Heat Shock Proteins in Cancer PDF
Preview Heat Shock Proteins in Cancer
Heat Shock Proteins in Cancer HEAT SHOCK PROTEINS Volume 2 Series Editors: A. A. A. Asea EffieandWoffordCainCentennialEndowedChairinClinicalPathology, Chief,DivisionofInvestigativePathology,Scott&WhiteMemorialHospitalandClinic andTheTexasA&MUniversitySystemHealthScienceCenterCollegeofMedicine S. K. Calderwood DivisionofMolecularandCellularRadiationOncology, BethIsraelDeaconessMedicalCenterandHarvardMedicalSchool Heat Shock Proteins in Cancer Edited by Stuart K. Calderwood HarvardMedicalSchool,Boston,U.S.A. Michael Y. Sherman BostonUniversitySchoolofMedicine,Boston,U.S.A. and Daniel R. Ciocca NationalResearchCouncilCONICET,Mendoza,Argentina AC.I.P.CataloguerecordforthisbookisavailablefromtheLibraryofCongress. ISBN978-1-4020-6400-5(HB) ISBN978-1-4020-6401-2(e-book) PublishedbySpringer, P.O.Box17,3300AADordrecht,TheNetherlands. www.springer.com Printedonacid-freepaper AllRightsReserved ©2007Springer Nopartofthisworkmaybereproduced,storedinaretrievalsystem,ortransmitted inanyformorbyanymeans,electronic,mechanical,photocopying,microfilming,recording orotherwise,withoutwrittenpermissionfromthePublisher,withtheexception ofanymaterialsuppliedspecificallyforthepurposeofbeingentered andexecutedonacomputersystem,forexclusiveusebythepurchaserofthework. TABLE OF CONTENTS List of Contributors vii 1. The Hsp90 Chaperone Machinery Acts at Protein Folding Clefts to Regulate Both Signaling Protein Function and Protein Quality Control 1 William B. Pratt, Yoshihiro Morishima and Yoichi Osawa 2. Implications of Heat Shock Proteins in Carcinogenesis and Cancer Progression 31 Daniel R. Ciocca, Mariel A. Fanelli, F. Dario Cuello-Carrión and Stuart K. Calderwood 3. HSF1: An Emerging Factor in Cancer 53 Stuart K. Calderwood, Md Abdul Khaleque, Ajit Bharti and Daniel R. Ciocca 4. Anti-apoptotic, Tumorigenic and Metastatic Potential of Hsp27 (HspB1) and (cid:2)B-Crystallin (HspB5): Emerging Targets for the Development of New Anti-Cancer Therapeutic Strategies 73 Andre-Patrick Arrigo 5. Heat Shock Protein-27 (Hsp-27) in Breast Cancers: Regulation of Expression and Function 93 Vishwanie S. Budhram-Mahadeo and Richard J. Heads 6. Role of Heat Shock Protein Hsp25/27 in the Metastatic Spread of Cancer Cells 131 María A. Bausero and Alexzander Asea 7. Heat Shock Chaperone Mortalin and Carcinogenesis 141 Custer C. Deocaris, Sunil C. Kaul and Renu Wadhwa 8. Role of Molecular Chaperones in Cell Senescence 159 Michael Y. Sherman and Julia Yaglom v vi Table of contents 9. Involvement of Heat Shock Proteins in Protection of Tumor Cells from Genotoxic Stresses 169 Cornelia O’Callaghan-Sunol and Vladimir L. Gabai 10. Hsp70 in Tumors: Friend or Foe? 191 Cristina Bonorino and Ana Paula Souza 11. Hsp70 and Hsp27 as Pharmacological Targets in Apoptosis Modulation for Cancer Therapy 209 M. Brunet, C. Didelot, S. Subramaniam, A.L. Rérole, A. de Thonel and C. Garrido 12. Heat Shock Protein 90: The Cancer Chaperone 231 Len Neckers 13. TargetingHsp90FunctiontoTreatCancer:MuchMoretobeLearned 253 Luke Whitesell and Catherine A. McLellan 14. Small-Molecule HSP90 Inhibitors: Applications in Cancer and Neurodegenerative Diseases 275 Adeela Kamal, Srinivas Kasibhatla, Marco Biamonte, Hong Zhang, LinZhang,KarenLundgren,MarcusF.BoehmandFrancisJ.Burrows 15. Drugging the Hsp90 Molecular Chaperone Machine for Cancer Treatment 295 J.L. Holmes, S.Y. Sharp and P. Workman 16. Cdc37 and Protein Kinase Folding 331 Robert Matts and Avrom J. Caplan 17. The Elevated Levels of Heat Shock Proteins in Cancer: A Suitable Case for Treatment? 351 Stuart K. Calderwood, Daniel R. Ciocca, Phillip J. Gray Jnr, Nava Zaarur, Stan Lepchammer and Michael Y. Sherman 18. Hsp70-Based Anticancer Vaccines: Chaperoning the Immune Response 367 Jianlin Gong, Jimmy R. Theriault and Stuart K. Calderwood 19. Piloting of Exogenous Antigen into Cross-Presentation Pathway by Heat Shock Proteins 383 Yasuaki Tamura, Goro Kutomi, Jun Oura, Toshihiko Torigoe and Noriyuki Sato Index 397 LIST OF CONTRIBUTORS Andre-Patrick Arrigo Stress, Chaperons and Cell Death Laboratory, CNRS UMR 5534, Centre de Génétique Moléculaire et Cellulaire, Université Claude Bernard, LYON 1, 16 rue Dubois, 69622 Villeurbanne Cedex, France, e-mail: [email protected] Alexzander Asea Division of Investigative Pathology, Scott & White Memorial ClinicandHospitalandtheTexasA&MUniversitySystemHealthScienceCenter College of Medicine, 1901 South 1st Street, Temple, Texas 76504, USA María A. Bausero Cell Biology and Flow Cytometry Unit, Institut Pasteur de Montevideo, Calle Mataojo 2020 CP 11400 Montevideo, Uruguay Ajit Bharti Boston University Medical Center, 650, Albany Street, Boston, MA 02118 MarcoBiamonte BiogenIdec,5200ResearchPlace,SanDiego,CA92122,USA Marcus F. Boehm Biogen Idec, 5200 Research Place, San Diego, CA 92122, USA CristinaBonorino FaculdadedeBiociênciaseInstitutodePesquisasBiomédicas, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil M.Brunet INSERMUMR-866,FacultyofMedicineandPharmacy,7Boulevard Jeanne d’Arc, 21039 Dijon, France VishwanieS.Budhram-Mahadeo MedicalMolecularBiologyUnit,Instituteof ChildHealth,UniversityCollegeLondon,30GuilfordStreet,London,WC1N1EH Francis J. Burrows Biogen Idec, 5200 Research Place, San Diego, CA 92122, USA StuartK.Calderwood DivisionofMolecularandCellularRadiationOncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;DepartmentofMedicine,BostonUniversitySchoolofMedicine,MA02118, USA, e-mail: [email protected] Avrom J. Caplan Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA Daniel R. Ciocca Oncology Laboratory, Institute of Experimental Medicine and Biology of Cuyo (CRICYT-CONICET), and Argentine Foundation for vii viii List of contributors Cancer Research (FAIC), Mendoza, C. C. 855, 5500 Mendoza, Argentina, e-mail: [email protected] F. Dario Cuello-Carrión Oncology Laboratory, Institute of Experimental Medicine and Biology of Cuyo (CRICYT-CONICET), and Argentine Foundation for Cancer Research (FAIC), Mendoza, C. C. 855, 5500 Mendoza, Argentina Custer C. Deocaris Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan C.Didelot INSERMUMR-866,FacultyofMedicineandPharmacy,7Boulevard Jeanne d’Arc, 21039 Dijon, France Mariel A. Fanelli Oncology Laboratory, Institute of Experimental Medicine andBiologyofCuyo(CRICYT-CONICET),andArgentineFoundationforCancer Research (FAIC), Mendoza, C. C. 855, 5500 Mendoza, Argentina VladimirL.Gabai BostonUniversityMedicalSchool,Boston,MA02118,USA C.Garrido INSERMUMR-866,FacultyofMedicineandPharmacy,7Boulevard Jeanne d’Arc, 21039 Dijon, France Jianlin Gong Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA Phillip J. Gray Jnr Division of Molecular and Cellular Radiation Oncology, BethIsraelDeaconessMedicalCenter,HarvardMedicalSchool,Boston,MA02215 Richard J. Heads Cardiovascular Division, King’s College London School of Medicine, Department of Cardiology, The Rayne Institute, St Thomas’s Hospital, Lambeth Palace Road, London SE1 7EH, UK J.L. Holmes Signal Transduction and Molecular Pharmacology Team, Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, Haddow Laboratories, Sutton, Surrey, SM2 5NG, UK Adeela Kamal Biogen Idec, 5200 Research Place, San Diego, CA 92122, USA Srinivas Kasibhatla Biogen Idec, 5200 Research Place, San Diego, CA 92122, USA Sunil C. Kaul National Institute of Advanced Industrial Science & Technology (AIST), Central 4, 1-1-1 Higashi, Tsukuba, Ibaraki, Japan Md Abdul Khaleque Division of Molecular and Cellular Radiation Oncology, BethIsraelDeaconessMedicalCenter,HarvardMedicalSchool,Boston,MA02215 GoroKutomi DepartmentofPathology,SapporoMedicalUniversity,Schoolof Medicine, South 1 West 16, Cho-ku, Sapporo 060-8556, Japan Stan Lepchammer Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA List of contributors ix Karen Lundgren Biogen Idec, 5200 Research Place, San Diego, CA 92122, USA Robert Matts Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK 74078, Oklahoma, USA Catherine A. McLellan Whitehead Institute for Biomedical Research Cambridge, MA 02142, USA Yoshihiro Morishima Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109-0630, USA Len Neckers Urologic Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA Cornelia O’Callaghan-Sunol Boston University Medical School, Boston, MA 02118, USA Yoichi Osawa Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109-0630, USA Jun Oura Department of Pathology, Sapporo Medical University, School of Medicine, South 1 West 16, Cho-ku, Sapporo 060-8556, Japan WilliamB.Pratt DepartmentofPharmacology,UniversityofMichiganMedical School, Ann Arbor, MI 48109-0630, USA A.L. Rérole INSERM UMR-866, Faculty of Medicine and Pharmacy, 7 Boulevard Jeanne d’Arc, 21039 Dijon, France Noriyuki Sato Department of Pathology, Sapporo Medical University, School of Medicine, South 1 West 16, Cho-ku, Sapporo 060-8556, Japan S.Y. Sharp Signal Transduction and Molecular Pharmacology Team, Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, Haddow Laboratories, Sutton, Surrey, SM2 5NG, UK MichaelY.Sherman DepartmentofBiochemistry,BostonUniversitySchoolof Medicine, Boston, MA 02118, USA AnaPaulaSouza FaculdadedeBiociênciaseInstitutodePesquisasBiomédicas, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil S. Subramaniam INSERM UMR-866, Faculty of Medicine and Pharmacy, 7 Boulevard Jeanne d’Arc, 21039 Dijon, France YasuakiTamura DepartmentofPathology,SapporoMedicalUniversity,School of Medicine, South 1 West 16, Cho-ku, Sapporo 060-8556, Japan Jimmy R. Theriault Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Boston, MA 02215
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