Table Of Content

HARRISON’S Gastroenterology and Hepatology Editors ANTHONY S. FAUCI, MD Chief, Laboratory of Immunoregulation; Director, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda DENNIS L. KASPER, MD William Ellery Channing Professor of Medicine, Professor of Microbiology and Molecular Genetics, Harvard Medical School; Director, Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, Boston DAN L. LONGO, MD Scientific Director, National Institute on Aging, National Institutes of Health, Bethesda and Baltimore EUGENE BRAUNWALD, MD Distinguished Hersey Professor of Medicine, Harvard Medical School; Chairman,TIMI Study Group, Brigham and Women’s Hospital, Boston STEPHEN L. HAUSER, MD Robert A. Fishman Distinguished Professor and Chairman, Department of Neurology, University of California, San Francisco J. LARRY JAMESON, MD, PhD Professor of Medicine; Vice President for Medical Affairs and Lewis Landsberg Dean, Northwestern University Feinberg School of Medicine, Chicago Derived from Harrison’s Principles of Internal Medicine, 17th Edition JOSEPH LOSCALZO, MD, PhD Hersey Professor of Theory and Practice of Medicine, Harvard Medical School; Chairman, Department of Medicine; Physician-in-Chief, Brigham and Women’s Hospital, Boston HARRISON’S Gastroenterology and Hepatology Editors Dan L. Longo, MD Scientific Director, National Institute on Aging, National Institutes of Health, Bethesda and Baltimore Anthony S. Fauci, MD Chief, Laboratory of Immunoregulation; Director, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda Associate Editor Carol A. Langford, MD, MHS Associate Professor of Medicine Cleveland Clinic, Cleveland New York Chicago San Francisco Lisbon London Madrid Mexico City Milan New Delhi San Juan Seoul Singapore Sydney Toronto Copyright © 2010 by The McGraw-Hill Companies, Inc. All rights reserved. Except as permitted under the United States Copyright Act of 1976, no part of this publication may be reproduced or distributed in any form or by any means, or stored in a database or retrieval system, without the prior written permission of the publisher. ISBN: 978-0-07-166334-2 MHID: 0-07-166334-7 The material in this eBook also appears in the print version of this title: ISBN: 978-0-07-166333-5, MHID: 0-07-166333-9. All trademarks are trademarks of their respective owners. Rather than put a trademark symbol after every occurrence of a trademarked name, we use names in an editorial fashion only, and to the benefit of the trademark owner, with no intention of infringement of the trademark. Where such designations appear in this book, they have been printed with initial caps. McGraw-Hill eBooks are available at special quantity discounts to use as premiums and sales promotions, or for use in corporate training programs. To contact a representative please e-mail us at