THIRD EDITION THIRD Handbook of Treatment Planning EDITION An Imprint of Springer Publishing in Radiation Oncology H Gregory M. M. Videtic, MD, CM, FRCPC, FACR, FASTRO a Andrew D. Vassil, MD n THIRD EDITION d Neil M. Woody, MD b o Handbook of o Revised and updated, Handbook of Treatment Planning in Radiation k Oncology, Third Edition continues its tradition of providing o evidence-based approaches to the specific technical aspects of f T Treatment Planning in r delivering radiation treatment. Easy to read and relevant to general e a practice, this popular pocket-sized manual leads radiation oncology t m Radiation Oncology trainees and clinicians through the basics of radiotherapy planning and e delivery for all major malignancies in a step-by-step manner. Organized n t by body site or system, each chapter provides technical details and P clinical updates to planning as a result of practice-changing paradigms la as well as new and updated equipment and techniques. Specialized n n topics such as palliative radiotherapy and pediatric radiotherapy round i n out the final chapters. g i n With over 40 new images in addition to detailed accounts of advances in R the field, this highly anticipated third edition provides important updates a while retaining the valued, practical features of the previous editions. d i a Written by members of staff in the Department of Radiation Oncology t i at the Cleveland Clinic, this is a valuable resource and reliable quick o n reference for clinical trainees and other professionals in the field such O as radiation therapists and technologists, radiation nurses, dosimetrists, n c physicists, and practicing physicians. o l o g Key Features: y n Presents concise summaries including target definitions and dose constraints for planning all major disease sites V n Provides updated coverage of planning associated with stereotactic id body radiation therapy (SBRT) for prostate, pancreatic, and liver cancers e n Includes over 190 full color images tic • n Outlines new practice standards for hypofractionated radiation therapy V in breast and prostate cancers as s n Edexplivlaeirnys o sfp reacdiifiacti otenc threnaictaml eanstpects important for the appropriate clinical il • W n Purchase includes digital access for use on most mobile devices or o Gregory M. M. Videtic computers od y Andrew D. Vassil Recommended Shelving Category: Neil M. Woody Oncology An Imprint of Springer Publishing 11 W. 42nd Street New York, NY 10036-8002 www.springerpub.com Handbook of Treatment Planning in Radiation Oncology Handbook of Treatment Planning in Radiation Oncology Third Edition Editors Gregory M. M. Videtic, MD, CM, FRCPC, FACR, FASTRO Professor of Medicine Cleveland Clinic Lerner College of Medicine Staff Physician Department of Radiation Oncology Taussig Cancer Institute Cleveland Clinic Cleveland, Ohio Andrew D. Vassil, MD Staff Physician Department of Radiation Oncology Taussig Cancer Institute Cleveland Clinic Cleveland, Ohio Neil M. Woody, MD Staff Physician Department of Radiation Oncology Taussig Cancer Institute Cleveland Clinic Cleveland, Ohio Copyright © 2021 Springer Publishing Company, LLC Demos Medical Publishing is an imprint of Springer Publishing Company. All rights reserved. First Springer Publishing edition 2011; subsequent editions 2015. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior permission of Springer Publishing Company, LLC, or authorization through payment of the appropriate fees to the Copyright Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA 01923, tel 978-750-8400, fax 978-646-8600, [email protected] or on the Web at www.copyright.com. Springer Publishing Company, LLC 11 West 42nd Street, New York, NY 10036 www.springerpub.com connect.springerpub.com/ Acquisitions Editor: David D’Addona Compositor: Transforma ISBN: 978-0-8261-6841-2 ebook ISBN: 978-0-8261-6842-9 DOI: 10.1891/9780826168429 20 21 22 23 / 5 4 3 2 1 Medicine is an ever-changing science. Research and clinical experience are continually expanding our knowledge, in particular our understanding of proper treatment and drug therapy. The authors, editors, and publisher have made every effort to ensure that all information in this book is in accordance with the state of knowledge at the time of production of the book. Nevertheless, the authors, editors, and publisher are not responsible for any errors or omissions or for any consequence from application of the information in this book and make no warranty, expressed or implied, with respect to the content of this publication. Every reader should examine carefully the package inserts accompanying each drug and should carefully check whether the dosage schedules therein or the contraindications stated by the manufacturer differ from the statements made in this book. Such examination is particularly important with drugs that are either rarely used or have been newly released on the market. Library of Congress Cataloging-in-Publication Data Names: Videtic, Gregory M. M., editor. | Vassil, Andrew D., editor. | Woody, Neil, editor. Title: Handbook of treatment planning in radiation oncology / editors, Gregory M. M. Videtic, Andrew D. Vassil, Neil M. Woody. Description: Third edition. | New York, NY : Demos Medical, [2021] | Includes bibliographical references and index. Identifiers: LCCN 2020020005 (print) | LCCN 2020020006 (ebook) | ISBN 9780826168412 (hardback) | ISBN 9780826168429 (ebook) Subjects: MESH: Neoplasms—radiotherapy https://id.nlm.nih.gov/mesh/D009369Q000532 | Patient Care Planning https://id.nlm.nih.gov/mesh/D010347 | Planning Techniques https://id.nlm.nih.gov/mesh/D010934 | Handbook https://id.nlm.nih.gov/mesh/D020479 Classification: LCC RC271.R3 (print) | LCC RC271.R3 (ebook) | NLM QZ 39 | DDC 616.99/40642—dc23 LC record available at https://lccn.loc.gov/2020020005 LC ebook record available at https://lccn.loc.gov/2020020006 Publisher’s Note: New and used products purchased from third-party sellers are not guaranteed for quality, authenticity, or access to any included digital components. Printed in the United States of America. Contents Preface vii Preface to the First Edition ix Contributors xi Abbreviations xiii 1. General Physics Principles 1 Andrew D. Vassil, Lama M. Mossolly, Neil M. Woody, and Gregory M. M. Videtic 2. Tools for Simulation and Treatment 17 Neil M. Woody and Gregory M. M. Videtic 3. Central Nervous System Radiotherapy 29 Samuel T. Chao, Jennifer S. Yu, and John H. Suh 4. Head and Neck Radiotherapy 47 Neil M. Woody, Shlomo A. Koyfman, and Nikhil P. Joshi 5. Breast Radiotherapy 71 Chirag Shah, Sheen Cherian, Cory Hymes, and Rahul D. Tendulkar 6. Thoracic Radiotherapy 93 Gregory M. M. Videtic 7. Gastrointestinal (Nonesophageal) Radiotherapy 113 Ehsan H. Balagamwala, Kevin L. Stephans, and Neil M. Woody 8. Genitourinary Radiotherapy 135 Rahul D. Tendulkar, Omar Y. Mian, Jay P. Ciezki, and Kevin L. Stephans 9. Gynecologic Radiotherapy 169 Sudha Amarnath and Sheen Cherian 10. Lymphoma and Myeloma Radiotherapy 187 Sheen Cherian, Chirag Shah, and Erin S. Murphy vi | Contents 11. Soft Tissue Sarcoma Radiotherapy 213 Chirag Shah, Jacob Scott, Erin S. Murphy, and Lisa Zickefoose 12. Pediatric Radiotherapy 227 Erin S. Murphy 13. Palliative Radiotherapy 251 Andrew D. Vassil and Gregory M. M. Videtic Index 273 Preface “When is your next handbook coming out? Can’t wait!” This was said sponta- neously to me by a fellow attendee at the 2019 American Society for Radiation Oncology Annual Meeting while we were in a session. His remarks were both gratifying and humbling and it was good to tell him that in fact, the next edition was in the works. The ongoing success of the Handbook of Treatment Planning in Radiation Oncology since its appearance in 2010 provides a tremendous affirmation of the worth and relevance of this pocket-sized reference to the Radiation Oncology community. With that in mind, the editors approached this third edition with the same guiding principles as the original: to provide approaches to radiotherapy planning that are descriptive and not overly pre- scriptive, easy to read, and pertinent to general practice. Also, as in previous editions, we incorporated detailed reviews of new planning topics when they were understood to be commonly used in routine practice. What has changed with this edition? The reins of primary authorship for the chapters were handed over from the residents to members of staff. In supporting this transition, the editorial staff was mindful of the tradition of excellence that the resident group has brought to producing the book, while at the same time wanting to give the current residents well-deserved relief from having a new project added to their substantial list of writing responsibilities. In this 10th anniversary year of its first publication, it is fitting that Dr. Andrew Vassil, coeditor of the first edition, and Dr. Neil Woody, coeditor of the second, are coeditors with me on the third. They again brought their passion and professionalism to this project and made doing the revision a great experience. No less important were the technical contributions of Lama Muhieddine Mossolly, MS, staff medical physicist, who was invaluable in producing images of consistently high quality. Gregory M. M. Videtic, MD, CM, FRCPC, FACR, FASTRO Andrew D. Vassil, MD Neil M. Woody, MD Preface to the First Edition The past decade has seen rapid changes in the field of radiation oncology, rang- ing from an increasing shift to “evidence-based” treatments to a constantly expanding technological armamentarium. In this setting, the discipline’s refer- ence literature has also blossomed, with a large variety of clinically oriented textbooks and manuals becoming available to meet the needs both of busy trainees and clinicians engaged in the care of patients with cancer. For all that, radiation oncology remains a “technical” discipline whose practice is gradually learned through experience as it is handed down from “master to apprentice,” typically in the familiar setting of the simulator room. Mindful of this, discussions with our residents at the Cleveland Clinic had suggested that there was a need for a focused, pocket-sized handbook to act as quick resource for them as they carried out the steps during the planning and delivery of radiation therapy. Handbook of Treatment Planning in Radiation Oncology is intended to be descriptive and not prescriptive. No treatment or equipment recommendations are being endorsed. Clinical stage descriptions employed the TNM defini- tions of the sixth edition of the AJCC Cancer Staging Handbook. In setting down the steps to follow in the treatment planning of an individual patient, there is no intent at providing comprehensive clinical algorithms for treatment decision-making. Rather, we have assumed that the indications for a particular therapy are known, and therefore our focus is on a series of suggested steps to follow to successfully complete effective radiotherapy planning. Sections are organized by body site or system, whichever proved best for consistency in presenting the general principles of planning; for example, the chapter on thoracic malignancies includes esophageal cancers. We have also presented specialized topics such as palliative therapy and pediatrics. After referencing general planning requirements, each specific subsite within a given section then provides more specific details on approaches to radiotherapy planning. Although drawn from the wealth of clinical experience at our institution and the copious notes of the residents, numerous sources were referenced and reviewed to present the most up-to-date standards in our discipline. Recogniz- ing that almost every component of radiation treatment can be considered an active area of investigation, we have deliberately limited our planning recom- mendations to what would be considered good and safe practice at this point.