Handbook of Acute Pain Management E l l i o About the book About the editors t t Pain is a pervasive symptom in medicine. It is JENNIFER A. ELLIOTT, M.D., Associate Professor, • imperative that physicians not only evaluate University of Missouri–Kansas City School of S and diagnose the source of pain, but that they Medicine, Kansas City, Missouri. Dr. Elliott is a m also recognize how to manage the actual pain Physician at Saint Luke’s Hospital of Kansas City. A symptoms with effective treatment. Addressing certified Anesthesiologist and Pain Management i t the latest developments in both pharmacologic specialist, Dr. Elliott is the author of multiple h and non-pharmacologic pain therapies, this text publications concerning pharmacologic pain is a useful reference for all those administering to therapies. She is a member of numerous medical patients with acute pain. organizations including the American Society of Anesthesiologists and the American Academy of This easy to use handbook covers: Pain Medicine. H • Important background on the anatomy and a neurobiology of pain HOWARD S. SMITH, M.D., F.A.C.P., Associate n Professor, Albany Medical College, Albany, • The most up-to-date information on d New York. Dr. Smith is the Academic Director pharmacologic treatments including local of Pain Management at the Albany Medical b anesthetics, NSAIDS, alpha-2 agonists, and opioids College‘s Department of Anesthesiology. He is o Handbook of certified in Internal Medicine, Nuclear Medicine, o • Potential drug-drug and drug-disease Anesthesiology, Palliative Medicine, Addiction interactions Medicine, and Pain Management. Dr. Smith k • The most up-to-date information on non- is a widely published expert in the field of o pharmacologic treatment like continuous Pain Medicine. A member of many medical Acute Pain catheter techniques and other injection-based organizations, Dr. Smith is a fellow of the American f therapies College of Physicians and the American College A of Nuclear Physicians. • Patient-controlled analgesia options c u • Anticoagulation guidelines during regional Management and neuraxial anesthetic techniques t e • Pain management issues in special populations – specifically pediatric, opioid- P tolerant, obstetric, trauma, and elderly a patients i n M a n a g e m e n t Edited by Jennifer A. Elliott Howard S. Smith [Vinit][D:/informa_Publishing/Elliott_2400062/z_production/z_3B2_3D_files/978-0- 7890-3168-6_CH0000_O.3d][21/11/010/13:20:8][1–12] Handbook of Acute Pain Management [Vinit][D:/informa_Publishing/Elliott_2400062/z_production/z_3B2_3D_files/978-0- 7890-3168-6_CH0000_O.3d][21/11/010/13:20:8][1–12] [Vinit][D:/informa_Publishing/Elliott_2400062/z_production/z_3B2_3D_files/978-0- 7890-3168-6_CH0000_O.3d][21/11/010/13:20:8][1–12] Handbook of Acute Pain Management Edited by Jennifer A. Elliott Department of Anesthesiology University of Missouri–Kansas City School of Medicine and Saint Luke’s Hospital of Kansas City Kansas City, Missouri, U.S.A. Howard S. Smith Department of Anesthesiology and Pain Management Albany Medical College Albany, New York, U.S.A. [Vinit][D:/informa_Publishing/Elliott_2400062/z_production/z_3B2_3D_files/978-0- 7890-3168-6_CH0000_O.3d][21/11/010/13:20:8][1–12] Publishedin2011byInformaHealthcare,TelephoneHouse,69-77PaulStreet,LondonEC2A4LQ,UK. Simultaneously published in the USA by Informa Healthcare, 52 Vanderbilt Avenue, 7th floor, NewYork,NY10017,USA. #2011InformaUKLtd,exceptasotherwiseindicated. NoclaimtooriginalU.S.Governmentworks. Reprintedmaterialisquotedwithpermission.Althougheveryefforthasbeenmadetoensurethat allownersofcopyrightmaterialhavebeenacknowledgedinthispublication,wewouldbegladto acknowledgeinsubsequentreprintsoreditionsanyomissionsbroughttoourattention. Allrightsreserved.Nopartofthispublicationmaybereproduced,storedinaretrievalsystem,or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, unless with the prior written permission of the publisher or in accordance with the provisions of the Copyright, Designs and Patents Act 1988 or under the terms of any licence permittinglimitedcopyingissuedbytheCopyrightLicensingAgency,90TottenhamCourtRoad, LondonW1P0LP,UK,ortheCopyrightClearanceCenter,Inc.,222RosewoodDrive,Danvers,MA 01923,USA(http://www.copyright.com/ortelephone978-750-8400). Productorcorporatenamesmaybetrademarksorregisteredtrademarks,andareusedonlyfor identificationandexplanationwithoutintenttoinfringe. Thisbookcontainsinformationfromreputablesourcesandalthoughreasonableeffortshavebeen made to publish accurate information, the publisher makes no warranties (either express or implied) as to the accuracy or fitness for a particular purpose of the information or advice containedherein.Thepublisherwishestomakeitclearthatanyviewsoropinionsexpressedinthis book by individual authors or contributors are their personal views and opinions and do not necessarilyreflecttheviews/opinionsofthepublisher.Anyinformationorguidancecontainedin thisbookisintendedforusesolelybymedicalprofessionalsstrictlyasasupplementtothemedical professional’sownjudgement,knowledgeofthepatient’smedicalhistory,relevantmanufacturer’s instructionsandtheappropriatebestpracticeguidelines.Becauseoftherapidadvancesinmedical science,anyinformationoradviceondosages,procedures,ordiagnosesshouldbeindependently verified.Thisbookdoesnotindicatewhetheraparticulartreatmentisappropriateorsuitablefora particularindividual.Ultimatelyitisthesoleresponsibilityofthemedicalprofessionaltomakehis orherownprofessionaljudgements,soasappropriatelytoadviseandtreatpatients.Savefordeath or personal injury caused by the publisher’s negligence and to the fullest extent otherwise permittedbylaw,neitherthepublishernoranypersonengagedoremployedbythepublishershall beresponsibleorliableforanyloss,injuryordamagecausedtoanypersonorpropertyarisingin anywayfromtheuseofthisbook. ACIPrecordforthisbookisavailablefromtheBritishLibrary. ISBN-13:978-0-7890-3168-6 Ordersmaybesentto:InformaHealthcare,SheepenPlace,Colchester,EssexCO33LP,UK Telephone:+44(0)2070175540 Email:[email protected] Website:http://informahealthcarebooks.com/ Forcorporatesalespleasecontact:[email protected] Forforeignrightspleasecontact:[email protected] Forreprintpermissionspleasecontact:[email protected] TypesetbyMPSLimited,aMacmillanCompany PrintedandboundintheUnitedKingdom [Vinit][D:/informa_Publishing/Elliott_2400062/z_production/z_3B2_3D_files/978-0- 7890-3168-6_CH0000_O.3d][21/11/010/13:20:8][1–12] Iwouldliketodedicatethisbooktomyparents,DavidE.andChristelM.Elliott,and my husband, Michael J. Bell, who have provided much guidance, unconditional love andsupport,and theinspiration to completethis book. Iwouldalsoliketogivethankstothemanycontributorsfortheirtimeandeffort, aswellasDeanShepardforhisassistancewithcreatingmanyofthefiguresandtables inthisbook. J.A.E. v [Vinit][D:/informa_Publishing/Elliott_2400062/z_production/z_3B2_3D_files/978-0- 7890-3168-6_CH0000_O.3d][21/11/010/13:20:8][1–12] [Vinit][D:/informa_Publishing/Elliott_2400062/z_production/z_3B2_3D_files/978-0- 7890-3168-6_CH0000_O.3d][21/11/010/13:20:8][1–12] Preface Pain is a universal experience and is the most frequent reason people seek medical attention. Medical students and residents receive comprehensive guidance in the evaluationanddiagnosisofthesourceofpaincomplaints,yetformaleducationonthe topic of pain symptom management has not traditionally been offered in medical training,leavingmanycliniciansuncomfortablewithprovidingtreatmentforpain.Pain cantherefore become‘‘painful’’ tothe treating practitioner aswellasthe patient.This book is intended to assist clinicians who are called upon to treat the patient in acute pain by enhancing their knowledge of and comfort with pain therapies. The scope of providerswhomaybeinapositiontomanagetheacutepainpatientiswideranging, from medical students and residents to primary care providers, as well as anesthesi- ologists, neurologists, physiatrists, andother specialists. Thisbookwillprovidethereaderwithbackgroundinformationontheanatomy and neurobiology of pain to lay a foundation for the understanding of pain patho- physiology. Pharmacologic approaches to acute pain management are thoroughly covered, including the use of local anesthetics, NSAIDS, opioids, and a agonists. 2 Patient-controlledanalgesiaoptionsincludingpatient-controlledepiduralanalgesiaare alsoexplored.Nonpharmacologicandinterventionalanesthetictechniquesarecovered, including the use of continuous catheter techniques for postoperative pain manage- ment. A chapter also reviews information about anticoagulation guidelines when considering the use of regional and neuraxial anesthetic techniques. Finally, a discus- sion of pain management issues in special populations such as pediatric, obstetric, trauma,opioid-tolerant, andelderly patients isprovided. The material in this book is intended to provide an up-to-date look at the emergingtreatmentstrategiesinthecontinuouslyexpandingfieldofpainmanagement and is accompanied by numerous figures and tables to give an at-a-glance review of important concepts discussed in the text. This text provides expanded information on topics such as opioids, including potential drug-drug and drug-disease interactions, which cannot readily be found in other similar texts currently on the market. It also highlights the evolution of new technologies such as ‘‘smart’’ patient-controlled anal- gesia devices along with associated safety innovations. Information on new develop- ments in the field of regional anesthesia, especially the emergence of continuous catheter techniques, is included to bring the reader up to date on the latest available injection-based therapies. My goal is that readers will find this book to be a user-friendly reference that addresses the most recent developments in the management of pain. I hope this will assistreadersintheapproachtothepatientsufferingacutepainandwillenhancetheir levelofcomfort as wellasthatof theirpatients. Jennifer A.Elliott vii [Vinit][D:/informa_Publishing/Elliott_2400062/z_production/z_3B2_3D_files/978-0- 7890-3168-6_CH0000_O.3d][21/11/010/13:20:8][1–12] [Vinit][D:/informa_Publishing/Elliott_2400062/z_production/z_3B2_3D_files/978-0- 7890-3168-6_CH0000_O.3d][21/11/010/13:20:8][1–12] Contents Preface. ...vii Contributors.. ..xi 1. Theanatomy ofpostoperative pain 1 Jun-MingZhang 2. Theneurobiology ofacute pain 10 EugeneE.Fibuch and JohnQ. Wang 3. Localanestheticsinthemanagementofacutepostoperativepain 19 GaryMcCleane 4. NSAIDs inthe managementofacute pain 28 JenniferA.Elliott, Eugene E.Fibuch,and Laura Textor 5. Opioidsin the managementofacutepain 73 JenniferA.Elliott 6. Patient-controlled analgesia inthe managementofacute pain 110 JenniferA.Elliott 7. Authorized agentcontrolledanalgesia 128 LauraTextor 8. a Agonists in the managementofacute pain 134 2 JenniferA.Elliott and HowardS. Smith 9. Nonpharmacological modalities for the treatmentofacute pain 154 LauraTextor 10. Perioperative epidural analgesia andpatient-controlled epidural analgesia 173 SonaliAgarwal andSudhir Diwan 11. Upper-extremity regional anesthetic techniques inthe managementofpostoperative pain 184 JamesRasinsky 12. Lower-extremityregional anesthetic techniques inthe managementofpostoperative pain 198 J.Mark Matthews ix
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