Recent advances in PCOS .............................................................i4
O-015-O-020 Session 04 – Male infertility ......................................................................i7
O-021-O-026 Session 05 – Managing endometriosis ..............................................................i9
O-027-O-032 Session 06 – Ovarian reserve and ageing ...........................................................i12
O-033-O-038 Session 07 – Developments in genetic analysis.......................................................i15
O-039-O-040 Session 08 – Fertility preservation and the role of surgery..............................................i17
O-041 Session 09 – Fertility Society of Australia Exchange Lecture ...........................................i18
O-042 Session 10 – Data reporting session ...............................................................i18
O-043-O-044 Session 11 – Paramedical invited session - Laboratory.................................................i19
O-045-O-046 Session 12 – When the Fallopian tube fails..........................................................i19
O-047-O-048 Session 13 – From pluripotent stem cells to gametes and back ..........................................i20
O-049-O-052 Session 14 – Novel techniques in the laboratory and IVF outcome .......................................i20
O-053-O-057 Session 15 – IVF from a vitrified perspective........................................................i22
O-058-O-062 Session 16 – Ovarian stimulation .................................................................i24
O-063-O-067 Session 17 – ART: Economics and epidemiology.....................................................i27
O-068-O-072 Session 18 – Quality within the laboratory..........................................................i29
O-073-O-077 Session 19 – New evidence in early pregnancy outcome ...............................................i31
O-078-O-082 Session 20 – Psychosocial issues and care in infertility ................................................i33
O-083-O-084 Session 21 – The latest findings from the Reprotrain consortia ..........................................i36
O-085-O-088 Session 22 – Reproductive surgery ................................................................i36
Tuesday 1 July 2014
O-089-O-090 Session 23 – Progress in ovarian stimulation for IVF..................................................i38
O-091-O-092 Session 24 – Oocyte activation ...................................................................i39
O-093-O-094 Session 25 – ASRM exchange session - “Omics of infertility” ..........................................i40
O-095-O-096 Session 26 – Paramedical invited session ...........................................................i40
O-097-O-102 Session 27 – Embryonic biomarkers - Are we getting nearer? ...........................................i41
Session 28 – Live surgical tutorial: Uterine pathology .................................................i44
O-103-O-108 Session 29 – Novel techniques in andrology.........................................................i44
O-109-O-114 Session 30 – Basic science endometriosis...........................................................i46
O-115-O-120 Session 31 – Clinical trials in ovarian stimulation.....................................................i49
O-121-O-126 Session 32 – Patients’ needs and wishes: Where to draw the line?........................................i52
O-127 Session 33 – European and Global ART Monitoring ..................................................i54
O-128-O-129 Session 34 – Long-term health in Turner syndrome women.............................................i55
O-130-O-133 Session 35 – The voice of donor sperm recipients ....................................................i56
O-134-O-135 Session 36 – Advances in genetic testing ...........................................................i58
O-136-O-139 Session 37 – Assisted reproduction and human rights (Joint session ESHRE SIG
Ethics and Law and FIGO’s Ethics Committee)............................................i58
O-140-O-143 Session 38 – Invited patient session - Social infertility (e.g. gamete freezing
for social reasons; delayed pregnancy; age factor ..........................................i60
O-144-O-145 Session 39 – Paramedical invited session ...........................................................i60
O-146-O-150 Session 40 – Time-lapse imaging - Which embryo gets the Oscar? .......................................i61
O-151-O-155 Session 41 – Improving ART outcome .............................................................i63
O-156-O-160 Session 42 – Sperm DNA integrity................................................................i65
O-161-O-165 Session 43 – Safety issues for mother and child......................................................i67
O-166-O-170 Session 44 – Underlying mechanisms of early pregnancy pathology......................................i70
O-171-O-175 Session 45 – Epigenetics in gamete competence and implantation........................................i72
O-176-O-179 Session 46 – Clinical endocrinology (1) ............................................................i74
O-180-O-183 Session 47 – Basic physiology in embryology .......................................................i76
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O-184-O-187 Session 48 – Implantation failure and the endometrium................................................i78
O-188-O-191 Session 49 – Nurses’ perspective in patient care and quality of life .......................................i80
O-192-O-195 Session 50 – The psychology of fertility preservation and gamete donation ................................i81
Wednesday 2 July 2014
O-196-O-197 Session 51 – Improving medical decision making ....................................................i83
O-198-O-199 Session 52 – Update on ultrasound in reproductive health care ..........................................i83
O-200-O-201 Session 53 – Paramedical invited debate session - Laboratory (Debate) -
Is there time for time-lapse in the laboratory?.............................................i84
O-202-O-208 Session 54 – Clinical endocrinology (2) ............................................................i85
O-209-O-215 Session 55 – Genes and embryo development........................................................i88
O-216-O-222 Session 56 – Stem cells & Translational research.....................................................i91
O-223-O-229 Session 57 – Female reproductive physiology........................................................i94
O-230-O-236 Session 58 – Male and female fertility preservation...................................................i97
O-237-O-238 Session 59 – Does delayed transfer give better results (freeze all policy)?.................................i100
O-239-O-240 Session 60 – Society of Reproductive Surgeons Symposium - “Prevention and
management of laparoscopic complications”.............................................i101
O-241-O-244 Session 61 – Infertility trials: Roadmap to success...................................................i101
O-245-O-249 Session 62 – A look inside the occyte.............................................................i102
O-250-O-254 Session 63 – Basic endocrinology................................................................i104
O-255-O-259 Session 64 – How to get the most out of your embryos ...............................................i106
O-260-O-264 Session 65 – Origin and diagnosis of meiotic errors..................................................i108
O-265-O-269 Session 66 – Female infertility: Diagnosis and treatment..............................................i110
O-270-O-274 Session 67 – Genetics in andrology...............................................................i112
Posters Presentations
P-001-P-028 Andrology ..................................................................................i115
P-029 Cross border reproductive care ..................................................................i126
P-030 Developing countries and infertility ..............................................................i127
P-031-P-064 Early pregnancy..............................................................................i127
P-065-P-184 Embryology.................................................................................i141
P-185-P-220 Endometriosis/Endometrium....................................................................i194
P-221-P-223 Ethics and Law...............................................................................i209
P-224-P-279 Female (in)fertility............................................................................i210
P-280 Male and female contraception ..................................................................i233
P-281-P-316 Male and female fertility preservation.............................................................i233
P-317-P-324 Paramedical - laboratory .......................................................................i251
P-325-P-333 Paramedical - nursing .........................................................................i254
P-334-P-379 Psychology and counselling ....................................................................i258
P-380-P-404 Safety and quality of ART......................................................................i276
P-405-P-456 Reproductive (epi)genetics .....................................................................i286
P-457-P-569 Reproductive endocrinology ....................................................................i307
P-570-P-579 Reproductive epidemiology and health economy ....................................................i352
P-580-P-591 Reproductive surgery..........................................................................i357
P-592-P-596 Stem cells...................................................................................i361
P-597-P-600 Translational research .........................................................................i363
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