Handbook of Dermatology: A Practical Manual PDF
Preview Handbook of Dermatology: A Practical Manual
Handbook of Dermatology Handbook of Dermatology A Practical Manual SeconD eDition Margaret W. Mann, MD Associate Professor and Director of Aesthetic Dermatology University Hospitals, Case Western School of Medicine Cleveland, OH, USA Co-Founder Innova Dermatology Hendersonville, TN, USA Daniel L. Popkin, MD PhD Assistant Chief of Dermatology, Louis Stokes VA Medical Center Assistant Professor of Dermatology University Hospitals, Case Western School of Medicine Cleveland, OH, USA Co-Founder Innova Dermatology Hendersonville, TN, USA This edition first published 2020 © 2020 by John Wiley & Sons Ltd Edition History [1e, 2009] All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by law. Advice on how to obtain permission to reuse material from this title is available at http://www.wiley.com/go/permissions. 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You should consult with a specialist where appropriate. Further, readers should be aware that websites listed in this work may have changed or disappeared between when this work was written and when it is read. Neither the publisher nor authors shall be liable for any loss of profit or any other commercial damages, including but not limited to special, incidental, consequential, or other damages. Library of Congress Cataloging‐in‐Publication Data Names: Mann, Margaret W., author. | Popkin, Daniel L., author. Title: Handbook of dermatology : a practical manual / Margaret W. Mann, Daniel L. Popkin. Description: Second edition. | Hoboken, NJ : Wiley Blackwell, 2020. | Preceded by Handbook of dermatology / Margaret W. Mann ... [et al.]. 2009. | Includes bibliographical references and index. | Identifiers: LCCN 2019003278 (print) | LCCN 2019004180 (ebook) | ISBN 9781118408537 (Adobe PDF) | ISBN 9781118408520 (ePub) | ISBN 9781118408544 (pbk.) Subjects: | MESH: Skin Diseases–diagnosis | Skin Diseases–therapy | Dermatologic Agents–therapeutic use | Handbook Classification: LCC RL74 (ebook) | LCC RL74 (print) | NLM WR 39 | DDC 616.5–dc23 LC record available at https://lccn.loc.gov/2019003278 Cover Design: Wiley Cover Images: © STEVE GSCHMEISSNER/SCIENCE PHOTO LIBRARY/Getty Images Set in 7.5/9.5 Frutiger by SPi Global, Pondicherry, India 10 9 8 7 6 5 4 3 2 1 Dedication This second edition is dedicated to our son Samuel. Without you, completing this second edition would have been so much faster and less fun. Contents Preface, xv Acknowledgments, xvii Part 1 General Dermatology, 1 Common Work-uPs, signs, And mAnAgement, 3 dermatologic differential Algorithm, 3 direct immunofluorescence (dif), 3 False positive/negative diFs, 3 Workup Quick reference orders, 4 Acne, 6 Alopecia Workup, 7 telogen effluvium, 10 Androgenic alopecia, 10 Alopecia areata, 11 other alopecia treatments, 12 Aphthosis Workup and treatment, 13 dermatologic signs, 15 Folliculitis, 21 melasma, 22 immunology And immunologiC diseAse, 24 lupus erythematosus, 24 Autoantibody, 26 sensitivities and specificities, 26 in connective tissue diseases, 28 Anti‐nuclear antibodies, 29 AnCA (Anti‐neutrophil cytoplasmic antibodies), 30 treatment of AnCA‐associated vasculitis, 30 Vasculitis, 31 small vessel vasculitis, 31 medium vessel vasculitis, 33 large vessel vasculitis, 34 Cryoglobulinemia, 34 Bullous disorders, 36 intracorneal/subcorneal, 36 intraepidermal, 36 suprabasilar, 37 subepidermal with little inflammation, 37 epidermolysis bullosa, 39 major bullous diseases – clinicopathologic findings, 42 vii Complement, 46 Angioedema and complement levels, 46 Complement deficiencies, 47 gVHd, 47 HlA associations, 48 th profiles, 50 sPeCiAl sites: glAnds, nAil, Bone, muCosA, 51 glands, 51 nail terminology, 53 disorders or drugs associated with nail, bone, or ocular findings, 57 genital ulcers, 67 inFeCtion And inFestAtions, 68 Fungal disease / mycoses, 68 laboratory tests, 68 superficial mycoses, 68 Cutaneous mycoses, 69 subcutaneous mycoses, 71 systemic mycoses, 73 opportunistic mycoses, 75 Viruses and diseases, 78 Human papilloma virus, 79 other viral diseases, 80 infections/Bugs, 83 Vector‐borne diseases, 83 Creatures in dermatology, 88 ContACt And PlAnt dermAtitis, 93 Patch testing, 93 Common contact allergens, 95 Allergic vs. irritant contact dermatitis, 104 Allergens – location specific, 105 Features suggestive of specific irritant/toxin, 106 Plants and dermatoses, 106 tumors snd inFiltrAtes, 109 Cutaneous t Cell lyphoma, 109 Cutaneous B‐cell lymphoma, 113 leukemia cutis, 113 monoclonal gammopathies in dermatology, 114 tumors and gene associations, 115 For melanoma, BCC, and sCC, see skin Cancer, 221 viii systemiC And metABoliC diseAses, 117 Amyloidoses, 117 Histiocytosis, 119 Xanthomas, 124 Hyperlipoproteinemias, 125 Vitamin deficiencies/Hypervitaminoses, 127 PediAtriC And PregnAnCy dermAtology, 131 Vascular tumors and malformation, 131 infantile Hemangioma (iH) management, 132 neonatal vesiculopustular eruptions, 137 genodermatoses, 142 Chromosome abnormalities, 171 disorders of cornification, 171 disorders of connective tissue, 175 ehlers–danlos, 177 Collagen types, 178 disorder of hair, nail, ectoderm, 179 tumor syndromes, 185 disorders of vascularization, 186 disorders of metabolism, 189 Porphyrias, 191 disorders of pigmentation, 193 immunodeficiency syndromes, 196 miscellaneous, 198 dermatoses of pregnancy, 200 dermosCoPy And dermAtoPAtHology, 202 dermoscopy, 202 dermatopathology, 206 Histochemical staining, 206 immunohistochemical staining, 207 Pathologic bodies, 210 Cysts, 214 other derm path buzzwords, patterns, ddx, 215 Part 2 Surgical and Cosmetic Dermatology, 219 surgiCAl dermAtology, 221 skin cancer, 221 surgical margin guidelines, 221 indication for mohs micrographic surgery, 222 melanoma, 223 squamous cell carcinoma (sCC), 228 ix Prophylactic antibiotics and antivirals, 230 guideline for Prophylactic antibiotics, 230 Algorithm for antibiotic prophylaxis, 231 guideline for prophylactic antivirals, 231 Antiseptic scrubs, 232 Anesthetics, 234 dose calculation, 234 standard formula for buffered lidocaine, 234 tumescent anesthesia, 234 topical anesthetic (see drug section pg. 316), 235 Adverse reaction to local anesthetics, 235 local anesthetic, 236 nerve blocks, 237 surgical anatomy, 237 Anatomy of the face, 237 danger zones in surgery, 242 dermatomal distribution of sensory nerves, 244 Anatomy of the lower extremity venous system, 245 Anatomy of the nail, 246 Cutaneous reconstruction, 247 undermining depths in reconstruction, 248 reconstruction algorithm: stAirs, 248 sutures, 260 Absorbable, 260 nonabsorbable, 261 suture removal time, 262 electrosurgery, 262 Wound healing, 262 Wound dressing, 263 CosmetiC dermAtology, 264 laser, 264 laser fundamentals, 264 laser treatment of tattoo pigment, 266 Photoinduced eye injury, 267 laser wavelength, depth of penetration and the electromagnetic spectrum, 268 Absorption spectra of major skin chromophores, 268 Photodynamic therapy, 269 Photosensitizer properties and options, 269 Pdt Protocol, 270 uV spectrum, 271 uV spectrum and wavelengths, 271 uVB protection vs sPF, 272 x uV protection measurements, 272 uV associations/specificities, 273 glogau wrinkle scale, 273 Fitzpatrick skin type, 274 Chemical peels, 274 Pre‐peel consideration, 274 Peeling agents, 275 Botulinum toxin, 277 injectable for adipolysis, 280 Fillers, 281 Protocol for vascular occlusion from fillers, 288 Venous disease treatment, 288 Vein treatment algorithm, 288 sclerotherapy, 289 Preparing dilution of sclerosants, 290 CeAP classification for venous disease, 292 Venous clinical severity score, 292 Part 3 Drugs and Therapies, 293 medication Quick reference, 295 topical steroids classified by strength, 295 nonsteroidals, 297 Commonly used drugs in dermatology, 297 systemic medications, 302 Antimalarials, 302 immunosuppressive agents, 303 systemic retinoids, 306 Biologics, 307 general reference, 310 metric measurements, 310 dose calculations, 310 topical medication dispensing and absorption, 310 Corticosteroid dosage equivalence, 311 Acne – topical, 311 Antibiotics/antimicrobial, 311 keratolytics, 312 retinoids, 313 others, 313 Acne – oral, 314 Antibiotics, 314 retinoids, 315 others, 315 Analgesics, 315 Anesthetics – topical (see also topical anesthetic pg. 235), 316 xi Anesthetics – topical compounded, 316 Antibiotics, 316 topical/antiseptic, 316 systemic, 317 Preoperative prophylaxis, see pg. 230 Postoperative skin infection, 319 sensitivity, 321 regimens, 322 stds, 323 Antifungals, 324 topical, 324 oral, 325 Antifungal regimens, 327 Candidal infection, 327 Pityrosporum folliculitis, 327 onychomycosis, 327 tinea versicolor (Malassezia), 328 tinea capitis, 328 tinea corporis, 328 tinea pedis, 329 Antiparasitics, 330 scabies, 330 lice, 330 Antivirals, 331 HsV, 331 Herpes zoster/VZV, 333 genital warts, 333 Verruca vulgaris, 334 molluscum, 334 Antihistamines, 334 sedating, 335 nonsedating, 335 H2‐blockers, 335 Antipruritic, 336 topical, 336 oral, 336 Anxiolytics/sedation, 338 Benzodiazepines, 338 Antihistamines , 339 Bleaching Agents/depigmenting Agents, 340 Hair, 341 Alopecia – androgenic, 341 Alopecia – areata, 341 Hypertrichosis, 342 Hypotrichosis – eyelash, 342 xii
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