Hepatitis C Virus II: Infection and Disease PDF
Preview Hepatitis C Virus II: Infection and Disease
Tatsuo Miyamura · Stanley M. Lemon Christopher M. Walker · Takaji Wakita Editors Hepatitis C Virus II Infection and Disease Hepatitis C Virus II Tatsuo Miyamura (cid:129) Stanley M. Lemon (cid:129) Christopher M. Walker (cid:129) Takaji Wakita Editors Hepatitis C Virus II Infection and Disease Editors TatsuoMiyamura StanleyM.Lemon NationalInstituteofInfectiousDiseases DepartmentsofMedicineandMicrobiology Tokyo,Japan &Immunology TheUniversityofNorthCarolina ChapelHill,NorthCarolina USA ChristopherM.Walker TakajiWakita CenterforVaccinesandImmunity NationalInstituteofInfectiousDiseases TheResearchInstituteatNationwide Tokyo,Japan Children’sHospital Columbus,Ohio USA ISBN978-4-431-56099-9 ISBN978-4-431-56101-9 (eBook) DOI10.1007/978-4-431-56101-9 LibraryofCongressControlNumber:2016951214 ©SpringerJapan2016 Thisworkissubjecttocopyright.AllrightsarereservedbythePublisher,whetherthewholeorpartof the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilarmethodologynowknownorhereafterdeveloped. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publicationdoesnotimply,evenintheabsenceofaspecificstatement,thatsuchnamesareexempt fromtherelevantprotectivelawsandregulationsandthereforefreeforgeneraluse. Thepublisher,theauthorsandtheeditorsaresafetoassumethattheadviceandinformationinthis book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained hereinorforanyerrorsoromissionsthatmayhavebeenmade. Printedonacid-freepaper ThisSpringerimprintispublishedbySpringerNature TheregisteredcompanyisSpringerJapanKK Contents PartI ChronicHepatitisC NaturalHistoryofChronicHepatitisC. . . . . . . . . . . . . . . . . . . . . . . . . 3 MarcG.GhanyandT.JakeLiang TheMultifacetedFeaturesofHCVInfectionBeyondtheLiver. . . . . . . 57 KazuhikoKoike HepaticFibrosisinHepatitisC. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 79 MelissaA.SheikoandHugoR.Rosen HepatocellularCarcinomaandHepatitisCVirus. . . . . . . . . . . . . . . . . 109 Sheng-HanWang,Shiou-HweiYeh,andPei-JerChen HCV,Alcohol,andtheLiver. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 137 TerenceN.Bukong,BanishreeSaha,andGyongyiSzabo ExtrahepaticReplicationofHCV. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 165 Wen-ChiSu,KeigoMachida,andMichaelM.C.Lai PartII HCVInfectionsinSpecialPopulations HepatitisCVirusInfectioninPregnancyandChildhood. . . .. . . . . . .. 187 JessicaWen,SamanthaOhmer,andJonathanHonegger PartIII ApproachestoTherapy HostGeneticsandResponsestoAntiviralTherapyinChronic HepatitisC. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 225 YasuhitoTanakaandMasashiMizokami ViralVariationandResponsetoTherapy. . . . . . . . . . . . . . . . . . . . . . . 243 ShinyaMaekawaandNobuyukiEnomoto v vi Contents HCVNS3/4AProteaseInhibitorsandtheRoadtoEffective Direct-ActingAntiviralTherapies. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 257 NicolasTremblay,AlexYoungPark,andDanielLamarre MechanismofActionofDirect-ActingAntivirals:NewInsights intotheHCVLifeCycle. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 287 SaraE.WillifordandDavidR.McGivern ModelingHCVDynamicsinClinicalPracticetoPersonalizeAntiviral Therapy. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 303 PieroColombatto,FerruccioBonino,LuigiCivitano,FilippoOliveri, GabrieleRicco,SergioIannazzo,andMauriziaR.Brunetto PartIV PreventionandControlofHCVInfection ProphylacticVaccinesfortheHepatitisCVirus. . . . . . . . . . . . . . . . . . 325 AndreaL.Cox GlobalControlofHepatitisCVirusInfection. . . . . . . . . . . . . . . . . . . . 347 TatsuoMiyamura Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 369 Contributors FerruccioBonino UPMCInstituteforHealth,ChiancianoTerme,Italy MauriziaR.Brunetto HepatologyUnit,UniversityHospitalofPisa,Pisa,Italy TerenceN.Bukong DepartmentofMedicine,UniversityofMassachusettsMed- icalSchool,Worcester,MA,USA Pei-Jer Chen Department of Microbiology, National Taiwan University College ofMedicine,Taipei,Taiwan NTUCenterforGenomicMedicine,NationalTaiwanUniversityCollegeofMed- icine,Taipei,Taiwan Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine,Taipei,Taiwan Department of Internal Medicine, National Taiwan University Hospital and NationalTaiwanUniversityCollegeofMedicine,Taipei,Taiwan LuigiCivitano HepatologyUnit,UniversityHospitalofPisa,Pisa,Italy PieroColombatto HepatologyUnit,UniversityHospitalofPisa,Pisa,Italy AndreaL.Cox DivisionofInfectiousDiseases,JohnsHopkinsUniversitySchool ofMedicine,Baltimore,MD,USA Nobuyuki Enomoto First Department of Internal Medicine, University of Yamanashi,Chuo,Yamanashi,Japan MarcG.Ghany LiverDiseasesBranch,NationalInstituteofDiabetesandDiges- tiveandKidneyDiseases,NationalInstitutesofHealth,Bethesda,MD,USA JonathanHonegger NationwideChildren’sHospital,TheOhioStateUniversity, Columbus,OH,USA vii viii Contributors SergioIannazzo SIHSHealth-Economics-Consulting,Turin,Italy KazuhikoKoike DepartmentofGastroenterology,GraduateSchoolofMedicine, TheUniversityofTokyo,Tokyo,Japan Michael M.C. Lai Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan Research Center for Emerging Viruses, China Medical University Hospital, Tai- chung,Taiwan Daniel Lamarre De´partement de Me´decine, Universite´ de Montre´al, Montre´al, QC,Canada T.JakeLiang LiverDiseasesBranch,NationalInstituteofDiabetesandDigestive andKidneyDiseases,NationalInstitutesofHealth,Bethesda,MD,USA Keigo Machida Department of Molecular Microbiology and Immunology, Uni- versityofSouthernCalifornia,LosAngeles,CA,USA Shinya Maekawa First Department of Internal Medicine, University of Yamanashi,Chuo,Yamanashi,Japan TatsuoMiyamura NationalInstituteofInfectiousDiseases,Tokyo,Japan MasashiMizokami TheResearch Center forHepatitis&Immunology,National CenterforGlobalHealthandMedicine,Ichikawa,Chiba,Japan Samantha Ohmer Medical Scientist Training Program, The Ohio State Univer- sity,Columbus,OH,USA FilippoOliveri HepatologyUnit,UniversityHospitalofPisa,Pisa,Italy Alex Young Park De´partement de Me´decine, Universite´ de Montre´al, Montre´al, QC,Canada GabrieleRicco HepatologyUnit,UniversityHospitalofPisa,Pisa,Italy Hugo R. Rosen Department of Medicine, Division of Gastroenterology and Hepatology,UniversityofColoradoDenverSchoolofMedicine,Aurora,CO,USA Banishree Saha Department of Medicine, University of Massachusetts Medical School,Worcester,MA,USA Melissa A. Sheiko Department of Pediatrics, Digestive Health Institute, Univer- sityofColoradoDenverSchoolofMedicine,Aurora,CO,USA Wen-Chi Su Research Center for Emerging Viruses, China Medical University Hospital,Taichung,Taiwan Gyongyi Szabo Department of Medicine, University of Massachusetts Medical School,Worcester,MA,USA Contributors ix Yasuhito Tanaka Department of Virology, Liver Unit, Nagoya City University GraduateSchoolofMedicalSciences,Nagoya,Japan NicolasTremblay De´partementdeMe´decine,Universite´ deMontre´al,Montre´al, QC,Canada Sheng-Han Wang Department of Microbiology, National Taiwan University CollegeofMedicine,Taipei,Taiwan JessicaWen UniversityofPennsylvania,Philadelphia,PA,USA Shiou-Hwei Yeh Department of Microbiology, National Taiwan University CollegeofMedicine,Taipei,Taiwan NTU Center for Genomic Medicine, National Taiwan University College of Medicine,Taipei,Taiwan Part I Chronic Hepatitis C
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