Table Of Content

VOLUME 44 * CONTENTS No 1 JANUARY 1999 Page Editorial ] Gut in 1999 M Farthing Leading article Intestinal IgA: novel views on its function in the defence of the largest mucosal surface ¥ Mestecky, M W Russell, C O Elson Commentaries ['ransabdominal bowel sonography in Crohn’s disease A McLean Nitric oxide and the migrating motor complex G Lindberg Science @lert Chronic pancreatitis and mutations of the cystic fibrosis gene C 7 Taylor Clinical @lert Ranitidine reduced clinically important gastrointestinal bleeding in patients who required mechanical ventilation Commentary by C F Hinds, S N Fletcher Molecular and cell biology Dietary polyamines are essential luminal growth factors for small intestinal and colonic mucosal growth and development Chr Loser, A Etsel, D Harms, U R Foélsch Increased expression of mRNA for matrix metalloproteinases-1 and -3 and tissue inhibitor of metalloproteinases-1 in intestinal biopsy specimens from patients with coeliac disease S Daum, U Bauer, H-D Foss, D Schuppan, H Stein, E-O Riecken, R Ullrich The effect of epidermal growth factor ca brush border surface area and function in the distal remnant following resection in the rabbit 7 A Hardin, B Chung, E V O’Loughlin, D G Gall Intestinal transport Proabsorptive and prosecretory roles for nitric oxide in cholera toxin induced secretion 7 L Turvill, F H Mourad, M F G Farthing Potassium secretion in rat distal colon during dietary potassium loading: role of pH regulated apical potassium channels G J Sandle, I Butterfield Motility Patterns of gas and liquid reflux during transient lower oesophageal sphincter relaxation: a study using intraluminal electrical impedance D Sifrim, 7 Silny, R H Holloway, F 7 Janssens Gastric accommodation in non-ulcer dyspepsia and the roles of Helicobacter pylori infection and vagal function M Thumshirn, M Camilleri, S B Saslow, D E Williams, D D Burton, R B Hanson Interstitial cells of Cajal in the human fetal small bowel as shown by c-kit immunohistochemistry 7 Wester, L Eriksson, Y Olsson, L Olsen Evidence that nitric oxide mechanisms regulate small intestinal motility in humans A Russo, R Fraser, K Adachi, M Horowitz, G Boeckxstaens Prospective comparison of faecal incontinence grading systems C 7 Vaizey, E Carapeti, 7 A Cahill, M A Kamm Nutrition Glucagon-like peptide-1: a potent regulator of food intake in humans 7-P Gutzwiller, B Géke, F Drewe, P Hildebrand, S Ketterer, D Handschin, R Winterhalder, D Conen, C Beglinger Percutaneous endoscopic gastrostomy feeding in patients with cystic fibrosis S Gf Williams, F Ashworth, A McAlweenie, S Poole, M E Hodson, D Westaby Inflammatory bowel disease Crohn’s disease severity in familial and sporadic cases F Carbonnel, G Macaigne, L Beaugerie, 7P Gendre, 7C osnes Different intestinal permeability patterns in relatives and spouses of patients with Crohn’s disease: an inherited defect in mucosal defence? 7 D Séderholm, G Olaison, E Lindberg, U Hannestad, A Vindels, C Tysk, G Farnerot, R Sjédahl Infection No relationship between gastric pH, small bowel bacterial colonisation, and diarrhoea in HIV-1 infected patients CM Wilcox, K B Waites, P D Smith Imaging Scintigraphic validation of a magnetic resonance imaging method to study gastric emptying of a solid meal in humans C Feinle, P Kunz, P Boesiger, M Fried, W Schwizer Transabdominal bowel sonography for the detection of intestinal complications in Crohn’s disease C Gasche, G Moser, K Turetschek, E Schober, P Moeschl, G Oberhuber Use of magnetic resonance cholangiography in the diagnosis of choledocholithiasis: prospective comparison with a reference imaging method S H Zidi, F Prat, O Le Guen, Y Rondeau, L Rocher, ¥ Fritsch, A D Chourv, G Pelletier Do gastroenterologists want to be trained in ultrasound? A national survey of trainees in gastroenterology C P Famieson, E R E Denton, W R Burnham Liver Inhibitory effect of oestradiol on activation of rat hepatic stellate cells in vivo and in vitro J Shimizu, Y Mizobuchi, M Yasuda, M Shiba, Y-R Ma, T Horie, F Liu, S Ito Review Oral tolerance in disease P Garside, A McI Mowat, A Khoruts No 2 FEBRUARY 1999 Leading article Role of nitric oxide in intestinal water and electrolyte transport F H Mourad, 7 L Turvill, M 7 G Farthing Commentaries Endothelins, pseudo-obstruction and Hirschsprung’s disease P ¥ Milla Back to the whale bone? A 7 PM Smout Genes means pancreatitis D C Whitcomb Cross-reacting antibodies in coeliac disease? K E A Lundin Science @lert Gastric leptin A Ballinger Clinical @lert Total parenteral nutrition with glutamine dipeptide shortened hospital stays and improved immune status and nitrogen economy after major abdominal surgery Commentary by ¥ Powell-Tuck Stomach Expression of Fas ligand by human gastric adenocarcinomas: a potential mechanism of immune escape in stomach cancer M W Bennett, ¥ O’Connell, G C O'Sullivan, D Roche, C Brady, F Kelly, 7 K Collins, F Shanahan Increased gastric Pco, during exercise is indicative of gastric ischaemia: a tonometric study 7 ¥ Kolkman, Small intestine Identification of common epitopes on gliadin, enterocytes, and calreticulin recognised by antigliadin antibodies of patients with coeliac disease S Krupickova, L Tuckova, Z Flegelova, M Michalak, ¥ R F Walters, A Whelan, ¥ Harries, 7 Vencovsky, H Tlaskalova-Hogenova Cisplatin impairs fluid and electrolyte absorption in rat small intestine: a role for 3-hydroxytryptamine C P Bearcroft, P Domizio, F H Mourad, E A Andrée, M F G Farthing Inflammation 5-Aminosalicylic acid prevents oxidant mediated damage of glyceraldehyde-3-phosphate dehydrogenase in colon epithelial cells SM McKenzie, W F Doe, G D Buffinton Anti-inflammatory drugs and endothelial cell adhesion molecule expression in murine vascular beds N Mori, Y Horie, M E Gerritsen, D C Anderson, D N Granger Detection of anti-colon antibodies in inflammatory bowel disease using human cultured colonic cells FC W Lee, A M Cevallos, A Naeem, ¥ E Lennard-fones, M F G Farthing The role of xanthine oxidase in platelet activating factor induced intestinal injury in the rat X¥ W Qu, RA Rozenfeld, W Huang, G B Bulkley, W Hsueh Infection Bovine immunoglobulin concentrate-Clostridium difficile retains C difficile toxin neutralising activity after passage through the human stomach and small intestine M Warny, A Fatimi, E F Bostwick, D C Laine, F Lebel, ¥ T LaMont, C Pothoulakis, C P Kelly Colon Macromolecular transport across the rabbit proximal and distal colon 7 A Hardin, M H Kimm, M Wirasinghe, D G Gall Comparison of a low dose polyethylene glycol electrolyte solution with lactulose for treatment of chronic constipation A Attar, M Lemann, A Ferguson, M Halphen, M-C Boutron, B Flourié, E Alix, M Salmeron, F Guillemot, S Chaussade, A-M Ménard, ¥ Moreau, G Naudin, M Barthet Motility Botulinum toxin versus pneumatic dilatation in the treatment of achalasia: a randomised trial M F Vaezi, FE Richter, C M Wilcox, P L Schroeder, S Birgisson, R L Slaughter, R E Koehler, M E Baker Effect of intravenous amino acids on interdigestive antroduodenal motility and small bowel transit time H A Ff Gielkens, A van den Biggelaar, ¥ Vecht, W Onkenhout, C B H W Lamers, A A M Masclee Expression of endothelin 3 by mesenchymal cells of embryonic mouse caecum M A Leibl, T Ota, M N Woodward, S E Kenny, D A Lloyd, C R Vaillant, D H Edgar Pancreas Inhibition of nuclear factor-«KB activation improves the survival of rats with taurocholate pancreatitis A Satoh, IT Shimosegawa, M Fujita, K Kimura, A Masamune, M Koizumi, T Toyota Mutations in exons 2 and 3 of the cationic trypsinogen gene in Japanese families with hereditary pancreatitis I Nishimori, M Kamakura, K Fujtkawa-Adachi, M Morita, S Onishi, K Yokoyama, I Makino, H Ishida, M Yamamoto, S Watanabe, M Ogawa Liver Single portal pressure measurement predicts survival in cirrhotic patients with recent bleeding D Patch, A Armonis, C Sabin, K Christopoulou, L Greenslade, A McCormick, R Dick, A K Burroughs Anti-inflammatory drugs and variceal bleeding: a case-control study V De Lédinghen, D Heresbach, O Fourdan, P Bernard, M P Liebaert-Bories, ¥ B Nousbaum, A Gourlaouen, M C Becker, D Ribard, P Ingrand, C Silvain, M Beauchant Relation between GB virus C/hepatitis G virus and fulminant hepatic failure may be secondary to treatment with contaminated blood and/or blood products R Halasz, L Barkholt, C Lara, C Hultgren, Y Ando, U Broome, B Fischler, A Nemeth, B-G Ericzon, A Sénnerborg, M Sadillberg Case report Diversion colitis: a trigger for ulcerative colitis in the in-stream colon? A G Lim, F L Langmead, R M Feakins, D S Rampton Review Cytokine regulation of epithelial permeability and ion transport D M McKay, A W Baird Letters to the Editor Book reviews Notes Abstracts from the Second International Inflammatory Bowel Disease Meeting No 3 MARCH 1999 Leading article Computed tomography colonography (virtual colonoscopy): a new method for colorectal screening C D Fohnson D A Ahilquist Commentaries Mind over matter in the postinfective irritable bowel D A Drossman CagA, the cag pathogenicity island and Helicobacter pylori virulence ¥ C Atherton Science (alert Activation of nuclear factor kB as a target for anti-inflammatory therapy S Schreiber Clinical @lert Smoking, use of oral contraceptives, and medical induction of remission were risk factors for relapse in Crohn’s disease Commentary by R F A Logan Ocesophagitis Preservation of postural control of transient lower oesophageal sphincter relaxations in patients with reflux oesophagitis A C Ireland, 7 Dent, R H Holloway Oesophageal epithelial innervation in health and reflux oesophagitis M Newton, M A Kamm, P O Soediono, P Milner, W R Burnham, G Burnstock Stomach Phenotypic and functional characterisation of myofibroblasts, macrophages, and lymphocytes migrating out of the human gastric lamina propria following the loss of epithelial cells K C Wu, L M Jackson, A M Galvin, T Gray, C F Hawkey, Y R Mahida Validation of the Rockall risk scoring system in upper gastrointestinal bleeding E M Vreeburg, C B Terwee, P Snel, E A F Rauws, J F W M Bartelsman, ¥ H P vd Meulen, G N F Tytgat Gastrointestinal infection Structure of cag pathogenicity island in Japanese Helicobacter pylori isolates S Maeda, H Yoshida, T Ikenoue, K Ogura, F Kanai, N Kato, Y Shiratori, M Omata Giardia induces proliferation and interferon y production by intestinal lymphocytes E C Ebert Ciprofloxacin decreases the rate of ethanol elimination in humans 7 Tillonen, N Homann, M Rautio, H Fousimies-Somer, M Salaspuro Intestinal transport Indirect evidence for cholinergic inhibition of intestinal bicarbonate absorption in humans A Mellander, H Sjévall Gastrointestinal cancer A blind comparison of the effectiveness of endoscopic ultrasonography and endoscopy in staging early gastric cancer H Yanai, T Noguchi, S Mizumachi, H Tokivama, H Nakamura, M Tada, K Okita Adenovirus mediated p53 tumour suppressor gene therapy for human gastric cancer cells in vitro and in vivo M Ohashi, F Kanai, H Ueno, T Tanaka, K Tateishi, T Kawakami, Y Koike, T Ikenoue, Y Shiratori, H Hamada, M Omata Incidence of rectosigmoid adenomatous polyps in subjects without prior colorectal adenoma or cancer: a prospective cohort study B Paillot, P Czernichow, P Michel, V Merle, A-M Queuniet, C Duval, H Daubert Evidence of improving survival of patients with rectal cancer in France: a population based study C Finn-Faitvre, F Maurel, A M Benhamiche, C Herbert, E Mitry, G Launoy, 7 Faivre Colon Biased J,, usage in plasma cell immunoglobulin gene sequences from colonic mucosa in ulcerative colitis but not in Crohn’s disease D K Dunn-Walters, L Boursier, M Hackett, ¥S pencer Sulphation and secretion of the predominant secretory human colonic mucin MUC2 in ulcerative colitis B F-W Van Klinken7,-W G Van der Wal, A W C Einerhand, H A Biiller, ?D ekker Modulation of distal colonic epithelial barrier function by dietary fibre in normal rats 7 M Mariadason, A Catto-Snuth, P R Gibson Motility and visceral sensation The role of psychological and biological factors in postinfective gut dysfunction K-A Gwee, Y-L Leong, C Graham, M W McKendrick, S M Collins, S ¥ Walters, 7 E Underwood, N W Read Effects of short term sacral nerve stimulation on anal and rectal function in patients with anal incontinence CF Vaizey, M A Kamm,IC Turner, R ¥ Nicholls, #W oloszko Pancreas Screening for mutations of the cationic trypsinogen gene: are they of relevance in chronic alcoholic pancreatitis? N Teich, ¥ Méssner, V Keim Liver Elevated carboxy terminal cross linked telopeptide of type I collagen in alcoholic cirrhosis: relation to liver and kidney function and bone metabolism S Moller, M Hansen, ¥ HillingsoJ,7- E B Fensen, 7 H Henriksen Hepatitis C virus (HCV) specific immune responses in anti-HCV positive patients without hepatitis C viraemia M E Cramp, P Carucci, S Rossol, S Chokshi, G Maertens, R Williams, N V Naoumov Predicting bone loss following orthotopic liver transplantation O M Crosbie, R Freaney, M 7 McKenna, M P Curry, F E Hegarty Review Gallstones: an intestinal disease? K ¥ van Erpecum, G P van Berge-Henegouwen Letters to the editor Bookreviews Notes No 4 APRIL 1999 Leading article What keeps hepatocytes on the straight and narrow? Maintaining differentiated function in the liver C Selden, M Khalil, H ¥ F Hodgson Commentaries Helicobacter pylori resists arrest R ¥ Owen Omeprazole: Helicobacter pylori makes thee greater yet D Pantoflickova, A L Blum, P Bercik The hiatus hernia slides back into prominence 7 Dent ‘he quality of quality of life E F Irvine New kids on the block: pancreatic stellate cells enter the fibrogenesis world M Pinzani Budd-Chiari syndrome: blocked veins, open mind D Patch, A Burroughs Science @lert Proteolytic release of membrane bound intercellular regulators V E Eysselein Clinical @lert ae : - Balsalazide led to greater remission rates and tolerance than mesalamine in acute ulcerative colitis Commentary by S B Hanauer Helicobacter pylori Role of apoptosis induced by Helicobacter pylori infection in the development of duodenal ulcer K Kohda, K Tanaka, Y Aiba, M Yasuda, T Miwa, Y Koga Direct detection of Helicobacter pylori resistance to macrolides by a polymerase chain reaction/DNA enzyme immunoassay in gastric biopsy specimens A Marais, L Monteiro, A Occhialini, M Pina, H Lamouliatte, F Megraud Helicobacter pylori infection potentiates the inhibition of gastric acid secretion by omeprazole D Gillen, A A Wirz, W D Neithercut, JE S Ardill, K EL McColl Motility | | The effect of hiatus hernia on gastro-oesophageal junction pressure P ¥ Kahrilas, S Lin, ¥C hen, M Manka Small intestine Geography of intestinal permeability and absorption J] S Menzies, M 7 Zuckerman, W S Nukajam, S G Somasundaram, B Murphy, A P Fenkins, R S Crane, G G Gregory Acute increase, stimulated by prostaglandin E,, in glucose absorption via the sodium dependent glucose transporter-1 in rat intestine B Scholtka, F Stiimpel, K fungermann Involvement of tachykinin receptors 1n sensitisation to cow’s milk proteins in guinea pigs 7 Gay, ¥ Froramontt, R Garcia-Villar, X Emonds-Alt, L Bueno Colon Bacteroides fragilis toxin 2 damages human colonic mucosa 1n vitro M Riegler, M Lotz, C Sears, C Pothoulakis, I Castagliuolo, C C Wang, R Sedivy, T Sogukoglu, E Cosentim, G Bischof, W Feil, B Teleky, G Hamilton, F T LaMont, E Wenzl Clinical spectral characterisation of colonic mucosal lesions using autofluorescence and 6 aminolevulinic acid sensitisation C Eker, S Montan, E Jaramillo, K Koizumi, C Rubio, S Andersson-Engels, K Svanberg, S Svanberg, P Slezak Inflammatory bowel disease Linkage of Crohn’s disease to the major histocompatibility complex region is detected by multiple non-parametric analyses H Yang, S E Plevy, K Taylor, D Tyan, N Fischel-Ghodsian, C McElree, S R Targan, F I Rotter Quality of life Validation of a specific quality of life questionnaire for functional digestive disorders O Chassany, P Marquis, B Scherrer, N W Read, T Finger, ¥ F Bergmann, B Fraitag, ¥G eneve, C Caulin Pancreatic disease Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis M V Apte, P S Haber, S ¥ Darby, S C Rodgers, GW McCaughan, M A Korsten, R C Pirola, ¥ S Wilson Underestimation of acute pancreatitis: patients with only a small increase in amylase/lipase levels can also have or develop severe acute pancreatitis P G Lankisch, S Burchard-Reckert, D Lehnick Immunoreactive pancreatic Reg protein in sera from cystic fibrosis patients with and without pancreatic insufhiciency 7 Carrere, O Guy-Crotte, E Gaia, C Figarella Bile and gallstones Effect of long term simvastatin administration as an adjunct to ursodeoxycholic acid: evidence for a synergistic effect on biliary bile acid composition but not on serum lipids in humans F Lanzarotto, B Panarotto, R Sorbara, M Panteghini, F Pagani, S Sosta, A Lanzini The role of apolipoprotein E and glucose intolerance in gallstone disease in middle aged subjects M Niemi, K Kervinen, A Rantala, H Kauma, M Pdaivansalo, M ¥ Savolainen, M Lilja, Y A Kesaniemi Liver disease The natural course of hepatitis C virus infection 18 years after an epidemic outbreak of non-A, non-B hepatitis in a plasmapheresis centre C Datz, M Cramp, T Haas, O Dietze, H Nitschko, G Froesner, N Muss, F Sandhofer, W Vogel Managing Budd-Chiari syndrome: a retrospective review of percutaneous hepatic vein angioplasty and surgical shunting N C Fisher, I] McCafferty, M Dolapct, M Wali, J A C Buckels, S P Olliff, E Elias Review Hepatitis C virus recurrence after liver transplantation T Bizollon, D Mutimer, C Ducerf, C Trepo Letters to the Editor Bookreviews Notes No 5 MAY 1999 Leading articles Colorectal neoplasia in acromegaly P 7 Jenkins, GM Besser, P D Fairclough Divergency of leptin response in intestinal inflammation A Ballinger Commentaries Double reflux: double trouble M F Vaez1, ¥ E Richter Is mycophenolate mofetil a new alternative in the treatment of inflammatory bowel disease? D H Present Beans means lectins 7 M Rhodes PBC and the gut: the villi atrophy, the plot thickens ¥ Neuberger Science @lert The adenomatous polyposis coli tumour suppressor gene regulates c-/YC transcription in colon cancer cells M Pignatelli Clinical @lert Review: substantial coffee consumption was associated with a lower risk of colorectal cancer in the general population Commentary by A Ekbom Gastro-oesophageal reflux Toxic bile acids in gastro-oesophageal reflux disease: influence of gastric acidity D Nehra, P Howell, C P Williams, : K Pye, F Beynon Cholinergic blockade inhibits gastro-oesophageal reflux and transient lower oesophageal sphincter relaxation through a central mechanism ¥ C Fang, I Sarosiek, Y Yamamoto, ¥ Liu, R K Mittal Small intestine The effects of glutamine on intestinal epithelial cell proliferation in parenterally fed rats N Mandir, R.A Goodlad Vagotomy inhibits the jejunal fluid secretion activated by luminal ileal Escherichia coli STa in the rat in vivo V E Rolfe, R F Levin Characterisation of penicillin G uptake in human small intestinal brush border membrane vesicles 7 F Poschet, S M Hammond, P D Fairclough Inflammation and inflammatory bowel disease Randomised trial of mycophenolate mofetil versus azathioprine for treatment of chronic active Crohn’s disease M F Neurath, R Wanitschke, M Peters, F Krummenauer, K-H Meyer zum Biischenfelde, ¥F Schlaak Enhanced production of monocyte chemotactic protein 3 in inflammatory bowel disease mucosa 7 Wedemeyer, A Lorentz, M Géke, P N Meter, P Flemming, C A Dahinden, M P Manns, S C Bischoff Trefoil peptide TFF2 (spasmolytic polypeptide) potently accelerates healing and reduces inflammation in a rat model of colitis C P Tran, G A Cook, N D Yeomans, L Thim, A S Giraud Mast cells are an important cellular source of tumour necrosis factor « in human intestinal tissue S C Bischoff, A Lorentz, S Schwengberg, G Weiter, R Raab, M P Manns Intestinal barrier function Bovine colostrum is a health food supplement which prevents NSAID induced gut damage R # Playford, D N Floyd, C E Macdonald, D P Calnan, R O Adenekan, W Fohnson, R A Goodlad, T Marchbank Acquired interferon y responsiveness during Caco-2 cell differentiation: effects on iNOS gene expression A M Chavez, M ¥ Morin, N Unno, M P Fink, R A Hodin Gastrointestinal motility Notable postnatal alterations in the myenteric plexus of normal human bowel T Wester, D S O’Briain, P Puri Prolonged large bowel transit increases serum deoxycholic acid: a risk factor for octreotide induced gallstones M Ff Vevsey, L A Thomas, A I Mallet, P ¥F enkins, G M Besser, ¥ A H Wass, G M Murphy, R H Dowling Selective stimulation of colonic transit by the benzofuran 5HT, agonist, prucalopride, in healthy humans E P Bouras, M Camilleri, D D Burton, S McKinzie Perception of and adaptation to rectal isobaric distension in patients with faecal incontinence L Siproudhis, E Bellissant, F Fuguet, H Allain, ¥-F Bretagne, M Gosselin Gastrointestinal cancer 693 Accuracy of screening for gastric cancer using serum pepsinogen concentrations F Kitahara, K Kobayashi, T Sato, Y Kojima, T Araki, M A Fujino 698 Cost comparison of predictive genetic testing versus conventional clinical screening for familial adenomatous polyposis B Bapat, H Nooram, Z Cohen, T Berk, A Mitri, B Gallie, K Pritzker, S Gallinger, A S Detsky 704 Expression of the insulin-like growth factors and their receptors in adenocarcinoma of the colon S Freier, O Weiss, M Eran, A Flyvbjerg, R Dahan, I Nephesh, T Safra, E Shiloni, I Raz 709 Vicia faba agglutinin, the lectin present in broad beans, stimulates differentiation of undifferentiated colon cancer cells M Fordinson, I El-Hariry, D Calnan, 7C alam, M Pignatelli Endoscopy Comparison of adrenaline injection and bipolar electrocoagulation for the arrest of peptic ulcer bleeding H-7 Lin, G-Y Tseng, C-L Perng, F-Y Lee, F-Y Chang, S-D Lee Endoscopic ultrasound guided fine needle aspiration biopsy: a large single centre experience D B Williams, A V Sahai, L Aabakken, I D Penman, A van Véelse, ¥ Webb, M Wilson, B ¥ Hoffman, R H Hawes Anal disease Randomised controlled trial shows that glyceryl trinitrate heals anal fissures, higher doses are not more effective, and there is a high recurrence rate E A Carapeti, M A Kamm, P ¥ McDonald, S 7 D Chadwick, D Melville, RK S Phillipss Liver disease The natural history of histologically proved drug induced liver disease P G Aithal, C P Day Risk of primary biliary liver cirrhosis in patients with coeliac disease: Danish and Swedish cohort data H T Sorensen, A M Thulstrup, P Blomqvist, B Norgaard, K Fonager, A Ekbom Gastric antral vascular ectasia in cirrhotic patients: absence of relation with portal hypertension L Spahr, F-P Villeneuve, M-P Dufresne, D Tassé, B Bui, B Willems, D Fenyves, G Pomier-Layrargues Cardiac function and haemodynamics in alcoholic cirrhosis and effects of the transjugular intrahepatic portosystemic stent shunt M Huonker, Y O Schumacher, A Ochs, S Sorichter, 7K eul, M Rossle Hepatic and splanchnic nitric oxide activity in patients with cirrhosis A I Sarela, F M A Mihaimeed, Ff 7 Batten, B R Davidson, R T Mathie Thrombopoietin concentrations are low in patients with cirrhosis and thrombocytopenia and are restored after orthotopic liver transplantation F7 Goulis, T N Chau, S fordan, A B Mehta, A Watkinson, K Rolles, A K Burroughs Review Mechanisms of immune escape in viral hepatitis W Rosenberg Letters to the Editor Bookreviews Notes No 6 JUNE 1999 Leading articles Towards immunotherapy of pancreatic cancer J F C McKenzie, V Apostolopoulos Management of bone disease in patients on long term glucocorticoid therapy 7 E Compston Commentaries Anticipating the onset of inflammatory bowel disease ¥ F Coiombel, D Laharie, B Grandbastien Intolerance of the dirty intestine A 7 S Macpherson, K 7 Maloy Barrett’s oesophagus and colorectal neoplasia: scope for screening R F A Logan, M M Skelly ANCAs away I G McFarlane Science @lert Labh : . Aggressive mucosa associated lymphoid tissue lymphomas are associated with mutations in Bell0 F Spencer Clinical @lert . bas Alendronate increased bone mineral density but did not reduce new fractures in glucocorticoid induced osteoporosis Commentary by F E Compston Gastro-oesophageal reflux . } An ambulant porcine model of acid reflux used to evaluate endoscopic gastroplasty S S Kadirkamanathan, E Yazaki, D F Evans, C C Hepworth, F Gong, C P Swain Helicobacter pylori . Effect of Helicobacter pylori infection and its eradication on cell proliferation, DNA status, and oncogene expression in patients with chronic gastritis G Nardone, S Staibano, A Rocco, E Mezza, F P D’Armiento, L Insabato, A Coppola, G Salvatore, A Lucariello, N Figura, G De Rosa, G Budillon Inflammation and infection . . Efficient gene delivery to the inflamed colon by local administration of recombinant adenoviruses with normal or modified fibre structure S Wirtz, P R Galle, M F Neurath Why children with inflammatory bowel disease are diagnosed at a younger age than their affected parent F CW Lee, S Bridger, C Mc¢ rregor, A 7 SA facpherson, F E Lennard Fones T cell specificity and cross reactivity towards enterobacteria, Bacteroides, Bifidobacterium, and antigens from resident intestinal flora in humans R Duchmann, E May, M Heike, P Knolle, M Neurath, K-H Meyer zum Biischenfelde Cancer No association between colon cancer and adenocarcinoma of the oesophagus in a population based cohort study in Sweden 7 Lagergren, O Nyren Molecular screening of patients with long standing extensive ulcerative colitis: detection of p53 and Ki-ras mutations by single strand conformation polymorphism analysis and differential hybridisation in colonic lavage fiuid S M Lang, D F Stratakis, M Heinzlmann, W Heldwein, B Wiebecke, K Loeschke Genetic epidemiology of mutated K-ras proto-oncogene, altered suppressor genes, and microsatellite instability in colorectal adenomas A Rashid, M Zahurak, S N Goodman, S R Hamilton Expression and activity of mitogen activated protein kinases in human colorectal carcinoma S Eggstem, M Franke, I Kutschka, G Manthey, B U von Specht, G Ruf, E H Farthmann Microsatellite instability—a useful diagnostic tool to select patients at high risk for hereditary non-polyposis colorectal cancer: a study in different groups of patients with colorectal cancer C Lambert, R Kruse, C Ruelfs, R Caspari, Y Wang, M Fungck, M Mathiak, H R H Malayer, W Friedl, T Sauerbruch, P Propping Nutrition Quality of life in patients receiving home parenteral nutrition P B Feppesen, E Langholz, P B Mortensen Motility RReeccttaall bib iopsy ‘foforr didaigangnoossiiss ooff iinntteessttiinnaall nneeuurroonnaall dydyssppllaassiiaa iinn cchhiillddrrene:n :: a prospsepeccttiivvee multlitciecnenttrree ssttuuddyy on interobserver variation and clinical outcome S Koletzko, I Fesch, T Faus-Kefsler, ¥ Briner, W Meier-Ruge, H Miintefering, W Coerdt, L Wessel, K M Keller, W Niitzenadel, P Schmittenbecher, A Holschneider, P Sacher Liver Serum hepatocyte growth factor as an index of extensive catabolism of patients awaiting liver transplantation C Miki, A D Mayer, ¥ A C Buckels, K Iriyvama, H Suzuki, P McMaster High mobility group (HMG) non-histone chromosomal proteins HMG1 and HMG2 are significant target antigens of perinuclear anti-neutrophil cytoplasmic antibodies in autoimmune hepatitis 7 Sobajima, S Ozaki, H Uesugi, F Osakada, M Inoue, Y Fukuda, H Shirakawa, M Yoshida, A Rokuhara, H Imai, K Kiyosawa, K Nakao Clinical course and risk factors of hepatitis C virus related liver disease in the general population: report from the Dionysos study S Bellentami, G Pozzato, G Saccoccio, M Crovatto, L S Croce, L Mazzoran, F Masutti, G Cristianini, C Tiribelli Case reports 88] Collagenous gastritis and collagenous colitis: a report with sequential histological and ultrastructural findings A B Pulimood, B S Ramakrishna, M M Mathan S86 Mesalazine (5-aminosalicylic acid) induced chronic hepatitis P Deltenre, A Berson, P Marcellin, C Degott, M Biour, D Pessayre Gut file 889 Paroxysmal nocturnal haemoglobinuria mimicking Crohn’s disease S Sivakumaran, R Hoyles, # O Hunter, S Middleton Review 890 Trefoil peptides WM Wong, R Poulsom, N A Wright 896 Letters to the editor Bookreview Notes Correction S99 Volume 44: Author Index 906 Volume 44: Subject Index Volume 44: Contents pw aft e