Herbs: Challenges 1 g 00 in Chemistry and Biology ubs.acs.or6-0925.fw p0 http://bk-20 2 | 21/ 10 01 uly 6, 2doi: 10. 6 on J006 | 32 63.34.1ary 12, 1u 89.Jan ed by Date: nloadation wc Doubli P In Herbs: Challenges in Chemistry and Biology; Wang, M., et al.; ACS Symposium Series; American Chemical Society: Washington, DC, 2006. 1 g 00 ubs.acs.or6-0925.fw p0 http://bk-20 2 | 21/ 10 01 uly 6, 2doi: 10. 6 on J006 | 32 63.34.1ary 12, 1u 89.Jan ed by Date: nloadation wc Doubli P In Herbs: Challenges in Chemistry and Biology; Wang, M., et al.; ACS Symposium Series; American Chemical Society: Washington, DC, 2006. A CS S Y M P O S I UM S E R I ES 925 Herbs: Challenges in Chemistry and Biology 1 g 00 pubs.acs.or06-0925.fw RutgMersi nTghef uSt aWte aUnngiv,e rEsDityI TofO NRe w Jersey http://bk-20 2 | 21/ Shengmin Sang, EDITOR 10 01 uly 6, 2doi: 10. The University of Hong Kong 6 on J006 | Lucy Sun Hwang, EDITOR 32 63.34.1ary 12, National Taiwan University 1u 89.Jan Chi-Tang Ho, EDITOR ed by Date: Rutgers The State University of New Jersey nloadation wc DoPubli Sponsored by the ACS Division of Agricultural and Food Chemistry, Inc. American Chemical Society, Washington, DC In Herbs: Challenges in Chemistry and Biology; Wang, M., et al.; ACS Symposium Series; American Chemical Society: Washington, DC, 2006. Library of Congress Cataloging-in-Publication Data Herbs: challenges in chemistry and biology / Chi-Tang Ho, editor... [et al.] ; sponsored by the ACS Division of Agricultural and Food Chemistry. p. cm. — (ACS symposium series ; 925) "Developed from a symposium sponsored by the Division of Agricultural and Food Chemistry at the 227th National Meeting of the American Chemical Society, Anaheim, California, March 28-April 1, 2004"—Pref. Includes bibliographical references and index. 1 ISBN-13: 978-0-8412-3930-2 (alk. paper) g 00 ubs.acs.or6-0925.fw CCoo1nn.gg Frreeussnsseecssti..o 3n.a Hl feorobdss——TChoenragpreeusstiecs .u 2se. —PhCyotoncghreemsseicsa. ls4—. MPehdyiscioinloe,g iCchali neefsfeec—t— p0 http://bk-20 FoIo.d H Coh, eCmhii-sTtrayn. gII, I1. 9A4m4-e rIiIc.a An mCehreicmainc aCl hSeomciiceatyl .S Moceieettiyn.g D (i2v2is7itoh n: 2o0f 0A4g :r iAcunlathueraiml a, nd 12 | 021/ Calif.). IV. Series. 01 uly 6, 2doi: 10. 6Q1P51'.4342.1F—85dHc4272 2005 6 on J006 | 2005048237 63.34.13ary 12, 2 NTMhaaettie orpniaaaplls eS,r At aNunsdSeaIdr Zd 3 inf9o .4rt h8Iin-s1f o9pr8um4ba.l tiicoanti oSnc iemnceeests— tPheer mmanineinmceu mo fr ePqaupierer mfoenr tPs rionfte dA mLiebrricaaryn 1u 89.Jan Copyright © 2006 American Chemical Society ed by Date: Distributed by Oxford University Press nloadation ISBN 10: 0-8412-3930-4 wc Doubli All Rights Reserved. Reprographic copying beyond that permitted by Sections 107 or P 108 of the U.S. Copyright Act is allowed for internal use only, provided that a per- chapter fee of $30.00 plus $0.75 per page is paid to the Copyright Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA 01923, USA. Republication or reproduction for sale of pages in this book is permitted only under license from ACS. Direct these and other permission requests to ACS Copyright Office, Publications Division, 1155 16th Street, N.W., Washington, DC 20036. 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Foreword The ACS Symposium Series was first published in 1974 to pro vide a mechanism for publishing symposia quickly in book form. The purpose of the series is to publish timely, comprehensive books devel oped from ACS sponsored symposia based on current scientific re search. Occasionally, books are developed from symposia sponsored by g 001 other organizations when the topic is of keen interest to the chemistry ubs.acs.or6-0925.fw taeundtise nisc eBr.e evfoierwe eadg rfeoeri nagp ptroo ppruibatlies han ad b cooomkp, rthehee pnsriovpeo sceodve traabglee oanf dco fno r p0 2 | http://21/bk-20 tinhtee rbeosot kto; oththee rasu dmieanyc eb. eS aodmdee dp atpoe rpsr omvaidye b ceo mexpcrluehdeends itvoe nbeestste. rW fohceuns 10 appropriate, overview or introductory chapters are added. Drafts of 01 uly 6, 2doi: 10. mchaanputesrcsr ipatrse a preee pr-rreepvaireewde idn pcarimore rtao- rfeiandayl afocrcmepatat.n ce or rejection, and 6 on J006 | As a rule, only original research papers and original review 63.34.13ary 12, 2 pouapsleyr sp uabreli sihnecdlu pdaepde rins athree nvootlu amcceesp.t eVde.r batim reproductions of previ 1u 89.Jan ed by Date: ACS Books Department nloadation wc Doubli P In Herbs: Challenges in Chemistry and Biology; Wang, M., et al.; ACS Symposium Series; American Chemical Society: Washington, DC, 2006. Preface There is an increasing use of botanicals, botanical extracts, and puri fied natural compounds for the treatment and prevention of disease, especially chronic disease, in North America and Europe—not to mention Asian countries, which already have a long history of applying herbal medicines. For example, in China, herbal medicine (Traditional Chinese Medicine) is viewed as a national treasure, and has equal status 1 with Western medicine. Traditional Chinese medicine is well-known to g 00 orpr be effective for all kinds of disease, especially for age-related diseases. s.5. s.ac092 In the United States, research and product development in nutraceuticals ub6- and functional foods are producing many novel botanicals, vitamins, and/or p0 2 | http://21/bk-20 bmoitnaenriacla lp prordoduuctcst s thisa,t haorwee vaeprp, eaarcicnogm pinan tihede bmya rhkigeht eTr heex preecetvaatilounatsio fnr oomf 0110 nutritionalists, physicians, pharmacists, and consumers who demand quality, uly 6, 2doi: 10. ssaidfeet ye,f faenctds eafnficda ctoyx ficriotym o tfh epsoep uplraord buocttsa.n Wicailt hp rthodeu ccotsn tsiuncuhin ga sr eEppohrtesd roaf atnhde n J6 | o0 Kava, consumers are starting to back away from botanical products and are 4.136 12, 20 beginning to lose faith in dietary supplements. Thus, it is time to present 9.163.3anuary urepsdpaetcetds roefs heaerrbchal r perlaotdinugct tso i nth oer dqeura tliot yr ecgoanitnro thl,e c hcoemnfiidcaeln,c aen do fp thhaer pmuabcloiclo. gical 8J ded by n Date: brinTg hteo gseythmepro sleiuamdin ugp roense awrhchicehr st hfriso mbo tohke Uis nbitaesded S twataess ,o Crghainnaiz,e Tda ti o nloaatio wan, Japan, and Canada to discuss future research directions in herbal Dowublic products and to share works in botanical research. The symposium P was held in Anaheim, California from March 28 to April 1, 2004 as part of the 227th American Chemical Society National meeting. This book is divided into four sections. In the overview (first) section, Dr. Betz first describes the National Institutes of Health's vision of clearing confusion in the marketplace via validated analytical methods and referenced botanical materials. This is followed by Chapter 2 on the development of patentable new drugs from Traditional Chinese Medi cine, Chapter 3 about bioactive polyphenols from foods and dietary sup plements, Chapter 4 about the application of instrumental methods to the analysis and the prevention of adulteration in popular dietary supple ments in the market, and Chapter 5 about assessing bioactive botanical xi In Herbs: Challenges in Chemistry and Biology; Wang, M., et al.; ACS Symposium Series; American Chemical Society: Washington, DC, 2006. ingredients in functional beverages. Finally, Chapter 6 covers bioactive natural products from Chinese tropical marine plants and invertebrate, and Chapter 7 reviews the potential health benefits of curcumin. The other three sections cover natural product chemistry and analysis, natural product bioavailability and stability, and finally the biological activities of various herbal products and single natural compounds. We thank all the authors for their contributions and efforts in the preparation of this book. May their insight and research lead us all to longer and healthier lives. Mingfu Wang 1 Department of Botany org pr00 The University of Hong Kong s.acs.0925. Pokfulam Road, Hong Kong ub6- p0 2 | http://21/bk-20 DShepeanrgtmmeinnt Sofa nCgh emical Biology 10 Ernest Mario School of Pharmacy 01 uly 6, 2doi: 10. R16u4tg Ferrse,l iTnghhey Sutsaetne URnoiavde rsity of New Jersey on J06 | Piscataway, NJ 08854 4.136 12, 20 Lucy Sun Hwang 9.163.3anuary NInasttiiotuntael oTfa Fiwooadn SUcnieivnecres iatny d Technology 8J d by Date: 1 Roosevelt Road, Sec. 4 den Taipei, Taiwan 10672 nloaatio Republic of China Dowublic P Chi-Tang Ho Department of Food Science Rutgers, The State University of New Jersey New Brunswick, NJ 08901 xii In Herbs: Challenges in Chemistry and Biology; Wang, M., et al.; ACS Symposium Series; American Chemical Society: Washington, DC, 2006. Herbs: Challenges g 001 in Chemistry and Biology orpr s.5. s.ac092 ub6- p0 2 | http://21/bk-20 10 01 uly 6, 2doi: 10. n J6 | o0 4.136 12, 20 9.163.3anuary 8J d by Date: den nloaatio Dowublic P In Herbs: Challenges in Chemistry and Biology; Wang, M., et al.; ACS Symposium Series; American Chemical Society: Washington, DC, 2006. Chapter 1 Botanical Quality Initiatives at the Office of Dietary Supplements, National Institutes of Health Joseph M. Betz Office of Dietary Supplements, National Institutes of Health, Bethesda, MD 20892 1 g 00 orch ubs.acs.6-0925. p0 http://bk-20 12 | 021/ Quality of botanical products is one of the biggest 01 uly 6, 2doi: 10. urensceearrtcahinertise sf acteh.a tD ecfoinnistuiomnesr so,f qculianliitcyia nabs,o unredg, ualantdo risn, cluandde n J6 | specifications for sanitation, adventitious agents (pesticides, 4.136 o12, 200 mdieettaalrsy, swuepepdlesm), enantsd (cDoSnt)e natr e oof ftneant ucraolm cphleexm imcaixlst.u rBese,c athuesey 9.163.3anuary dpiofsfeic ualtn. aIlny tricesapl ocnhsael lteon gperso dauncdt qmuaeltihtyo dcso nvcaelrindsa tainodn tmhea yn eebde wnloaded by 8cation Date: J ta(fhoOner D vUSoa.)nlS iga.d toaC ittnhoegden gNarnemadstesi o tphdnuoiabrdlel sicIc ntleysdtv i atatuvhltiaeed isalO atoibfoffli necH eme paoelrtftoh hDco e(disNesst a.I fHroyr) T tSDohu eSpa pcalcnDeeamilleeyetrsaanirttseys, Doubli Supplements Methods and Reference Materials Program was P created. The program was constructed from stakeholder input and incorporates several federal procurement and granting mechanisms in a coordinated and interlocking framework. The framework facilitates validation of analytical methods, analytical standards, and reference materials. 2 © 2006 American Chemical Society In Herbs: Challenges in Chemistry and Biology; Wang, M., et al.; ACS Symposium Series; American Chemical Society: Washington, DC, 2006.
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