Heterocyclic Antitumor Antibiotics

267 Pages·2011·8.2 MB·English

2
Topics in Heterocyclic Chemistry
SeriesEditor:R.R.Gupta
EditorialBoard:
D.Enders·S.V.Ley·G.Mehta·A.I.Meyers
K.C.Nicolaou·R.Noyori·L.E.Overman·A.Padwa
TopicsinHeterocyclicChemistry
RecentlyPublishedandForthcoming Volumes
BioactiveHeterocyclesI QSARandMolecularModelingStudies
VolumeEditor:S.Eguchi inHeterocyclicDrugsI
Volume6,2006 VolumeEditor:S.P.Gupta
Volume3,2006
MarineNaturalProducts
VolumeEditor:H.Kiyota HeterocyclicAntitumorAntibiotics
Volume5,2006 VolumeEditor:M.Lee
Volume2,2006
QSARandMolecularModelingStudies
inHeterocyclicDrugsII Microwave-AssistedSynthesisofHeterocycles
VolumeEditor:S.P.Gupta VolumeEditors:E.VanderEycken,C.O.Kappe
Volume4,2006 Volume1,2006
Heterocyclic Antitumor Antibiotics
Volume Editor: Moses Lee
Withcontributionsby
D.P.Arya·T.Brown·M.Daneshtalab·J.T.Gupton
H.HoltJr.·R.P.KamaleshBabu·M.Lee·B.E.Love
S.N.Maiti·R.Shan
123
TheseriesTopicsinHeterocyclicChemistrypresentscriticalreviewson“HeterocyclicCompounds”
withintopic-relatedvolumesdealingwithallaspectssuchassynthesis,reactionmechanisms,structure
complexity,properties,reactivity,stability,fundamentalandtheoreticalstudies,biology,biomedical
studies,pharmacologicalaspects,applicationsinmaterialsciencesetc.Metabolismwillbealsoincluded
whichwillprovideinformationusefulindesigningpharmacologicallyactiveagents.Pathwaysinvolving
destructionofheterocyclicringswillalsobedealtwithsothatsynthesisofspecificallyfunctionalized
non-heterocyclicmoleculescanbedesigned.
Theoverallscopeistocovertopicsdealingwithmostoftheareasofcurrenttrendsinheterocyclic
chemistrywhichwillsuittoalargerheterocycliccommunity.
Asarulecontributionsarespeciallycommissioned.Theeditorsandpublisherswill,however,always
bepleasedtoreceivesuggestionsandsupplementaryinformation.PapersareacceptedforTopicsin
HeterocyclicChemistryinEnglish.
In references Topics in HeterocyclicChemistry is abbreviated Top HeterocyclChemandis cited as
ajournal.
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LibraryofCongressControlNumber:2006922798
ISSN1861-9282
ISBN-103-540-30982-9SpringerBerlinHeidelbergNewYork
ISBN-13978-3-540-30982-6SpringerBerlinHeidelbergNewYork
DOI10.1007/11413073
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SeriesEditor
Prof.R.R.Gupta
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LaneNo.1,TonkRoad
Jaipur-302018,India
[email protected]
VolumeEditor
Prof.Dr.MosesLee
DeanofNaturalSciencesandProfessorofChemistry
ChemistryDepartment
HopeCollege
ScienceCenterRm.2000
35E.12thSt.,Holland
MJ49422-9000,USA
[email protected]
EditorialBoard
Prof.D.Enders Prof.A.I.Meyers
RWTHAachen EmeritusDistinguishedProfessorof
InstitutfürOrganischeChemie DepartmentofChemistry
D-52074,Aachen,Germany ColoradoStateUniversity
[email protected] FortCollins,CO80523-1872,USA
[email protected]
Prof.StevenV.LeyFRS
Prof.K.C.Nicolaou
BP1702Professor
andHeadofOrganicChemistry Chairman
UniversityofCambridge DepartmentofChemistry
DepartmentofChemistry TheScrippsResearchInstitute
LensfieldRoad 10550N.TorreyPinesRd.
Cambridge,CB21EW,UK LaJolla,California92037,USA
[email protected] [email protected]
and
Prof.G.MehtaFRS ProfessorofChemistry
DepartmentofChemistryandBiochemistry
Director
UniversityofCalifornia
DepartmentofOrganicChemistry
SanDiego,9500GilmanDrive
IndianInstituteofScience
LaJolla,California92093,USA
Bangalore-560012,India
[email protected]
VI EditorialBoard
Prof.RyojiNoyoriNL Prof.LarryE.Overman
President DistinguishedProfessor
RIKEN(TheInstituteofPhysicalandChem- DepartmentofChemistry
icalResearch) 516RowlandHall
2-1Hirosawa,Wako UniversityofCalifornia,Irvine
Saitama351-0198,Japan Irvine,CA92697-2025
and [email protected]
UniversityProfessor
DepartmentofChemistry Prof.AlbertPadwa
NagoyaUniversity
WilliamP.TimmieProfessorofChemistry
Chikusa,Nagoya464-8602,Japan
DepartmentofChemistry
[email protected]
EmoryUniversity
Atlanta,GA30322,USA
[email protected]
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PrefacetotheSeries
TopicsinHeterocyclicChemistrypresentscriticalaccountsofheterocycliccom-
pounds(cycliccompoundscontainingatleastoneheteroatomotherthancar-
boninthering) ranging fromthreemembers tosupramolecules. Morethan
50%ofbillionsofcompoundslistedinChemicalAbstractsareheterocycliccom-
pounds.Thebranchofchemistrydealingwiththeseheterocycliccompounds
iscalledheterocyclicchemistry,whichisthelargestbranchofchemistryand
as such the chemical literature appearing every year as research papers and
reviewarticlesisvastandcannotbecoveredinasinglevolume.
Thisseriesinheterocyclicchemistryisbeingintroducedtocollectivelymake
availablecriticallyandcomprehensively reviewedliteraturescatteredinvari-
ousjournalsaspapersandreviewarticles.Allsortsofheterocycliccompounds
originatingfromsynthesis,naturalproducts,marineproducts,insects,etc.will
be covered. Several heterocyclic compounds play a significant role in main-
taininglife.Bloodconstituenthemoglobinandpurinesaswellaspyrimidines,
are constituents of nucleic acid (DNA and RNA) are also heterocyclic com-
pounds. Several amino acids, carbohydrates, vitamins, alkaloids, antibiotics,
etc. are also heterocyclic compounds that are essential for life. Heterocyclic
compoundsarewidelyusedinclinicalpracticeasdrugs,butallapplicationsof
heterocyclicmedicinescannotbediscussedindetail.Inadditiontosuchappli-
cations,heterocycliccompoundsalsofindseveralapplicationsintheplastics
industry,inphotographyassensitizersanddevelopers,andindyeindustryas
dyes,etc.
Each volume will be thematic, dealing with a specific and related subject
that willcover fundamental, basic aspects including synthesis, isolation, pu-
rification,physicalandchemicalproperties,stabilityandreactivity,reactions
involvingmechanisms,intra-andintermoleculartransformations,intra-and
intermolecular rearrangements, applications as medicinal agents, biological
andbiomedicalstudies,pharmacologicalaspects,applicationsinmaterialsci-
ence,andindustrialandstructuralapplications.
The synthesis of heterocyclic compounds using transition metals and us-
ingheterocycliccompoundsasintermediatesinthesynthesisofotherorganic
compoundswillbeanadditionalfeatureofeachvolume.Pathwaysinvolvingthe
destructionofheterocyclicringswillalsobedealtwithsothatthesynthesisof
specificallyfunctionalizednon-heterocyclicmoleculescanbedesigned.Each