Handbook of Child and Adolescent Psychopharmacology PDF
Preview Handbook of Child and Adolescent Psychopharmacology
HCAP-Prelims.qxd 2/7/2006 6:06 PM Page i Handbook of Child and Adolescent Psychopharmacology HCAP-Prelims.qxd 2/7/2006 6:06 PM Page iii Handbook of Child and Adolescent Psychopharmacology Edited by Benedetto Vitiello MD Gabriele Masi MD Donatella Marazziti MD CRC Press Taylor & Francis Group 6000 Broken Sound Parkway NW, Suite 300 Boca Raton, FL 33487-2742 © 2006 by Taylor & Francis Group, LLC CRC Press is an imprint of Taylor & Francis Group, an Informa business No claim to original U.S. Government works Version Date: 20130325 International Standard Book Number-13: 978-0-203-69663-7 (eBook - PDF) This book contains information obtained from authentic and highly regarded sources. While all reasonable efforts have been made to publish reliable data and information, neither the author[s] nor the publisher can accept any legal responsibility or liability for any errors or omissions that may be made. The publishers wish to make clear that any views or opinions expressed in this book by individual editors, authors or contributors are personal to them and do not necessarily reflect the views/opinions of the publishers. The information or guid- ance contained in this book is intended for use by medical, scientific or health-care professionals and is provided strictly as a supplement to the medical or other professional’s own judgement, their knowledge of the patient’s medical history, relevant manufacturer’s instructions and the appropriate best practice guidelines. Because of the rapid advances in medical science, any information or advice on dosages, procedures or diagnoses should be independently verified. The reader is strongly urged to consult the drug companies’ printed instructions, and their websites, before administering any of the drugs recommended in this book. This book does not indicate whether a particular treatment is appropriate or suitable for a particular individual. Ultimately it is the sole responsibility of the medical professional to make his or her own professional judgements, so as to advise and treat patients appropriately. The authors and publishers have also attempted to trace the copyright holders of all material reproduced in this publication and apologize to copyright holders if permission to publish in this form has not been obtained. If any copyright material has not been acknowledged please write and let us know so we may rectify in any future reprint. Except as permitted under U.S. Copyright Law, no part of this book may be reprinted, reproduced, transmit- ted, or utilized in any form by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying, microfilming, and recording, or in any information storage or retrieval system, without written permission from the publishers. For permission to photocopy or use material electronically from this work, please access www.copyright.com (http://www.copyright.com/) or contact the Copyright Clearance Center, Inc. (CCC), 222 Rosewood Drive, Dan- vers, MA 01923, 978-750-8400. CCC is a not-for-profit organization that provides licenses and registration for a variety of users. For organizations that have been granted a photocopy license by the CCC, a separate system of payment has been arranged. Trademark Notice: Product or corporate names may be trademarks or registered trademarks, and are used only for identification and explanation without intent to infringe. Visit the Taylor & Francis Web site at http://www.taylorandfrancis.com and the CRC Press Web site at http://www.crcpress.com HCAP-Prelims.qxd 2/7/2006 6:06 PM Page v Contents List of contributors vii Foreword xi 1. Introduction: psychopharmacotherapy in the developmental age 1 2. Practicing evidence-based pediatric psychopharmacology: essential concepts 5 Benedetto Vitiello 3. Pharmacotherapy of anxiety disorders in children and adolescents 15 Gabriele Masi 4. Pharmacologic treatment of children and adolescents with major depressive disorder 53 Benedetto Vitiello, Dario Calderoni, and Luigi Mazzone 5. Pharmacotherapy of bipolar disorder in children and adolescents 81 Gabriele Masi 6. Therapeutic strategies of obsessive-compulsive disorder in children and adolescents 123 Donatella Marazziti, Chiara Pfanner, Mario Catena, Francesco Mungai, Laura Vivarelli, and Silvio Presta HCAP-Prelims.qxd 2/7/2006 6:06 PM Page vi vi Handbook of Child and Adolescent Psychopharmacology 7. Tourette syndrome: treatment 145 Ana G. Hounie, Maria C. Rosário-Campos, Lucas Quarantini, Aline S. Sampaio, Pedro G. Alvarenga, Juliana B. Diniz, Antonio C. Lopes, André A. Seixas, Adriana Pinto, Priscila Chacon, Helena S. Prado, Cristina Belotto, Márcia Motta, Maria Alice De Mathis, Maria Eugênia De Mathis, Sonia Borcatto, Maura Carvalho, and Eurípedes C. Miguel 8. Pharmacotherapy of psychotic disorders in children and adolescents 195 Gabriele Masi 9. Pharmacologic treatment of children and adolescents with attention deficit hyperactivity disorder 255 Benedetto Vitiello, Alessandro Zuddas, and Gabriele Masi 10. Pharmacologic treatment of children and adolescents with impulsive aggression and related behaviors 297 Benedetto Vitiello and Dario Calderoni 11. Pharmacotherapy of eating disorders in children and adolescents 315 Gabriele Masi 12. Pharmacotherapy of pervasive developmental disorders in children and adolescents 343 Gabriele Masi Index 387 HCAP-Prelims.qxd 2/7/2006 6:06 PM Page vii Contributors Pedro G Alvarenga Maura Carvalho Department of Psychiatry Department of Psychiatry University of São Paulo University of São Paulo Medical School Medical School São Paulo, SP São Paulo, SP Brazil Brazil Cristina Belotto Mario Catena Department of Psychiatry Department of Psychiatry, University of São Paulo Neurobiology, Pharmacology, Medical School and Biotechnology São Paulo, SP University of Pisa Brazil Pisa Italy Sonia Borcato Department of Psychiatry Priscilla Chacon University of Department of Psychiatry São Paulo Medical School University of São Paulo São Paulo, SP Medical School Brazil São Paulo, SP Brazil Dario Calderoni Child and Adolescent Maria Alice De Mathis Neurologist and Department of Psychiatry Psychiatrist University of São Paulo University of Rome Medical School Rome São Paulo, SP Italy Brazil HCAP-Prelims.qxd 2/7/2006 6:06 PM Page viii viii Handbook of Child and Adolescent Psychopharmacology Maria Eugênia De Mathis Gabriele Masi Department of Psychiatry Head of Psychopathology University of São Paulo and Psychopharmacology Medical School Research Branch São Paulo, SP Stella Maris Scientific Institute Brazil of Child Neurology and Psychiatry Pisa Juliana B Diniz Italy Department of Psychiatry University of São Paulo Luigi Mazzone Medical School Division of Child Neurology São Paulo, SP and Psychiatry Brazil Department of Pediatrics University of Catania Ana G Hounie Catania Department of Psychiatry Italy University of São Paulo Medical School Eurípedes C Miguel São Paulo, SP Department of Psychiatry Brazil University of São Paulo Medical School São Paulo, SP Antonio C Lopes Brazil Department of Psychiatry University of São Paulo Márcia Motta Medical School Department of Psychiatry São Paulo, SP University of São Paulo Brazil Medical School São Paulo, SP Donatella Marazziti Brazil Professor of Psychiatry Department of Psychiatry, Francesco Mungai Neurobiology, Department of Psychiatry, Pharmacology, and Neurobiology, Pharmacology, Biotechnology and Biotechnology University of Pisa University of Pisa Pisa Pisa Italy Italy HCAP-Prelims.qxd 2/7/2006 6:06 PM Page ix Contributors ix Chiara Pfanner Maria C do Rosário-Campos Division of Child Neurology Department of Neuropsychiatry and Psychiatry Federal University of Bahia IRCCS Stella Maris, Calambrone Salvador University of Pisa Brazil Italy Aline S Sampaio Department of Psychiatry Adriana Pinto University of São Paulo Department of Psychiatry Medical School University of São Paulo São Paulo, SP Medical School Brazil São Paulo, SP Brazil André A Seixas Department of Psychiatry Helena S Prado University of São Paulo Department of Psychiatry Medical School University of São Paulo São Paulo, SP Medical School Brazil São Paulo, SP Brazil Benedetto Vitiello Chief, Child and Adolescent Silvio Presta Treatment and Preventative Department of Psychiatry, Intervention Research Branch Neurobiology, Pharmacology, Division of Services and and Biotechnology Intervention Research University of Pisa National Institute of Mental Pisa Health Italy Bethesda, MD USA* Lucas Quarantini and Department of Adjunct Associate Professor Neuropsychiatry of Psychiatry Federal University of Bahia John Hopkins University Salvador Baltimore, MD Brazil USA *The opinions and assertions contained in this author’s chapters are the privateviewsoftheauthorandarenottobeconstruedasofficialorasreflect- ingtheviewsoftheNationalInstituteofMentalHealth,theNationalInstitute ofHealth,ortheUSDepartmentofHealthandHumanServices HCAP-Prelims.qxd 2/7/2006 6:06 PM Page x x Handbook of Child and Adolescent Psychopharmacology Laura Vivarelli Alessandro Zuddas Department of Psychiatry, Child Neuropsychiatry Neurobiology, Pharmacology, Department of and Biotechnology Neuroscience University of Pisa University of Cagliari Pisa Cagliari Italy Italy HCAP-Prelims.qxd 2/7/2006 6:06 PM Page xi Foreword The purposeofthishandbookistoprovideclinicianswhoaredirectly involved in the care of children and adolescents with mental disor- ders with updated, practically useful information on how to best use psychotropic medications. Research in pediatric psychopharmacology has greatly expanded in recent years. This handbook includes the latest research findings with special attention to the clinical context in which care is delivered and treatment decisions are made. To this end, the material has been arranged and presented by disorder rather than by type of med- ication. Psychopathology is, in fact, the target of treatment and a care- ful diagnostic evaluation is the foundation of any rational therapy. Few treatments in medicine can raise more controversy than the use of medications to mange emotional and behavioral disturbances in childhood. Safety concerns should certainly be paramount when con- sidering exposing children to pharmacological agents, and, whenever possible, the possibility of using alternative, psychosocial interventions should be weighed before choosing medications. It remains however that, for many children, a cautions, scientifically informed, and care- fully monitored pharmacotherapy can produce major improvements. In this spirit, the handbook is meant to be a contribution towards prac- ticing evidence-based pediatric psychopharmacology. Benedetto Vitiello, Gabriele Masi, Donatella Marazziti
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