Hematology: Basic Principles and Practice, Expert Consult - Online and Print (Expert Consult Title: Online + Print), 5th Edition

2543 Pages·2008·95.42 MB·English

CONTRIBUTORS
Janis L. Abkowitz MD As´ok C. Antony MD
Professor of Medicine, Director, Hematology Clinic, Seattle Cancer Professor, Department of Medicine, Division of Hematology-
Care Alliance; Head, Division of Hematology, University of Oncology, Indiana University School of Medicine; Attending Physician
Washington, Seattle, Washington and Consultant, Indiana University Hospitals; Roudebush Veterans
Affairs Medical Center, Indianapolis, Indiana
Janet L. Abrahm MD
Associate Professor, Department of Medicine and Anesthesia, Harvard Robert J. Arceci MD, PhD
Medical School; Director, Pain and Palliative Care Program, King Fahd Professor of Pediatric Oncology; Professor of Pediatrics,
Department of Medical Oncology, Dana-Farber Cancer Institute; Oncology and Cellular and Molecular Medicine, Kimmel
Director, Palliative Care Program, Department of Medicine, Brigham Comprehensive Cancer Center at Johns Hopkins, Bunting-Blaustein
and Women’s Hospital, Boston, Massachusetts Cancer Research Building, Baltimore, Maryland
Charles S. Abrams MD Scott A. Armstrong MD, PhD
Associate Professor, Department of Medicine, Division of Hematology- Assistant Professor of Pediatrics, Harvard Medical School; Attending
Oncology, University of Pennsylvania School of Medicine; Attending Physician, Department of Hematology/Oncology, Children’s Hospital/
Physician, Division of Hematology-Oncology, Department of Dana-Farber Cancer Institute, Boston, Massachusetts
Medicine, Hospital of the University of Pennsylvania, Philadelphia,
Pennsylvania Irit Avivi MD
Senior Lecturer, Bruce Rappaport Faculty of Medicine, Technion,
Steven J. Ackerman PhD Israel Institute of Technology; Senior Attending Hematologist,
Professor of Medicine (Hematology-Oncology), Biochemistry and Department of Hematology and Bone Marrow Transplantation,
Molecular Genetics, Department of Biochemistry and Molecular Rambam Medical Center, Haifa, Israel
Genetics, University of Illinois at Chicago College of Medicine,
Chicago, Illinois Farrukh T. Awan MD, MS
Clinical Instructor, Clinical Fellow-Hematology Oncology, James
Sharon Adams MT CHS Cancer Center, The Ohio State University, Columbus, Ohio
HLA Laboratory Supervisor, National Institute of Health, Warren G.
Magnuson Clinical Center, Bethesda, Maryland Aleksandar Babic PhD, MD
Instructor in Pathology, Harvard Medical School; Associate Medical
Adeboye H. Adewoye MD Director, Adult Transfusion Service, Brigham and Women’s Hospital,
Assistant Professor of Medicine, Boston University School of Medicine; Boston, Massachusetts
Attending Physician, Boston Medical Center, Boston, Massachusetts
Tiziano Barbui MD
Claudio Agostinelli MD Professor of Hematology, Scientific Director, Research Foundation,
Researcher, Bologna University School of Medicine, Bologna, Italy Ospedali Riuniti di Bergamo, Bergamo Italy
Amin Alousi MD Giovanni Barosi MD
Assistant Professor of Medicine, Department of Stem Cell Transplant Director, Unit of Clinical Epidemiology and Center for the Study of
and Cellular Therapy, University of Texas, M.D. Anderson Cancer Myelofibrosis, IRCCS Policlirico S. Matteo Foundation, Pavia, Italy
Center, Houston, Texas
Robert A. Barrington MD
Claudio Anasetti MD Postdoctoral Fellow, Department of Pathology, Harvard University
Professor, Department of Interdisciplinary Oncology, University of Medical School and CBR Institute for Biomedical Research, Boston,
South Florida School of Medicine; Leader, Blood and Marrow Massachusetts
Transplant Program, H. Lee Moffitt Cancer Center and Research
Institute, Tampa, Florida Kenneth A. Bauer MD
Professor of Medicine, Harvard Medical School, Boston; Chief,
John Anastasi, MD Hematology Section, VA Boston Healthcare System, West Roxbury;
Associate Professor of Pathology, University of Chicago, Pritzker Director, Thrombosis Clinical Research, Division of Hemostasis and
School of Medicine, Chicago, Illinois Thrombosis, Beth Israel Deaconess Medical Center, Boston,
Massachusetts
Nancy C. Andrews MD, PhD
Dean and Vice Chancellor, Duke University School of Medicine, Linda G. Baum MD
Durham, North Carolina Professor, Department of Pathology and Laboratory Medicine,
David Geffen School of Medicine at UCLA, Los Angeles,
California
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viii Contributors
Johanna Bendell MD Malcolm K. Brenner MD, PhD
Instructor, Department of Medicine, Harvard Medical School, Professor of Medicine and Pediatrics, Director, Center for Cell and
Assistant, Department of Medicine, Massachusetts General Gene Therapy; Fayez Sarofim Chair, Baylor College of Medicine;
Hospital Cancer Center, Boston, Massachusetts Director, Center for Cell and Gene Therapy, The Methodist Hospital,
Texas Children’s Hospital, Houston, Texas
Joel S. Bennett MD
Professor of Medicine and Pharmacology, University of Pennsylvania Gary M. Brittenham MD
School of Medicine; Attending Physician, Hospital of the University of James A. Wolff Professor of Pediatrics and Medicine, Columbia
Pennsylvania, Philadelphia, Pennsylvania University College of Physicians and Surgeons; Attending Pediatrician,
Children’s Hospital of New York–Presbyterian, Hospital New York,
Don M. Benson, Jr. MD, PhD New York
Assistant Professor of Medicine, The Ohio State University; Attending
Physician, Comprehensive Cancer Center, The Ohio State University Robert A. Brodsky MD
Columbus, Ohio Director, Division of Hematology, Johns Hopkins University School
of Medicine, Johns Hopkins University, Baltimore, Maryland
Edward J. Benz, Jr. MD
Richard and Susan Smith Professor of Medicine, Professor of Hal E. Broxmeyer PhD
Pediatrics, and Professor of Pathology, Harvard Medical School; Chairman and Mary Margaret Walther Professor of Microbiology and
President and CEO, Dana-Farber Cancer Institute; Director, Immunology; Professor of Medicine; Indiana University School of
Dana-Farber/Harvard Cancer Center, Boston, Massachusetts Medicine; Scientific Director, Walther Oncology Center, Indianapolis,
Indiana
Stacey L. Berg MD
Professor of Pediatrics, Section of Hematology/Oncology, Baylor Claudio G. Brunstein MD, PhD
College of Medicine Houston, Texas Assistant Professor, Division of Hematology, Oncology, and
Transplantation Department of Medicine, University of Minnesota,
Nancy Berliner MD Medical School; Attending Physician, Medical Director of Unrelated
Professor of Medicine, Brigham and Women’s Hospital, Harvard Donor Transplant, University of Minnesota Medical Center,
Medicine School, Boston, Massachusetts Minneapolis, Minnesota
Kapil N. Bhalla MD Michael P. Busch MD, PhD
Director, Medical College of Georgia Cancer Center; Professor, School Professor of Laboratory Medicine, University of California, San
of Medicine, Medical College of Georgia; Vice-Dean for Cancer Francisco, School of Medicine; Vice President, Blood Systems Research
Research and Services, Medical College of Georgia; Chief, Clinical Institute, San Francisco, California
Cancer Services, MCG Health System, Augusta, Georgia
James B. Bussel MD
Nina Bhardwaj MD, PhD Professor of Pediatrics and Professor of Pediatrics in Obstetrics and
Professor of Medicine, Pathology and Dermatology, New York Gynecology and in Medicine, Weill Medical College of Cornell
University School of Medicine; Director, Tumor Vaccine Program, University; Director, Platelet Research and Treatment Program, and
New York University Cancer Institute, New York, New York Attending, Department of Pediatric Hematology Oncology, New York
Hospital; Attending Pediatrician, New York Presbyterian Hospital,
Ravi Bhatia MD New York, New York
Professor, Division of Hematology and Hematopoietic Cell
Transplantation, Director, Division of Hematopoietic Stem Cell and Joseph H. Butterfield MD
Leukemia Research, City of Hope National Medical Center, Duarte, Professor of Medicine, Mayo Medical School, Mayo Clinic, Rochester,
California Minnesota
Smita Bhatia MD, MPH John C. Byrd MD
Professor and Chair, Division of Population Sciences, City of Hope Professor of Medicine and Medical Chemistry, D Warner Brown
National Medical Center, Duarte, California Professor of Leukemia Research, The Ohio State University,
Columbus, Ohio
Craig D. Blinderman MD, MA
Instructor, Harvard Medical School; Co-Director, MGH Cancer Pain Michael A. Caligiuri MD
Clinic; Attending Physician, Palliative Care Service, Massachusetts Professor, The Ohio State University; Director/Chief Executive
General Hospital, Boston, Massachusetts Officer, Comprehensive Cancer Center, Arthur James Cancer Hospital
and Richard Solove Research Institute, Columbus, Ohio
Catherine M. Bollard MBChB, FRACP, FRCPA
Associate Professor, Department of Pediatrics, Baylor College of Alan B. Cantor MD, PhD
Medicine; Department of Pediatric Hematology/Oncology, Texas Assistant Professor of Pediatrics, Harvard Medical School; Assistant in
Children’s Hospital, Houston, Texas Medicine, Children’s Hospital Boston, Dana-Farber Cancer Institute,
Boston, Massachusetts
Douglas E. Brandoff MD
Instructor in Medicine, Harvard Medical School; Attending Physician Christopher L. Carpenter MD, PhD
and Co-Director of Outpatient Services, Pain and Palliative Care Assistant Professor, Department of Medicine, Harvard Medical School;
Program, Dana-Farber Cancer Institute/Brigham and Women’s Department of Medicine, Beth Israel Deaconess Medical Center,
Hospital, Boston, Massachusetts Boston, Massachusetts
Lawrence F. Brass MD, PhD Michael C. Carroll PhD
Professor of Medicine and Pharmacology, University of Pennsylvania Professor of Pediatrics and Pathology, Harvard Medical School; Senior
School of Medicine, Philadelphia, Pennsylvania Investigator, CBR Institute for Biomedical Research, Boston,
Massachusetts
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Contributors ix
Paula M. Charuhas MS, RD, FADA, CD, CNSD Björn Dahlbäck MD, PhD
Nutrition Education Coordinator, Nutrition Program Seattle Cancer Professor of Blood Coagulation Research, Department of Laboratory
Care Alliance, Seattle, Washington Medicine, Section of Clinical Chemistry University Hospital, Lund
University, Malmo˝, Sweden
David H.K. Chui MD
Professor of Medicine, Boston University School of Medicine, Boston, Alan D. D’ Andrea MD
Massachusetts Fuller-American Cancer Society Professor, Department of Radiation
Oncology, Harvard Medical School; Dana-Farber Cancer Institute,
Douglas Cines MD Boston, Massachusetts
Professor, Department of Pathology and Laboratory Medicine,
University of Pennsylvania School of Medicine; Director, Coagulation Chi Van Dang MD, PhD
Laboratory, Hospital of the University of Pennsylvania, Philadelphia, Professor of Medicine, Oncology, Pathology and Cell Biology, Johns
Pennsylvania Hopkins University School of Medicine; Attending Physician, Johns
Hopkins Hospital, Baltimore, Maryland
David B. Clark PhD
President, Platte Canyon Consulting, Inc., Shawnee, Coloràdo Ayelet Dar PhD
Weizmann Institute of Science, Rehovot, Israel
Thomas D. Coates MD
Professor of Pediatrics and Pathology, University of Southern Stella M. Davies MBBS, PhD, MRCP
California Keck School of Medicine; Section Head of Hematology, Professor of Pediatrics, University of Cincinnati; Director, Blood and
Children’s Center for Cancer and Blood Disease, Children’s Hospital Marrow Transplantation Program, Division of Hematology/Oncology,
Los Angeles, Los Angeles, California Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio
Aileen C, Cohen MD PhD Marcos De Lima MD
Instructor of Pediatrics, Division of Hematology/Oncology, Associate Professor of Medicine, Department of Stern Cell
Department of Pediatrics, Stanford University School of Medicine; Transplantation and Cell Therapy, University of Texas M.D.
Attending Physician at Lucile Packard Children’s Hospital, Lucile Anderson Cancer Center, Houston, Texas
Packard Children’s Hospital, Stanford, California
Daniel J. De Angelo MD, PhD
Désiré Collen MD, PhD Assistant Professor of Medicine, Harvard Medical School; Attending
Professor Center for Molecular and Vascular Biology, University of Physician, Dana-Farber Cancer Institute, Boston, Massachusetts
Leuven Faculty of Medicine, Leuven, Belgium
H. Joachim Deeg MD
Barry S. Coller MD Professor of Medicine, Division of Oncology, University of
David Rockefeller Professor of Medicine, Rockefeller University School Washington; Member, Fred Hutchinson Cancer Research Center,
of Medicine; Head, Laboratory of Blood and Vascular Biology and Clinical Research Division, HCRC, Seattle, Washington
Physician-in-Chief, Rockefeller University Hospital; Clinical Professor
of Medicine, Mount Sinai School of Medicine, New York, New York David De Remer PHARM D, BCOP
Clinical Assistant Professor, University of Georgia; Clinical
Elizabeth Diana Cooke RN MN ANP AOCN Hematology/Oncology Pharmacy Specialist, Medical College of
School of Medicine, Hamilton, Ontario, Canada Georgia, Augusta, Georgia
Richard J. Creger PHARM D Bimalangshu R. Dey MD, PhD
Associate Professor of Medicine, Case Western Reserve University; Assistant Professor of Medicine, Harvard Medical School,
Ireland Cancer Center, University Hospitals Case Medical Center, Massachusetts General Hospital, Bone Marrow Transplantation
Cleveland, Ohio Program, Boston, Massachusetts
Mark A. Crowther MD, MSc, FRCPC Volker Diehl MD
Professor of Medicine (Hematology and Thromboembolism), Professor, Department of Medicine, University of Cologne Faculty of
McMaster University; Senior Research Specialist and Nurse Medicine, Cologne, Germany
Practitioner, Department of Nursing, Beckman Research Institute at
the City of Hope, Duarte, California Mary C. Dinauer MD, PhD
Nora Letzter Professor of Pediatrics (Hematology/Oncology) and
Melissa M. Cushing MD Professor of Microbiology/Immunology and of Medical and Molecular
Assistant Professor, Department of Pathology and Laboratory Genetics, Department of Pediatrics, Indiana University School of
Medicine, Weill Cornell Medical College; Assistant Director, Medicine; Professor of Pediatrics, Riley Hospital for Children,
Transfusion Medicine and Cellular Therapy, New York—Presbyterian Indianapolis, Indiana
Hospital-Weill Cornell Medical Center, New York, New York
Angela Dispenzieri MD
Gary V. Dahl MD Consultant, Division of Hematology, Mayo Clinic, Associate Professor
Professor of Pediatrics, Department of Pediatric Hematology/ of Medicine, Mayo Clinic College of Medicine; Mayo Clinic,
Oncology, Lucile Packard Children’s Hospital, Stanford University Rochester, Minnesota
School of Medicine, Palo Alto, California
Michele L. Donato MD
Richard Dahl PhD Core Faculty, Touro University College of Medicine; Collection
Research Assistant Professor, University of New Mexico Health Facility Medical Director, Blood and Marrow Transplantation
Sciences Center, Albuquerque, New Mexico Program, Hackensack University Medical Center, Hackensack, New
Jersey
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