Handbook of Blood Banking and Transfusion Medicine

366 Pages·2012·3.97 MB·English

Handbook of
Blood Banking and
Transfusion Medicine
Disclaimer: This eBook does not include ancillary media that was packaged with the printed
version of the book.
Handbook of
Blood Banking and
Transfusion Medicine
Editors
Gundu HR Rao PhD
Professor
Department of Laboratory Medicine and Pathology
University of Minnesota Medical School
Minneapolis, Minnesota 55455, USA
Ted Eastlund MD
Co-director, Division of Transfusion Medicine
Department of Laboratory Medicine and Pathology
University of Minnesota Medical School
Minneapolis, Minnesota 55455, USA
Latha Jagannathan MD
Medical Director and Managing Trustee Rotary/TTK Blood Bank
Bangalore Medical Services Trust and Research Institute
Bangalore
Sponsored by: Minneapolis/University Rotary Club, Edina Rotary Club,
World Community Service, the Rotary Club of Bangalore, and the Rotary Foundation
JAYPEE BROTHERS
MEDICAL PUBLISHERS (P) LTD
New Delhi
Disclaimer: This eBook does not include ancillary media that was packaged with the
printed version of the book.
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Jaypee Brothers Medical Publishers (P) Ltd
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Handbook of Blood Banking and Transfusion Medicine
© 2006, Gundu HR Rao, Ted Eastlund, Latha Jagannathan
All rights reserved. No part of this publication and CD ROM should be reproduced, stored in a retrieval system,
or transmitted in any form or by any means: electronic, mechanical, photocopying, recording, or otherwise, without
the prior written permission of the editors and the publisher.
This book has been published in good faith that the material provided by contributors is original. Every effort is
made to ensure accuracy of material, but the publisher, printer and editors will not be held responsible for any
inadvertent error(s). In case of any dispute, all legal matters to be settled under Delhi jurisdiction only.
First Edition: 2006
ISBN 81-8061-718-1
Typeset at JPBMP typesetting unit
Printed at Replika Press Pvt. Ltd.
Contributors
Noryati Abu Amin MD Dr Ashrani is a hematologist and oncologist with
Blood Transfusion Safety special interests in coagulation disorders at the
Essential Health Technologies Fairview-University Medical Center of of the
World Health Organization-Headquarters University of Minnesota Medical School where he
Avenue Appoa 20 takes care of patients, conducts research and teaches
CH-1211 students, residents and fellows.
Geneva, Switzerland
Sabeen Askari MD
Mukta Arora MD Pathology and Laboratory Medicine Service
Department of Medicine, Division of Hematology, Veterans Administration Medical Center
Oncology and Blood Transplantation One Veterans Drive
University of Minnesota Medical School Minneapolis MN 55417 USA
420 Delaware Street S. E. Email: [email protected]
Mineapolis MN 55455 USA
Dr Askari is a pathologist at the Veterans Administ-
Email: [email protected]
ration Hospital, serves as a blood bank attending
And
physician, teaches students, fellows and residents,
Center for International Blood and Marrow
directs a pathology residency training program and
Transplant Research
conducts research in pathology and transfusion
Minneapolis Campus
medicine.
3001 Broadway St. N.E., Suite 500
Minneapolis, MN 55413
Agnes Aysola MD
Dr Arora is an attending transplant physician in the Medical Director
adult Blood and Marrow Transplant Division at the Special Coagulation Laboratory
University of Minnesota Medical School. She also Department of Laboratory Medicine and Pathology
works as Assistant Scientific Director at the Center University of Minnesota Medical School
for International Blood and Marrow Transplant Box MMC 198
Research, Minneapolis, Minnesota. Dr Arora’s clinical 420 Delaware Street S.E.
interest is in treatment of hematologic malignancies Mineapolis MN 55455 USA
and blood and marrow transplantation. Her research And
interests focus on studying new therapies for Associate Medical Director
management of chronic graft versus host disease and American Red Cross North Central Blood Services
methods to improve outcomes following trans- 100 South Robert Street
plantation therapy for multiple myeloma. St Paul MN 55107 USA
Email: [email protected]
Aneel A Ashrani MD
Dr Aysola directs the coagulation laboratory at the
Department of Medicine, Division of Hematology,
Fairview-University Medical Center at the University
Oncology and Blood Transplantation
of Minnesota Medical School and is a medical director
University of Minnesota Medical School
of a Red Cross regional blood center that serves 140
420 Delaware Street S. E.
hospitals. She is an attending blood bank physician
Mineapolis MN 55455 USA
at the University of Minnesota, teaches medical
Email: [email protected]
students, trains visiting physicians, transfusion
vi Handbook of Blood Banking and Transfusion Medicine
medicine fellows and pathology residents in blood Mammen Chandy MD
banking, transfusion medicine, apheresis and Professor and Head
coagulation and participates in coagulation and Hematology Department
transfusion medicine research Christian Medical College Hospital
Vellore 632004, TN, India
David Beebe MD Email: [email protected]
Department of Anesthesiology
Dr Chandy is the head of the clinical hematology and
University of Minnesota Medical School
bone marrow transplantation services at the Christian
Box MMC 195
Medical College Hospital in Vellore, India. The
420 Delaware Street S. E.
department treats most hematological problems
Minneapolis MN 55455 USA
including acute leukemia, provides hematological
Email: [email protected]
support for surgery in hemophilia and does about 45
Dr Beebe is an anesthesiologist and Director of the allogeneic marrow transplants every year, many of
Anesthesiology Resident Training Program at the which are for thalassemia.
University of Minnesota Medical School, Minneapolis,
Minnesota. His research interests are in pediatric Jeffrey G Chipman MD
anesthesia and anesthesia for minimally-invasive Department of Surgery
surgery. University of Minnesota Medical School
Box MMC 195
Kumar Belani MD 420 Delaware Street S. E.
Department of Anesthesiology Minneapolis MN 55455 USA
University of Minnesota Medical School Email: [email protected]
Box MMC 195 And
420 Delaware Street S. E. Department of Surgery
Minneapolis MN 55455 USA Veterans Administration Medical Center
Email: [email protected] One Veterans Drive
Minneapolis MN 55417 USA
Dr Belani is a Professor of Anesthesiology at the
University of Minnesota Medical School, Minneapolis, Dr Jeffrey Chipman trained in general surgery at
Minnesota, has served as department chair, residency University of Arizona and in Surgical Critical Care at
program director and teaches students and residents the University of Minnesota Medical School where
and conducts research. For many years he has he is on the faculty and an Assistant Professor of
collaborated with physicians and scientists in India Surgery. He is also a surgeon at the Veterans
to promote medical education, improved medical Administration Medical Center in Minneapolis,
services and research. Minnesota, USA, where he is the Chair of the
Transfusion Committee. He has studied blood salvage
Abramf Burgher MD techniques in trauma surgery.
Mayo Clinic and Mayo Medical School
Department of Anesthesiology S Yoon Choo MD
200 First Street S.W. Associate Medical Director of Blood Bank,
Rochester, MN 55905 USA Director of HLA Laboratory
Email: [email protected] Mount Sinai Medical Center
One Gustave L. Levy Pl.
Dr Burgher was graduated from the University of
Box 1024
Minnesota Medical School and is an anesthesiology
New York, NY 10029 USA
resident at the Mayo Clinic and Mayo Medical School,
Email: [email protected]
Rochester, Minnesota. His interests include blood
component transfusion in the perioperative period Dr Choo is a clinical pathologist by training and a
and in critically ill patients. certified full-time blood banker. He is an Associate
Contributors vii
Professor of Pathology and Internal Medicine at the Dr Crosson is a Professor, Laboratory Medicine and
Mount Sinai School of Medicine in New York. His Pathology, and the director of the residency training
career in HLA started as a research scientist and program in the Department of Laboratory Medicine
extended to directing clinical HLA laboratories. He and Pathology at the University of Minnesota Medical
currently directs a full-spectrum blood banking/ School. He directs the blood bank at the Hennepin
transfusion service (blood donor center, blood bank County Medical Center, Minneapolis, Minnesota and
lab, apheresis, stem cell processing lab, and outpatient is a pathologist with special expertise in kidney
transfusion services) and a clinical HLA lab. He pathology.
teaches and trains clinical pathology residents and
hematology/oncology fellows during their trans- David Dennison MD
fusion medicine rotations. Head, Department of Hematology
Director of Bone Marrow Transplantation
Mary E Clay MS Sultan Qaboos University Hospital
Department of Laboratory Medicine and Pathology PO Box 35, Al Khod
University of Minnesota Medical Medical School Muscat, Oman
Box MMC 198, Room D242 Mayo Building Email: [email protected]
420 Delaware Street S. E.
Dr Dennison was graduated fron the Christian
Minneapolis MN 55455 USA
Medical College, Vellore, India, where he also trained
Email: [email protected]
in Internal Medicine. He completed hematology and
Mary Clay is the Director of the Transfusion Medicine oncology fellowship training at the University of
Research and Development Program in the Depart- Nebraska Medical Center, Omaha, Nebraska and was
ment of Laboratory Medicine and Pathology at the professor of medicine in the hematology department
University of Minnesota Medical School, Minneapolis, at the Christian Medical College Hospital, Vellore
Minnesota. She has over 32 years of experience in until 1998. He is currently head of the department of
transfusion medicine with 27 years focusing on hematology and director of the bone marrow
conducting, managing and administering transfusion transplant program at the Sultan Qaboos University
medicine R & D projects directed toward the Hospital in Oman. His program has special interests
production, clinical use and evaluation of standard in hereditary disorders prevalent in Oman such as
and investigational hematopoietic stem cell and beta thalassemia, immune system disorders and other
somatic cell products. She has special expertise in rare hematologic disorders.
conducting clinical trials and the administrative
management of cord blood banks. Neelam Dhingra MD
Ag Coordinator
John Crosson MD Blood Transfusion Safety
Department of Laboratory Medicine and Pathology Essential Health Technologies
University of Minnesota Medical Medical School World Health Organization-Headquarters
Box MMC 609 Avenue Appoa 20
420 Delaware Street S. E. CH-1211, Geneva, Switzerland
Minneapolis MN 55455 USA Email: [email protected]
Email: [email protected]
And Ted Eastlund MD
Blood Bank Co-director, Division of Transfusion Medicine
Department of Pathology Department of Laboratory Medicine and Pathology
Hennepin County Medical Center University of Minnesota Medical School
Minneapolis, Minnesota Box MMC 198, Room D242 Mayo Building
Email: [email protected] 420 Delaware Street S.E.
viii Handbook of Blood Banking and Transfusion Medicine
Minneapolis MN 55455, USA Dr Frey completed a transfusion medicine fellowship
Email: [email protected] at the University of Minnesota Medical School and
And is a pathologist at Fairview-Southdale Medical
Medical Director Center where she is the medical director of the
Blood Bank, Transfusion Service and Therapeutic blood bank and transfusion service and a co-investi-
Apheresis Services gator in clinical trials of virally-inactivated blood
Veterans Administration Medical Center components.
One Veterans Drive
Minneapolis MN 55417, USA Jed B Gorlin MD
Email: [email protected] Associate Clinical Professor,
Departments of Laboratory Medicine and
Dr Eastlund runs the blood bank, transfusion service,
Pathology and Pediatrics,
and apheresis donor center at the Fairview-University
University of Minnesota Medical School
Medical Center at the University of Minnesota
And
Medical School and the Veterans Administration
Medical Director
Medical Center. He takes care of patients, teaches
Memorial Blood Centers
medical students, trains visiting physicians,
2304 Park Ave.
transfusion medicine fellows and pathology residents
Minneapolis MN 55404 USA
and participates in research.
Email: [email protected]
Daniel Ericson PhD Dr Gorlin directs a large regional blood center serving
Director, Research and Development hospitals in Minnesota, teaches at the University of
Medical Innovations International Minnesota Medical School and conducts research in
6256 34th Avenue, NW transfusion medicine.
Rochester, MN 55901 USA
Email: [email protected] Annette Sauer-Heilborn MD
An der Quelle 10
Dr Ericson is a biomedical engineer and inventor of
30539 Hanover
medical devices. He is the president of a start-up
Germany
company (SUBC Inc) in Rochester, Minnesota. He is
Email: [email protected]
the chief of Research and Development at Medical
Innovations International, Rochester, Minnesota and Dr Sauer-Heilborn was trained as oncologist and
had worked for several years on problems with hematologist in Germany and completed a fellowship
storage of platelets and point-of-care testing for in transfusion medicine at the University of Minnesota
platelet function. Medical School in Minneapolis, Minnesota, where she
taught medical students and residents and
Jan Fordham participated in research in transfusion medicine.
Blood Transfusion Safety
Essential Health Technologies Latha Jagannathan MD
World Health Organization-Headquarters Medical Director and Managing Trustee
Avenue Appoa 20 CH-1211 Rotary/TTK Blood Bank
Geneva, Switzerland Bangalore Medical Services Trust and Research
Institute
Kathrine Frey MD New Thippasandra Main Road
Department of Pathology HAL 111 Stage
Fairview-Southdale Medical Center Bangalore 560 075
Edina MN 55435 USA India
Email: [email protected] Email: [email protected]
Contributors ix
Dr Jagannathan founded the Bangalore Medical Ulrike F Koenigbauer MD
Services Trust in 1984 and was responsible for Tuebingen
establishing the Rotary/TTK Blood Bank and Germany
Transfusion Center, HLA Laboratory and HIV/AIDS Email: [email protected]
Services where she is responsible for its management
Dr Koenigbauer trained in hematology in Germany
and administration as its medical director and
and completed a fellowship in transfusion medicine
managing trustee. She is also a designated expert in
at the University of Minnesota Medical School,
blood banking for the Government of India’s Drug
Minneapolis, Minnesota, where she taught medical
Control Department and a member of the National
students and residents and conducted research in
Blood Transfusion Council of India and Karnataka’s
transfusion medicine.
Task Force on Health and Family Welfare. She is the
southern zone chair, Indian Society of Blood
Rachel Koreth MD
Transfusion and Immunohematology.
Hematologist
Veterans Affairs Medical Center
Chatchada Karanes MD 510 East Stoner Avenue
Medical Director
Shreveport LA 71101 USA
National Marrow Donor Program
Email: [email protected]
3001 Broadway St. N.E., Suite 500
Dr Koreth finished fellowships in hematology,
Minneapolis, MN 55413
oncology and transfusion medicine at the University
Email: [email protected]
of Minnesota Medical School, Minneapolis,
Dr Karanes graduated from the Ramathibodi Medical Minnesota, conducted research in clinical bleeding
School, Bangkok, Thailand and completed Clinical
assessment. She is a hematologist and oncologist at
and Research Fellowships in Hematology/Oncology
the Veterans Affairs Medical Center, Shreveport,
and Bone Marrow Transplantation at the Washington
Louisiana.
University School of Medicine in St. Louis, Missouri.
She served as Professor, Division of Hematology/ David Mair MD
Oncology and Director of the Unrelated BMT
Assistant Medical Director
Program at Wayne State University School of
Transfusion and Therapeutic Apheresis Services
Medicine in Detroit, Michigan, USA. Since September
Department of Laboratory Medicine and Pathology
2000, Dr Karanes has been the Medical Director of
University of Minnesota Medical School
the National Marrow Donor Program in Minneapolis,
Box MMC 198, Room D242 Mayo Building
Minnesota.
420 Delaware Street S. E.
Minneapolis MN 55455 USA
Nigel S Key MD Email: [email protected]
Division of Hematology, Oncology and Blood And
Transplantation Associate Medical Director
Department of Medicine American Red Cross North Central Blood Services
University of Minnesota Medical School 100 South Roberts Street
420 Delaware Street S.E. St Paul MN 55107
Minneapolis MN 55455 USA Email: [email protected]
Email: [email protected]
Dr Mair is a blood bank, transfusion service and
Dr Key is a Professor of Medicine and hematologist therapeutic apheresis service medical director the
with special interests in coagulation disorders at the Fairview-University Medical Center at the University
Fairview-University Medical Center of of the of Minnesota Medical School and is a medical director
University of Minnesota Medical School where he of a Red Cross regional blood center that provides
takes care of patients, conducts research and teaches blood components to 140 regional hospitals. He is an
students, residents and fellows. attending blood bank physician at the University of