Harrison's Principles of Internal Medicine, Twenty-First Edition (Vol.1 & Vol.2)

2 Pages·2022·521.34 MB·english

by  Joseph Loscalzo

Harrison's Principles of Internal
Medicine, Twenty-First Edition (Vol1 &
Vol2)
1. Cover
2. Nav
3. Cover
4. Title Page
5. Copyright Page
6. Contents
7. Contributors
8. Preface
9. Harrison’s Related Resources
10. PART 1 The Profession of Medicine
1. 1 The Practice of Medicine
2. 2 Promoting Good Health
3. 3 Vaccine Opposition and Hesitancy
4. 4 Decision-Making in Clinical Medicine
5. 5 Precision Medicine and Clinical Care
6. 6 Screening and Prevention of Disease
7. 7 Global Diversity of Health System Financing and Delivery
8. 8 The Safety and Quality of Health Care
9. 9 Diagnosis: Reducing Errors and Improving Quality
10. 10 Racial and Ethnic Disparities in Health Care
11. 11 Ethical Issues in Clinical Medicine
12. 12 Palliative and End-of-Life Care
11. PART 2 Cardinal Manifestations and Presentation of Diseases
1. SECTION 1 Pain
1. 13 Pain: Pathophysiology and Management
2. 14 Chest Discomfort
3. 15 Abdominal Pain
4. 16 Headache
5. 17 Back and Neck Pain
2. SECTION 2 Alterations in Body Temperature
1. 18 Fever
2. 19 Fever and Rash
3. 20 Fever of Unknown Origin
3. SECTION 3 Nervous System Dysfunction
1. 21 Syncope
2. 22 Dizziness and Vertigo
3. 23 Fatigue
4. 24 Neurologic Causes of Weakness and Paralysis
5. 25 Numbness, Tingling, and Sensory Loss
6. 26 Gait Disorders, Imbalance, and Falls
7. 27 Confusion and Delirium
8. 28 Coma
9. 29 Dementia
10. 30 Aphasia, Memory Loss, and Other Cognitive
Disorders
11. 31 Sleep Disorders
4. SECTION 4 Disorders of Eyes, Ears, Nose, and Throat
1. 32 Disorders of the Eye
2. 33 Disorders of Smell and Taste
3. 34 Disorders of Hearing
4. 35 Upper Respiratory Symptoms, Including Earache,
Sinus Symptoms, and Sore Throat
5. 36 Oral Manifestations of Disease
5. SECTION 5 Alterations in Circulatory and Respiratory
Functions
1. 37 Dyspnea
2. 38 Cough
3. 39 Hemoptysis
4. 40 Hypoxia and Cyanosis
5. 41 Edema
6. 42 Approach to the Patient with a Heart Murmur
7. 43 Palpitations
6. SECTION 6 Alterations in Gastrointestinal Function
1. 44 Dysphagia
2. 45 Nausea, Vomiting, and Indigestion
3. 46 Diarrhea and Constipation
4. 47 Unintentional Weight Loss
5. 48 Gastrointestinal Bleeding
6. 49 Jaundice
7. 50 Abdominal Swelling and Ascites
7. SECTION 7 Alterations in Renal and Urinary Tract Function
1. 51 Interstitial Cystitis/Bladder Pain Syndrome
2. 52 Azotemia and Urinary Abnormalities
3. 53 Fluid and Electrolyte Disturbances
4. 54 Hypercalcemia and Hypocalcemia
5. 55 Acidosis and Alkalosis
8. SECTION 8 Alterations in the Skin
1. 56 Approach to the Patient with a Skin Disorder
2. 57 Eczema, Psoriasis, Cutaneous Infections, Acne,
and Other Common Skin Disorders
3. 58 Skin Manifestations of Internal Disease
4. 59 Immunologically Mediated Skin Diseases
5. 60 Cutaneous Drug Reactions
6. 61 Photosensitivity and Other Reactions to Sunlight
9. SECTION 9 Hematologic Alterations
1. 62 Interpreting Peripheral Blood Smears
2. 63 Anemia and Polycythemia
3. 64 Disorders of Granulocytes and Monocytes
4. 65 Bleeding and Thrombosis
5. 66 Enlargement of Lymph Nodes and Spleen
12. PART 3 Pharmacology
1. 67 Principles of Clinical Pharmacology
2. 68 Pharmacogenomics
13. PART 4 Oncology and Hematology
1. SECTION 1 Neoplastic Disorders
1. 69 Approach to the Patient with Cancer
2. 70 Prevention and Early Detection of Cancer
3. 71 Cancer Genetics
4. 72 Cancer Cell Biology
5. 73 Principles of Cancer Treatment
6. 74 Infections in Patients with Cancer
7. 75 Oncologic Emergencies
8. 76 Cancer of the Skin
9. 77 Head and Neck Cancer
10. 78 Neoplasms of the Lung
11. 79 Breast Cancer
12. 80 Upper Gastrointestinal Tract Cancers
13. 81 Lower Gastrointestinal Cancers
14. 82 Tumors of the Liver and Biliary Tree
15. 83 Pancreatic Cancer
16. 84 Gastrointestinal Neuroendocrine Tumors
17. 85 Renal Cell Carcinoma
18. 86 Cancer of the Bladder and Urinary Tract
19. 87 Benign and Malignant Diseases of the Prostate
20. 88 Testicular Cancer
21. 89 Gynecologic Malignancies
22. 90 Primary and Metastatic Tumors of the Nervous
System
23. 91 Soft Tissue and Bone Sarcomas and Bone
Metastases
24. 92 Carcinoma of Unknown Primary
25. 93 Paraneoplastic Syndromes:
Endocrinologic/Hematologic
26. 94 Paraneoplastic Neurologic Syndromes and
Autoimmune Encephalitis
27. 95 Cancer Survivorship and the Long-Term Impact of
Cancer and Its Treatment
2. SECTION 2 Hematopoietic Disorders
1. 96 Hematopoietic Stem Cells
2. 97 Iron Deficiency and Other Hypoproliferative
Anemias
3. 98 Disorders of Hemoglobin
4. 99 Megaloblastic Anemias
5. 100 Hemolytic Anemias
6. 101 Anemia Due to Acute Blood Loss
7. 102 Bone Marrow Failure Syndromes Including
Aplastic Anemia and Myelodysplasia
8. 103 Polycythemia Vera and Other Myeloproliferative
Neoplasms
9. 104 Acute Myeloid Leukemia
10. 105 Chronic Myeloid Leukemia
11. 106 Acute Lymphoid Leukemia
12. 107 Chronic Lymphocytic Leukemia
13. 108 Non-Hodgkin’s Lymphoma
14. 109 Hodgkin’s Lymphoma
15. 110 Less Common Lymphoid and Myeloid
Malignancies
16. 111 Plasma Cell Disorders
17. 112 Amyloidosis
18. 113 Transfusion Therapy and Biology
19. 114 Hematopoietic Cell Transplantation
3. SECTION 3 Disorders of Hemostasis
1. 115 Disorders of Platelets and Vessel Wall
2. 116 Coagulation Disorders
3. 117 Arterial and Venous Thrombosis
4. 118 Antiplatelet, Anticoagulant, and Fibrinolytic Drugs
14. PART 5 Infectious Diseases
1. SECTION 1 Basic Considerations in Infectious Diseases
1. 119 Approach to the Patient with an Infectious Disease
2. 120 Molecular Mechanisms of Microbial Pathogenesis
3. 121 Microbial Genomics and Infectious Disease
4. 122 Approach to the Acutely Ill Infected Febrile Patient
5. 123 Immunization Principles and Vaccine Use
6. 124 Health Recommendations for International Travel
7. 125 Climate Change and Infectious Disease
2. SECTION 2 Clinical Syndromes: Community-Acquired
Infections
1. 126 Pneumonia
2. 127 Lung Abscess
3. 128 Infective Endocarditis
4. 129 Infections of the Skin, Muscles, and Soft Tissues
5. 130 Infectious Arthritis
6. 131 Osteomyelitis
7. 132 Intraabdominal Infections and Abscesses
8. 133 Acute Infectious Diarrheal Diseases and Bacterial
Food Poisoning
9. 134 Clostridioides difficile Infection, Including
Pseudomembranous Colitis
10. 135 Urinary Tract Infections, Pyelonephritis, and
Prostatitis
11. 136 Sexually Transmitted Infections: Overview and
Clinical Approach
12. 137 Encephalitis
13. 138 Acute Meningitis
14. 139 Chronic and Recurrent Meningitis
15. 140 Brain Abscess and Empyema
16. 141 Infectious Complications of Bites
3. SECTION 3 Clinical Syndromes: Health Care–Associated
Infections
1. 142 Infections Acquired in Health Care Facilities
2. 143 Infections in Transplant Recipients
4. SECTION 4 Therapy for Bacterial Diseases
1. 144 Treatment and Prophylaxis of Bacterial Infections
2. 145 Bacterial Resistance to Antimicrobial Agents
5. SECTION 5 Diseases Caused by Gram-Positive Bacteria
1. 146 Pneumococcal Infections
2. 147 Staphylococcal Infections
3. 148 Streptococcal Infections
4. 149 Enterococcal Infections
5. 150 Diphtheria and Other Corynebacterial Infections
6. 151 Listeria monocytogenes Infections
7. 152 Tetanus
8. 153 Botulism
9. 154 Gas Gangrene and Other Clostridial Infections
6. SECTION 6 Diseases Caused by Gram-Negative Bacteria
1. 155 Meningococcal Infections
2. 156 Gonococcal Infections
3. 157 Haemophilus and Moraxella Infections
4. 158 Infections Due to the HACEK Group and
Miscellaneous Gram-Negative Bacteria
5. 159 Legionella Infections
6. 160 Pertussis and Other Bordetella Infections
7. 161 Diseases Caused by Gram-Negative Enteric Bacilli
8. 162 Acinetobacter Infections
9. 163 Helicobacter pylori Infections
10. 164 Infections Due to Pseudomonas, Burkholderia, and
Stenotrophomonas Species
11. 165 Salmonellosis
12. 166 Shigellosis
13. 167 Infections Due to Campylobacter and Related
Organisms
14. 168 Cholera and Other Vibrioses
15. 169 Brucellosis
16. 170 Tularemia
17. 171 Plague and Other Yersinia Infections
18. 172 Bartonella Infections, Including Cat-Scratch
Disease
19. 173 Donovanosis
7. SECTION 7 Miscellaneous Bacterial Infections
1. 174 Nocardiosis
2. 175 Actinomycosis
3. 176 Whipple’s Disease
4. 177 Infections Due to Mixed Anaerobic Organisms
8. SECTION 8 Mycobacterial Diseases
1. 178 Tuberculosis
2. 179 Leprosy
3. 180 Nontuberculous Mycobacterial Infections
4. 181 Antimycobacterial Agents
9. SECTION 9 Spirochetal Diseases
1. 182 Syphilis
2. 183 Endemic Treponematoses
3. 184 Leptospirosis
4. 185 Relapsing Fever and Borrelia miyamotoi Disease
5. 186 Lyme Borreliosis
10. SECTION 10 Diseases Caused by Rickettsiae,
Mycoplasmas, and Chlamydiae
1. 187 Rickettsial Diseases
2. 188 Infections Due to Mycoplasmas
3. 189 Chlamydial Infections
11. SECTION 11 Viral Diseases: General Considerations
1. 190 Principles of Medical Virology
2. 191 Antiviral Chemotherapy, Excluding Antiretroviral
Drugs
12. SECTION 12 Infections Due to DNA Viruses
1. 192 Herpes Simplex Virus Infections
2. 193 Varicella-Zoster Virus Infections
3. 194 Epstein-Barr Virus Infections, Including Infectious
Mononucleosis
4. 195 Cytomegalovirus and Human Herpesvirus Types 6,
7, and 8
5. 196 Molluscum Contagiosum, Monkeypox, and Other
Poxvirus Infections
6. 197 Parvovirus Infections
7. 198 Human Papillomavirus Infections
13. SECTION 13 Infections Due to DNA and RNA Respiratory
Viruses
1. 199 Common Viral Respiratory Infections, Including
COVID-19
2. 200 Influenza
14. SECTION 14 Infections Due to Human Immunodeficiency
Virus and Other Human Retroviruses
1. 201 The Human Retroviruses
2. 202 Human Immunodeficiency Virus Disease: AIDS
and Related Disorders
15. SECTION 15 Infections Due to RNA Viruses
1. 203 Viral Gastroenteritis
2. 204 Enterovirus, Parechovirus, and Reovirus Infections
3. 205 Measles (Rubeola)
4. 206 Rubella (German Measles)
5. 207 Mumps
6. 208 Rabies and Other Rhabdovirus Infections
7. 209 Arthropod-Borne and Rodent-Borne Virus
Infections
8. 210 Ebolavirus and Marburgvirus Infections
16. SECTION 16 Fungal Infections
1. 211 Pathogenesis, Diagnosis, and Treatment of Fungal
Infections
2. 212 Histoplasmosis
3. 213 Coccidioidomycosis
4. 214 Blastomycosis
5. 215 Cryptococcosis
6. 216 Candidiasis
7. 217 Aspergillosis
8. 218 Mucormycosis
9. 219 Less Common Systemic Mycoses and Superficial
Mycoses
10. 220 Pneumocystis Infections
17. SECTION 17 Protozoal and Helminthic Infections: General
Considerations
1. 221 Introduction to Parasitic Infections
2. 222 Agents Used to Treat Parasitic Infections
18. SECTION 18 Protozoal Infections
1. 223 Amebiasis and Infection with Free-Living Amebae
2. 224 Malaria
3. 225 Babesiosis
4. 226 Leishmaniasis
5. 227 Chagas Disease and African Trypanosomiasis
6. 228 Toxoplasma Infections
7. 229 Protozoal Intestinal Infections and Trichomoniasis
19. SECTION 19 Helminthic Infections
1. 230 Introduction to Helminthic Infections
2. 231 Trichinellosis and Other Tissue Nematode
Infections
3. 232 Intestinal Nematode Infections
4. 233 Filarial and Related Infections
5. 234 Schistosomiasis and Other Trematode Infections
6. 235 Cestode Infections
15. PART 6 Disorders of the Cardiovascular System
1. SECTION 1 Introduction to Cardiovascular Disorders
1. 236 Approach to the Patient with Possible
Cardiovascular Disease
2. 237 Basic Biology of the Cardiovascular System
3. 238 Epidemiology of Cardiovascular Disease
2. SECTION 2 Diagnosis of Cardiovascular Disorders