Handbook of mouse mutations with skin and hair abnormalities animal models and biomedical tools PDF
Preview Handbook of mouse mutations with skin and hair abnormalities animal models and biomedical tools
HANDBOOK OF MOUSE MUTATIONS WITH SKIN AND HAIR ABNORMALITIES Animal Models and Biomedical Tools EDITED BY John P. Sundberg, D.V.M., Ph.D. The Jackson Laboratory Bar Harbor, Maine CRC Press Boca Raton London New York Washington, D.C. Library of Congress Cataloging-in-Publication Data Handbook of mouse mutations with skin and hair abnormalities : animal models and biomedical tools / edited by John P. Sundberg. p. cm. - (CRC series in dermatology) Includes bibliographical references and index. ISBN 0-8493-8372-2 1. Skin—Diseases-Animal models—Handbooks, manuals, etc. 2. Hair—Diseases—Animal models—Handbooks, manuals, etc. 3. Mice as laboratory animals—Handbooks, manuals, etc. 4. Mice-Genetics- Handboooks, manuals, etc. 5. Mice—Diseases—handbooks, manuals, etc. 1. Sundberg, John P II. Series. [DNLM: 1. Skin Diseases—genetics. 2. Disease Models, Animal. 3. Mice, Transgenic. 4. Mutation. 5. Hair—abnormalities. QY 60.R6 H235 1994] RL79.H36 1994 616.5'027-dc20 DNLM/DLC for Library of Congress 93-41187 CIP This book contains information obtained from authentic and highly regarded sources. Reprinted material is quoted with permission, and sources are indicated. A wide variety of references are listed. Reasonable efforts have been made to publish reliable data and information, but the author and the publisher cannot assume responsibility for the validity of all materials or for the consequences of their use. Neither this book nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, microfilming, and recording, or by any information storage or retrieval system, without prior permission in writing from the publisher All rights reserved. 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Trademark Notice: Product or corporate names may be trademarks or registered trademarks, and are used only for identification and explanation, without intent to infringe. © 1994 by CRC Press LLC No claim to original U S. Government works International Standard Book Number 0-8493-8372-2 Library of Congress Card Number 93-41187 4 5 6 7 8 9 0 CRC Series in DERMATOLOGY: CLINICAL AND BASIC SCIENCE Edited by Dr. Howard I. Maibach The CRC Dermatology Series combines scholarship, basic science, and clinical relevance. These comprehensive references focus on dermal absorption, dermabiology, dermatopharmacology, dermatotoxicology, and occupational and clinical dermatology. The intellectual theme emphasizes in-depth, easy to comprehend surveys that blend advances in basic science and clinical research with practical aspects of clinical medicine. Published Titles: Hand Eczema Torkil Menne and Howard I. Maibach Health Risk Assessment: Dermal and Inhalation Exposure and Absorption of Toxicants Rhoda G. M. Wang, James B. Knaak, and Howard 1. Maibach Pigmentation and Pigmentary Disorders Norman Levine Protective Gloves for Occupational Use Gunh Mellstrom, Jan E. Walhberg, and Howard 1. Maibach Forthcoming Titles: Bioengineering of the Skin: Water and the Stratum Corneum Peter Eisner, Enzo Berardesca, and Howard I. Maibach Bioengineering of the Skin: Cutaneous Blood Flow and Erythema Enzo Berardesca, Peter Eisner, and Howard (. Maibach Handbook of Contact Dermatitis Christopher J. Dannaker, Daniel J. Hogan, and Howard 1. Maibach Human Papillomavirus Infections in Dermatovenereology Gerd Gross and Geo von Krogh Skin Cancer: Mechanisms and Relevance Hasan Mukhtar The Contact Urticaria Syndrome Arto Lahti and Howard I. Maibach The Irritant Contact Dermatitis Syndrome Pieter Van der Valk, Pieter Coenrads, and Howard I. Maibach THE EDITOR John P. Sundberg, D.V.M., Ph.D., is Head of the Pathology program at the Jackson Laboratory in Bar Harbor, Maine. Dr. Sundberg graduated in 1973 from the University of Vermont with a B.S. degree in Animal Science (summa cum laude) and obtained his D.V.M. degree in 1977 from Purdue University School of Veterinary Medicine, West Lafayette, Indiana. Following a brief period in private practice. Dr. Sundberg earned a Ph.D. degree in comparative pathology in 1981 from The University of Connecticut in Storrs. Dr. Sundberg served as an assistant professor at the University of Illinois College of Veterinary Medicine from 1981 to 1986. In 1986 he assumed his present position. Dr. Sundberg is a diplomate of the American College of Veterinary Pathologists. He is a member of the American Veterinary Medical Association, American Association for Labo ratory Animal Science, Society for Investigative Dermatology, Hair Research Society, New England Veterinary Pathology Colloquy, and the Maine Veterinary Medical Association. Dr. Sundberg has been the recipient of research grants from the National Institutes of Health, American Cancer Society, National Alopecia Areata Foundation, and private industry. He has published over 125 research and clinical papers, 50 technical bulletins, and 15 book chapters. His current major research interests relate to mouse mutations as models of human and animal diseases, the comparative pathology and molecular evolution of nonhuman papillomaviruses, and spontaneous diseases of inbred laboratory mice. CONTRIBUTORS WesJey G. Beamer, Ph.D. Marion J. J. Gijbels The Jackson Laboratory TNO Research Institute Bar Harbor, Maine Gaubius Laboratory Leiden, The Netherlands Hendrick G. Bedigian, Ph.D. The Jackson Laboratory Lowell A. Goldsmith, M.D. Bar Harbor, Maine Department of Dermatology University of Rochester Manfred Blessing, Ph.D. Rochester, New York Department of Cell Biology Vanderbilt University Virginia L. Godfrey, D.V.M., Ph.D. Nashville, Tennessee Oak Ridge National Laboratory Biology Division Dawnalyn Boggess, B.S. Oak Ridge, Tennessee The Jackson Laboratory Bar Harbor, Maine Susan F. Grammer, B.A. Roderick Bronson, D.V.M. Department of Molecular Immunology Department of Pathology Baxter Diagnostics Tufts University School of Veterinary Miami, Florida Medicine Boston, Massachusetts Jean Louis Guenet, D.V.M. Unite de Genetique des Mammiferes Kathy S. Brown, M.A. lnstitut Pasteur The Jackson Laboratory Paris, France Bar Harbor, Maine Brigid L. M. Hogan, Ph.D. Claudio J. Conti, D.V.M., Ph.D. Department of Cell Biology The University of Texas Vanderbilt University School of Medicine M.D. Anderson Cancer Center Nashville, Tennessee Science Park Research Division Smithville, Texas Margaret E. Hogan, Ph.D. Muriel T. Davisson, Ph.D. The Jackson Laboratory The Jackson Laboratory Bar Harbor, Maine Bar Harbor, Maine Harm HogenEsch, D.V.M., Ph.D. Donald P. Doolittle, Ph.D. Department of Pathobiology The Jackson Laboratory School of Veterinary Medicine Bar Harbor, Maine Purdue University West Lafayette, Indiana Robert W. Dunstan, D.V.M., M.S. Department of Pathology Robert A. Kennis, D.V.M. Animal Health Diagnostic Laboratory Kaneohe Pet Dermatology Michigan State University Kaneohe, Hawaii East Lansing, Michigan Ronald E. Gates, Ph.D. Lloyd E. King, Jr., M.D., Ph.D. Department of Medicine Department of Medicine Division of Dermatology Division of Dermatology Vanderbilt University Vanderbilt University Nashville, Tennessee Nashville, Tennessee M. Lynn Lamoreux, Ph.D. Joseph A. Rothnagel, Ph.D. Department of Veterinary Pathobiology Departments of Cell Biology and Texas A&M University Dermatology College Station, Texas Baylor College of Medicine Houston, Texas Robert M. Lavker, Ph.D. Department of Dermatology Josselyne Salaun, Ph.D. University of Pennsylvania Institut d’Embryologie du C.N.R.S. Philadelphia, Pennsylvania et du College de France Nogent sur Marne, France William M. McMahon, M.D. Howard Hughes Medical Institute Berthe Salzgeber Research Laboratories Institut d’Embryologie du C.N.R.S. University of Utah et du College de France Eccles Institute of Human Genetics Nogent sur Marne, France Salt Lake City, Utah Xavier Montagutelli, D.V.M. Leonard D. Shultz, Ph.D. Unite de Genetique des Mammiferes The Jackson Laboratory Institut Pasteur Bar Harbor, Maine Paris, France J. Wayne Streilein, M.D. Lillian B. Nanney, Ph.D. Schepens Eye Research Institute Departments of Cell Biology and Boston, Massachusetts Plastic Surgery Vanderbilt University Tung-Tien Sun, Ph.D. Nashville, Tennessee Department of Dermatology NYU Medical School Seth J. Orlow, M.D., Ph.D. New York, New York Department of Dermatology NYU Medical School John P. Sundberg, D.V.M., Ph.D. New York, New York The Jackson Laboratory Mark R. Pittelkow, M.D. Bar Harbor, Maine Departments of Dermatology, Biochemistry, and Molecular Biology Hope O. Sweet, B.S. Mayo Clinic The Jackson Laboratory Rochester, Minnesota Bar Harbor, Maine Barry C. Powell, Ph.D. Colleen M. Vallee, B.S. Department of Biochemistry The Jackson Laboratory University of Adelaide Bar Harbor, Maine South Australia, Australia Erby Wilkinson, D.V.M., Ph.D. George E. Rogers, Ph.D., D.Sci. Department of Pathobiology Department of Biochemistry University of Tennessee University of Adelaide College of Veterinary Medicine South Australia, Australia Knoxville, Tennessee Dennis R. Roop, Ph.D. Departments of Cell Biology and Chris Zurcher, M.D., Ph.D. Dermatology TNO Research Institute Baylor College of Medicine Gaubius Laboratory Houston, Texas Leiden, The Netherlands TABLE OF CONTENTS PART I. BIOLOGY OF SKIN AND HAIR OF LABORATORY MICE AND HUMAN BEINGS Introduction............................................................................................................................................3 Chapter 1. Applications and Needs of Models for Dermatological Research....................5 Lowell A. Goldsmith Chapter 2. Inbred Laboratory Mice as Animal Models and Biomedical Tools: General Concepts..........................................................................................................9 John P. Sundberg Chapter 3. The Jackson Laboratory Mouse Mutant Resource..............................................21 Muriel T. Davisson Chapter 4. Hair Follicle Stem Cells..........................................................................................29 Robert M. Lavker, Tung-Tien Sun, and John P. Sundberg Chapter 5. The Mouse Skin as a Model for Chemical Carcinogenesis.............................39 Claudio J. Conti Chapter 6. Viral Induced Skin Tumors in Mice.....................................................................47 John P. Sundberg, Hendrick G. Bedigian, and Roderick Bronson Chapter 7. Hair Types and Subtypes in the Laboratory Mouse..........................................57 John P. Sundberg and Margaret E. Hogan Chapter 8. Growth Factors and Cutaneous Pathology...........................................................69 Lloyd E. King, Jr., Lillian B. Nanney, and Ronald E. Gates Chapter 9. Transgenic Mice with Cytokine Mutations Affecting the Skin.......................81 Manfred Blessing, Erby Wilkinson, and Brigid L. M. Hogan Chapter 10. Epidermal Keratins....................................................................................................95 Joseph A. Rothnagel and Dennis R. Roop Chapter 1 1. Hair Follicle Keratins .............................................................................................105 George E. Rogers and Barry C. Powell Chapter 12. Keratinocyte Cultures as Models for DermatologicaJ Disease.......................1 17 Mark R. Pittelkow Chapter 13. Mouse Mutations with Endocrine Functional Consequences.........................129 Wesley G. Beamer Chapter 14. The Immune System in Cutaneous Disease: the Search for a Mouse Model of the Immunopathology of Psoriasis.........................................143 Susan F. Grammer and J. Wayne Streilein PART II. ANIMAL MODELS OF GENETIC BASED SKIN DISEASES Section A. Mouse Single Gene Mutations Introduction........................................................................................................................................157 Chapter 1. The Adrenocortical Dysplasia (acd) Mutation, Chromosome 8.....................159 John P. Sundberg, Seth J. Orlow, Hope O. Sweet, and Wesley G. Beamer Chapter 2. The Angora (go) Mutation, Chromosome 5.......................................................165 John P. Sundberg Chapter 3. The Asebia (ab, ab1) Mutations, Chromosome 19............................................171 John P. Sundberg
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