Table Of Content

»1 JULY 200] Editorial Getting our journals to developing countries M 7 G Fart Leading article P)r ospects for interventi_o—n— in gastr+i c carcinogene. sis: onr everssimabli li|t y M F Dixon Commentaries (GRP and Pavlov’s dogs M Feldman Surviving too long in Crohn’s disease A Di Sabatino, G R ¢ The subtleties of intestinal metaplasia R Rouzier, S Robine Clinical ‘alert Methotrexate: a useful alternative in Crohn’s disease? A B Ha Stomach Conservation of the cag pathogenicity island 1s associate vacA allele gastroduodena! d Atrican Hy licobac fe p / } j ates M Kidd y 1 ? Lastoz icd, ; y thre rron, }. ! LL Mc Helicobacter pylori induced transactivation of SRE and AP-1 through the ERK signalling pathway ie y Mit 10, H Yoshida, S Maeda, K Ogura, Y Hirata, T Kawabe, Y Shuratort, R»e gula] tion of gastric f. unct+i on by e. ndog‘ en. ous. gastri- n r“ealloe asing pep" tide " ' In :. :s tudies > ‘w istt}h a spec" ific’ gy astri- n releasing peptide receptor antagonist P Hildebrand, F S Lehmann, S Ketterer,. hrist, T Stingelin, F Belting A H Gibbons, D H Coy, ¥ Calam, F Larsen, C Beglin Age and alarm symptoms do not predict endoscopic findings among patients with dyspepsia: a multicentre database study M B Wallace, V L Durkalski, J Vaughan, Y Y Palesch, E D Libby, P S Jowell, N F Nickl, S M Schu J W Leung, P B Cotton Inflammatory bowel disease Decreased Bax expression by mucosal T cells favours resistance to apoptosis in Crohn’s disease 7 C dela Motte, S A Strong, A D Levine, C Fiocchi Interleukin 10 (Tenovil) in the prevention of postoperative recurrence of Crohn’s disease 7-F ¢ H Mal how, M FacvnO Ha N,iel s n, ¥ Rask-Madsen, S Lan Deventer, A Ferguson, P Desreumaux, L Me M Cohard Gastrointestinal infection Eschericina coli strains colonising the gastrointestinal tract protect g infection S Hudault, J Guignot, A L Se Involvement of nerves and calcium channels in the intestinal resp mental study 1n rats in vivo F Sdérensson, M Fodal, O Lundgren Functional abdominal disorders Low socioeconomic cl] ass 1s a risk factor for upper and lower gastrointestinal symptoms: a population based stud) inl5 000 Australian adults P Bytzer, S Howell, MI Leemon, L F Young, M P Fones, N F Talle. Gastrointestinal cancer [.I-cadherin: a marker of gastric metapilf asia and neoplasia C Grétzinger, 7 Knetfel, D Pat I Anagnostopoulos, S Faiss, R Tauber, )B) Wiedenmann, R Ge Genomic homogeneity in fibrolamellar carcinomas Y Sz RCN Williamson, B R Davidson Cof fee consumption and risk of colorectal cancer in a population based prospective cohort of Swedish women P li rry, L B. rgek7 IST, I Holmberg,~ 4 | Wolk Risks, costs, and compliance limit colorectal adenoma surveillance: lessons from a randomised trial 7 N Lund, ¥ H Scholefield, M F Grainge, S F¥ Snuth, CCM angham, N C Armitage, M H Robinson, R F A Loga Effects of cellular redox balance on induction of apoptosis by eicosapentaenoic acid in HT29 colorectal adenocar- cinoma cells and rat colon in vivo P Latham, E K Lund, 7 C Brown, I T Fohnson Liver disease Gene expression of interleukin 18 in unstimulated peripheral blood mononuclear cells of patients with alcoholic cirrhosis C Hanck, T Manigold, U Bocker, M Kurimoto, C iedK olbel, M V Singer, S Ross High arterial compliance in cirrhosis is related to low adrenaline and elevated circulating calcitonin gene related peptide but not to activated vasoconstrictor systems 7 H Henriksen, S Moller, S Schifter, ¥ Abrahamsen, U Bech After portal branch ligs ation In the rat, cellular proliferation in associated withselective induction of c-Ha-ras, p53 cyclin E, and Cdk2 P Stdrkel, L Lambotte, CS empoux, C De Saeger, A Saliez, D Maiter, Y Hon ‘Tumour necrosis factor « impairs function of liver derived T lym ediuea pow" anand killer cells in patients with primary sclerosing cholangitis X Bo, U Broome, M Remberger, S Sumitran-Ho Case report Pathological documentation of complete elimination of Barrett’s metaplasia following sage a" elec- trocoagulation therapy M B Fennerty, C L Corless, B Sheppard, D O Faigel, D A Lieberman, R E Sampliner Review Classification of oesophageal motility abnormalities S 7 Spechler, D O Cast Therapy update Recurrent Clostridium difficile diarrhoea L Kyne, C P Kells Letters to wey editor Measurement of the stiffness of endoscopes—< for commonality G D Bell, K Burn Research outcomes in sited gastroenterology: an audit of the subsequent full publication of abstracts presented at the British Society of Gastroenterology D S Sa , M F Carter, D P Hurlstone, A F Lobo, N Hoggard Leptin in the human stomach S Cintt, R de Mattes, E Ceresi, C Pico, J Oliver, P Oliver, A Palou, A Obrador, C Maffeis heya il and genetic heterogeneity in synchronous hepatocellular carcinoma F Certa, M Zukerm M T Ercolam, A Mazziott Phenotypic expression of the HFE gene mutation (C282Y) among the hospitalised population S 7 Moodie, 7 D Maxwell The African enigma: the parasite’s perspective 7 G Fox, TC Wang, C Nagler-Anderson Liver biopsy: “blind” or under ultrasound control J Af Murray-Lyon, R de Wild Notes Detection of keratinocyte growth factor mRNA by 1n situ saciacchiathians From the paper by Salvati er a/, pp 176-81. cozor. gut. com No 2 AUGUST 2001 Leading article Intestinal zonulin: open sesame! A Fasano Commentaries The father figure in coeliac disease L Greco Signals on the immune tract M F Neurath Descartes and the gut: “I’m pink therefore lam” D G Thompson Science (alert Serum antibody responses to Clostridium difficile toxin A: predictive and protective? C Phillips Small intestine Coeliac disease in the father affects the newborn 7 F Ludvigsson, 7 Ludvigsson Keratinocyte growth factor and coeliac disease V M Salvati, M Bajaj-Elhott, R Poulsom, G Mazzarella, K EA Lundin, EM Nilsen, R Troncone, T T MacDonald Erythropoietin acts as a trophic factor in neonatal rat intestine S E Juul, D F Ledbetter, A E Joyce, CC Dame, R D Christensen, Y Zhao, V DeMarco Inflammation and inflammatory bowel disease Loss of transforming growth factor } signalling in the intestine contributes to tissue injury in inflammatory bowel disease K-B Hahm, Y-H Im, T W Parks, S-H Park, S Markowitz, H-Y Fung, ¥ Green, S-F Kim Inflammatory bowel disease and laterality: is left handedness a risk? D L Morris, S M Montgomery, M L Galloway, R E Pounder, A F Wakefield Motility and visceral sensation Perception of changes in wall tension of the proximal stomach in humans H Plessevaux, F Tack, A Wilmer, B Coulie, A Geubel, F Fanssens Relationship between psychological state and level of activity of extrinsic gut innervation in patients with a functional gut disorder A V Emmanuel, H 7 Mason, M A Kamm Response to a behavioural treatment, biofeedback, in constipated patients is associated with improved gut transit and autonomic innervation A V Emmanuel, M A Kamm SOX 10 is abnormally expressed in aganglionic bowel of Hirschsprung’s disease infants MH Sham, VC H Lui, M Fu, B Chen, PK H Tam Cancer The prognostic value of quality of life scores during treatment for oesophageal cancer 7 M Blazeby, S T Brookes, D Alderson Decision analysis in the surgical treatment of patients with familial adenomatous polyposis: a Dutch-Scandinavian collaborative study including 659 patients H F A Vasen, P van Duyvendik, E Buskens, C Biilow, F Bjork, H F Farvinen, S Biilox Overexpression of the CD/55 gene in human colorectal carcinoma D Masson, A Farry, B Baury, P Blanchardie, C Laboisse, P Lustenberger, M G Denis 2ancreatic disease Arginine induced acute pancreatitis alters the actin cytoskeleton and increases heat shock protein expression 1n rat pancreatic acinar cells M Tashiro, C Schafer, H Yao, S A Ernst, J A Williams Interferon y inhibits growth of human pancreatic carcinoma cells via caspase-1 dependent induction of apoptosis K M Deten, K Farwig, M Welzel, B Wiedenmann, S Rosewicz Liver disease Interferon responsiveness in patients infected with hepatitis C virus 1b differs depending on viral subtype I Nakano, Y Fukuda, Y Katano, H Toyoda, K Hayashi, T Hayakawa, T Kumada, S Nakano The cardiac response to exercise in cirrhosis F Wong, N Girgrah, ¥G raba, Y Allidina, P Liu, L Blends Jaundice in non-cirrhotic primary biliary cirrhosis: the premature ductopenic variant F P Vieggaar, H R van Buuren, P E Zondervan, F F7 W ten Kate, W C F Hop, the Dutch Multicentre PBC study group Osteoporosis in primary biliary cirrhosis revisited 7 Newton, R Francis, M Prince, O James, M Bassendine, D Rawlings, D Fones Association of the tumour necrosis factor @ —308 but not the interleukin 10 -627 promoter polymorphism with genetic susceptibility to primary sclerosing cholangitis S A Mitchell, #G rove, A Spurkland, K M Boberg, KA Fleming, C P Day, E Schrumpf, RW Chapman, the European Study Group of Primary Sclerosing Cholangitis Occasional report International gastroenterology research: subject areas, impact, and funding G Lewuson, ¥ Grant, P Fansen Review Angiotensin converting enzyme inhibitors and angiotensin I] antagonists as therapy in chronic liver disease F Vlachogiannakos, A K W Tang, D Patch, A K Burroughs Therapy update Which PPI? M 7 S Langman Letters to the editor Ulcerative colitis is more strongly linked to chromosome 12 than Crohn’s disease M Parkes, ¥ Satsangi, D PF ewell, D E Weeks, M M Barmada, R H Duerr, Intestinal permeability: the cellobiose/mannitol test R M Craig, Evaluation of the role of CFTR in alcohol related pancreatic disease 7 Ockenga, M Stuhrmann, M P Manns Alcohol, obesity, and TINF-a A Poullis, M A Mendall Book reviews Corrections Notes No 3 SEPTEMBER 2001 Leading article What comes after macrolides and other motilin stimulants? ¥ Jack, T Peeters Commentaries H pylori: the bug is not all bad 7 E Richter Beyond acid suppressants in gastro-oesophageal reflux disease R C Fitzgerald Clinical (alert Ulcerative colitis extent varies with time but endoscopic appearances may be deceptive 7 M Rhodes Helicobacter pylori Gastric leptin and Helicobacter pylori infection T Azuma, H Suto, Y Ito, M Ohtani, M Dojo, M Kurtyama, T Kato Helicobacter pylori infection prevents erosive reflux oesophagitis by decreasing gastric acid secretion T Koike, S Ohara, H Sekine, K lima, Y Abe, K Kato, T Toyota, T Shimosegawa Inverse background of Helicobacter pylori antibody and pepsinogen in reflux oesophagitis compared with gastric cancer: analysis of 3732 Japanese subjects Y Yamaji, T Mitsushima, H Ikuma, M Okamoto, H Yoshida, T Kawabe, Y Shiratori, K Saito, K Yokouchi, M Omata wee. gurni.com The significance of cagA” Helicobacter pylori in reflux oesophagitis V ¥ Warburton-Timms, A Charlett, R M Valori, FS Uff, N A Shepherd, H Barr, C A M McNulty 347 = =Gastric cancer and Helicobacter pylort: a combined analysis of 12 case control studies nested within prospective cohorts Helicobacter and Cancer Collaborative Group Gastro-oesophageal reflux 354 Prolonged measurement of lower oesophageal sphincter function in patients with intestinal metaplasia at the oesophagogastric junction C Wolf, R Timmer, R Breumelhof, C A Seldenrijk, A 7 PM Smout 359s Bile reflux gastritis and Barrett’s oesophagus: further evidence of a role for duodenogastro-oesophageal reflux? M F Dixon, P M Neville, N P Mapstone, P Moayyedi, A T R Axon 364 Oxidative stress is more important than acid in the pathogenesis of reflux oesophagitis in rats T Y Oh,7 S Lee, BO Ahn, H Cho, W B Kim, Y B Kim, Y F Surh, S W Cho, K M Lee, K B Hahm Gastrointestinal haemorrhage Drug treatments in upper gastrointestinal bleeding: value of endoscopic findings as surrogate end points G M Hawkey, A T Cole, A S McIntyre, R G Long, C ¥ Hawkey Coeliac disease 380, Intraepithelial and lamina propria lymphocytes show distinct patterns of apoptosis whereas both populations are active in Fas based cytotoxicity in coeliac disease A Di Sabatino, R Ciccoctoppo, S D’Alo, R Parroni, D Millimaggzi, M G Cifone, G R Corazza Inflammatory bowel disease Expression of nitric oxide synthases and effects of L-arginine and 1-NMMaA on nitric oxide production and fluid transport in collagenous colitis A Perner, L Andresen, M Normark, B Fischer-Hansen, S Sorensen, JE ugen-Olsen, F Rask-Madsen Motility 395 Effects of a motilin receptor agonist (AB1-229) on upper gastrointestinal symptoms in type | diabetes mellitus: a randomised, double blind, placebo controlled trial N 7 Talley, M Verlinden, D ¥ Geenen, R B Hogan, D Riff, R W McCallum, R ¥ Mack Colorectal cancer $02 Faecal calprotectin and faecal occult blood tests in the diagnosis of colorectal carcinoma and adenoma 7 77bble, G Sigthorsson, R Foster, R Sherwood, M Fagerhol, I Biarnason 109 Overexpression of activin A in stage IV colorectal cancer S Wildi, F¥K leeff, H Maruyama, C A Maurer, M W Biichler, M Kor $18 Increased rectal cell proliferation following alcohol abuse U A Simanowski, N Homann, M Kniihl, L Arce, R Waldherr, C Conradt, F X Bosch, H K Seitz Liver disease 123 ‘The natural course of hepatitis C virus infection after 22 years in a unique homogenous cohort: spontaneous viral clearance and chronic HCV infection S Barrett, 7G oh, B Coughlan, E Ryan, S Stewart, A Cockram, 7 C O’ Keane, F Crowe $31 Outcome of liver disease in children with Alagille syndrome: a study of 163 patients P Lvkavieris, M Hadchouel, C Chardot, O Bernard Case report Successful treatment with adefovir dipivoxil in a patient with fibrosing cholestatic hepatitis and lamivudine resistant hepatitis B virus K M Walsh, T Woodall, P Lamy, D G D Wight, S Bloor, G ¥ M Alexander Therapy update 44] Drug therapy for portal hypertension D Lebrec Review 143 Cyclooxygenase 2——implications on maintenance of gastric mucosal integrity and ulcer healing: controversial issues and perspectives F Halter, A S Tarnawski, A Schmassmann, B M Peskar | Letters to the editor $54 Primary biliary cirrhosis and primary sclerosing cholangitis are of infectious origin! 7 Wadstrém, A Ljungh, | R Willen 154 Measurement of tumour necrosis factor u A Austin ! 155 Chromosome 3p and inflammatory bowel disease 7 Satsangi, S Vermeire 455 Indecision and irritable bowel 7 W Paulley 156 = Bookreviews Notes | No 4 OCTOBER 2001 Leading article | 459 Changes in gut function during hibernation: implications for bowel transplantation and surgery H V Carey, M F Mangino, ¥ H Southard Commentaries 462 Counting the cost of proton pump inhibitors P Moayvedi 463 The external world of gluten and autoimmunity M Londei Science (alert 465 New horizons in the regulation of bile acid and lipid homeostasis: critical role of the nuclear receptor FXR as an intracellular bile acid sensor M Arrese, S 7 Karpen Helicobacter pylori 167 Post-immunisation gastritis and Helicobacter infection in the mouse: a long term study PS utton, S F¥D anon, M Walker, L ¥ Thompson, ¥ Wilson, T Kosaka, A Lee 174 Helicobacter pylori and two ultrastructurally distinct layers of gastric mucous cell mucins in the surface mucous gel layer E Hidaka, H Ota, H Hidaka, M Hayama, K Matsuzawa, T Akamatsu, J}N akayama, T Katsuyama 481 Expression of human f-defensin 2 (hBD-2) in Helicobacter pylori induced gastritis: anubacterial effect of hBD-2 against Helicobacter pylori Y Hamanaka, M Nakashima, A Wada, M Ito, H Kurazono, H Hojo, Y Nakahara, S Kohno, T Hirayama, I Sekine Gastro-oesphageal reflux and dyspepsia 488 The cost of long term therapy for gastro-oesophageal reflux disease: a randomised trial comparing omeprazole and open antireflux surgery H E Myrvold, L Lundell, P Miettinen, S A Pedersen, B Liedman, J Hatlebakk, R Fulkunen, K Levander, M Lamm, C Mattson, ¥ Carlsson, N O Stahlhammar, Nordic GORD Study Group 495 Reducing community dyspepsia drug costs: a controlled trial RM Valort, C M Brown, P Strangeways, M Bradburn Coeliac disease . es . | 502 Duration of gluten exposure in adult coeliac disease does not correlate with the risk for autoimmune disorders C Sategna Guidetti, E Solerto, N Scaglione, G Aimo, G Mengozz1 coz. gutnil.com Guinea pig transglutaminase immunolinked assay does not predict coeliac disease in patients with chronic liver disease A Carroccio, L Giannitrapani, M Soresi, T Not, G Iacono, C Di Rosa, E Panfili, A Notarbartolo, G Montalto Gut immunology Human gastric B cell responses can be induced by intestinal immunisation M Quiding-Farbrink, H Lénroth, I Ahlstedt, 7 Holmgren, A-M Svennerholm Homing commitment of lymphocytes activated in the human gastric and intestinal mucosa M Quiding-Farbrink, I Ahlstedt, C Lindholm, E-L Fohansson, H Lénroth MIP-2 secreted by epithelial cells increases neutrophil and lymphocyte recruitment in the mouse intestine Y Ohtsuka, F Lee, D S Stamm, I R Sanderson Cancer A systematic review of the staging performance of endoscopic ultrasound in gastro-oesophageal carcinoma S Kelly, K M Harris, E Berry, J Hutton, P Roderick, ¥ Cullingworth, L Gathercole, M A Smith Variability in the severity of colonic disease in familial adenomatous polyposis results from differences in tumour initiation rather than progression and depends relatively little on patient age M D Crabtree, 1 P M Tomlinson, IC Talbot, RK S Phillips Inflammatory bowel disease Mucin gene expression in intestinal epithelial cells in Crohn’s disease M-P Buasine, P Desreumaux, E Leteurtre, M-C Copin, F¥-F Colombel, N PorchJ-eP tAub,er t Olsalazine is not superior to placebo in maintaining remission of inactive Crohn’s colitis and ileocolitis: a double blind, parallel, randomised, multicentre study N Mahmud, M A Kamm, ¥ L Dupas, D P Jewell, C A O’Morain, DG Wer, D Kelleher Liver disease Evidence for altered hepatic gluconeogenesis in patients with cirrhosis using in vivo 31-phosphorus magnetic reso- nance spectroscopy K K Changani, R Jalan, I ¥ Cox, M Ala-Korpela, K Bhakoo, S D Taylor-Robinson, F D Bell Identification of novel molecules and pathogenic pathways in primary biliary cirrhosis: CDNA array analysis of intrahepatic differential gene expression N A Shackel, PH McGuinness, C A Abbott, M D Gorrell, @ W McCaughan Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in vivo E F Wilhams, RC Benyon, N Trim, R Hadwin, B H Grove, M F P Arthur, E N Unemori,F P Iredale Case report Regression of gastric high grade mucosa associated lymphoid tissue (MALT) lymphoma after Helicobacter pylori eradication C Montalban, A Santon, D Boixeda, C Bellas Gut file Recurrent diarrhoea and weight loss associated with cessation of smoking in a patient with undiagnosed coeliac disease S F¥ O Véldhuyzen van Zanten Review Autoimmune hepatitis and its variant syndromes Z Ben-Ari, A F Czaja, Letters to the editor Small bowel biopsies in patients with iron deficiency anaemia C B Pearce, H D Duncan, D Sinclair, D N Poiler Is coeliac disease a confounding factor in the diagnosis of NASH? A Grieco, L Miele, G Pignataro, M Pompilt, G L Rapaccim, G Gasbarrini Induction of multiple autoantibodies to islet cell antigens during treatment with interferon alpha for chronic hepa- tins C H E Wasmuth, C Stolte, A Geier, C Gartung, S Matern ERCP training D Bullimore Reinnervation after childbirth—a new paradigm for sensory bowel syndromes? M Quinn Book reviews Notes No 5 NOVEMBER 2001 Leading article Non-pylori helicobacter species in humans 7 L O’Rourke, MI Grehan, A Lee Commentaries Life, death, and varices D Lebrec Can endoscopic papillary balloon dilation really preserve sphincter of Oddi function? D L Carr-Locke Clinical @ lert Intravenous omeprazole after endoscopic treatment of bleeding peptic ulcers K R Palmer Science alert Genomics at work: the global gene response to enteric bacteria D Kelly, S Conway Debate Protagonist: Should we eradicate Helicobacter pylori before long term antireflux therapy? 7 Labenz Antagonist: Should we eradicate Helicobacter pylori before long term antireflux therapy? 7 W Freston Oesophagus Expression of the p53 homologue p63u and ANp63u in the neoplastic sequence of Barrett’s oesophagus: correla- tion with morphology and p53 protein PA Hail, A C Woodman, S 7 Campbell, N A Shepherd Duodenal fat intensifies the perception of heartburn 7 H Meyer, A Lembo, ¥ D Elashoff, R Fass, E A Mayer Helicobacter pylori Analysis of iced genotypes in South African Helicobacter pylori strains and relationship to clinically significant disease M Kidd, R M Peek, A F Lastovica, D A Israel, A F Kummer, J A Louzw Inflammation and inflammatory bowel disease Interleukin 2 modulates ion secretion and cell proliferation in cultured human small intestinal enterocytes E V O’Loughlin, G P Pang, R Noltorp, C Koina, R Batey, R Clancy Allelic variation at the interleukin 1{} gene is associated with decreased bone mass in patients with inflammatory bowel diseases A Nemetz, M Toth, M A Garcia-Gonzalez, T Zagoni, J Fehér, A S Pena, Z Tulassay Acute gastrointestinal permeability responses to different non-steroidal anti-inflammatory drugs E Smecuol, FC Bai, E Sugai, H Vazquez, S Niveloni, S Pedreira, E Maurino, 7 Meddings Leucopenia resulting from a drug interaction between azathioprine or 6-mercaptopurine and mesalamine, sulphasalazine, or balsalazide P W Lowry, C L Franklin, A L Weaver, C L Ssumlanski, D C Mays, E V Loftus, W F Tremaine, F FJ Lipsky, RM Weinshilboum, WF Sandborn Measurement of thiopurine methyltransferase activity and azathioprine metabolites in patients with inflammatory bowel disease P W Lowry, C L Franklin, A L Weaver, M Gennett Pike, D C Mays, W F TremaineF, F Lipsky, W ¥ Sandborn High level perinuclear antineutrophil cytoplasmic antibody (pANCA) in ulcerative colitis patients before colec- tomy predicts the development of chronic pouchitis after ileal pouch-anal anastomosis P R Fleshner, EA Vasiliauskas, L Y Kam, N E Fleshner, ¥ Gatennie, M T Abreu-Martin, S R Targan evevev. gutnl.com 2ancreas and biliary tract Risk of pancreatic cancer after cholecystectomy: a cohort study in Sweden WY, 7 Lagergren, O Nyrén, A Ekbom Improving prognosis following a first variceal haemorrhage over four decades P A McCormick, C O’Keefi Can endoscopic papillary balloon dilation really preserve sphincter of Oddi function? J Yasuda, E Tomita, M Em ifs I’ Kato, H Morizwaki Motility and visceral sensation 692 Inhibitory motor innervation of the gall bladder musculature by intrinsic neurones containing nitric oxide in the Australian Brush-tailed possum (7richosurus vulpecula) A C B Meedeniya, B O Al-fiffry, H Konomi, A C Schloithe, 7F Tooull, (; T P Saccone 699 Interaction of human chagasic IgG with human colon muscarinic acetylcholine receptor: molecular and functional evidence L Sterin-Borda, J C Goin, C R Bilder, G Iantorno, A C Hernando, E Borda 706 Cardiac autonomic function and oesophageal acid sensitivity in patients with non-cardiac chest pain G Tougas , R Spaziam, S Hollerbach, V Djuric, C Pang, A R M Upton, E L Fallen, M V Kamath Liver disease Regulation of E-box DNA binding during in vivo and in vitro activation of rat and human hepatic stellate cells K F Vincent, E Jones, M ¥ P Arthur, D E Smart, ¥ Trim, M C Wright, DA Mann 720 Extrahepatic portal vein thrombosis: aetiology and determinants of survival H L A Fanssen, A Wijnhoud, E B Haagsma, S H M van Uum, C M F van Nieuwkerk, R P Adang, RA F M Chamuleau, ¥ van Hattum, F P Vleggaar, B E Hansen, F R Rosendaal, B van Hoek Case report [reatment of intestinal Behcet’s syndrome with chimeric tumour necrosis factor u antibody S PL Travis M Czajkowski, D P B McGovern, R G P Watson, A L Bell 799 Review he hepatorenal syndrome L Dagher, K Moore Letters to the editor -) o° Coeliac disease and birth defects in offspring K K Hozyasz ~~] H pylori and functional dyspepsia N F Talley ~J The future of ERCP training in the UR] A Murray, S Pathmakanthan, R Heeley, M T Donnell, Book reviews Notes No 6 DECEMBER 2001 Leading article ‘The putative role of inflammation in the irritable bowel syndrome S M Collins, T Piche, P Rampal Commentary 746 The continuing tale of cytokeratins in Barrett’s mucosa: As you like it A Latchford, B EksteFeJ Jnan,ko wski Monocytes or T cells in Crohn’s disease: does [L-16 allow both to play at that game? S Schreiber 748 Sodium in preascitic cirrhosis: please pass the salt 7 Claria,F ¥R odes Clinical (a lert Heavy drinking greatly increases the risk of cirrhosis in patients with HCV hepatitis C P Day Science (alert NOD2 (CARD15), the first susceptibility gene for Crohn’s disease D P B McGovern, D A van Heel, T Ahmad, D P Fewell Debate J JI Protagonist: Mvycobactertum avium subspecies paratuberculosis is a cause of Crohn’s disease 7 Hermon-Taylor Antagonist: Mycobacterium avium subspecies paratuberculosis is a cause of Crohn’s disease P Quirke Gastro-oesophangeail reflux Cytokeratin immunoreactivity of intestinal metaplasia at normal oesophagogastric junction indicates its aetiology A Couvelard, J-M Cauvin, D Goldfain, A Rotenberg, M Robaszkiewicz, F-F Flejou, members of the Groupe d’Etude de P’Ocsophage de Barrett Temporal associations between coughing or wheezing and acid reflux in asthmatics B Avidan, A Sonnenberg, TG Schnell, S F Sontag Inflammation and inflammatory bowel disease Diagnostic misclassification reduces the ability to detect linkage in inflammatory bowel disease genetic studies M S Silverberg, M F Daly, D N Moskovitz, 7D Rioux, R S McLeod, Z Cohen, G R Greenberg, T 7 Hudson, K A Siminovitch, A H Steinhart ~ ~ ~ Behaviour of Crohn’s disease according to the Vienna classification: changing pattern over the course of the disease E Louis, A Collard, A F Oger, E Degroote, F Aboul Nasr El Yafi, ¥B elaiche Low dose balsalazide (1.5 g twice daily) and mesalazine (0.5 g three times daily) maintained remission of ulcerative colitis but high dose balsalazide (3.0 g twice daily) was superior in preventing relapses W Aruis, S Schreiber, D Theuer, 7-W Brandes, E Schiitz, S Howaldt, B Krakamp, 7 Hamling, H Ménntkes, I Koop, M Stolte, D Pallant, U Ewald A randomised controlled trial of high versus low long chain triglyceride whole protein feed in active Crohn’s disease K Leiper, 7 Woolner, M M C Mullan, T Parker, M van der Vliet, S Fear, ¥M Rhodes, J O Hunter Interleukin 16 expression and phenotype of interleukin 16 producing cells in Crohn’s disease P Middel, K Reich, F Polzien, V Blaschke, B Hemmerlein, ¥ Herms, M Korabiowska, H-F Radzun Immunology 804 Frequency of clonal intraepithelial T lymphocyte proliferations in enteropathy-type intestinal T cell lymphoma, coeliac disease, and refractory sprue S Daum, D Weiss, M Hummel, R Ullrich, W Heise, H Stein, E-O Riecken, H-D Foss, the Intestinal Lymphoma Study Group Motility and visceral sensation Prolonged manometric recordings of oesophagus and lower oesophageal sphincter in achalasia patients M A van Herwaarden, M Samsom, A 7 PM Smout Intestinal inflammation and activation of sensory nerve pathways: a functional and morphological study in the nematode infected rat R De Giorgio, G Barbara, P Blennerhassett, L Wang, V Stanghellini, R Corinaldest, S M Collins, G Tougas 828 Effects of cisapride on gall bladder emptying, intestinal transit, and serum deoxycholate: a prospective, randomised, double blind, placebo controlled trial M F Véysey, P Malcolm, A I Mallet, P F Jenkins, G M Besser, G M Murphy, R H Dozeling Cancer Bile acid metabolism by fresh human colonic contents: a comparison of caecal versus faecal samples L A Thomas, M 7 Vevsey, G French, P B Hylemon, GM Murphy, R H Dowling eve. gutnl.com Pancreatitis Effect of somatostatin on the sphincter of Oddi 1n patients with acute non-biliary pancreatitis K-H Lai, G-H Lo, }-S Cheng, M-T Fu, E-M Wang, H-H Chan, Y-Y Wang, P-I Hsu, C-K Lin Liver disease Sodium homeostasis with chronic sodium loading in preascitic cirrhosis F Wong, P Liu, L Blendis Anuphospholipid antibodies associated with alcoholic liver disease specifically recognise oxidised phospholipids R Rolla, D Vay, E Mottaran, M Parodi, M Vidali, M Sartori, C Rigamonu, G Bellomo, E Albano Case Report SOO Acute liver graft failure due to emergence of lamivudine resistant hepatitis B virus: rapid resolution during treatment with adefovir D Mutimer, B H Feraz-Neto, R Harrison, K O’Donnell, ¥S haw, P Cane, D Pillay S64 Dengue virus induced hepatitis with chronic calcific changes A Fabre, A Couvelard, C Degott, C Lagorce-pages, F Bruneel, E Bouvet, F Vachon Review SOO Portal hypertensive gastropathy and gastric antral vascular ectasia (GAVE) syndrome K W Burak, S S Lee, P L Beck Letters to the editor Aminosalicylate as prophylaxis for Crohn’s disease Probiotics in IBD Probiotics in Crohn’s disease Survey of informed consent for endoscopy Why measure thiopurine methyltransferase activity? Direct administration of 6-thioguanine might be the alternative for 6-mercaptopurine or azathioprine Book reviews Notes Supplement No | Page Clinical guidelines of the management of hepatitis C JULY i] i2] Supplement No II Page European Helicobacter pylori Study Group SEPTEMBER Al All 9 Supplement No III Page UEGW abstract book (CD-ROM) NOVEMBER Supplement No IV Pag e Management of gastrointestinal fistulae DECEMBER Iv] iv39 wee. gurnil.com