Hormone Signaling PDF
Preview Hormone Signaling
Hormone Signaling ENDOCRINE UPDATES Shlomo Melmed, MD., Series Editor 1. E.R. Levin and J.L. Nadler (eds.): Endocrinology of Cardiovascular Function. 1998. ISBN: 0-7923-8217-X 2. J.A. Fagin (ed.): Thyroid Cancer. 1998. ISBN: 0-7923-8326-5 3. J.S. Adams and B.P. Lukert (eds.): Osteoporosis: Genetics, Prevention and Treatment. 1998. ISBN: 0-7923-8366-4. 4. B.-A. Bengtsson (ed.): Growth Hormone. 1999. ISBN: 0-7923-8478-4 5. C. Wang (ed.): Male Reproductive Function. 1999. ISBN 0-7923-8520-9 6. B. Rapoport and S.M. McLachlan (eds.): Graves' Disease: Pathogenesis and Treatment. 2000. ISBN: 0-7923-7790-7. 7. W. W. de Herder (ed.): Functional and Morphological Imaging of the Endocrine System. 2000. ISBN 0-7923-7923-9 8. H.G. Burger (ed.): Sex Hormone Replacement Therapy. 2001. ISBN 0-7923-7965-9 9. A. Giustina (ed.): Growth Hormone and the Heart. 2001. ISBN 0-7923-7212-3 10. W.L. Lowe, Jr. (ed.): Genetics ofDiabetes Mellitus. 2001. ISBN 0-7923-7252-2 11. J.F. Habener and M.A. Hussain (eds.): Molecular Basis of Pancreas Development and Function. 2001. ISBN 0-7923-7271-9 12. N. Horseman (ed.): Prolactin. 2001 ISBN 0-7923-7290-5 13. M. Castro (ed.): Transgenic Models in Endocrinology. 2001 ISBN 0-7923-7344-8 14. R. Bahn (ed.): Thyroid Eye Disease. 2001 ISBN 0-7923-7380-4 15. M.D. Bronstein (ed.): Pituitary Tumors in Pregnancy ISBN 0-7923-7442-8 16. K. Sandberg and S.E. Mulroney (eds.): RNA Binding Proteins: New Concepts in Gene Regulation. 2001. ISBN 0-7923-7612-9 17. V. Goffin and P. A. Kelly (eds.): Hormone Signaling. 2002 ISBN 0-7923-7660-9 Hormone Signaling edited by Vincent Goffin, PhD, and Paul A. Kelly, PhD Molecular Endocrinology, Faculty ofM edicine Necker, Paris, France SPRINGER SCIENCE+B USINESS MEDIA, LLC ISBN 978-1-4419-4948-6 ISBN 978-1-4757-3600-7 (eBook) DOI 10.1007/978-1-4757-3600-7 Library of Congress Cataloging-in-Publication Data A C.I.P. Catalogue record for this book is available from the Library of Congress. Copyright © 2002 by Springer Science+Business Media New York Originally published by Kluwer Academic Publishers in 2002 Softcover reprint ofthe hardcover Ist edition 2002 AII rights reserved. No part ofthis publication may be reproduced, stored in a retrieval system Of transmitted in any form Of by any means, mechanical, photo-copying, fecording, or otherwise, without the prior written permission ofthe publisher, Springer Science+Business Media, LLC. Printed an acid-free pap er. The Publisher offers discounls on Ihis book for course use and bulk purchases. For further information, send email Contents v List of Contributors vii Signaling Websites lX Preface xi Acknowledgements xiii Section I Fundamental Mechanisms in Signaling 1 1 Protein Phosphorylation and Protein-Protein Interactions 3 Vincent Goffin and Paul A. Kelly 2 Control of Signaling by Tyrosine Phosphatases 21 Yu Zhao and Zhang-Yin Zhang 3 Spatio-Temporal Parameters: The Case of the MAP Kinase Pathway 37 Veronique Volmat and Jacques Pouyssegur Section II Receptor Tyrosine Kinases 55 4 The EGF Receptor Signaling System. A Model for Growth Factor Receptor Signaling 57 Alan Wells 5 Insulin and Insulin-Like Growth Factor-1 Receptors and Signaling Pathways: Similarities and Differences 81 Derek LeRoith, Michael J. Quon and Yehiel Zick Section III Cytokine Receptors 101 6 The JAK-STAT Pathway 103 Warren J. Leonard 7 Prolactin and Growth Hormone Receptors. Signal Transduction and Crosstalk 121 Li-yuan Yu-Lee and Sebastien Jeay 8 Erythropoietin, Thrombopoietin and Leptin Receptors 145 Fabrice Gouilleux VI Section IV G Protein-Coupled Receptors 179 9 G Proteins and G Protein-Coupled Receptors: Overview 181 Michael A. Shetzline and Marc G. Caron 10 Gonadotropin and TSH Receptors 199 Nicolas de Raux, Beate Doeker and Edwin Milgram 11 Endothelin G Protein-Coupled Receptors 221 Gastone G. Nussdorfer and Gian Paolo Rossi Section V Nuclear Receptors 239 12 Signal Transduction and Structure of Nuclear Receptors 241 William Bourguet, Pierre Germain and Hinrich Gronemeyer 13 Estrogen Receptor Beta: How Awareness of ERB Affects Our Understanding of Estrogen Action 269 Zhang Weihua, Guojun Cheng, Ling Wang, Hideki Sakaguchi, Margaret Warner and Jan-Ake Gustafsson 14 Sensors for Metabolic Control. A Regulatory Network of Nuclear Receptors 283 Beatrice Desvergne, Liliane Michalik and Walter Wahli *** List of Contributors William Bourguet Institute of Genetics and Molecular and Cellular Biology, University of Strasbourg, France Marc G. Caron Howard Hughes Medical Institute Laboratories and Department of Cell Biology and Medicine, Duke University Medical Center, Durham, USA Guojun Cheng Department of Medical Nutrition and Department of Bioscience, Karolinska Institute, Huddinge, Sweden Nicolas de Roux lnserm Unit 135, Hormone and Molecular Biology Laboratory, Hopi tal Bicetre, Le Kremlin Bicetre, France Beatrice Desvergne Institute of Animal Biology, Faculty of Sciences, University of Lausanne, Switzerland Beate Doeker lnserm Unit 135, Hormone and Molecular Biology Laboratory, Hopi tal Bicetre, Le Kremlin Bicetre, France Pierre Germain Institute of Genetics and Molecular and Cellular Biology, University of Strasbourg, France Vincent Goffin Inserm Unit 344, Molecular Endocrinology, Faculty of Medicine Necker, Paris, France Fabrice Gouilleux Laboratory of Immunology, School of Medicine, University of Picardie, Amiens, France Hinrich Gronemeyer Institute of Genetics and Molecular and Cellular Biology, University of Strasbourg, France Jan-Ake Gustafsson Department of Medical Nutrition and Department of Bioscience, Karolinska Institute, Huddinge, Sweden Sebastien Jeay Inserm Unit 344, Molecular Endocrinology, Faculty of Medicine Necker, Paris, France Current address: Boston University, School of Medicine, Department of Biochemistry, Boston, USA Paul A. Kelly Inserm Unit 344, Molecular Endocrinology, Faculty of Medicine Necker, Paris, France Warren J. Leonard Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, NIH, Bethesda, USA Derek LeRoith Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, USA Liliane Michalik Institute of Animal Biology, Faculty of Sciences, University of Lausanne, Switzerland Edwin Milgrom Inserm Unit 135, Hormone and Molecular Biology Laboratory, Hopi tal Bicetre, Le Kremlin Bicetre, France viii Gastone G. Nussdorfer Department of Human Anatomy and Physiology, School of Medicine, University of Padua, Italy. Jacques Pouyssegur Institute of Signaling, Developmental Biology and Cancer Research, Centre Antoine Lacassagne, Nice, France Michael J. Quon Cardiology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, USA Gian Paolo Rossi Department of Clinical and Experimental Medicine, School of Medicine, University of Padua, Italy. Hideki Sakaguchi Department of Medical Nutrition and Department of Bioscience, Karolinska Institute, Huddinge, Sweden Michael A. Shetzline Howard Hughes Medical Institute Laboratories and Department of Cell Biology and Medicine. Duke University Medical Center, Durham, USA Veronique Volmat Institute of Signaling, Developmental Biology and Cancer Research, Centre Antoine Lacassagne, Nice, France Walter Wahli Institute of Animal Biology, Faculty of Sciences, University of Lausanne, Switzerland Ling Wang Department of Medical Nutrition and Department of Bioscience, Karolinska Institute, Huddinge, Sweden Margaret Warner Department of Medical Nutrition and Department of Bioscience, Karolinska Institute, Huddinge, Sweden Zhang Weihua Department of Medical Nutrition and Department of Bioscience, Karolinska Institute, Huddinge, Sweden Alan Wells Department of Pathology, University of Pittsburgh and V AMC, Pittsburgh, USA Li-yuan Yu-Lee Departments of Medicine, Molecular & Cellular Biology, and Immunology, and Cell & Molecular Biology Program, Baylor College of Medicine, Houston, USA Zhong-Yin Zhang Department of Molecular Pharmacology, Albert Einstein College of Medicine, New York, USA Yu Zhao Department of Molecular Pharmacology, Albert Einstein College of Medicine, New York, USA Yehiel Zick Department of Molecular Cell Biology, the Weizmann Institute of Science, Rehovot, Israel *** Signaling Websites Below are listed access addresses of a few websites related to intracellular signaling (this list is not exhaustive). General information on signaling and cell biology http://www. bio.davidson.edu/people/kabemd/cb/We b.htm http://stke.sciencemag.org/ http://www .elsevier.cornllocate/cellsig http://www .sugen.com/webpage_templates/sec. php3 ?page_name=inside_signal http://www .new-science-press.corn/cells-primer.asp http://www .apnet.corn/cytokinereference/ http://web.indstate.edu/thcme/mwking/signal-transduction.htrnl Signaling, cancer, development, cell motility http://www.unice.fr/biochirnie/ http://path.upmc.edu/divisions/wells-lab/wells.htm http://researchportfolio.cancer.gov/ http://www.aecom.yu.edu/asb/segall/segall.htm Sequence abalysis/domain research/protein structure http://www.ncbi.nlm.nih.gov/Entrezl http://www .rcsb.org/pdb/ http://smart.embl-heidelberg.de/ http://www .mshri.on.calpawson/research 1.htrnl http://saturn.med.nyu.edu/groups!HubbardLab/ Nuclear receptors http://receptors.ucsf.edu/NRI G protein-coupled receptors http://archi ve.uwcm.ac. uk/uwcrn/mg/search/ 125313 .htrnl http://www.cmbi.kun.nl/7tm/ http://www .gpcr .org/7tm/ http://www.expasy.org/cgi-bin!lists?7tmrlist.txt http://tinyGRAP.uit.no/ http://www .tumor-gene.org/GPCR/gpcr.htrnl **** Preface Multicellular organisms require a means of intracellular communication, in order to first organize and develop the complex body plan that occurs during embryogenesis and then for the cell and organ systems to access and respond to an ever changing milieu. The mediators of this constant exchange of information are growth factors, neurotransmmitters, peptide and protein hormones which bind to cell suiface receptors and transduce their signals from the extracellular space to the intracellular compartment. Via multiple signaling pathways, receptors of this general class affect varying processes, including growth, development and differentiation. Other small, hydrophobic signaling molecules, such as steroids and non-steroid hormones, some vitamins and certain metabolic mediators interact with receptors that form a large family known as nuclear receptors. These receptors function as transcription factors affecting gene expression, to regulate the multiple aspects of animal and human physiology, including development, reproduction and homeostasis. The aim of this book is to cover in five sections various aspects of intracellular signaling involving hormone receptors. The first section is a general overview of the process of hormonal signaling, with a description of the important role of protein phosphorylation and protein-protein interactions. This is followed by a chapter on the function of protein dephosphorylation by tyrosine phosphatases. Since mitogen activated protein kinase (MAPK) pathways play such a key role in physiology and pathology, they are discussed in the last of these introductory chapters, with particular emphasis given to the spatia-temporal context that one should always consider when trying to understand the complex field of hormone signaling. Section II deals with the specific class of receptor tyrosine kinases ( RTK) signaling. This covers the broad category of growth factors in general, and two specific cases are described in two separate chapters: epidermal growth factor (EGF) receptors, and insulin and insulin-like growth factor (IGF) receptors.
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