Harvard Medical School/Harvard School of Dental Medicine

32 Pages·2015·0.27 MB·English

by  Annarosa Leri

Harvard Medical School/Harvard School of Dental Medicine
Curriculum Vitae
Date Prepared: January 20, 2014
Name: Annarosa Leri, M.D.
Office Address: Brigham and Women’s Hospital
Departments of Anesthesia and Medicine,
and Cardiovascular Division
Laboratories for Regenerative Medicine
Thorn 1317
Boston, MA 02115

Home Address: 160 Commonwealth Avenue Apt. 212
Boston, MA 02116

Work Phone: [phone]
Work Email: [email protected]
Work FAX: [phone]
Place of Birth: Reggio Emilia, Italy
Education

1982 Diploma di Maturita’ Biology and Italian Literature Liceo Scientifico,

summa cum laude Castelnovo ne’ Monti,

Italy

1990 MD summa cum laude Medicine
University of Parma,
Medical School, Parma,
Italy
Postdoctoral Training

1990-1994 Resident/Fellow Dermatology University of Parma,

(summa cum laude) Medical School

1996-1999 Fellow Molecular Biology Cardiovascular Research
Institute, Department of
Medicine, New York
Medical College, Valhalla,
NY

1
Faculty Academic Appointments

1994-1996 Instructor Department of Dermatology University of Parma,

Medical School

1999-2002

Assistant Professor Department of Medicine New York Medical College
2002-2006
Associate Professor Department of Medicine New York Medical College
with Tenure
2002-2007
Associate Professor Department of Dermatology New York Medical College
2006-2007
Associate Professor Department of Physiology New York Medical College
2006-2007
Professor with Tenure Department of Medicine New York Medical College

2007-2010 Lecturer Department of Anesthesia Harvard Medical School,
Boston, MA

2007- Adjunct Professor Department of Medicine New York Medical College
(no voting privileges)

2010- Associate Professor Department of Anesthesia Harvard Medical School

2013- Associate Professor Department of Medicine Harvard Medical School

Appointments at Hospitals/Affiliated Institutions

12/2007- Scientist, Research Department of Anesthesiology Brigham and Women’s

Staff Hospital, Boston, MA

Major Administrative Positions
2010-2012 Center for Regenerative Therapeutics, Brigham and Women’s Hospital
BWH Biomedical Research Institute Co-Leader

2010-2012 Research Oversight Committee Brigham and Women’s Hospital
Member

2012- BWH Regenerative Center Member Steering Committee

2
Committee Service
Local

2011 Basic Science Research Task Force Brigham and Women’s Hospital
BWH Biomedical Research Institute Member

2 013 B-BIC Technology Assessment and Brigham and Women’s Hospital
Development Group Member

International

2011- Call for Scientific Projects Committee Ministry of Health, Rome, Italy

Member

Professional Societies

1994-1996 Italian Society of Dermatology and Member

Venereology

19 96- American Heart Association

1996- Fellow

2000- Member, Abstract Grading Committee

2005-2008 Member, Marcus Young Investigator
Award Committee

2006-2009 Chair, Council on Basic Cardiovascular
Sciences, Committee on Scientific Sessions
Program

2006-2011 Member, Leadership Committee, Council
on Basic Cardiovascular Sciences

2007 Chair, First International Symposium on
Myocardial Regeneration

2010-2012 Member, Leadership Committee, Council
on Functional Genomics and Translational
Biology
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2010-2012 Nominating Committee, Council on Basic
Cardiovascular Science

2011 Co-Chair, Organizing Committee for Basic
Cardiovascular Science Scientific Sessions

1998- International Society for Heart Research Member
2000- American Physiological Society Member

2009- Heart Failure Society of America

2009- Member

2009-2012 Member, Organizing Committee of the
Annual Meeting
Grant Review Activities

2000-2002 Peer Review Group National American Heart Association

Cardiovascular Pathophysiology Group 1

Member

2003 Biology of Aging Review Committee Member

2003-2006 Peer Review Group North East Consortium American Heart Association
Cardiovascular Pathophysiology Group 2
Member

2004 Myocardial Ischemia and Metabolism NIH
Review Committee
Ad Hoc Member

2004 Special Emphasis Panel “Proteomics and NIH
Aging”
Member

2004 Special Emphasis Panel for the Review of NIH
Program Project Grant Applications
Member

2005 Special Emphasis Panel for the Review of NIH
R01 Grants
Member

2005 Special Emphasis Panel “Centers of NIH
4
Excellence in Translational Human Stem
Cell Research”
Member

2006-2010 Cardiac Contractility, Hypertrophy and NIH
Failure Study Section
2006-2007 Ad Hoc Member
2007-2010 Permanent Member

2009 Biology of Aging Review Committee NIH

Ad Hoc Member

2010- Regenerative Cell Biology 2 Peer Review American Heart association
Committee
Co-Chair

2011 BRI Seed Grant Review Committee Biomedical Research Institute, Brigham and
Women’s Hospital

Member

2011 Harvard Stem Cell Institute Seed Grants Harvard Medical School
(Translational Research)
Member

2011 Call for Scientific Projects Italian Ministry of Health
Reviewer
Member, Executive Council Committee

2011 Metabolism and Myocardial Ischemia NIH
Review Committee
Ad Hoc Member

2011 Developmental Biology 2 Study Section NIH

Ad Hoc Member

2012 Call for Scientific Projects Italian Ministry of Health
Reviewer

2012 Post-doctoral fellowships Regione Marche Italian Ministry of Health
ISSNAF Reviewer

2012 Peer Review Group AHA Innovative Grants American Heart Association
5
Reviewer
AHA Inn ovative Grants
2012-2016 Metabolism and Myoc ardial IsMchyeomcaiard ial IscheNmIiHa and Reviewer NIH/National Heart Lung
Review Committee
Standing Member
2013 SEP NHLBI Review Committee Chairman

2014 Young Investigator Award Competition Ministry of Health, Italy
Reviewer
Editorial Activities
Ad Hoc Reviewer
Circulation
American Journal of Physiology
Journal of Molecular and Cellular Cardiology
American Journal of Pathology
Gene
Stem Cells
Journal of Clinical Investigation

Other Editorial Roles
2004- Editorial Board Member Circulation Research

2008-2014 Academic Editor PLoS One

Honors and Prizes

2001 Angiotensin II Young Louisville, Young Investigators Research

Investigators Award Angiotensin II Symposium

2008-2009 Mentorship as Sarnoff Sarnoff Foundation Teaching
Preceptor

2012 Plaque of Appreciation Chonnam National University Research
Medical School, Gwangju, South
Korea

2014 George E. Brown AHA Scientific Session 2014 Research
Memorial Lecturer

Report of Funded and Unfunded Projects
Funding Information
6
Past

2000-2005 Myocyte Stem Cells in the Mammalian Heart
NHLBI/R01-65577
PI ($875,000)
The objective of this project was the documentation of the existence of a pool of resident
stem cells in the normal and diseased heart, regulating cardiac turnover and repair.

2005-2011 Aging and Homeostasis of Cardiac Stem Cell Niches
NIA/R01AG026107
PI ($1,025,000)
The goal of this project was to establish whether myocyte apoptosis plays a positive role in
cardiac homeostasis, by promoting the activation and differentiation of cardiac stem cells
within the niches.

2010-2012 Cardiac Progenitor Cell Therapy for Advanced Ischemic Cardiomyopathy
NHLBI/P20HL101866
Co-Investigator
This application aims at the development of cell-based strategies in a pre-clinical model of
ischemic cardiomyopathy.

2004-2012 Aging of Cardiac Stem Cells
NIA/P01-AG023071
Project Leader
The objective of this project is to define the role of the telomere-telomerase system in
cardiac stem cell growth, death, differentiation, and senescence with aging.

2006-2012 Bone Marrow and Cardiac Progenitor Cells in Cardiac Repair
NHLBI/R01HL65577
PI ($1,125,000)
The objective of this project is to compare the therapeutic efficacy of bone marrow and
cardiac progenitors in animal models of acute myocardial infarction.

2007-2012 Cardiac Stem Cells and Diabetic Cardiomyopathy
NHLBI/R01HL65573
Co-PI
The objective of this application is to demonstrate that reactive oxygen species induce
death of cardiac stem cells leading to the development of a diabetic cardiomyopathy.

2007-2013 Identification of a Coronary Vasculature Progenitor Cell in Human Ischemic Heart Failure
NHLBI/R01HL039902
PI (MultiPI)
The objective of this application is to characterize a novel class of cardiac stem cells with
high vasculogenic potential and define their role in vessel homeostasis and repair.

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Current

2008-2015 Epigenetic Mechanisms Regulate Cardiac Progenitor Cell Function
NHLBI/P01 HL092668
Project Leader ($1,330,000)
The goal of this proposal is to identify the epigenetic regulation of the expression of
stemness (Oct3/4) and differentiation (Nkx2.5) genes in human cardiac stem cells.

2010-2016 Telomeric Shortening, p53 and miR-34a Condition Senescence of Cardiac Progenitors
NIA/R01 AG37490
PI ($1,690,000)
The objective of this application is to establish whether miR-34a is an essential regulator
of senescence in cardiac stem cells carrying short telomeres.

2011-2017 Redefining Human Cardiac Biology
NHLBI/R01 HL114346
PI (MultiPI) ($2,690,000)
The objective of this application is to define the origin of cardiac stem cells and the rate of
their activation and differentiation throughout life.

2013-2015 Cardiac Stem Cells and Angiomyogenesis
NHLBI/R01 HL111183
PI ($1,259,646)
The objective of this application is to establish whether c-kit-positive cardiac stem cells
play a role in myocyte renewal throughout development and during adulthood and
senescence in the mouse heart.

2013-2016 Cardiomyogenesis in the Adult Heart
NHLBI/R01HL114346
PI (MultiPI) $1,705,000
The objective of this application is to determine whether oscillations in intracellular Ca2+
occurring in cardiac stem cells and bone marrow stem cells are responsible for cell cycle
entry and fate specification of these two progenitor cell classes.

2013-2017 Hypoxic and Normoxic Niches in the Aging Mouse Heart
NHLBI/P01 AG043353
Project Leader ($1,637,000)
The objective of this application is to establish whether intracellular oxygen content
controls the functional properties of cardiac stem cells and whether the proportion of
hypoxic and normoxic cardiac niches changes with aging.

Report of Local Teaching and Training
Teaching of Students in Courses

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2000-2007 Stem Cells Department of Physiology, New York
Medical College
2-hr sessions per wk for 2 weeks
2008 PhD Students
HST 521 Course Students Harvard Medical School
Overview of Cardiac Regeneration and 3-hr session
Stem Cell Therapy

Formal Teaching of Residents, Clinical Fellows and Research Fellows (post-docs)

1 994-1996 Skin Pharmacology Department of Dermatology, University of

Dermatology Fellows Parma Medical School

2-hr sessions per wk. for 16 weeks

1 999-2001 Cardiomyocyte Apoptosis Cardiovascular Research Institute, New

Research Fellows York Medical College

2001-2007 Molecular Mechanisms of Cardiac Stem Cardiovascular Research Institute, New
Cell Growth and Differentiation York Medical College
Research Fellows 2-hr sessions per wk.

2007- Molecular Mechanisms of Cardiac Stem Center for Regenerative Medicine, Brigham
Cell Growth and Differentiation and Women’s Hospital
2-hr sessions per wk

Laboratory and Other Research Supervisory and Training Responsibilities

1999-2007 Supervision of post-doctoral research Daily mentorship

fellows/Cardiovascular Research Institute,

New York Medical College

1999-2007 Supervision of high school, college, and Daily mentorship
medical students/Cardiovascular Research
Institute, New York Medical College

2007- Supervision of post-doctoral research Daily mentorship
fellows/Center for Regenerative Medicine,
Brigham and Women’s Hospital

2007- Supervision of high school and college Daily mentorship
students/ Center for Regenerative Medicine,
Brigham and Women’s Hospital
Formally Supervised Trainees and Faculty

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1999-2003 Antonio P. Beltrami, MD, PhD, Assistant Professor, Department of Hematology and
Oncology, University of Udine, Medical School, Udine, Italy
Research mentor; Published 7 manuscripts, including one in Cell and one in The New
England Journal of Medicine

1999-2003 Daniela Cesselli, MD, PhD, Assistant Professor, Department of Hematology and
Oncology, University of Udine, Medical School, Udine, Italy
Research mentor; Published two manuscripts in Circulation Research and in The
Proceedings of the National Academy of Sciences

2003-2007 Toru Hosoda, MD, PhD, Assistant Professor, Department of Anesthesia, Brigham and
Women’s Hospital
Research mentor; Published several manuscripts, including two in The Proceedings of the
National Academy of Sciences

2004-2007 Angelo Nascimbene, MD, Fellow in Cardiology, Texas Heart Institute, Houston, TX
Research mentor; Published six manuscripts, including two in The Proceedings of the
National Academy of Sciences

2005-2007 Serena Vitale, PhD, Staff Scientist, Department of Medicine, University of Perugia,
Perugia, Italy
Research mentor; Published seven manuscripts, including three in The Proceedings of the
National Academy of Sciences

2005-2007 Arantxa Gonzalez, PhD, Assistant Professor, Department of Medicine, University of
Navarra, Pamplona
Research mentor; Published five manuscripts, including one in Circulation Research and
four in The Proceedings of the National Academy of Sciences

2005-2007 Alessandro Boni, PhD, Staff Scientist, University of Geneva, Geneva, Switzerland
Research mentor; Published six manuscripts, including two in The Proceedings of the
National Academy of Sciences

2008-2009 Research co-mentor; Derin Tugal, BS, Resident, Cleveland Clinic, Cleveland, OH,
Recipient, Sarnoff Fellowship
Manuscript in its final phase of completion

2008-2010 Polina Goihberg, PhD, Instructor, Center for Regenerative Medicine, Departments of
Anesthesia and Medicine, and Cardiovascular Division, Brigham and Women’s
Hospital, Harvard Medical School.
Research mentor; Published five manuscripts in Circulation Research

2008-2010 Hanqiao Zheng, MD, PhD, Career in Clinical Medicine
Research mentor; Published ten manuscripts, including 2 in Circulation, 6 in Circulation
Research and two in The Proceedings of the National Academy of Sciences

2009-2011 Mauricio Cabral-Da-Silva, PhD, Post-doctoral fellow, University of Sao Paulo, Brazil
Research mentor; Published four manuscripts, including two in Circulation, one in
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