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D ow nloaded from https://onlinelibrary.w iley.com /doi/ by ibrahim ragab - C HumanandAnimalFilariases ochrane Germ any , W iley O nline L ibrary on [25/10/2022]. See the T erm s and C onditions (https://onlinelibrary.w iley.com /term s-and-conditions) on W iley O nline L ibrary for rules of use; O A articles are governed by the applicable C reative C om m ons L icense D ow nloaded from Titles of the Series “Drug Discovery in Infectious Diseases” https://onlinelibrary.w Selzer,P.M.(ed.) Doerig,C.,Späth,G.,Wiese,M. iley.com ADnrutigpaDriassciotviceraynd Antibacterial PPraoratesiintePshosphorylation in /doi/ by ibrahim FromMolecularTargetstoDrug NovelTargetsforAntiparasitic ragab - C Candidates Intervention ochrane G 2009 2013 erm PrintISBN:978-3-527-32327-2,alsoavailablein Print-ISBN:978-3-527-33235-9,alsoavailable any , W digitalformats indigitalformats iley O nline L BAMDeropuclikgececDoru,elmKav.rep(lAeolpdpep.m)xroeaanncthPesatroawsairtdeTsargeted UHManniodcdrseAotnbn,–itaGiil.nP,MfTaeehctttihanivboeeosgs,liEesm.n,S,IcPnhaüttheffloregare,cnAti.cioi(teynds) ibrary on [25/10/2022]. 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Geary ibrary on [25/10/2022]. See the T erm s and C SPearuilesME.dSietlozrer onditions (https://onlinelibrary.w iley.com /term s-and-conditions) on W iley O nline L ibrary for rules of use; O A articles are governed by the applicable C reative C om m ons L icense D ow Editors AllbookspublishedbyWILEY-VCHarecarefully nloaded from RPA79oaln6treaa8nCl5dsoHtKneaäisnmgu-li1Ent3ishnkrgysberg ppctinooruonbmbdtelaiiusnficrhndeeeeedtrdh.odiNafnoteestnrvhtroeaoerttsrteweshm.eabRelroerneosaatsknsd,s,tea,dtruihasnttehacarloi,uenridlsfalo,iudnresvmgdtiristaatehottdiiirosostnn,obasok,noedke,p https://onlinelibrary.w GTMI2SCan1ianaemcsi1dnrntGo1miattt1iedhula-lLyatnAeUaGynkon.nefGisvePehe-aadrorrseyrai-estByiRteoolllaoedvguye,H9X3V9QC piLBAfBnririrobbaioctmrldaciaisoevtrhatdgeyhlrrLuooaetirgefbpaBunCrhlaretoidlircnytyreiigestnbCcrahfeeaoioltsLrirsasndmilobCaofarrcagotacrourirdoutiytnnhrhN.gaeipot-sruei.:nib.bta-oelPpiomsuphkbsleilidemiscdaabatvyfyioaorinlaDbaleta iley.com/doi/ by ibrahim ragab - Cochrane G Queen’sUniversity-Belfast theDeutscheNationalbibliothek erm SM1N9coihcCrotrhhoolbeloreornsfin&BIerieoPGllaaoatngrhddioceganelsnS,cBBieeionlflcaoesgstyBT95DL TtNdhahaitsetaipoDanureeabullatbiscvicabahtliiileooanbNgrlaeiantfioiotenhn;etdahleDbetieaIbuinllteitsoedctrhhnbeeiebktlailoitsgtrsaphic any , Wiley Online L SPBB5G5eaioenru2erilg1emhMe6srariE.InnSnSdgytegiretleaozrlßerhIrenegi1me7l3haemimRhAeninimalHealth <©Attprhhahlil2onst0rttsbpio2lgoa:p3h/otr/iWtkidosnnnmIrtLiebinas.nEdgeytY-r,obnvm-VeoebditC.rchderH(eepio>nrrfiGocl.laldmmunudbg,ciuoHenradggaietnnhsy)oa.osnNetyhoofeofprramrt–ofby ibrary on [25/10/2022]. See the Term CTBcwtRfohaohrehreuvupeiedsgBcuhareihabattuislaivimtosicielnmisaolaglnsfogueertefisehpintleraecataonhsrCtpidaeoaolpdfeeBnttberWfghruryoeoug2am(dic)ca.wihostPmeuehohraroeaeotsdlreDetaiesoayeenyimclbeofiarapeforgnedhcPucri.atrtrahMnsiotnetifäicetais,oseifrs, mmftncPerroProoaieanDtndmacstFsehnipmIdtIisSehSneB–acBereiNreNnfipkld:a:ocus9n9a,rub77glentll8u8rtiyps-ca-a3hr.3mngo-ue-s5e5tarsm2e2srewc7.k7idt-tiRe-e3tt8idehden42dgo6a3btiu5sohs4y9ttr3siel-swu-ta2r7rbcwerahodi.nt,otnseaklanra,emtepevnedeeosrni,mtntwtiooshsbaieeonn s and Conditions (https://onlinelibrary.w ScBocYilel4en.c0ct)eio;MnCDu(wsCee/ulRlmc.SoL.mCoenrcadoiogllne(,cpWthioieln.lcl.codorcgm.g;oeCvTC)r.uTshte eoPBuobokISIBSBNN:9:7987-83--35-2572-78-28324324-10-3 iley.com/term gpcccchayaraaunctephlmsiedheosisogic.cfehaTnsDlekhiai.ceneritmtDticwenhirmrnoveoreeisfimtrnitlshctaidiweroriicnslaiitlefehpiaemiesrnceermyiptiochnridlteeeisdss.meooaDnfgnatt.smshdiametmpnhaomdeantleoiliitinmatfihsentaiealrl CTGyoepvreemsreaDtnteiysniggn StAradiavme,CDheseingnna,iW,Ienidnihaeim, s-and-conditions) on Wiley O host(dog)andthevector(mosquito).The nline L ltoodehupenevttgieedotrlhenocvspioermdflcoetleheppnmeestnhaoedornfrwittnohstwgiepmosprnaeeapvrtohpeafnsreeiottasixeotci.anmhMgeasaatntoacedfgrlyoetr.creyTeacflhtlemeiccetsnt ibrary for rules of use; O ltLoecprfaroeaffino3ocpns6lmtaceyto0b-nalnirlefcdndeeeeiangfdoesLeyitidusac4ssaitstrgncpelieaanoargogreunnosvoadss.tabn-ieeEnhileddncdsesfuttataoaeoassrargcpgeotdstpweaduiuraosrnoetlna.ntovrdsMdmDeaip1tngcei.r8caaalteia0iimtdivvdnsruedes,emsnolarsttteytmriiDotcdesmiriia.sudn,tiocemmewsi,,nqmehitugshniiictettthhiousesp A articles are governed by the applicable C petoatel.n,tfioarldfoertainilfsesceteiocnh(acpotuerrt9e)s.yofS.Noack reative Com m ons L icense D ow nloaded from v https://onlinelibrary.w iley.com /doi/ by ibrahim ragab - C Contents ochrane Germ any , W iley O ListofContributors ix nline L PPForaerreftawIcoerdHxuixmxvanandAnimalFilariaeandTheirDiseases 1 ibrary on [25/10/2022]. See the T erm 1 BreakingtheSilos–ObstaclesandOpportunitiesfor s and C 2 ORFPioanlsnaecaraiHlaldeeMKaaäaltssmheOirin*rngskFayinl*aisarmniadsseTsim17o3thyG.Geary* onditions (https://onlinelibrary.w 3 HumanFilarialInfections:ReflectionsontheCurrent iley.com UMChnaadnrealergssetDamn.eMdniantcgkeo3nf3zTieh*eirImportance,Pathobiology,and /terms-and-conditions) on W 4 CanineFilariasis(Heartworm)–DiseaseandCurrentGaps 75 iley O DwightD.Bowman*andTimothyK.Wu nline L 5 DCChuiaargrrelnenostsDSis.taMatnaudcskAaesnnsdzeiesC*sh,maAleslhneltnegoyefSsHouumz9a7a,nanFdilaTrimiaoltIhnyfeGc.tiGoenasr:y ibrary for rules of use; O A 67 VSCAAaehnnbtrdteiiirsfinretielownapSarMhiprayeeolrcoDChErihhtva*eaeg,mnaJnodsoo,s*steNhipsielhsoraKfPpaFilymiol:tagtCreniu,aorSl,rtaeIennnvfdteenOcTtipWimotiionloltinhasym1fG2so5,.raGHneduamryans 161 articles are governed by the applicable C reative C om m ons L icense D ow nloaded from vi 8Contents AMnetdifiiclianreialC1h91emotherapy:CurrentOptionsinVeterinary https://onlinelibrary.w JenniferKetzisandChristianEpe* iley.com 9 HPeerasrptewcotrivmeDi2se1a5se–InterventionandIndustry /doi/ by ibrahim SPaanudlrMa.NSoealzcekr,*JohnHarrington,DouglasS.Carithers,RonaldKaminsky,and ragab - C ochrane G 10 CurrentAntifilarialDrugs–MechanismsofAction 249 erm TimothyG.Geary*,AlanLong,andLucienneTritten any , W iley O 11 DrugResistanceinFilariae 283 nline L 12 RBJEoloohigamnekiyrOnePa.rAGtiic.yohaBnaporaoadnnt*idgn*E,rFardainckatOio.nRiochfaHrudmsJar,nKFaiplaarDia.sReasma3ia0h7,and ibrary on [25/10/2022]. See the T erm s and C 13 DPGalaorrtrbeaIlIllEKclDuogrnu*ogamnDidcissJcaoosfvoeHnreyDarfraotkwreNoromveDliAsneatisfielari3a3ls1 329 onditions (https://onlinelibrary.w 14 FPirloadriuacstisPro3fi4l5esforNewDrugsAgainstHumanandAnimal iley.com/term 15 ASDasisbscaionyvese)Srpye3ac6nh7dt*DaenvdeRloopnmaldenKtaomfiNnsekwy*AntifilarialDrugs(InVitro s-and-conditions) on W LucienRufener*,AlexandreVernudachi,RonaldKaminsky,and iley O ThomasDuguet nline L 16 DSInarnuVdgivrsoaMS3co9hd1oerdlserfeotr-WtheebDeri*scaonvdeSryaboifnNeeSwpeAchnttifilarial ibrary for rules of use; O A 1178 ANHITnhneaViettnaiifiAzvliolenSatAarAiigfisa.esllHaarD*ary,iwrsaRurl–egyDglsDuirnikuinas*gcCLoPoivzimpeurenpyldaiainnanei,odannD4dAe8nvW1iemillolaipalsmmeHn4.5tW9ohfiNteew articles are governed by the applicable C reative C om m ons L icense D ow nloaded from PartIII NDiesweaFsreosntie49rs3forControlofAntifilarial Contents vii https://onlinelibrary.w 19 TheHost–HelminthInterfaceasaRichResourceforNovel iley.com DThruogmaTasrBg.eDtsugu4e9t5andLucienneTritten* /doi/ by ibrahim 20 FunctionalGenomicsofFilariae 517 ragab - C EileenDevaney*andColletteBritton* ochrane G erm 21 DevelopmentofaVaccineAgainstOnchocercavolvulus 531 any , W DavidAbraham,BenMakepeace,andSaraLustigman* iley O 2232 SLHVVyoeeurficcimcttjaooaBrrnTaoCCrFdoothionnloarttolrrroivooamillclAAa,PTyppaa*pprnarrjoosaiaatMccehhsceeKssa5ytf4o*o,5rIanCntadenrPirnhueiplltFipiTlraKaraniaussfmmisiasnsi5o6n5of nline Library on [25/10/2022]. See the T erm 24 WDMIniaodsrleebcaxaPsc.ehHs6iaü1b5E5nn8ed9r*o,sKyemnbnieotnhtPsfaasrr,TarenadtmAcehnimtTHarogeeratsufforFilarial s and Conditions (https://onlinelibrary.w iley.com /term s-and-conditions) on W iley O nline L ibrary for rules of use; O A articles are governed by the applicable C reative C om m ons L icense D ow nloaded from ix https://onlinelibrary.w iley.com /doi/ by ibrahim ragab - C List of Contributors ochrane Germ any , W iley O DavidAbraham DwightD.Bowman* nline L TSDIPUmihheSdiopmAnlmaaeudryatnemsKlopJleiohemnffgitamyeo,rePfslAoMMn1iceU9rd1oni0bci7vaioelrlCosigotylyleagned CCDIIUmtooheSrlpmAalncaeueargtln,elmNooUleYfonnVgi1tyve4oet8efr5rsMii3nt-iya6crr4oy0b1Mioeldoigcyinaend ibrary on [25/10/2022]. 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See the T c.chormistian.epe@boehringer-ingelheim [email protected] erms and C CUCDhoenrlpiilvsaetergortepmsihoteefynrVotEefovtGefarIneinosnfraegrciyatiMouesdDiciisneeases AUMancnehdidivmPiecaraHrslaiotMseyirtiHoaclurooofsgbpyiiotlaolgByo,nImn,mInusntoitluotgeyfor onditions (https://onlinelibrary.w Athens,GA30602 Venusberg-Campus1 iley.com USA Building63,53127Bonn /term TMInimcstGoittiulhltyeUGon.fiGvPeeararsraiyst*yitology GCoBfoleuBnrsmontnearnnoyfExcellenceoftheUniversity s-and-conditions) on W 21111LakeshoreRoad Germany iley O Sainte-Anne-de-Bellevue,H9X3V9QC GermanCenterforInfectionResearch nline L CQS&cauhPneaoaetodnhla’osogfUeBnniioBvleioorglsioictgayyl-BSeclifeansctes,Microbes (PBGDaoerZnrtmInnFea)rnsyiteBonn-Cologne ibrary for rules of use; O A 1Nti9moCrothhthleoyr.rngin.IgereeaGlraaynr@ddemncsg,iBlle.clfaastBT95DL MUMIV5m3enae1nmrid2vcui7uecsPrban.BsleHooirtMlünygobn-giHcCnyreoaoarsmb*npidpiotulaPoslagB1rya,osBnitunoi,lloIdnginsytgit6u3te, for articles are governed by the applicable C reative C om m ons L icense D ow nloaded from GCleursmtearnoyfExcellenceoftheUniversity DDaarrrreellllKKlluugg*ConsultingListofContributors xi https://onlinelibrary.w oBfoBnonnn 5UWSAaldronCt.,Greensboro,NC27408 iley.com GGeerrmmaannyCenterforInfectionResearch [email protected] /doi/ by ibrahim (BDoZnInF)PartnersiteBonn-Cologne REelagnincaoLTiizeurngdeisaundheitAG ragab - C [email protected] MSwaitttzeenrsltarnadsse24A,4058Basel ochrane Germ any , W JosephKamgno AlanLong iley O ECoSCUDttpeaenrhnmiepiedvetareeretremrTrt1omsrf.iioo4ooten1ryplno1iRoct,gfeaoFyslYfoeaDaPuanoiurddsucbaehnBlaQidisocoéeunHssaItF(raeCtiatelilRasrttrhFYiic,aiaslFsoMiauscTnau)ndltedyof B3DUSL2aiouSn3reAlad9uhsLtrSlhiuean,sytgetGiFelgAlrimK-tIe3ainm0Bng0*leb9vla6dhlleNiRmWesearchInstitute nline Library on [25/10/2022]. See the T MP.Oed.iBcoinxe1a3n64d,BYiaoomuenddiécalSciences NMeowlecYuolrakrBPlaoroadsitCoelongteyr,,Laboratoryof erms and C CRPAoaaltrnmeaanCeldsrotoneKoisannuml1ti3nin,sgk7y9*685Häg-Ehrsberg NUsClhueSawAsrtliYegsmorDak.n,[email protected]*g onditions (https://onlinelibrary.w Germany NeglectedTropicalDiseaseSupport iley.com [email protected] Center /term PTDehexiplalaisprAtKm&aeuMnfmtUoafnnEivnetrosmityology T3DU3aeS0scAkaWtFueorsr,tcGPeAoGn3lco0eb0da3le0HLeeaolnthAvenue, s-and-conditions) on W CollegeStation,TX77843-2475 [email protected] iley O USA nline L JRMeonesndsiifUceirnnKeiv,eeBtrzisiositmyeSdcihcoaollSocifeVnecteesrinary BUIDneenfnpeivcaMetriratomsknieteyp&neotaGfocLlefoiIbvneafrlepHcoteiooaln,ltIhBnisotiltougtyeof ibrary for rules of use; O A BWaesssteItnerdriee,sSt.Kitts LUiKverpoolL35RF articles are governed by the applicable C reative C om m ons L icense