H C P C I ANDBOOK OF OMPLEX ERCUTANEOUS AROTID NTERVENTION C C ONTEMPORARY ARDIOLOGY CHRISTOPHER P. CANNON, MD SERIES EDITOR ANNEMARIE M. ARMANI, MD EXECUTIVE EDITOR Cardiovascular Magnetic Resonance Imaging, Principles of Molecular Cardiology,editedby edited byRaymond Y. Kwong, MD,2007 Marschall S. Runge, MD, and Cam Patterson, Essential Echocardiography: A Practical Handbook MD, 2005 With DVD, edited by Scott D. Solomon, MD, Heart Disease Diagnosis and Therapy: A Practical 2007 Approach, Second Edition, byM. Gabriel Khan, Management of Acute Pulmonary Embolism, MD,FRCP(LONDON),FRCP(C),FACP,FACC, 2005 edited by Stavros Konstantinides, MD, 2007 Cardiovascular Genomics: Gene Mining for Stem Cells and Myocardial Regeneration,edited Pharmacogenomics and Gene Therapy, byMarc S. Penn, MD,PhD, 2007 editedbyMohan K. Raizada, PhD, Julian F. Handbook of Complex Percutaneous Carotid R. Paton, PhD, Michael J. Katovich, PhD, and Intervention,edited by Jacqueline Saw, MD, Sergey Kasparov, MD,PhD, 2005 Jose Exaire, MD, David S. Lee, MD, Sanjay Surgical Management of Congestive Heart Failure, Yadav,MD, 2007 editedbyJames C. Fang, MD Preventive Cardiology:Insights Into the Prevention and Gregory S. Couper, MD, 2005 and Treatment of Cardiovascular Disease, Cardiopulmonary Resuscitation,editedbyJoseph P. Second Edition,edited by JoAnne Micale Ornato,MD,FACP,FACC,FACEPand Mary Ann Foody,MD, 2006 Peberdy,MD,FACC, 2005 The Art and Science of Cardiac Physical CT of the Heart: Principles and Applications, edited Examination:With Heart Sounds and Pulse byU. Joseph Schoepf, MD, 2005 Wave Forms on CD,byNarasimhan Coronary Disease in Women:Evidence-Based Diag- Ranganathan,MD, Vahe Sivaciyan, MD, nosis and Treatment,edited by Leslee J. Shaw, and Franklin B. Saksena, MD, 2006 PhDand Rita F. 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FRCP(C), and Aristidis Veves, MD,DSc, 2005 Wackers,MD,PhD, Wendy Bruni, BS,CNMT, Angiogenesis and Direct Myocardial and Barry L. Zaret, MD, 2004 Revascularization,editedbyRoger J. Minimally Invasive Cardiac Surgery, Second Laham,MD, and Donald S. Baim, MD, 2005 Edition,edited by Daniel J. Goldstein,MD, Interventional Cardiology: Percutaneous and Mehmet C. Oz, MD 2004 Noncoronary Intervention, editedbyHoward Cardiovascular Health Care Economics, edited by C. Herrmann, MD, 2005 William S. Weintraub, MD, 2003 H C ANDBOOK OF OMPLEX P C ERCUTANEOUS AROTID I NTERVENTION Edited by J S , ACQUELINE AW MD Division of Cardiology, University of British Columbia, Vancouver, BC, Canada J. E E , MILIO XAIRE MD Department of Interventional Cardiology, Instituto Nacional de Cardiología “Ignacio Chávez,” Mexico City, Mexico D S. L , AVID EE MD Interventional Cardiology, Hillsboro Cardiology, Hillsboro, OR J S. Y , AY ADAV MD Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, OH © 2007 Humana Press Inc. 999 Riverview Drive, Suite 208 Totowa, New Jersey 07512 www.humanapress.com All rights reserved. No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise without written permission from the Publisher. The content and opinions expressed in this book are the sole work of the authors and editors, who have warranted due diligence in the creation and issuance of their work. The publisher, editors, and authors are not responsible for errors or omissions or for any consequences arising from the information or opinions presented in this book and make no warranty, express or implied, with respect to its contents. 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[et al.]. p. ; cm. — (Contemporary cardiology) Includes bibliographical references and index. ISBN 1-58829-605-9 (alk. paper) 1. Carotid artery—Surgery. 2. Carotid artery—Stenosis. 3. Stents (Surgery) I. Saw, Jacqueline. II. Series: Contemporary cardiology (Totowa, N.J. : Unnumbered) [DNLM: 1. Carotid Stenosis—surgery—Case Reports. 2. Angioplasty,Balloon—methods—Case Reports. 3. Stents—Case Reports.WL 355 H2356 2007] RD598.6.H36 2007 617.4'13—dc22 2006004982 D EDICATIONS To my husband, David, and our son, Evan, and my family, who make my life endeavors worthwhile. And to my mentors in Interventional and General Cardiology (Drs. Donald Beanlands, Deepak Bhatt, Irvine Franco, John Jue, David Moliterno, Eric Topol, and Jay Yadav), for their guidance and support through my training, and for inspiring me to excel. Jacqueline Saw, MD To my wife, Karin, and my parents, Cristina and Emilio, with all my love and gratitude. This book would not be possible without the teachings of Dr. Jay Yadav and the remark- able Peripheral Intervention Staff at the Cleveland Clinic Foundation. J. Emilio Exaire, MD To Megan and my family for their love, support, and encouragement, and to the interventional cardiologists at the Cleveland Clinic (especially Drs. Yadav, Franco, Whitlow, Topol, and Bajzer) for their mentorship, friendship, time, and investment in me.I would not be who I am and where I am without you. David S. Lee, MD To my family for their unfailing support and understanding, and to the interventional cardiology fellows at the Cleveland Clinic for their curiosity and inspiration. Jay S. Yadav, MD v P REFACE Since the first carotid angioplasty that was performed in 1980, this technique has undergone tremendous modifications and improvements. Stents for the carotid artery were utilized in the early 1990s, and emboli protection devices were introduced about 2000. Advances in equipment (guidewires, catheters, balloons, stents, and emboli pro- tection devices) have improved the technical success and safety of carotid stenting. With the recent SAPPHIRE publication revealing non-inferiority of carotid stenting compared with carotid endarterectomy for high-risk surgical patients, this percutaneous procedure is now considered a viable alternative to endarterectomy for these patients. In fact, the FDA has approved carotid stenting for high-risk patients using the AccuLink™ stent and AccuNet™ device (Guidant Corporation, Santa Clara, CA) in August 2004, and the XactTM and EmboShieldTM system (Abbott Vascular Devices, Redwood City, CA) in September 2005. Increasing numbers of carotid stenting are being performed around the world, and established interventionalists and trainees alike are seeking to be instructed in performing this meticulous procedure. Unfortunately, there are insufficient well-established periph- eral vascular training programs to meet this increasing demand. Only a small proportion of current trainees are enrolled in fellowship programs with dedicated carotid interven- tional training that perform high-volume extracranial carotid stenting; even fewer are enrolled in programs that also partake in intracranial and acute stroke interventions. In North America, this shortage of dedicated training programs leaves interested interven- tionalists pursuing carotid stent training through short educational courses, and often haphazard and limited “hands-on” experience in other institutions. The purpose of our Handbook of Complex Percutaneous Carotid Intervention is to provide a learning resource to complement the “hands-on” training of established inter- ventionalists and trainees. This handbook is intended for various disciplines participating in the management of patients with carotid and vertebral artery stenosis, including inter- ventional cardiologists, vascular surgeons, interventional radiologists, and interventional neurologists. The focus of this handbook is on percutaneous intervention of patients with extracranial carotid artery stenosis. As interventionalists of the cerebrovasculature are often faced with stenosis involving other cerebral vessels, we complemented our hand- book with sections on percutaneous interventions of intracranial stenosis, vertebral artery stenosis, and acute stroke. We have provided a detailed introduction to the techniques of extracranial and intrac- ranial, carotid, and vertebral interventions. We reviewed the indications, approaches, equipment, and potential complications of these percutaneous interventions. As many patients undergoing such procedures are elderly and high-risk with challenging anatomy, we also provided some useful pearls and troubleshooting of technically difficult cases. In addition, our section on challenging cases illustrates our approach to frequently en- countered challenges at the Cleveland Clinic. TheHandbook of Complex Percutaneous Carotid Intervention is also meant to pro- vide a comprehensive review of the management of carotid artery stenosis. Thus, we have vii viii Preface included chapters reviewing the epidemiology and significance of carotid stenosis, medical therapy, noninvasive and invasive imaging of the carotid artery, and carotid endarterectomy. In this current era of evidence-based medicine, we have also included chapters reviewing sentinel studies supporting carotid endarterectomy and carotid stent- ing. Carotid stenting is an exciting and burgeoning field. It is often a challenging proce- dure, which may expose patients to life-threatening complications. Its success as the preferred revascularization therapy of high-risk patients is contingent upon low peripro- cedural complications, which in turn is highly dependent on operator skills. As studies comparing carotid stenting and endarterectomy for low-risk patients are completed, we may see a further increase in the volume of carotid stenting. We hope that our Handbook of Complex Percutaneous Carotid Intervention will provide a useful resource to guide interventionalists through this challenging and important revascularization procedure of the 21st century. Jacqueline Saw, MD J. Emilio Exaire, MD David S. Lee, MD Jay S. Yadav, MD C ONTENTS Dedications ....................................................................................................................v Preface ................................................................................................................. vii Contributors...................................................................................................................xi Companion CD........................................................................................................... xiii P I C E ART LINICAL XPERIENCE 1 Epidemiology and Significance of Carotid Artery Stenosis............3 Anthony Y. Fung and Jacqueline Saw 2 Medical Therapy for Carotid Artery Stenosis................................11 David S. Lee 3 Carotid Endarterectomy: Techniques and Evidence-Based Medicine................................33 Joël Gagnon and York N. Hsiang 4 Carotid Angioplasty and Stenting Trials: A Historical Perspective and Evidence-Based Medicine..........47 David S. Lee and Jay S. Yadav 5 Cerebrovascular Anatomy ..............................................................65 Ravish Sachar and Samir Kapadia 6 Noninvasive Imaging of the Carotid Artery...................................83 J. Emilio Exaire, Mikhael Mazighi, Jacqueline Saw, and Alex Abou-Chebl 7 Cerebrovascular Angiography........................................................99 J. Emilio Exaire, Jacqueline Saw, and Christopher Bajzer 8 Indications for Carotid Artery Stenting........................................111 Cameron Haery, Sharat Koul, and Deepak L. Bhatt P II T C V A S ART ECHNIQUES OF AROTID AND ERTEBRAL RTERY TENTING 9 The Approach to Extracranial Carotid Artery Stenting...............131 Jacqueline Saw and Jay S. Yadav 10 Equipment for Extracranial Carotid Artery Stenting...................147 Jacqueline Saw and J. Emilio Exaire 11 Emboli Protection Devices...........................................................159 Jacqueline Saw 12 Complications of Carotid Artery Stenting ...................................175 Jacqueline Saw ix x Contents 13 The Approach to Intracranial Carotid Artery Intervention..........189 Ivan P. Casserly and Jay S. Yadav 14 The Approach to Intracranial and Extracranial Vertebral Artery Stenting .........................................................................211 J. Emilio Exaire and Jacqueline Saw 15 Endovascular Treatment of Acute Ischemic Stroke.....................229 Mikhael Mazighi, Qashim Bashir, and Alex Abou-Chebl P III C C I P ART HALLENGING ASE LLUSTRATIONS AND EARLS 16 Case: Left Carotid Artery Stenting with a Challenging Type III Aortic Arch.................................................................249 Jacqueline Saw 17 Case: Stenting of a Tortuous Left Internal Carotid Artery..........259 J. Emilio Exaire 18 Case: Stenting of a Critical Internal Carotid Artery Stenosis with String Sign........................................................................265 Jacqueline Saw 19 Case: Stenting of a Carotid Endarterectomy Patch Restenosis and Aneurysm...........................................................................275 J. Emilio Exaire 20 Case: Carotid Stenting with Slow Flow and Distal Embolization...........................................................283 J. Emilio Exaire 21 Case: Acute Stroke Intervention with a Large Thrombotic Burden...................................................................289 Jacqueline Saw 22 Case: Left Internal Carotid Artery Stenting in a Bovine Aortic Arch ...........................................................295 David S. Lee 23 Case: Right Carotid Artery Stenting via Right Brachial Artery Approach........................................................305 David S. Lee 24 Case: Ostial Innominate Artery Intervention...............................317 David S. Lee Index .......................................................................................................329