Description:This book constitutes the refereed proceedings of the 14th International Conference on High-Performance Computing, HiPC 2007, held in Goa, India, in December 2007. The 53 revised full papers presented together with the abstracts of 5 keynote talks were carefully reviewed and selected from 253 submissions. The papers are organized in topical sections on applications on I/O and FPGAs, microarchitecture and multiprocessor architecture, applications of novel architectures, system software, scheduling, energy-aware computing, P2P and internet applications, communication and routing, cluster and grid applications, as well as mobile computing.