Handbook of Therapeutic Antibodies PDF
Preview Handbook of Therapeutic Antibodies
Editedby StefanDu¨beland JaniceM.Reichert HandbookofTherapeuticAntibodies RelatedTitles Chamow,S.M.,Ryll,T.,Lowman,H.B., Kratz,F.,Senter,P.,Steinhagen,H.(eds.) Farson,D.(eds.) DrugDeliveryinOncology TherapeuticFc-FusionProteins FromBasicResearchtoCancerTherapy 2014 2011 PrintISBN:978-3-527-33317-2,alsoavailablein PrintISBN:978-3-527-32823-9,alsoavailablein digitalformats digitalformats Knäblein,J.(ed.) Tovey,M.G.(ed.) ModernBiopharmaceuticals DetectionandQuantificationof RecentSuccessStories Antibodies to Biopharmaceuticals 2013 PrintISBN:978-3-527-32283-1,alsoavailablein PracticalandAppliedConsiderations digitalformats 2011 PrintISBN:978-0-470-56666-4,alsoavailablein Pathak,Y.,Benita,S.(eds.) digitalformats Antibody-Mediated Drug DeliverySystems Concepts,Technology,andApplications 2012 PrintISBN:978-0-470-61281-1,alsoavailablein digitalformats Edited by Stefan Du¨bel and Janice M. Reichert Handbook of Therapeutic Antibodies Volume I: Defining the Right Antibody Composition Second Edition Edited by Stefan Du¨bel and Janice M. Reichert Handbook of Therapeutic Antibodies Volume II: Clinical Development of Antibodies Second Edition Edited by Stefan Du¨bel and Janice M. Reichert Handbook of Therapeutic Antibodies Volume III: Approved Therapeutic Antibodies Second Edition Edited by Stefan Du¨bel and Janice M. Reichert Handbook of Therapeutic Antibodies Volume IV: Approved Therapeutic Antibodies and in vivo Diagnostics Second Edition Editors LimitofLiability/DisclaimerofWarranty: Whilethepublisherandauthorhaveused theirbesteffortsinpreparingthisbook, Prof.Dr.StefanDu¨bel theymakenorepresentationsorwarranties TechnischeUniversita¨tBraunschweig withrespecttotheaccuracyorcompleteness InstituteofBiochemistry ofthecontentsofthisbookandspecifi- BiotechnologyandBioinformatics callydisclaimanyimpliedwarrantiesof Spielmannstr.7 merchantabilityorfitnessforaparticular 38106Braunschweig purpose.Nowarrantycanbecreatedor Germany extendedbysalesrepresentativesorwritten salesmaterials.TheAdviceandstrategies Dr.JaniceM.Reichert containedhereinmaynotbesuitablefor ReichertBiotechnologyConsultingLLC yoursituation.Youshouldconsultwitha ProspectStreet247 professionalwhereappropriate.Neitherthe Framingham,MA publishernorauthorsshallbeliableforany USA lossofprofitoranyothercommercialdam- ages,includingbutnotlimitedtospecial, Cover incidental,consequential,orotherdamages. LibraryofCongressCardNo.:appliedfor Antibodieshavebecomestandardtherapy inmanytherapeuticareasincludingcancer, BritishLibraryCataloguing-in-Publication inflammation,osteoporosis,autoimmune, Data cardiovascular,ophthalmicandinfectious Acataloguerecordforthisbookisavailable diseases.Earlysuccessesinthetreatmentof fromtheBritishLibrary. leukemiaandlymphomabyrituximaband alemtuzumabspawnedthedevelopment Bibliographicinformationpublishedbythe ofofatumumabandobinutuzumab,anti- DeutscheNationalbibliothek bodiesthatkilltumorcellsmorepotently TheDeutscheNationalbibliothek viadiversemechanisms.Thecoverisan liststhispublicationintheDeutsche artist’simpressionoflymphocyticleukemia Nationalbibliografie;detailedbibliographic cellsundertherapeuticantibodyattack.The dataareavailableontheInternetat imagewasdevelopedbyJoostM.Bakker, <http://dnb.d-nb.de>. www.scicomvisuals.com. (cid:2)c 2014Wiley-VCHVerlagGmbH&Co. KGaA,Boschstr.12,69469Weinheim, Germany Wiley-BlackwellisanimprintofJohnWiley &Sons,formedbythemergerofWiley’s globalScientific,Technical,andMedical businesswithBlackwellPublishing. Allrightsreserved(includingthoseof translationintootherlanguages).Nopart ofthisbookmaybereproducedinany form–byphotoprinting,microfilm,orany othermeans–nortransmittedortranslated intoamachinelanguagewithoutwritten permissionfromthepublishers.Registered names,trademarks,etc.usedinthisbook, evenwhennotspecificallymarkedassuch, arenottobeconsideredunprotectedbylaw. PrintISBN:978-3-527-32937-3 ePDFISBN:978-3-527-68245-4 ePubISBN:978-3-527-68244-7 MobiISBN:978-3-527-68243-0 oBookISBN:978-3-527-68242-3 CoverDesign Formgeber,Mannheim, Germany Typesetting LaserwordsPrivateLimited, Chennai,India PrintingandBinding MarkonoPrintMedia, PteLtd.,Singapore Printedonacid-freepaper V Contents VolumeI:DefiningtheRightAntibodyComposition QuickReferenceListofAntibodiesbyInternationalNonproprietary Name XXIII QuickReferenceListofAntibodiesbyBrandName XXV AGreetingbytheEditors XXVII ForewordtotheFirstEdition XXIX ForewordtotheSecondEdition XXXI ListofContributors XXXIII Abbreviations LI Appendix:MarketedMonoclonalAntibodiesCompendium LXXXIII 1 TherapeuticAntibodies – fromPasttoFuture 1 StefanDu¨belandJaniceM.Reichert 1.1 AnExcitingStart – andaLongTrek 1 1.2 TheGoldRush 6 1.3 SuccessandSetbacks 7 1.4 TheGleamingHorizon 10 References 12 FurtherReading 12 PartI:SelectingandShapingtheAntibodyMolecule 15 2 SelectionStrategiesforMonoclonalAntibodies 17 GerhardMoldenhauer 2.1 Introduction 17 2.2 HistoricalRemarks 18 2.3 AntibodyStructureandFunction 19 2.3.1 Membrane-BoundandSecretedFormsofAntibodies 19 2.3.2 MonoclonalAntibodies 21 2.4 ProductionofMonoclonalAntibodies 21 2.4.1 Immunization 21
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