Hormone Replacement Therapy and Osteoporosis PDF
Preview Hormone Replacement Therapy and Osteoporosis
Ernst Schering Research Foundation Workshop Supplement 4 Hormone Replacement Therapy and Osteoporosis Springer-Verlag Berlin Heidelberg GmbH Ernst Schering Research Foundation Workshop Supplement 4 Hormone Replacement Therapy and Osteoporosis J. Kato, H. Minaguchi, Y. Nishino Editors With 74 Figures and 15 Tables Springer Series Editors: G. Stock and M. Lessl ISSN 0947-6075 ISBN 978-3-662-04023-2 CIP data applied for Die Deutsche Bibliothek - CIP-Einheitsaufnahme Schering-Forschungsgesellschaft <Berlin>: [Ernst Schering Research Foundation Workshop / Supplement]. Ernst Schering Research Foundation Workshop. Supplement. -1-... Erscheint unregelmaBig. -Bibliographische Deskription nach 5 (1999) Reihe Supplemnt zu: Schering-Forschungsgesellschaft <Berlin>: Ernst Schering Re search Foundation Workshop 4. Hormone replacement therapy and osteoporosis. -2000 Hormone replacement therapy and osteoporosis / Ernst Schering Research Foundation. J. Kato ... ed. (Ernst Schering Research Foundation Workshop: Supplement; 4) ISBN 978-3-662-04023-2 ISBN 978-3-662-04021-8 (eBook) DOI 10.1007/978-3-662-04021-8 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illus trations, recitation, broadcasting, reproduction on microfilms or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag Berlin Heidelberg GmbH. Viola-tions are liable for prosecution under the German Copyright Law. © Springer-Verlag Berlin Heidelberg 2000 Originally published by Springer-Verlag Berlin Heidelberg New York in 2000 Softcover reprint of the hardcover 1st edition 2000 The use of general descriptive names, registered names, trademarks, etc. in this publica tion does not imply, even in the absence of a specific statement, that such names are ex empt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Typesetting: Data conversion by Springer-Verlag SPIN: 10691243 21/3 I 34/AG-5 4 3 21 O-Printedon acid-free paper Preface This book presents the Proceedings of the International Joint Work shop of Nihon Schering and the Ernst Schering Research Foundation on "Hormone Replacement Therapy," which took place on 9-11 No vember 1998 in Osaka, Japan. In cases of advanced age, hormone replacement therapy (HRT) is becoming increasingly important both for women's health and for the doctors in our profession. In-depth understanding of HRT is needed. The organizers and editors intended the workshop to consist of six ses sions, as follows: 1. Overview of HRT 2. Basic aspects of steroid hormones 3. HRT and the brain 4. The influence of HRT on lipids and the cardiovascular system 5. HRT and bone 6. HRT - its effects and risks It was also intended that each session should be a combination of basic and clinical lectures. Without a basic understanding of sex steroid hormones in targets such as the reproductive organs, including the breast and uterus, and the brain, as well as non-targets (bone), possibilities for improving treatment would not emerge. This we firmly believe. The front-runners from at home and abroad in this field joined the workshop to provide the most advanced knowledge and state-of-the-art information, basic and clinical, regarding HRT. VI Preface The participants in the workshop Active and useful discussions and comments also emerged during the course of the workshop. funza Kata, Hiroshi Minaguchi, Yukishige Nishina Table of Contents General Aspects of Worldwide HRT Use HP.G. Schneider ........ . 2 General Aspects of HRT in Japan T. Aono, K. Azuma, M. Irahara .. 29 3 Recent Advances in Steroid Receptor Research: Focusing on Estrogen Receptors M. Muramatsu, S. Ogawa, T. Watanabe, K. Ikeda, H Hiroi, A. Orimo, S. Inoue . . . . . . . . . . . . . . . .. 43 4 Global Effects of Estrogens in the Adult Central Nervous System D.W. Pfaff . ............. . 63 5 HRT and Brain Function - Clinical Aspects T. Ohkura, K. Isse, K. Tanaka, K. Akazawa, M. Hamamoto, N. Iwasaki . . . . . . . . . . . . . . . . . . . . . . . . . .. 75 6 Hormone Replacement Therapy and Lipids H Honjo, M. Urabe, K. Tanaka, T. Kashiwagi, T. Okubo, H Tsuchiya, K. Iwasa, N. Kikuchi, T. Yamamoto 99 7 HRT and the Vascular System- Direct Action of Estrogen on Vascular Smooth Muscle Cells M. Nozaki . . . . . . . . . . . . . . . . . . . . . . . . . . . 115 VIII Table of Contents 8 The Place of Estriol Add-Back Therapy in Women Treated with GnRH Agonist, with Reference to Bone Protection T. Yano, A. Kikuchi, H. Matsumi, Y. Wang, H. Nakayama, Y. Taketani ......................... 127 9 Hypoestrogenic Bone Loss and HRT: The Predictive Value of Biochemical Markers of Bone Turnover H. Minaguchi, M.G. Zhang, M. Taga ............ 143 10 HRT and Climacteric Symptoms: Characteristics in Japanese Women T. Aso ............... . 165 11 The Mechanisms of Bone Loss due to Estrogen Deficiency: Possible Role of Increased B-Lymphopoiesis in Bone Resorption C. Miyaura .......................... 171 Subject Index ......................................... 185 Previous Volumes Published in this Series .................. 187 List of Editors and Contributors Editors J. Kato Teikyo Heisei Junior College, 6-29-1 Ichiharadai, lchihara-shi, Chiba, 290-0192, Japan H. Minaguchi Minaguchi Hospital, 1-7-7 Minamicho, Kichijoji Musashino-shi, Tokyo,ISO-0003,Japan Y. Nishino Preclinical Development Department, Nihon Schering K.K., 6-64, Nishimiyahara 2-Chome, Yodogawa-ku, Osaka-shi, Osaka, 532-0004, Japan Contributors K. Akazawa Dokkyo Medical University, Department of Obstetrics and Gynecology, Koshigaya Hospital, 2-1-50 Minami-koshigaya, Koshigaya-shi, Saitama, 343-8555, Japan T. Aono Tokushima University, School of Medicine, Department of Obstetrics and Gynecology, 3-18-15 Kuramoto-cho, Tokushima-shi, Tokushima, 770-8503, Japan x List of Editors and Contributors T. Aso Tokyo Medical and Dental University, School of Medicine, Department of Obstetrics and Gynecology, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-0034, Japan K. Azuma Tokushima University, School of Medicine, Department of Obstetrics and Gynecology, 3-18-15, Kuramoto-cho, Tokushima-shi, Tokushima, 770-8503, Japan M. Hamamoto Dokkyo Medical University, Department of Obstetrics and Gynecology, Koshigaya Hospital, 2-1-50 Minami-koshigaya, Koshigaya-shi, Saitama, 343-8555, Japan H. Hirai Saitama Medical School, Department of Biochemistry, 38 Morohongo, Moroyama-machi, Irima-gun, Saitama, 350-0495, Japan H. Honjo Kyoto Prefectural University of Medicine, Department of Obstetrics and Gynecolgy, 465 Kajii-cho, Hirokojiagaru, Kawaramachidori, Kamigyo-ku, Kyoto, 602-0841, Japan K. Ikeda Saitama Medical School, Department of Biochemistry, 38 Morohongo, Moroyama-machi; lrima-gun, Saitama, 350--0495, Japan S.Inoue Saitama Medical School, Department of Biochemistry, 38 Morohongo, Moroyama-machi, Irima-gun, Saitama, 350--0495, Japan M.Irahara Tokushima University, School of Medicine, Department of Obstetrics and Gynecology, 3-18-15, Kuramoto-cho, Tokushima-shi, Tokushima, 770-8503, Japan K. Isse Dokkyo Medical University, Department of Obstetrics and Gynecology, Koshigaya Hospital, 2-1-50 Minami-koshigaya, Koshigaya-shi, Saitama, 343-8555, Japan
The list of books you might like
