Hematopathology: Genomic Mechanisms of Neoplastic Diseases PDF
Preview Hematopathology: Genomic Mechanisms of Neoplastic Diseases
Molecular and Translational Medicine SeriesEditors WilliamB.Coleman GregoryJ.Tsongalis Forfurthervolumes: http://www.springer.com/series/8176 Domnita Crisan Editor Hematopathology Genomic Mechanisms of Neoplastic Diseases Editor DomnitaCrisan WilliamBeaumontHospital DepartmentofClinicalPathology MolecularPathologyLab 3601West13MileRoad 48073-6769RoyalOak,Michigan USA [email protected] ISBN978-1-60761-261-2 e-ISBN978-1-60761-262-9 DOI10.1007/978-1-60761-262-9 SpringerNewYorkDordrechtHeidelbergLondon LibraryofCongressControlNumber:2010931434 ©SpringerScience+BusinessMedia,LLC2010 Allrightsreserved.Thisworkmaynotbetranslatedorcopiedinwholeorinpartwithoutthewritten permissionofthepublisher(HumanaPress,c/oSpringerScience+BusinessMedia,LLC,233Spring Street,NewYork,NY10013,USA),exceptforbriefexcerptsinconnectionwithreviewsorscholarly analysis.Useinconnectionwithanyformofinformationstorageandretrieval,electronicadaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. Theuseinthispublicationoftradenames,trademarks,servicemarks,andsimilarterms,eveniftheyare notidentifiedassuch,isnottobetakenasanexpressionofopinionastowhetherornottheyaresubject toproprietaryrights. Whiletheadviceandinformationinthisbookarebelievedtobetrueandaccurateatthedateofgoing topress,neithertheauthorsnortheeditorsnorthepublishercanacceptanylegalresponsibilityforany errorsoromissionsthatmaybemade.Thepublishermakesnowarranty,expressorimplied,withrespect tothematerialcontainedherein. Printedonacid-freepaper HumanaPressispartofSpringerScience+BusinessMedia(www.springer.com) Idedicatethisbooktomymotherwhogaveme hergeneforoptimism,tomybravefatherwho losthislifefightingcommunists,andtomy husband,Dan,whoofferedhislovingsupport, withpatienceandenthusiasmduringworkonthis bookandmyentireprofessionalcareer Preface Hematopathology: Genomic Mechanisms of Neoplastic Diseases in the book series Molecular and Translational Medicine addresses our current knowledge of genomics as applied to the pathogenesis, diagnosis, prognosis, monitoring, and targeted therapy of hematologic malignancies. Hematology has been at the van- guardoftheapplicationofmoleculartechnologiesindiagnosis,classification,risk stratification,anduseofmolecularlydefinedtherapeutictargets.Theseadvancesin moleculartechnologies,diagnostics,andgene-relatedtherapyhaveseenanextraor- dinaryrapidpacesincethecompletionoftheHumanGenomeProject.Hematology hasintegratedthediscoveriesofgenomiclesionsunderlyinghematologicmalignan- ciesandappliedthetoolsofmolecularpathology,makingthemessentialinclinical practice. The scope of this book is to keep pathologists and clinicians abreast of the rapid and complex changes in genomic medicine, as exemplified by the molecu- larpathologyofleukemiasandlymphomas.Thisisatimelyopportunitytonotonly update physicians on the complexity of genomic abnormalities but also offer an integrated framework encompassing molecular diagnostics, the new WHO (World HealthOrganization)classificationofhematologicneoplasmswithfocusonmolec- ular pathology, prognostic value of molecular tests, and molecular monitoring of responsetogene-targetedtherapy. Therapidpaceofdiscovery,theexplosioningenomicinformation,andtheever changingmoleculartechnologiesmakeitnecessarytoconstantlyupdateourknowl- edgeandIhopethatthereaderswillusethisbookasapracticalresourceandplace itnexttotheirmicroscope,intheirlaboratoriesorclinicaloffices. Thefirsttwochaptersshouldbehelpfulforpracticingpathologistsandforclin- icians, providing overviews of molecular techniques and cytogenetics, both well establishedandnew,asusedinmolecularhematology.Chapter3isaconcisereview of the new 2008 WHO classification, which integrates molecular abnormalities in the diagnosis of hematologic neoplasms. The following chapters offer compre- hensive discussions of the molecular pathology of lymphoid and myeloid acute leukemias, the mature B-cell and T-cell lymphomas, the myeloproliferation neo- plasms, chronic lymphocytic leukemia, overall representing the major diagnostic entitiesinneoplastichematology. vii viii Preface ThenewfieldsoftargetedtherapyinhematologicmalignanciesandmicroRNAs as applied in hematologic malignancies are reviewed in the last two chapters and offercomprehensivediscussionsofthecurrentstateofthesenovelapproaches. Iamextremelygratefultoalltheauthorsfortheirexcellentcontributionstothis book; each chapter is an in-depth and thought-provoking update, as well as easily readableandpractical. In a specialty as exciting and rapidly evolving as Molecular Hematology, it is my hope that this will be just the first of many editions of this book. It will be interestingandchallengingtoseetheprogressingenomicsinthenextyearsandask thequestion,QuoVadisHematology? RoyalOak,Michigan DomnitaCrisan Contents 1 MolecularTechniquesinHematopathology . . . . . . . . . . . . . 1 BobbyL.BoyantonJr.andJenniferR.Rushton 2 Classical and Molecular Cytogenetic Analysis ofHematolymphoidDisorders . . . . . . . . . . . . . . . . . . . . 39 MarkA.Micale 3 Using Cytogenetic and Molecular Tests in Diagnostic WorkupswiththeWHOClassification–2008 . . . . . . . . . . . 79 ClarenceC.Whitcomb 4 Update on the Molecular Pathology ofPrecursorLymphoidLeukemias . . . . . . . . . . . . . . . . . 103 RobertB.Lorsbach 5 MolecularPathologyofAcuteMyeloidLeukemias . . . . . . . . . 127 KarenP.MannandDebraF.Saxe 6 MolecularPathologyofMatureB-CellandT-CellLymphomas . . 157 SophiaL.Yohe,DavidW.Bahler,andMarshaC.Kinney 7 MolecularPathologyofMyeloproliferativeNeoplasms . . . . . . 215 DavidS.Bosler 8 MolecularPathologyofChronicLymphocyticLeukemia . . . . . 255 DanielaHoehn,L.JeffreyMedeiros,andSergejKonoplev 9 TargetedTherapyinHematologicMalignancies . . . . . . . . . . 293 BarbaraZehnbauerandMonaNasser 10 Micro-RNAsinHematologicMalignancies . . . . . . . . . . . . . 325 MullerFabbriandGeorgeA.Calin Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 341 ix Contributors DavidW.Bahler,MD,PhD DepartmentofPathology,UniversityofUtah,Salt LakeCity,UT,USA DavidS.Bosler,MD DepartmentofClinicalPathology,ClevelandClinic, Cleveland,OH,USA BobbyL.BoyantonJr,MD DepartmentofClinicalPathology,Beaumont Hospitals,RoyalOak,MI,USA GeorgeA.Calin,MD,PhD DepartmentsofExperimentalTherapeuticsand CancerGenetics,UniversityofTexas,M.D.AndersonCancerCenter,Houston, TX,USA MullerFabbri,MD DepartmentofMolecularVirology,Immunologyand MedicalGenetics,TheOhioStateUniversityComprehensiveCancerCenter, Columbus,OH,USA DanielaHoehn,MD DepartmentofHematopathology,M.D.AndersonCancer Center,Houston,TX,USA MarshaC.Kinney,MD DivisionofHematopathology,UniversityofTexas HealthSciencesCenter,SanAntonio,TX,USA SergejKonoplev,MD,PhD DepartmentofHematopathology,M.D.Anderson CancerCenter,Houston,TX,USA RobertB.Lorsbach,MD,PhD DepartmentofPathology,UniversityofArkansas forMedicalSciences,LittleRock,AR,USA KarenP.Mann,MD,PhD DepartmentofPathologyandLaboratoryMedicine, EmoryUniversity,Atlanta,GA,USA L.JeffreyMedeiros,MD DepartmentofHematopathology,M.D.Anderson CancerCenter,Houston,TX,USA MarkA.Micale,PhD BeaumontLaboratory,DepartmentofAnatomic Pathology,BeaumontHospitals,RoyalOak,MI,USA xi xii Contributors MonaNasser,MD DepartmentofClinicalChemistry,SchoolofMedicine,Beni SuefUniversity,BeniSuef,Egypt JenniferR.Rushton,MD DepartmentofPathology,BaylorCollegeof Medicine–BCM315,Houston,TX,USA DebraF.Saxe,PhD DepartmentofPathologyandLaboratoryMedicine,Emory University,Atlanta,GA,USA ClarenceC.Whitcomb,MD DepartmentofPathology,MillerSchoolof Medicine,UniversityofMiami,Miami,FL,USA SophiaL.Yohe,MD DepartmentofLaboratoryMedicineandPathology, UniversityofMinnesotaMedicalCenter,Minneapolis,MN,USA BarbaraZehnbauer,PhD DivisionofLaboratorySystems,LaboratoryPractice EvaluationandGenomicsBranch,CentersforDiseaseControlandPrevention, Atlanta,GA,USA
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