Hazardous reagent substitution a pharmaceutical perspective

194 Pages·2018·6.569 MB·English

by  Bandichhor, Rakeshwar, Sharma, Rakesh Kumar

Hazardous Reagent Substitution
A Pharmaceutical Perspective
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Green Chemistry Series
Editor-in-Chief:
James H. Clark, Department of Chemistry, University of York, UK
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9/ Titles in the Series:
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0.1 1: The Future of Glycerol: New Uses of a Versatile Raw Material
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or 4: Sustainable Solutions for Modern Economies
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htt 8: The Future of Glycerol: 2nd Edition
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17: Natural Polymers Volume 2: Nanocomposites
18: Integrated Forest Biorefineries
19: Sustainable Preparation of Metal Nanoparticles: Methods and
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20: Alternative Solvents for Green Chemistry: 2nd Edition
21: Natural Product Extraction: Principles and Applications
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23: Green Materials for Sustainable Water Remediation and Treatment
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25:BiomassforSustainableApplications:PollutionRemediationandEnergy
26: From C–H to C–C Bonds: Cross-Dehydrogenative-Coupling
27: Renewable Resources for Biorefineries
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31:BallMillingTowardsGreenSynthesis:Applications,Projects,Challenges
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10 Elements, Part 1
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org | 42: Green Photo-active Nanomaterials
sc. 43: Commercializing Biobased Products: Opportunities, Challenges,
bs.r Benefits, and Risks
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htt 45: White Biotechnology for Sustainable Chemistry
on 46: Green and Sustainable Medicinal Chemistry: Methods, Tools and
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n 2 50: Fast Pyrolysis of Biomass: Advances in Science and Technology
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ed 51: Catalyst-free Organic Synthesis
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Hazardous Reagent Substitution
A Pharmaceutical Perspective
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82 Edited by
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c. ISSN:1757-7039
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8 Foreword
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oi: This book covers the contemporary topic ‘‘Hazardous Reagents Substi-
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or chemical transformations. Despite the ready availability of many journals
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htt involved and environmental footprint associated with it. This book, edited
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n 28 for diverse transformations is also included in the book. The extent of in-
o formationandtrendsinpharmaceuticaldevelopmentcapturedinthisbook
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he makes it an essential resource for scientists working at the frontiers of re-
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bli search both in industry and in academia. All the chapters are written with
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considerable rigor and duly factor-in the context of each example and the
choice of reagents employed in a particular synthesis. All the chapters pro-
videtherelevantbackgroundandincluderelevantreferences.Thebookcan
be regarded as a benchmark for the development and evolution of non-
hazardous reagents and facilitate making a ‘reagent switch’ wherever con-
siderations of sustainability, green chemistry and safety (non-hazardous
handling) so warrant. Taken as a whole, this contribution has the potential
toofferanextremelyusefulguidetoarrive atsafer reagentsforsynthesisof
not only pharmaceutically relevant molecules but also for useful materials
deployed in diverse domains.
The Editors of the book, Prof. Rakesh K. Sharma, University of Delhi and
DrRakeshwarBandichhor, DrReddy’s Laboratories,Hyderabad,alongwith
GreenChemistrySeriesNo.52
HazardousReagentSubstitution:APharmaceuticalPerspective
EditedbyRakeshKumarSharmaandRakeshwarBandichhor
rTheRoyalSocietyofChemistry2018
PublishedbytheRoyalSocietyofChemistry,www.rsc.org
vii
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viii Foreword
otherswhohavecontributedchaptersdeservetobecomplementedfortheir
efforts and fordrawing attentionto theimportantissueoftheavoidance of
hazardouschemicalsandmaterials.Itistobehopedthatthisendeavorwill
enthuse scientists in industry and academia to revisit and devise processes
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2 Goverdhan Mehta, University Distinguished Professor
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8 Introduction
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or expandedandconsolidatedinsuchawaythatoneneedsonlymentionafew
c.
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s.r termstounderstandthatchemicalsystemsthatdidnotexistroughlytwenty
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htt include the name reactions, organometallics, organocatalysis, oxidation,
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No a sustainable world. The purpose of this book is to sensitize the chemistry
n 28 fraternitytotheideathattheusageofhazardousreagentsinmanufacturing
o of goods no longer fits in any business, environmental or technical prop-
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he ositions. It is rather mandatory or unavoidable to find alternates for all re-
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material production. These reagents, their by-products and demanding
process conditionshavefoundtoposeahighdegreeofchallengesinterms
ofsafetyandoccupationalexposuretothepeople(especiallythoseareinthe
vicinity of operation) and imbalances to the ecosystem. This book features
eight chapters as well as the foreword. Chapter I, entitled Introduction to
HazardousReagentSubstitutioninthePharmaceuticalIndustry,talksabout
substitution of hazardous reagents with less or non-hazardous ones as one
of the most essential parts of risk management in the work place, whether
it is a research and development or a manufacturing set-up. Chapter II,
entitled Recyclability of Reagents, emphasizes the reduction and disposal
GreenChemistrySeriesNo.52
HazardousReagentSubstitution:APharmaceuticalPerspective
EditedbyRakeshKumarSharmaandRakeshwarBandichhor
rTheRoyalSocietyofChemistry2018
PublishedbytheRoyalSocietyofChemistry,www.rsc.org
ix
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x Introduction
of the reagents meaningfully. Chapter III, entitled Recoverable Polymer-
Supported DMAP Derivatives, elaborates on the significance of polymer-
supported catalysis for chemists to recycle the reagents and reduce the
overall carbon footprint of synthesis. Chapter IV, entitled Synthesis of
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org | the scope and limitations of industry-academia collaborative research.
sc. This book attempts to provide a perspective of finding non- or less-
bs.r hazardous reagents for the hazardous reagents in practice which can be
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