Hormone Action Part H: Neuroendocrine Peptides

761 Pages·1983·20.113 MB·English

by  P. Michael Conn (Eds.)

Contributors to Volume 103
elcitrA srebmun are ni parentheses gniwollof the names of .srotubirtnoc
snoitailiffA listed era .tnerruc
VINCENT ARGIRO (20), Biological Sciences PETER BI~HLEN (5), Laboratories for Neu-
Group, University of Connecticut, Storrs, roendocrinology, The Salk Institute, La
Connecticut 06268 Jolla, California 92037
JUN ARITA (41), Second Department of MILTON W. BRIGHTMAN (ll), Section on
Physiology, Yokohama City University Neurocytology, Laboratory of Neuropa-
School of Medicine, Yokohama, Japan thology and Neuroanatomical Sciences,
National Institute of Neurological and
ANTHONY AUERBACH (9), Department of
Communicative Disorders and Stroke,
Biophysical Sciences, State University of
National Institutes of Health, Bethesda,
New York, Buffalo, New York 41241
Maryland 50202
JEEFERY L. BARKER (6), Laboratory of Neu- RICHARD D. BROADWELL (11), Department
rophysiology, National Institute of Neu-
of Pathology, Division of Neuropathol-
rological and Communicative Disorders
ogy, University of Maryland School of
and Stroke, National Institutes of Health,
Medicine, Baltimore, Maryland 10212
Bethesda, Maryland 50202
THOMAS BRUHN (38), Peptide Biology Lab-
JORGE BARTOLOME (40), Department of oratory, The Salk Institute, La Jolla, Cali-
Pharmacology, Duke University Medical
fornia 92037
Center, Durham, North Carolina 27710
JOHN C. CAMBIER (13), Division of Basic
ELENA L. F. BATTENaERG (46), Division of Immunology, Department of Medicine,
Pre-Clinical Neuroseience and Endocri- National Jewish Hospital Research Cen-
nology, Research Institute of the Scripps ter~National Asthma Center, Denver,
Clinic, La Jolla, California 73029 Colorado 80206
NIRA BEN-JONATHAN (14), Department of J. PATRICK CARD (42), Department of Neu-
Physiology, Indiana University School of rology, State University of New York at
Medicine, Indianapolis, Indiana 46223 Stony Brook, Stony Brook, New York
BARBARA A. BENNETT (33), Department of 49711
Medicine and Clinical Pharmacology, MARC G. CARON (39), Departments of Phys-
University of Colorado Health Science iology and Medicine, Duke University
Center, Denver, Colorado 26208 Medical Center, Durham, North Carolina
CYNTHIA BETHEA (16), Department of Re- 01772
productive Physiology, Oregon Regional KWEN-JEN CHANG (12), Molecular Biology
Primate Center, Beaverton, Oregon 60079 Department, The Wellcome Research
STEVEN G. BLANCHARD (12), Molecular Bi- Laboratory, Research Triangle Park,
ology Department, The Wellcome Re- North Carolina 27709
search Laboratories, Research Triangle RICHARD N. CLAYTON (2), Department of
Park, North Carolina 27709 Medicine, University of Birmingham, Bir-
mingham B15 2TH, England
FLOYD E. BLOOM (46), Division of Pre-Clin-
ical Neuroscience and Endocrinology, P. MICHAEL CONN (3, 26), Department of
Research Institute of the Scripps Clinic, Pharmacology, Duke University Medical
La Jolla, California 92037 Center, Durham, North Carolina 27710
ix
X CONTRIBUTORS TO VOLUME 103
HPLAR L. REPOOC (32), Center for the Study School of Medicine, San Francisco, Cali-
of Aging and Human Development and fornia 34149
Department of Psychiatry, Duke Univer-
TREBOR S. DOOWNEERG (8), Department of
sity Medical Center, Durham, North Car-
Neurology, University of North Carolina,
olina 27710
Chapel Hill, North Carolina 27514
MICHAEL J. CRONIN (17), Department of KENNETH A. GRUBER (35), Department of
Physiology, University of Virginia Medi- Medicine, Bowman Gray School of Medi-
cal Center, Charlottesville, Virginia 22908 cine of Wake Forest University, Winston-
ORDEP SASACERTAUC (12), Molecular Biol- Salem, North Carolina 27103
ogy Department, The Wellcome Research
CURTIS C. HARRIS (27), Laboratory of Hu-
Laboratories, Research Triangle Park,
man Carcinogenesis, National Cancer In-
North Carolina 27709
stitute, National Institutes of Health, Be-
DAVID NOTLAD (38), Peptide Biology Labo- thesda, Maryland 50202
ratory, The Salk Institute, La Julia, Cali-
J. MICHAEL HATFIELD (15), Department of
fornia 92037
Biochemistry, Microbiology, Molecular
NYLORAC DOUGLAS (38), Peptide Biology and Cell Biology, Pennsylvania State
Laboratory, The Salk Institute, La Julia, University, University Park, Pennsylva-
California 92037 nia 20861
FERNAND DRAY (27), Radioimmunoassay JAMES N. HAYWARD (8), Department of
Unit, INSERM U.207 and Institut Pas- Neurology, University of North Carolina,
teur, 75015 Paris, France Chapel Hill, North Carolina 27514
DRANREB DUFY (6), Laboratoire de Neuro- ELI HAZUM (4), Department of Hormone
physiologie, Universitd de Bordeaux H, Research, The Weizmann Institute of Sci-
67033 Bordeaux Cedex, France ence, Rehovot 76100, Israel
LUCE DUFY-BARBE (6), Laboratoire de R. WAYNE HENDREN (37), Chemistry and
Neurophysiologie, Universitd de Bor- Life Sciences Group, Research Triangle
deaux H, 33076 Bordeaux Cedex, France Institute, Research Triangle Park, North
EGROEG S. HTRABNESIE (30), Joslin Diabe- Carolina 27709
tes Center~Brigham Hospital, Harvard MICHAEL T. HOEFER (14), Department of
Medical School, Boston, Massachusetts
Physiology, University of Pittsburgh
51220 School of Medicine, Pittsburgh, Pennsyl-
FRED S. ESCH (5), Laboratories for Neu- vania 06251
roendocrinology, The Salk Institute, La
GNOYHS-UAJ HONG (37), Laboratory of Be-
Jolla, California 92037
havioral and Neurological Toxicology,
WILLIAM S. EVANS (17), Department of In- National Institute of Environmental
ternal Medicine, University of Virginia Heatlh Sciences, Research Triangle Park,
Medical Center, Charlottesville, Virginia North Carolina 27709
80922 YELSEW C. HYMER (15), Department of Bio-
Debra A. Evenson (25), Department of chemistry, Microbiology Molecular and
Pharmacology, Duke University Medical Cell Biology, Pennsylvania State Univer-
Center, Durham, North Carolina 27710 sity, University Park, Pennsylvania 20861
ANNIE FAIVRE-BAUMAN (19), Groupe de EPPILIHP JAQUET (16), Clinique Endocrino-
Neuro-endocrinologie Cellulaire, egOlloC logique, Hopital la Conception, 13385
de France, 13257 Paris Cedex ,50 France Marseille, France
DENIS J. ZCIWORADOPSOG (16), Cancer RAHTOL JENNES (29), Department of Anat-
Research Center, University of California omy, University of North Carolina School
CONTRIBUTORS TO VOLUME 103 xi
of Medicine, Chapel Hill, North Carolina JOHN G. EORNOM (13), Department of Pa-
27514, and Department of Pharmacology, thology, Harvard Medical School, Bos-
Duke University Medical Center, Dur- ton, Massachusetts 51120
ham, North Carolina 27710
TREBOR Y. MOORE (42), Department of
YRAM I. JOHNSON (20), Department of Neurology, State University of New York
Anatomy and Neurobiology, Washington at Stony Brook, Stony Brook, New York
University School of Medicine, St. Louis, 49711
Missouri 01136
JOHN I. LLERROM (44), The Rockefeller Uni-
NAMRON W. KASTING (10), Department of versity, New York, New York 12001
Physiology, Faculty of Medicine, Univer- ANAIRAM MORRIS (33, 35), Department of
sity of British Columbia, Vancouver, Brit- Physiology and Pharmacology, Bowman
ish Columbia V6T 1W5, Canada Gray School of Medicine of Wake Forest
NAIRB F. KCIRTAPLIK (39), Departments of University, Winston-Salem, North Caro-
lina 27103
Physiology and Medicine, Duke Univer-
sity Medical Center, Durham, North Car- J. VICTOR NADLER (25), Department of
olina 27710 Pharmacology, Duke University Medical
Center, Durham, North Carolina 27710
NAMRON KIRSHNER (18), Department of
Pharmacology, Duke University Medical PHILLIP G. NELSON (7), Laboratory of De-
Center, Durham, North Carolina 27710 velopmental Neurobiology, National In-
stitute of Child Health and Human Devel-
JOHN STEPHEN KIZER (28), Biological Sci-
opment, National Institutes of Health,
ences Research Center, University of
Bethesda, Maryland 50202
North Carolina School of Medicine,
Chapel Hill, North Carolina 27514 JOHN W. OLNEY (24), Department of Psy-
chiatry, Washington University School of
SEMAJ E. KRAUSE (34, 36), Department of Medicine, St. Louis, Missouri 01136
Neurobiology and Behavior, State Uni-
SOLKIM STIVOKLAP (23), First Department
versity of New York at Stony Brook,
of Anatomy, Semmelweis University
Stony Brook, New York 49711
Medical School, Budapest ,0541-1-1 Hun-
SALOHCIN C. LING (5), Laboratories for gary
Nearoendocrinology, The Salk Institute,
EDNA PELEG (14), Department of Physiol-
La Jolla, California 92037
ogy, Indiana University School of Medi-
CATHERINE LOUDES (19), Groupe de cine, Indianapolis, Indiana 46223
Neuro-endocrinologie Cellulaire, Col-
TREBOR A. DNUERFRETEP (21), Peptide Bi-
ldge de France, 75231 Paris Cedex ,50
ology Laboratory, The Salk Institute, La
France
Jolla, California 92037
HPESOJ B. MARTIN (10), Harvard Medical DONALD W. PFAFF (44), The Rockefeller
School and Massachusetts General Hos- University, New York, New York 12001
pital, Boston, Massachusetts 41120
PAUL M. YKSTOLP (31), Peptide Biology
YERFFEJ F. MCKELVY (34, 36), Department Laboratory, The Salk Institute, La Jolla,
of Neurobiology and Behavior, State Uni- California 92037
versity of New York at Stony Brook,
JOHN C. PORTER (41), Cecil H. and Ida
Stony Brook, New York 49711
Green Center for Reproductive Biology
RICK B. MEEKER (8), Department of Neu- Sciences, Departments of Obstetrics and
rology, University of North Carolina, Gynecology and Physiology, The Univer-
Chapel Hill, North Carolina 27514 sity of Texas Health Science Center at
xii CONTRIBUTORS TO VOLUME 103
Dallas, Southwestern Medical School, JANICE F. SISSOM (41), Cecil H. and Ida
Dallas, Texas 53257 Green Center for Reproductive Biology
Sciences, Department of Obstetrics and
NOLEDAM T. PRICE (24), Department of
Gynecology, ehT University of Texas
Psychiatry, Washington University
Health Science Center at Dallas, Dallas,
School of Medicine, St. Louis, Missouri
Texas 53257
01136
JOHN S. LLEDSMAR (16), Laboratory of -xoT ERODOEHT A. NIKTOLS (40), Department of
icology, Harvard School of Public Pharmacology, Duke University Medical
Health, Boston, Massachusetts 50079 Center, Durham, North Carolina 01772
TRoY A. REAVES, JR. (8), Department of JOHN M. STEWART (1), Department of Bio-
Neurology, University of North Carolina, chemistry, University of Colorado School
Chapel Hill, North Carolina 41572 of Medicine, Denver, Colorado 26208
ENNAIRAM J. REYMOND (41), Division of RETLAW E. STUMPF (29, 43), Department of
Endocrinology, Department of Internal Anatomy, University of North Carolina
Medicine, C.H.U. V., Lausanne, Switzer- School of Medicine, Chapel Hill, North
land Carolina 41572
ENIREHTAC RIVIER (38), Peptide Biology DAVID K. GREBDNUS (33, 35), Department
Laboratory, ehT Salk Institute, La Jolla, of Physiology and Pharmacology, Bow-
California 73029 man Gray School of Medicine, Wake For-
JEAN RIVIER (38), Peptide Biology Labora- est University, Winston-Salem, North
tory, ehT Salk Institute, La Jolla, -rofilaC Carolina 30172
ain 73029 YRRAL W. NOSNAWS (45), ehT Salk Insti-
CATHERINE ROUGEOT (27), Radioimmu- tute, La Jolla, California 73029
noassay Unit, INSERM U.207 and Insti- LEAHCIM O. RENROHT (17), Department of
tut Pasteur, 75015 Paris, France Internal Medicine, University of ainigriV
KCIREDERF SACHS (9), Department of Bio- Medical Center, Charlottesville, Virginia
physical Sciences, State University of 80922
New York, Buffalo, New York 41241 E~IRDNA TIXIER-VIDAL (19), Groupe de
ADNANABAHDAM RAS (43), Department of Neuro-endocrinologie Cellulaire, Colldge
Anatomy, University of North Carolina, de France, 13257 Paris Cedex ,50 France
Chapel Hill, North Carolina 41572
DOOWNNELG E. SREVIRT (27), Laboratory
DRAHCIR M. ECRAECS (30), Department of of Human Carcinogenesis, National Can-
Medicine, Duke University Medical Cen- cer Institute, National Institutes of
ter, Durham, North Carolina 01722 Health, Bethesda, Maryland 50202
SEMAJ M. SCHAEFFER (22), Department of WYLIE VALE (21, 38), Peptide Biology Lab-
Reproductive Medicine, University of oratory, ehT Salk Institute, La Jolla, Cali-
California, San Diego, La Jolla, Califor- fornia 73029
nia 39029 JOAN NAHGUAV (38), Peptide Biology Labo-
WILLIAM J. REKAMEOHS (21), A. .V Davis ratory, ehT Salk Institute, La Jolla, Cali-
Center, ehT Salk Institute, La Jolla, Cali- fornia 73029
fornia 73029
DRAHCIR F. WALKER (32), Department of
DIVAD R. SIBLEY (39), Departments of Bio- Anatomy and Sanders-Brown Research
chemistry and Medicine, Duke University Center on Aging, University of Kentucky
Medical Center, Durham, North Carolina Medical Center, Lexington, Kentucky
01772 ~. 63504
CONTRIBUTORS TO VOLUME 103 xiii
DRAHCIR I. WEINER (16), Department of NEVETS P. WILSON (18), Department of
,scirtetsbO Gynecology and evitcudorpeR ,ygolocamrahP Duke ytisrevinU Medical
Sciences, University of ainrofilaC School ,retneC Durham, North aniloraC 01772
of Medicine, San Francisco, ainrofilaC
ELYAG OTOMAMAY (38), Peptide Biology
34149
,yrotarobaL ehT Salk Institute, La ,alloJ
ainrofilaC 73029
YRAG KOORBTSEW (7); yrotarobaL of -leveD
IKAUZAK AWAK1HSOY (37), Laboratory of
opmental Neurobiology, National Insti-
laroivaheB and Neurological ,ygolocixoT
tute of dlihC Health and Human -poleveD
National Institute of Environmental
ment, National Institutes of Health,
Health Sciences, Research elgnairT ,kraP
Bethesda, Maryland 50202
North aniloraC 90772
YERFFEJ D. WHITE (34), Department of MAILLIW W. DOOLBGNUOY (28), lacigoloiB
Neurobiology and Behavior, State -inU Sciences Research Center, University of
versity of New York at Stony Brook, North Carolina School of Medicine,
Stony Brook, New York 49711 lepahC Hill, North aniloraC 41572
Preface
A survey of the current biological literature will convince even the
most skeptical individual of the substantive and pervasive advances that
have occurred in neuroendocrinology. It was the observation that this
rapid growth resulted in large part from methodological improvements
which first suggested the need for this volume.
Some of the advances can be easily recognized. High pressure liquid
chromatography, once a tool of the solvent chemist, is now a routine
analytical and preparative method in biological laboratories. It has en-
hanced the speed and resolution with which neuroendocrine substances
can be separated. Likewise, peptide synthesis, modification, and analysis
are no longer the ken of those whose work is dedicated solely to this task,
rather, as one of the authors put it, "almost anyone can synthesize a
peptide." Analytical advances have extended the sensitivity and specific-
ity of assay techniques. Culture techniques have been devised which
allow us to purify and maintain isolated cells and tissue. In turn, these
enhancements have revealed the presence and biological roles of new
neuroendocrine substances; in other cases, novel and surprising sites of
action have been identified for substances already described.
Every effort has been made to provide a comprehensive volume. In
some instances, techniques relevant to neuroendocrinology have been
described in previous volumes. To facilitate locating these chapters, a
cross-index is provided at the end of the volume. Omissions are certainly
present. These result from prior commitments of some potential authors,
editorial oversight, or timing of new developments relative to the publica-
tion deadlines.
I certainly appreciate the guidance of Drs. Colowick and Kaplan as
well as the staff of Academic Press. Particular thanks are also extended to
the individual authors for their effort, patience, and cooperation in meet-
ing editorial deadlines.
P. MICHAEL CONN
VX
METHODS IN ENZYMOLOGY
EDITED BY
Sidney P. Colowick and Nathan O. Kaplan
VANDERBILT UNIVERSITY DEPARTMENT OF CHEMISTRY
SCHOOL OF MEDICINE UNIVERSITY OF CALIFORNIA
NASHVILLE, TENNESSEE AT SAN DIEGO
LA JOLLA, CALIFORNIA
I. Preparation and Assay of Enzymes
II. Preparation and Assay of Enzymes
III. Preparation and Assay of Substrates
IV. Special Techniques for the Enzymologist
V. Preparation and Assay of Enzymes
VI. Preparation and Assay of Enzymes )deunitnoC(
Preparation and Assay of Substrates
Special Techniques
VII. Cumulative Subject Index
iivx
METHODS IN ENZYMOLOGY
EDITORS-IN-CHIEF
Sidney P. Colowick Nathan O. Kaplan
EMULOV VIII. Complex Carbohydrates
Edited by ELIZABETH F. NEUFELD DNA ROTCIV GRUBSNIG
EMULOV IX. Carbohydrate Metabolism
Edited by SILLIW A. DOOW
EMULOV X. Oxidation and Phosphorylation
Edited by RONALD W. KOORBATSE DNA DRANYAM E. NAMLLUP
EMULOV XI. Enzyme Structure
Edited by C. H. W. SRIH
EMULOV XII. Nucleic Acids (Parts A and B)
Edited by ECNERWAL NAMSSORG DNA KIVlE EVADLOM
EMULOV XIII. Citric Acid Cycle
Edited yb J. M. NIETSNEWOL
EMULOV XIV. Lipids
Edited by J. M. NIETSNEWOL
EMULOV XV. Steroids and Terpenoids
Edited by DNOMYAR B. NOTYALC
EMULOV XVI. Fast Reactions
Edited yb HTENNEK NITSUK
EMULOV XVII. Metabolism of Amino Acids and Amines (Parts A and )B
Edited yb TREBREH ROBAT DNA AILEC ETIHW ROBAT
EMULOV XVIII. Vitamins and Coenzymes (Parts A, B, and C)
Edited by DONALD B. KCIMROCCM DNA LEMUEL D. WRIGHT
EMULOV XIX. Proteolytic Enzymes
Edited by GERTRUDE E. NNAMLREP DNA LASZLO DNAROL
xix
XX METHODS IN ENZYMOLOGY
EMULOV XX. Nucleic Acids and Protein Synthesis (Part )C
Edited by KIVIE EVADLOM DNA ECNERWAL NAMSSORG
EMULOV XXI. Nucleic Acids (Part D)
Edited by ECNERWAL NAMSSORG DNA KIVIE EVADLOM
EMULOV XXII. Enzyme Purification and Related Techniques
Edited by MAILLIW I. YBOKAJ
EMULOV XXIII. Photosynthesis (Part A)
Edited by YNOHTNA NAS ORTEIP
EMULOV XXIV. Photosynthesis and Nitrogen Fixation (Part )B
Edited by YNOHTNA NAS ORTEIP
EMULOV XXV. Enzyme Structure (Part B)
Edited by C. H. W. SRIH DNA EGRES N. FFEHSAMIT
EMULOV XXVI. Enzyme Structure (Part )C
Edited by C. H. W. HIRS DNA EGRES N. FFEHSAMIT
EMULOV XXVII. Enzyme Structure (Part D)
Edited by C. H. W. HIRS DNA EGRES N. FFEHSAMIT
EMULOV XXVIII. Complex Carbohydrates (Part )B
Edited by ROTCIV GRUBSNIG
EMULOV XXlX. Nucleic Acids and Protein Synthesis (Part E)
Edited by ECNERWAL NAMSSORG DNA KIVIE EVADLOM
EMULOV XXX. Nucleic Acids and Protein Synthesis (Part F)
Edited by KIVIE EVADLOM DNA ECNERWAL NAMSSORG
LXXX~EMULOV Biomembranes (Part A)
Edited by YENDIS REHCSIELF DNA RETSEL REKCAP
EMULOV XXXII. Biomembranes (Part B)
Edited by SIDNEY REHCSIELF DNA RETSEL REKCAP
EMULOV XXXIII. Cumulative Subject Index Volumes I-XXX
Edited by AHTRAM G. DNA,SINNED DRAWDE A. SINNED
xxi
METHODS IN ENZYMOLOGY
EMULOV XXXIV. Affinity Techniques (Enzyme Purification: Part )B
Edited by MAILLIW B. YBOKAJ DNA MEIR KEHCLIW
EMULOV XXXV. Lipids (Part B)
Edited by NHOJ M. NIETSNEWOL
EMULOV XXXVI. Hormone Action (Part A: Steroid Hormones)
Edited by TREB W. YELLAM'O DNA LEOJ G. NAMDRAH
EMULOV XXXVII. Hormone Action (Part :B Peptide Hormones)
Edited yb TREB W. YELLAM'O DNA LEOJ G. NAMDRAH
EMULOV XXXVIII. Hormone Action (Part :C Cyclic Nucleotides)
Edited by LEOJ G. NAMDRAH DNA TREB W. YELLAM'O
EMULOV XXXIX. Hormone Action (Part D: Isolated Cells, Tissues, and
Organ Systems)
Edited yb LEOJ G. NAMDRAH DNA TREB W. YELLAM'O
EMULOV XL. Hormone Action (Part E: Nuclear Structure and Function)
Edited by TREB W. YELLAM'O DNA LEOJ G. NAMDRAH
EMULOV XLI. Carbohydrate Metabolism (Part )B
Edited yb W. A. DOOW
EMULOV XLII. Carbohydrate Metabolism (Part )C
Edited by W. A. DOOW
EMULOV XLIII. Antibiotics
Edited by NHOJ H. HSAH
EMULOV XLIV. Immobilized Enzymes
Edited by SUALK HCABSOM
EMULOV XLV. Proteolytic Enzymes (Part )B
Edited by OLZSAL DNAROL
EMULOV XLVI. Affinity Labeling
Edited yb MAILLIW B. YBOKAJ DNA MEIR KEHCLIW
EMULOV XLVII. Enzyme Structure (Part E)
Edited yb C. H. W. HIRS DNA EGRES N. FFEHSAMIT