Handbook of Laboratory Animal Anesthesia and Pain Management: Rodents

215 Pages·2017·33.09 MB·English

by  Cholawat Pacharinsak

HANDBOOK OF
LABORATORY ANIMAL
ANESTHESIA PAIN
and
MANAGEMENT
RODENTS
The Laboratory Animal Pocket Reference Series
Series Editor
Mark A. Suckow, D.V.M.
Freimann Life Science Center
University of Notre Dame
South Bend, Indiana
Published Titles
Handbook of Laboratory Animal Anesthesia and
Pain Management: Rodents
The Laboratory Bird
Critical Care Management for Laboratory Mice and Rats
The Laboratory Canine
The Laboratory Cat
The Laboratory Ferret
The Laboratory Guinea Pig, Second Edition
The Laboratory Hamster and Gerbil
The Laboratory Mouse, Second Edition
The Laboratory Nonhuman Primate
The Laboratory Rabbit, Second Edition
The Laboratory Rat, Second Edition
The Laboratory Small Ruminant
The Laboratory Swine, Second Edition
The Laboratory Xenopus sp.
The Laboratory Zebrafish
A Volume in The Laboratory Animal Pocket Reference Series
HANDBOOK OF
LABORATORY ANIMAL
ANESTHESIA PAIN
and
MANAGEMENT
RODENTS
Edited by
Cholawat Pacharinsak
Director of Anesthesia, Pain Management, and Surgery
Department of Comparative Medicine, Stanford University
School of Medicine, California, USA
Jennifer C. Smith
Boca Raton London New York
CRC Press is an imprint of the
Taylor & Francis Group, an informa business
CRC Press
Taylor & Francis Group
6000 Broken Sound Parkway NW, Suite 300
Boca Raton, FL 33487-2742
© 2017 by Taylor & Francis Group, LLC
CRC Press is an imprint of Taylor & Francis Group, an Informa business
No claim to original U.S. Government works
Printed on acid-free paper
Version Date: 20160725
International Standard Book Number-13: 978-1-4665-8567-6 (Paperback)
This book contains information obtained from authentic and highly regarded sources. Reasonable efforts
have been made to publish reliable data and information, but the author and publisher cannot assume
responsibility for the validity of all materials or the consequences of their use. The authors and publishers
have attempted to trace the copyright holders of all material reproduced in this publication and apologize to
copyright holders if permission to publish in this form has not been obtained. If any copyright material has
not been acknowledged please write and let us know so we may rectify in any future reprint.
Except as permitted under U.S. Copyright Law, no part of this book may be reprinted, reproduced, transmit-
ted, or utilized in any form by any electronic, mechanical, or other means, now known or hereafter invented,
including photocopying, microfilming, and recording, or in any information storage or retrieval system,
without written permission from the publishers.
For permission to photocopy or use material electronically from this work, please access www.copyright.
com (http://www.copyright.com/) or contact the Copyright Clearance Center, Inc. (CCC), 222 Rosewood
Drive, Danvers, MA 01923, 978-750-8400. CCC is a not-for-profit organization that provides licenses and
registration for a variety of users. For organizations that have been granted a photocopy license by the CCC,
a separate system of payment has been arranged.
Trademark Notice: Product or corporate names may be trademarks or registered trademarks, and are used
only for identification and explanation without intent to infringe.
Library of Congress Cataloging‑in‑Publication Data
Names: Pacharinsak, Cholawat, author. | Smith, Jennifer C. (Jennifer Capra),
1967- author.
Title: Handbook of laboratory animal anesthesia and pain management : rodents
/ Cholawat Pacharinsak and Jennifer C. Smith.
Other titles: Laboratory animal pocket reference series.
Description: Boca Raton : Taylor & Francis, 2017. | Series: Laboratory animal
pocket reference series | Includes bibliographical references and index.
Identifiers: LCCN 2016032842| ISBN 9781466585676 (pbk. : alk. paper) | ISBN
9781466585683 (alk. paper)
Subjects: | MESH: Anesthesia--veterinary | Animals, Laboratory | Rodentia |
Pain--prevention & control | Anesthetics | Handbooks
Classification: LCC SF914 | NLM QY 39 | DDC 636.089/796--dc23
LC record available at https://lccn.loc.gov/2016032842
Visit the Taylor & Francis Web site at
http://www.taylorandfrancis.com
and the CRC Press Web site at
http://www.crcpress.com
CRC Press
Taylor & Francis Group
6000 Broken Sound Parkway NW, Suite 300
Boca Raton, FL 33487-2742
© 2017 by Taylor & Francis Group, LLC
CRC Press is an imprint of Taylor & Francis Group, an Informa business
No claim to original U.S. Government works
I would like to dedicate this work to my parents,
Printed on acid-free paper
Version Date: 20160725 Anek and Pattraporn Pacharinsak.
International Standard Book Number-13: 978-1-4665-8567-6 (Paperback)
Cholawat Pacharinsak
This book contains information obtained from authentic and highly regarded sources. Reasonable efforts
have been made to publish reliable data and information, but the author and publisher cannot assume
To my mom, Lucille Capra, who continually
responsibility for the validity of all materials or the consequences of their use. The authors and publishers
have attempted to trace the copyright holders of all material reproduced in this publication and apologize to
shares her passion for the written word.
copyright holders if permission to publish in this form has not been obtained. If any copyright material has
not been acknowledged please write and let us know so we may rectify in any future reprint.
Jennifer C. Smith
Except as permitted under U.S. Copyright Law, no part of this book may be reprinted, reproduced, transmit-
ted, or utilized in any form by any electronic, mechanical, or other means, now known or hereafter invented,
including photocopying, microfilming, and recording, or in any information storage or retrieval system,
without written permission from the publishers.
For permission to photocopy or use material electronically from this work, please access www.copyright.
com (http://www.copyright.com/) or contact the Copyright Clearance Center, Inc. (CCC), 222 Rosewood
Drive, Danvers, MA 01923, 978-750-8400. CCC is a not-for-profit organization that provides licenses and
registration for a variety of users. For organizations that have been granted a photocopy license by the CCC,
a separate system of payment has been arranged.
Trademark Notice: Product or corporate names may be trademarks or registered trademarks, and are used
only for identification and explanation without intent to infringe.
Library of Congress Cataloging‑in‑Publication Data
Names: Pacharinsak, Cholawat, author. | Smith, Jennifer C. (Jennifer Capra),
1967- author.
Title: Handbook of laboratory animal anesthesia and pain management : rodents
/ Cholawat Pacharinsak and Jennifer C. Smith.
Other titles: Laboratory animal pocket reference series.
Description: Boca Raton : Taylor & Francis, 2017. | Series: Laboratory animal
pocket reference series | Includes bibliographical references and index.
Identifiers: LCCN 2016032842| ISBN 9781466585676 (pbk. : alk. paper) | ISBN
9781466585683 (alk. paper)
Subjects: | MESH: Anesthesia--veterinary | Animals, Laboratory | Rodentia |
Pain--prevention & control | Anesthetics | Handbooks
Classification: LCC SF914 | NLM QY 39 | DDC 636.089/796--dc23
LC record available at https://lccn.loc.gov/2016032842
Visit the Taylor & Francis Web site at
http://www.taylorandfrancis.com
and the CRC Press Web site at
http://www.crcpress.com

contents
preface ...........................................................................................ix
acknowledgments ..........................................................................xi
editors .........................................................................................xiii
contributors ..................................................................................xv
1 terms and definitions .............................................................1
Travis Seymour
2 understanding anesthetic-related equipment ..........................3
Daniel Pang
3 anesthetic pharmacology and research-related anesthetic
considerations ......................................................................29
Robert D. Keegan
4 management of anesthesia ...................................................55
Jennifer C. Smith
5 anesthesia monitoring ..........................................................75
Andre Shih
6 special techniques and species .............................................89
Janlee Jensen
vii
viii contents
7 pain management ...............................................................117
Patricia Foley
8 euthanasia .........................................................................137
C. Tyler Long
9 regulatory management of rodent anesthesia ......................157
Patrick Sharp
index ..........................................................................................189
preface
Rodents are the most commonly used species in biomedical research.
In many instances, individuals performing such research are charged
with broad responsibilities, including the performance of techni-
cal procedures that directly or indirectly require anesthesia or pain
management. Therefore, the animals’ comfort is a critical component
of conducting ethical, compassionate, scientifically valid biomedical
research. Taken together or individually, anesthesia and pain man-
agement are complex concepts involving several components (anes-
thetic machine/equipment, anesthetic monitoring, pharmacology of
anesthetics or analgesics, pain management, etc.) toward producing
sound, safe, and effective anesthesia and pain management. This
complexity can challenge researchers, scientists, veterinarians, or
technicians. This book emphasizes rodent anesthesia and pain man-
agement in the research setting, including understanding the anes-
thetic machine and related equipment, anesthetic management and
monitoring, anesthesia and analgesia pharmacology, euthanasia,
and record keeping. The format is different than other textbooks, as
bullet points are used to facilitate navigation through each chapter.
In this regard, this handbook was written to provide a quick ref-
erence source for investigators, technicians, and animal caretakers
charged with the care and/or use of rodents in a research setting.
It should be particularly valuable to those at small institutions or
facilities lacking a large, well-organized animal resource unit and
to those individuals who need to conduct research programs using
rodents starting from scratch.
This handbook is organized into nine chapters: (1) terms and defi-
nitions; (2) understanding anesthetic-related equipment; (3) anes-
thetic pharmacology and research-related anesthetic considerations;
ix