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Handbook of Oxidative Stress in Cancer: Mechanistic Aspects (cid:129) (cid:129) Sajal Chakraborti Bimal K. Ray Susanta Roychoudhury Editors Handbook of Oxidative Stress in Cancer: Mechanistic Aspects With388Figuresand101Tables Editors SajalChakraborti BimalK.Ray DepartmentofBiochemistryand DepartmentofVeterinaryPathobiology Biophysics UniversityofMissouri UniversityofKalyani Columbia,MO,USA Kalyani,WestBengal,India SusantaRoychoudhury CSIR-IndianInstituteofChemicalBiology Kolkata,India ISBN978-981-15-9410-6 ISBN978-981-15-9411-3(eBook) ISBN978-981-15-9412-0(printandelectronicbundle) https://doi.org/10.1007/978-981-15-9411-3 ©SpringerNatureSingaporePteLtd.2022 Thisworkissubjecttocopyright.AllrightsarereservedbythePublisher,whetherthewholeorpartofthe materialisconcerned,specificallytherightsoftranslation,reprinting,reuseofillustrations,recitation, broadcasting,reproductiononmicrofilmsorinanyotherphysicalway,andtransmissionorinformation storageandretrieval,electronicadaptation,computersoftware,orbysimilarordissimilarmethodology nowknownorhereafterdeveloped. Theuseofgeneraldescriptivenames,registerednames,trademarks,servicemarks,etc.inthispublication doesnotimply,evenintheabsenceofaspecificstatement,thatsuchnamesareexemptfromtherelevant protectivelawsandregulationsandthereforefreeforgeneraluse. Thepublisher,theauthors,andtheeditorsaresafetoassumethattheadviceandinformationinthisbook arebelievedtobetrueandaccurateatthedateofpublication.Neitherthepublishernortheauthorsorthe editorsgiveawarranty,expressedorimplied,withrespecttothematerialcontainedhereinorforanyerrors oromissionsthatmayhavebeenmade.Thepublisherremainsneutralwithregardtojurisdictionalclaims inpublishedmapsandinstitutionalaffiliations. ThisSpringerimprintispublishedbytheregisteredcompanySpringerNatureSingaporePteLtd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore Mr. Ratan Naval Tata, born on December 28, 1937, is an Indian industrialist, philanthropist, and head of the charitable trusts founded by the Tata Group. He is recipient of two of the highest civilian awards of India, the Padma Bhushan (2000) and Padma Vibhushan (2008). Mr. Ratan Tata graduated from Riverdale Country School in New York City in 1955. He receivedadegreeinarchitecturefromCornell Universityin1959.In1975,heparticipatedin the 7-week Advanced Management Program of Harvard Business School, an institution which he has since endowed. Tata Education and Development Trust, a philanthropicaffiliateoftheTataGroupunder the leadership of Mr. Ratan Tata, endowed a $28 million Tata Scholarship Fund, allowing Cornell University to provide financial aid to undergraduate students from India. In 2010, the Tata Group and Tata Trusts donated $50 million for the construction of an executive center at Harvard Business School. In 2014, the Tata Group donated 950 million rupees to IIT Bombay for the formation of the Tata Centre for Technology and Design to develop design and engineering principles suited to the needs of people and communities with limited resources. The group formed the MIT Tata Centre of Technology and Design at the Massachusetts Institute of Technology (MIT) with a mission to address the challenges of resource-constrained communities, with an initialfocusonIndia.In2020,Mr.RatanTata donated `1,500 crore to fight the Covid-19 pandemic. Over 65% of his shares in Tata Group are invested in charitable trusts. The Tata Trusts’ entry into cancercare dates backto1941whentheTataMemorialHospital opened in Mumbai. The management of the hospital was handed over to the Ministry of Health, Govt. of India, in 1962. In 2012, Tata Trusts launched the Tata Medical Centre in Kolkata to address the high prevalence of cancer and the lack of suitable facilities in the eastern and north-eastern regions of India. Tata Trusts have developed cancer research and treatment centers in Varanasi, Tirupati, Bhubaneshwar, Ranchi, Allahabad, and Mangalore. They are also partnering state governments in building state-wide cancer facilitynetworksinAssam,Odisha,Jharkhand, Telangana, and Nagaland. Mr.RatanTataisundoubtedlyalivinglegendary figureinpromotinghighereducationand researchnotablyincancerresearchand treatmentfacilitiesinIndia.Hehastheabilityto inspireandmotivateyoungscholarsand entrepreneurs.Wefeelhonoredtodedicatethis booktoMr.RatanNavalTataandwishhimgood healthandsuccessinallhisfutureendeavors. Preface AfterIfinishedtheAtlanticswimIsaidneveragain,butitdidn’ttakelongformetochange mymind.Iliketopushmylimits.Iwanttoraisemoneyforcancerresearchandtoinspire otherstofollowtheirdreams. BenoitLecomte Cancer seems to be a uniquely unsolved problem in biology, and there are many fundamental aspects of multicellular dynamics in cancer which are currently unknown. In the recent past, different key topics have emerged in cancer research such as modulation of molecular targets by gene expression, epigenetic processes, andstemcellfunctions.Thereislittledoubtthatpartoftheincreaseinincidenceof cancer is also due to environmental pollution. The carcinogenic effect of certain chemicals is well understood at a biological level. Positive correlation has been established between environmental quality and health for large populations. For instance, the5-year study of water pollution and cancer in the Huai river valley of Chinahasdemonstratedaclearrelationshipbetweenwaterpollutionandhighrates of digestive tract cancer at the county level (Atlas of the Huai River Basin Water Environment: Digestive Cancer Mortality. Eds: Gonghuan Yang, Dafang Zhuang; Springer,NewYork,2014). Ithasalsolongbeenrecognizedthatabnormalregulationofproteinphosphory- lationplaysanimportantroleintheinitiationandprogressionofcancer.Thisbook provides reviews devoted to the emergingroles of signaltransduction events asso- ciatedwithcelltransformationandtumorprogression.Theauthorssuggesthowthe activitiesofcertainkeysignaltransductionproteinsmightbemanipulatedincancer therapy. Non-codingRNAs(ncRNAs)arecapableofreprogrammingmultipleoncogenic cascades and, therefore, can be used as target agents. Recently, profiling and sequencing of ncRNAs showed discernible genomic deregulation, which leads to humancancersmostlyduetoaberrantmechanismsofncRNAsbiogenesis,suchas amplification,deletion,andabnormalepigeneticortranscriptionalregulation.Given theemergingimportanceofncRNAsinmalignancy,somechaptersofthisbookhave been devoted towards understanding the role of non-codingtranscription in cancer progressionandmetastasiswithaneyeonrisingclinicalrelevanceofncRNAs. vii viii Preface Nanotechnologyasappliedtocancerresearchisbynaturemultidisciplinaryand relies on research mostly by chemists, cell biologists, and pharmacologists. Nano- technology provides novel tools to manipulate cellular machineries and possesses theabilitytobringaparadigmshiftinhowcanceriscurrentlyimagedortreated.The chaptersinthisbookrangefromenumeratingbasicresearchtoclinicalapplications of nanoparticles in the field of nanotechnology. Additionally, the development of bioinformatic tools and studies on the correlation between computational analyses and experimental observations shed light on new mechanisms on ROS-induced cancerinitiationandprogressionandalsotherapeuticsofROS-inducedcancer. Themotivationfororganizingthisbookstemsprimarilyfromanurgetopresent readers with the latest research on the mechanisms associated with ROS-induced cancer. This book does not claim to cover the entire field of ROS-induced cancer. However,itprovidesaplethoraofreviewsthatwillenablereaderstohaveaglimpse ofthebasicmechanismsassociatedwithROS-inducedinitiationandprogressionof differenttypesofcancerwithglobalperspectives. Thanksareduetoallcontributorsfortheconsiderableenergy,time,andeffortthat theyspentinmakingthisbookanadvancementofknowledgeforunderstandingthe mechanismsassociatedwithROS-inducedcancer.ThanksarealsoduetoDr.(Ms.) Mokshika Gaur, Dr. (Ms.) Madhurima Kahali, Ms. Divya Nithyanandam, and Ms. Ilakkia Sathiyaseelan of Springer Nature for their understanding, cooperation, andsupportduringthepreparationofthebook. SajalChakraborti CorrespondingEditor Contents Volume 1 PartI OxidativeStressinCarcinogenesis ..................... 1 1 ReactiveSpeciesandER-MitochondrialPerformancefor GlioblastomaMultiformeTreatmentStrategy ................. 3 TinaNasrin,SajalChakraborti,andSoniShaikh 2 OxidativeStressandThyroidDisorders ...................... 23 LoganayakiPeriyasamy,KokelavaniNampalliBabu, SnehaKrishnamoorthy,JonathanBehlen,SridharMuthusami,and JoneA.Stanley 3 SkinCancerInducedbyPollution-MediatedROS .............. 35 KarenE.Burke 4 Rolesofβ-GlucansinOxidativeStressandCancer ............. 57 EvelineA.I.F.Queiroz,PâmelaAlegranci, AneliM.Barbosa-Dekker,andRobertF.H.Dekker 5 OralCancerandOxidativeStress .......................... 77 GokulSridharan 6 OxidativeStressinGenitourinaryCancer .................... 87 MasakiShiota 7 OxidativeStress,Microenvironment,andOralCancer .......... 99 GargiSarode,NikunjManiyar,SachinSarode,andMamathaG.S. 8 OxidativeStressandGlyoxalasePathwayinCancer ............ 119 NupurandA.B.Tiku 9 TheImplicationofROSHomeostasisintheModulation ofEMTSignalingandItsRoleinManipulatingTumor Microenvironment ....................................... 137 SouneekChakrabortyandAnindyaGoswami ix x Contents 10 FunctionalRegulationBetweenMatrixMetalloproteasesandCell JunctionProteinsinGastricCancer ........................ 153 TapasiRoy,VineetKumarMishra,SudiptaMallick,and SnehasiktaSwarnakar 11 AssociationofOxidativeStressandMitochondrialDysfunction toGynecologicalMalignancies ............................ 165 DeepshikhaGhosh,PritiChatterjee,TulikaMitra,andSibSankarRoy 12 ImpactofCaenorhabditiselegansinCancerDrugResistance Development .......................................... 185 G.Shanmugam,S.Kannan,andK.Senthilkumar 13 Scaffold-BasedSelectiveROSGenerationasViableTherapeutic StrategiesAgainstCancer ................................ 197 MdYousuf,MohammedTanveerAhmed,andRajkumarBanerjee 14 TargetingOxidativeStressinCancer ....................... 217 ParamitaMandal,AninditaGoswami,SarmisthaAdhikari,and SubhamSarkar 15 TargetingMitochondriaasaNovelDisease-ModifyingTherapeutic StrategyinCancer ..................................... 241 GurjitKaurBhatti,ParasPahwa,AnshikaGupta,UmaShanker Navik,P.HemachandraReddy,andJasvinderSinghBhatti 16 CutaneousUnfoldedProteinResponse(UPR)andEndoplasmic Reticulum(ER)Stress ................................... 263 RatherA.Rafiq,RamA.Vishwakarma,andSheikhA.Tasduq 17 IronSulfurClustersandROSinCancer .................... 291 JoelJames,DanielAndrewM.Gideon,DebasishRoy,and AmritlalMandal 18 FreeRadicals,ReactiveOxygenSpecies,andTheirBiomarkers ... 307 JiafuFeng 19 ZymographicTechniques ................................ 327 VibhaRani,KanishkaAggarwal,SristisVarshney,andNehaAtale 20 BiomarkersofOxidativeStressandItsDynamicsinCancer .... 341 A.K.ChaudharyandP.K.Gupta 21 GlutathioneasOxidativeStressMarkerinCancer ............ 353 N.Thirumoorthy,R.Senthilkumaran,L.Panayappan, BabuThandapani,andK.Ranganathan 22 SalivaryOxidativeStressBiomarkersinOralPotentially MalignantDisordersandSquamousCellCarcinoma .......... 373 GokulSridharan Contents xi 23 RecentDevelopmentofMonoclonalAntibodiesTargetingTyrosine KinaseinROS-MediatedCancer .......................... 383 YashodharaDalalandMaushmiS.Kumar 24 FluorideasaCarcinogen:AMythorFact? .................. 399 ArnadiRamachandrayyaShivashankaraand ManjeshwarShrinathBaliga 25 TheRoleofROSinChemicalCarcinogenesisInducedbyLead, Nickel,andChromium .................................. 405 AleksandraBuhaDjordjevic,MilenaAndjelkovic,DraganaJavorac, LukaManic,ZoricaBulat,YasmeenTalab,EmilianoPanieri, LucianoSaso,andDavidWallace 26 EnvironmentalContaminants,OxidativeStress,and ReproductiveCancer ................................... 423 C.Latchoumycandane,MeenuManiradhan,andP.P.Mathur 27 EnvironmentalToxicantsandCarcinogenicity:RoleofOxidative Stress ................................................ 437 SanjaySaini,JagdishGopalPaithankar,AnuragSharma,and DebapratimKarChowdhuri 28 EnvironmentalandOccupationalExposuretoPesticidesand CancerDevelopment .................................... 451 TamaraLazarević-Pašti 29 Benzo(a)Pyrene-InducedROS-MediatedLungCancer ......... 463 RebaiBenAmmar,FatmaJ.AlSaeedi,EmadA.Ahmed,and PeramaiyanRajendran 30 EssentialRoleofOccupationalHazardsin CancerAmongWomen .................................. 477 V.Saritha,K.GraceTheodora,andK.VijayaRachel 31 Arsenic:AnEnvironmentalToxicant-InducedOxidativeStressand Carcinogenesis ......................................... 491 AbhilashM,PrathapanAyyappan,HarikumaranNairR,and MathewsValuparampilVarghese 32 ROSinApoptosisofCancerCells ......................... 503 AyseGünes-Bayir 33 RoleofROSinTriggeringDeathReceptor-MediatedApoptosis ... 517 SamanehH.ShabaniandAzamBolhassani 34 AdvancedGlycationEndProducts-MediatedOxidativeStressand RegulatedCellDeathSignalinginCancer ................... 535 ChandramaniPathak,ForamU.Vaidya,BhargavN.Waghela, AbuSufiyanChhipa,BudhiSagarTiwari,andKishuRanjan