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Access to the eBook is limited to the first individual who redeems the PIN, located on the inside cover of this book, at expertconsult.inkling.com and may not be transferred to another party by resale, lending, or other means. Hoffman and Abeloff’s HEMATOLOGY- ONCOLOGY REVIEW This page intentionally left blank Hoffman and Abeloff’s HEMATOLOGY- ONCOLOGY REVIEW Editor Claudine Isaacs, MD Naiyer A. Rizvi, MD Professor of Medicine and Oncology Director of Thoracic Oncology and Co-Director, Breast Cancer Program Immunotherapeutics Medical Director, Fisher Center for Hereditary Division of Hematology and Oncology Cancer and Clinical Genomics Research Columbia University Medical Center Georgetown University New York, New York Washington, District of Columbia Bruce D. Cheson, MD Professor of Medicine Section Editors Head of Hematology Sanjiv S. Agarwala, MD Director of Hematology Research Professor and Chief Lombardi Comprehensive Cancer Center Department of Oncology and Hematology Georgetown University St. Luke’s Cancer Center Washington, District of Columbia Temple University Bethlehem, Pennsylvania Alice D. Ma, MD Professor of Medicine John L. Marshall, MD Hemophilia and Thrombosis Center Chief, Division of Hematology/Oncology University of North Carolina – Chapel Hill MedStar Georgetown University Hospital Chapel Hill, North Carolina Associate Director, Clinical Research Lombardi Comprehensive Cancer Center Georgetown University Washington, District of Columbia 1600 John F. Kennedy Blvd. Ste 1800 Philadelphia, PA 19103-2899 HOFFMAN AND ABELOFF’S HEMATOLOGY-ONCOLOGY REVIEW ISBN: 978-0-323-42975-7 Copyright © 2018 by Elsevier, Inc. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions. This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein). Notices Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary. Practitioners and researchers must always rely on their own experience and knowledge in evalu- ating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility. With respect to any drug or pharmaceutical products identified, readers are advised to check the most current information provided (i) on procedures featured or (ii) by the manufacturer of each product to be administered, to verify the recommended dose or formula, the method and duration of administration, and contraindications. It is the responsibility of practitioners, relying on their own experience and knowledge of their patients, to make diagnoses, to determine dosages and the best treatment for each individual patient, and to take all appropriate safety precautions. To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any liability for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instruc- tions, or ideas contained in the material herein. Library of Congress Cataloging-in-Publication Data Names: Isaacs, Claudine, editor. Title: Hoffman and Abeloff’s hematology-oncology review / editor, Claudine Isaacs ; section editors, Sanjiv Agarwala, John Marshall, Naiyer Rizvi, Bruce Cheson, Alice Ma. Other titles: Hematology-oncology review Description: First edition. | Philadelphia, PA : Elsevier, [2018] | Includes bibliographical references and index. Identifiers: LCCN 2017029350 | ISBN 9780323429757 (pbk. : alk. paper) Subjects: | MESH: Neoplasms | Hematologic Diseases | Examination Questions Classification: LCC RC266.5 | NLM QZ 18.2 | DDC 616.99/40076--dc23 LC record available at https://lccn.loc.gov/2017029350 Content Strategist: Kayla Wolfe Content Development Specialist: Lisa Barnes Publishing Services Manager: Patricia Tannian Senior Project Manager: Cindy Thoms Book Designer: Ashley Miner Printed in China Last digit is the print number: 9 8 7 6 5 4 3 2 1 To all of our colleagues, contributors, trainees, and patients who have taught us so much The Editors The authors would like to thank Lisa Barnes and Kayla Wolfe for their valuable contributions in publishing this book. This page intentionally left blank CONTRIBUTORS Ghassan K. Abou-Alfa, MD Corey Cutler, MD, MPH, FRCP(C) Assistant Attending Physician Associate Professor of Medicine Memorial Sloan Kettering Cancer Center Harvard Medical School Assistant Professor Senior Physician Weill Medical College at Cornell University Department of Medical Oncology New York, New York Dana-Farber Cancer Institute Boston, Massachusetts Sanjiv S. Agarwala, MD Professor and Chief Don S. Dizon, MD Department of Oncology and Hematology Head of Women’s Cancers St. Luke’s Cancer Center Lifespan Cancer Institute Temple University Director of Medical Oncology Bethlehem, Pennsylvania Rhode Island Hospital Associate Professor of Medicine Jeanny B. Aragon-Ching, MD, FACP Warren Alpert Medical School of Brown University Clinical Program Director of Genitourinary Cancers Providence, Rhode Island Inova Schar Cancer Institute Associate Professor of Medicine Nathan Fowler, MD Virginia Commonwealth University Associate Professor of Medicine Fairfax, Virginia Co-Director, Clinical and Translational Research Lead, New Drug Development Program Nilofer Azad, MD Department of Lymphoma/Myeloma Associate Professor University of Texas – MD Anderson Cancer Center Department of Gastrointestinal Oncology Houston, Texas Johns Hopkins Medical Institutions Baltimore, Maryland Geoffrey Gibney, MD Co-Leader Melanoma Program Julie Brahmer, MD, MSc Lombardi Comprehensive Cancer Center Associate Professor of Oncology MedStar Georgetown University Hospital Department of Medical Oncology Washington, District of Columbia Johns Hopkins Kimmel Cancer Center Baltimore, Maryland Ann Gramza, MD Medical Oncology Director of Head and Neck Cancer Susana Campos, MD, MPH Lombardi Comprehensive Cancer Center Medical Oncology Medical Oncologist Dana-Farber Cancer Institute Head and Neck and Endocrine Cancers Assistant Professor of Medicine Washington Cancer Institute Harvard Medical School MedStar Washington Hospital Center Boston, Massachusetts Washington, District of Columbia Edward Chu, MD, MMS, BS Peter Hammerman, MD, PhD Professor and Chief Dana-Farber Cancer Institute Division of Hematology-Oncology Boston, Massachusetts University of Pittsburgh School of Medicine Deputy Director University of Pittsburgh Cancer Institute University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania vii viii Contributors Christine L. Hann, MD, PhD Christopher H. Lieu, MD Assistant Professor Assistant Professor Department of Oncology Division of Medical Oncology Johns Hopkins University School of Medicine University of Colorado Denver Baltimore, Maryland Denver, Colorado Steven Horwitz, MD Caio Max Rocha Lima, MD Medical Oncologist Associate Director for Translational Research Memorial Sloan Kettering Cancer Center Gibbs Cancer Center and Research Institute, New York, New York Spartanburg, South Carolina David Ilson, MD, PhD Filipa Lynce, MD Attending physician Assistant Professor Gastrointestinal Oncology Service Department of Medicine Department of Medicine Lombardi Comprehensive Cancer Center Memorial Sloan Kettering Cancer Center MedStar Georgetown University Hospital New York, New York Washington, District of Columbia Fabio M. Iwamoto, MD Alice D. Ma, MD Columbia University Medical Center Professor of Medicine New York, New York Hemophilia and Thrombosis Center University of North Carolina – Chapel Hill Marc J. Kahn, MD, MBA Chapel Hill, North Carolina Peterman-Prosser Professor, Sr. Associate Dean Department of Medicine Ravi A. Madan, MD Section of Hematology/Medical Oncology Clinical Director, Genitourinary Malignancies Branch Tulane University School of Medicine National Cancer Institute Center for Cancer Research New Orleans, Louisiana Bethesda, Maryland Nikhil I. Khushalani, MD Molly Weidner Mandernach, MD, MPH Vice-Chair and Associate Member Assistant Professor, Hematology/Oncology Cutaneous Oncology Department of Medicine H. Lee Moffitt Cancer Center University of Florida Associate Professor Gainesville, Florida Department of Oncological Sciences Morsani College of Medicine Erica Mayer, MD, MPH University of South Florida Assistant Professor of Medicine Tampa, Florida Susan F. Smith Center for Women’s Cancers Dana-Farber Cancer Institute Ann Steward LaCasce, MD, MMSc Assistant Professor in Internal Medicine Assistant Professor of Medicine Harvard Medical School Medical Oncology Boston, Massachusetts Dana-Farber Cancer Institute Boston, Massachusetts Jason Meadows, MD Assistant Attending, Supportive Care Service Andrew B. Lassman, MS, MD Memorial Sloan Kettering Cancer Center Chief, Neuro-Oncology Division New York, New York Department of Neurology Columbia University Medical Center Ara Metjian, MD Medical Director Assistant Professor Clinical Protocol & Data Management Office Division of Hematology Herbert Irving Comprehensive Cancer Center Department of Medicine New York, New York Duke University Durham, North Carolina