Hematologic Abnormalities and Acute Lung Syndromes

264 Pages·2017·7.19 MB·English

by  Janet S. Lee

Respiratory Medicine
Series Editor: Sharon I.S. Rounds
Janet S. Lee
Michael P. Donahoe Editors
Hematologic
Abnormalities
and Acute Lung
Syndromes
Respiratory Medicine
Series Editor:
Sharon I.S. Rounds
More information about this series at h ttp://www.springer.com/series/7665
Janet S. Lee • Michael P. Donahoe
Editors
Hematologic Abnormalities
and Acute Lung Syndromes
Editors
Janet S. Lee, MD Michael P. Donahoe, MD
Professor of Medicine Professor of Medicine
Division of Pulmonary, Allergy, Division of Pulmonary, Allergy,
and Critical Care Medicine and Critical Care Medicine
Department of Medicine Department of Medicine
University of Pittsburgh School of Medicine University of Pittsburgh School of Medicine
Pittsburgh , PA , USA Pittsburgh , PA , USA
ISSN 2197-7372 ISSN 2197-7380 (electronic)
Respiratory Medicine
ISBN 978-3-319-41910-7 ISBN 978-3-319-41912-1 (eBook)
DOI 10.1007/978-3-319-41912-1
Library of Congress Control Number: 2016951643
© Springer International Publishing Switzerland 2017
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Pref ace
Standard textbooks in Respiratory Medicine do not typically organize their contents
to specifi cally address hematologic abnormalities in acute lung syndromes.
However, the main function of the lung is gas exchange at the interface between the
external environment and blood. Thus, by defi nition, blood and its components are
an integral part of the lungs and, given the large surface area of the pulmonary vas-
cular beds, the lungs harbor a signifi cant fraction of the circulating blood volume at
any one time. While red cells are the vehicles for gas transfer, platelets provide
hemostasis, and leukocytes vital for lung homeostasis and immunity, components of
the hematopoietic system, can also serve as agents of injury to the lungs in disease
states. So, it is not surprising that primary hematologic disorders or disorders sec-
ondary to immunopathology can lead to acute lung dysfunction. The purpose of this
book is to provide a unique framework for acute lung syndromes that arise from
hematologic disorders or is defi ned by a hematologic abnormality as a key feature.
These acute lung processes can present as life-threatening conditions, and as such,
the pulmonary physician or critical care physician is often directly involved in their
care or called upon to provide expertise.
The book emphasizes the pathogenesis and current understanding of mecha-
nisms and is organized into three parts. It begins with an overview containing the
central theme of the lungs as the direct interface between the external environment
and blood and a description of individual components of the hematopoietic system,
their function, and relevance to the lungs. The overview also discusses the concept
of the lungs as an organ site of leukocyte sequestration and a target organ of injury
and how cells of hematopoietic origin can serve as agents of injury. The second part
of the book focuses upon primary hematologic disorders that can lead to acute pul-
monary manifestations. This section is organized by benign and malignant hemato-
logic disorders and the specifi c clinical entities affecting the lungs associated with
these disorders. The third part of the book focuses upon transfusion-related compli-
cations occurring in the ICU setting.
These chapters provide a unique framework for discussing unusual clinical enti-
ties encountered largely in the acute hospital setting. These acute pulmonary syn-
dromes are typically not organized in such a way for easy reference. However,
v
vi Preface
recent advances in medicine have allowed for patients with severe comorbidities
such as sickle cell anemia, hemophilia, hematologic malignancies, or immunopa-
thologies to survive, and thus many of the syndromes discussed have not had full
representation in respiratory medicine textbooks historically. Thus, the book encom-
passes disease entities that specialists will encounter. The book is written in detail,
emphasizing primary literature and pathophysiology, and catered to clinicians who
take care of these patients.
Pittsburgh, PA, USA Janet S. Lee, MD
Pittsburgh, PA, USA Michael P. Donahoe, MD
Contents
Part I Overview
1 The Lung–Blood Interface ..................................................................... 3
Peng Zhang and Janet S. Lee
2 Leukocyte Kinetics and Migration in the Lungs .................................. 19
Prithu Sundd and Margaret F. Bennewitz
Part II Acute Pulmonary Manifestations Arising
From Primary Hematologic Disorders
3 Sickle Cell Disease and Acute Chest Syndrome:
Mechanisms and Pathogenenesis ........................................................... 49
Olufolake Adetoro Adisa , Amma Owusu-Ansah ,
Afua Darkwah Abrahams , Samit Ghosh ,
and Solomon Fiifi Ofori-Acquah
4 Sickle Cell Disease and Acute Chest Syndrome:
Epidemiology, Diagnosis, Management, Outcomes ............................. 67
Justin R. Sysol and Roberto Machado
5 Thrombophilias and Acute Pulmonary
Thromboembolic Disease ....................................................................... 89
Shani Gunning-Carter , Gregory J. Kato , and Belinda Rivera-Lebron
6 Bleeding Disorders: Diagnosis and Treatment of Hemorrhagic
Complications in the Intensive Care Unit ............................................. 109
Craig D. Seaman and Margaret V. Ragni
7 Acute Pulmonary Manifestations of Hematologic Malignancies ........ 131
Andra Fee-Mulhearn and Patrick Nana-Sinkam
8 Acute Pulmonary Complications of Bone Marrow
and Stem Cell Transplantation .............................................................. 147
Guang-Shing Cheng and David K. Madtes
vii
viii Contents
Part III Transfusion-Related Complications
9 Storage Lesion: Evolving Concepts and Controversies ....................... 175
Stefanie Forest , Francesca Rapido , and Eldad A. Hod
10 Transfusion and Acute Respiratory Distress Syndrome:
Pathogenesis and Potential Mechanisms .............................................. 193
Nicole P. Juffermans and Alexander P. Vlaar
11 Transfusion and Acute Respiratory Distress Syndrome:
Clinical Epidemiology, Diagnosis, Management, and Outcomes ....... 213
Hannah C. Mannem and Michael P. Donahoe
12 Transfusion Associated Circulatory Overload ..................................... 229
Mario V. Fusaro and Giora Netzer
13 Transfusion-Related Immunomodulation (TRIM):
From Renal Allograft Survival to Postoperative Mortality
in Cardiac Surgery .................................................................................. 241
Eleftherios C. Vamvakas
Index ................................................................................................................. 261
Contributors
Afua Darkwah Abrahams , MBChB, FWACP Department of Pathology ,
U niversity of Ghana Medical School and Korle Bu Teaching Hospital, University of
Ghana , Accra , Ghana
Olufolake Adetoro Adisa , MD Department of Pediatrics , Emory University ,
Atlanta , GA , USA
Margaret F. Bennewitz , PhD Division of Pulmonary, Allergy and Critical Care
Medicine, P ittsburgh Heart, Lung, and Blood Vascular Medicine Institute, University
of Pittsburgh School of Medicine , Pittsburgh , PA , USA
Guang-Shing Cheng , MD F red Hutchinson Cancer Research Center, U niversity
of Washington School of Medicine , Seattle , WA , USA
Michael P. Donahoe , MD Division of Pulmonary, Allergy, and Critical Care
Medicine , Department of Medicine, University of Pittsburgh School of Medicine ,
Pittsburgh , PA , USA
Andra Fee-Mulhearn , DO, MPH D ivision of Pulmonary, Allergy, Critical Care
and Sleep Medicine , The Ohio State University , Columbus , OH , USA
Stefanie Forest , MD, PhD Department of Pathology and Cell Biology at Columbia
University Medical Center , New York Presbyterian Hospital , New York , NY , USA
Mario V. F usaro , MD Division of Telehealth, Division of Pulmonary and Critical
Care Medicine, Westchester Medical Center , Valhalla , NY , USA
Division of Pulmonary and Critical Care Medicine, Department of Medicine, and
Department of Epidemiology and Public Health, University of Maryland School of
Medicine , Baltimore , MD , USA
Samit Ghosh , PhD Division of Hematology/Oncology, Department of Medicine ,
University of Pittsburgh School of Medicine , Pittsburgh , PA , USA
ix
x Contributors
Shani Gunning-Carter , MD Division of Hematology/Oncology , Department of
Medicine, Monongahela Valley Hospital , Monongahela , PA , USA
Eldad A. Hod , MD Department of Pathology and Cell Biology at Columbia
University Medical Center , New York Presbyterian Hospital , New York , NY , USA
Nicole P. Juffermans , MD, PhD L aboratory of Experimental Intensive Care and
Anesthesiology, Department of Intensive Care Medicine, A cademic Medical Center,
Amsterdam , The Netherlands
Gregory J. Kato , MD Division of Hematology-Oncology, Department of
Medicine, Monongahela Valley Hospital , Monongahela , PA , USA
Division of Hematology/Oncology, Pittsburgh Heart, Lung, and Blood Vascular
Medicine Institute, Department of Medicine, University of Pittsburgh School of
Medicine , Pittsburgh , PA , USA
Janet S. Lee , MD Division of Pulmonary, Allergy, and Critical Care Medicine ,
P ittsburgh Heart, Lung, and Blood Vascular Medicine Institute, Department of
Medicine, University of Pittsburgh School of Medicine , Pittsburgh , PA , USA
Roberto Machado , MD Division of Pulmonary, Critical Care, Sleep and Allergy ,
Department of Medicine, University of Illinois College of Medicine at Chicago ,
Chicago , IL , USA
Department of Pharmacology, University of Illinois at Chicago , Chicago , IL , USA
David K. Madtes , MD Fred Hutchinson Cancer Research Center , University of
Washington School of Medicine , Seattle , WA , USA
Hannah C. Mannem , MD D ivision of Pulmonary, Allergy, and Critical Care
Medicine, Department of Medicine, University of Pittsburgh School of Medicine ,
Pittsburgh , PA , USA
Patrick Nana-Sinkam , MD Division of Pulmonary, Allergy , Critical Care and
Sleep Medicine, The Ohio State University , Columbus , OH , USA
Division of Medical Oncology , The Ohio State University , Columbus , OH , USA
James Thoracic Oncology Center , The Ohio State University , Columbus , OH , USA
Faculty Advancement, Mentorship and Engagement , Center for FAME, The Ohio
State University , Columbus , OH , USA
Giora Netzer , MD, MSCE D ivision of Pulmonary and Critical Care Medicine,
Department of Medicine, and Department of Epidemiology and Public Health,
University of Maryland School of Medicine , Baltimore , MD , USA
Solomon Fiifi Ofori-Acquah , PhD Department of Pathology , University of Ghana
Medical School and Korle Bu Teaching Hospital University of Ghana, A ccra, G hana
Center for Translational and International Hematology, Pittsburgh Heart, Lung, and
Blood Vascular Medicine Institute, University of Pittsburgh , Pittsburgh , PA , USA