Gunderson & Tepper’s Clinical Radiation Oncology PDF
Preview Gunderson & Tepper’s Clinical Radiation Oncology
ASSOCIATE EDITORS Jeffrey A. Bogart, MD Abram Recht, MD Professor and Chair Professor Department of Radiation Oncology Department of Radiation Oncology SUNY Upstate Medical University Harvard Medical School Syracuse, New York Vice Chair Department of Radiation Oncology Minesh P. Mehta, MBChB, FASTRO Beth Israel Deaconess Medical Center Professor and Chair Boston, Massachusetts Department of Radiation Oncology FIU Herbert Wertheim College of Medicine Christopher L. Tinkle, MD, PhD Deputy Director and Chief Assistant Member Miami Cancer Institute Department of Radiation Oncology Baptist Health South Florida St. Jude Children’s Research Hospital Miami, Florida Memphis, Tennessee Andrea K. Ng, MD, MPH Akila N. Viswanathan, MD, MPH Professor Professor Department of Radiation Oncology Department of Radiation Oncology and Molecular Radiation Sciences Harvard Medical School Johns Hopkins University School of Medicine Dana-Farber Cancer Institute Baltimore, Maryland Brigham and Women’s Hospital Boston, Massachusetts 5 th EDITION Gunderson & Tepper’s C L I N I C A L R A D I AT I O N O N C O L O G Y SENIOR EDITORS Joel E. Tepper, MD, FASTRO Hector MacLean Distinguished Professor of Cancer Research Department of Radiation Oncology University of North Carolina Lineberger Comprehensive Cancer Center University of North Carolina School of Medicine Chapel Hill, North Carolina Robert L. Foote, MD, FACR, FASTRO Hitachi Professor of Radiation Oncology Research Department of Radiation Oncology Mayo Clinic College of Medicine and Science, Mayo Clinic Rochester, Minnesota Jeff M. Michalski, MD, MBA, FACR, FASTRO Carlos A. Perez Distinguished Professor Vice Chair of Radiation Oncology Washington University School of Medicine in St. Louis St. Louis, Missouri Elsevier 1600 John F. Kennedy Blvd. Ste. 1600 Philadelphia, PA 19103-2899 GUNDERSON & TEPPER’S CLINICAL RADIATION ONCOLOGY, ISBN: 978-0-323-67246-7 FIFTH EDITION Copyright © 2021 by Elsevier Inc. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies, and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency can be found at our website: www.elsevier.com/permissions. This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein). Notices Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary. Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility. With respect to any drug or pharmaceutical products identified, readers are advised to check the most current information provided (i) on procedures featured or (ii) by the manufacturer of each product to be administered, to verify the recommended dose or formula, the method and duration of administration, and contraindications. It is the responsibility of practitioners, relying on their own experience and knowledge of their patients, to make diagnoses, to determine dosages and the best treatment for each individual patient, and to take all appropriate safety precautions. To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any liability for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein. The Publisher Previous editions copyrighted © 2014, 2008, 2001, 1995, 1988, 1983 by Saunders and Churchill Livingstone, imprints of Elsevier Inc. Library of Congress Control Number: 2019949699 Executive Content Strategist: Robin Carter Senior Content Development Specialist: Anne Snyder Publishing Services Manager: Catherine Jackson Senior Project Manager: John Casey Book Designer: Patrick Ferguson Printed in China 9 8 7 6 5 4 3 2 1 To my wife Laurie, for her support and for teaching me what is important in life, and who has made me a better person; and to my family, including Miriam, Adam, Abigail, Agustin, Zekariah, Zohar, Sammy, Marcelo, Jonah, and Aurelio for the love and support they have given me for many years. To my parents, who taught me the importance of education, learning, and doing that which should be done. To my many mentors who taught me in the past and those who continue to teach me. To my professional colleagues, both at the University of North Carolina and around the country, who have made me a better physician. JET To Kally, who, during our 40 years of marriage, has made innumerable, selfless, personal sacrifices for my patients and for my professional career. To my father, Leonard, who introduced me to the art, science, and practice of medicine. To John Earle, Len Gunderson and John Noseworthy. Their mentorship has enriched my professional life with experiences, opportunities, and growth beyond my wildest dreams. To the Mayo Clinic for providing a patient-centered, collegial, cooperative, compassionate, respectful, scholarly, integrated, professional, innovative, and healing environment in which to work and serve. RLF To Sheila, my loving wife of 31 years, for her steadfast support of my career and academic endeavors while also encouraging me to enjoy life with our family. To our children, Basia, Sophie, and Jeffrey, who have enriched my life with their love and support. To my parents, Richard and Rita, who both faced their own challenges of cancer therapy and taught me perspectives of care that you don’t get in medical school. To my mentors, especially Drs. Jim Cox and Larry Kun, who we lost this past year during the development of this new edition. They inspired me to reach higher. And finally, to my colleagues at Washington University in St. Louis who have patiently given me the time and support to contribute to this work. JMM Downloaded for [email protected] upr07 ([email protected]) at Autonomous University of Guadalajara from ClinicalKey.com by Elsevier on April 23, 2020. For personal use only. No other uses without permission. Copyright ©2020. Elsevier Inc. All rights reserved. C O N T R I B U TO R S Christopher D. Abraham, MD Jonathan B. Ashman, MD, PhD Philippe L. Bedard, MD, FRCPC Assistant Professor Assistant Professor Medical Oncologist Department of Radiation Oncology Department of Radiation Oncology Princess Margaret Cancer Centre Washington University School of Medicine Mayo Clinic College of Medicine and Science Associate Professor in St. Louis Phoenix, Arizona Department of Medicine St. Louis, Missouri University of Toronto Matthew T. Ballo, MD Toronto, Ontario, Canada Ross A. Abrams, MD Professor Department of Radiation Oncology Radiation Oncology Jonathan J. Beitler, MD, MBA, FACR, Rush University Medical Center West Cancer Center and Research Institute FASTRO Chicago, Illinois Memphis, Tennessee Professor Departments of Radiation Oncology, Aydah Al-Awadhi, MBBS Lucia Baratto, MD Otolaryngology, and Hematology and Department of Cancer Medicine Research Fellow Medical Oncology University of Texas MD Anderson Cancer Department of Radiology Emory University School of Medicine Center Division of Nuclear Medicine and Molecular Georgia Research Alliance Clinical Scientist Houston, Texas Imaging Winship Cancer Institute of Emory Stanford University University Kaled M. Alektiar, MD Stanford, California NRG Institutional Principal Investigator Member Atlanta, Georgia Department of Radiation Oncology Christopher Andrew Barker, MD Memorial Sloan Kettering Cancer Center Radiation Oncologist Sushil Beriwal, MD, MBA New York, New York Director of Clinical Investigation Professor Department of Radiation Oncology Department of Radiation Oncology Jan Alsner, PhD Memorial Sloan Kettering Cancer Center UPMC Hillman Cancer Center Professor New York, New York University of Pittsburgh School of Medicine Department of Experimental Clinical Pittsburgh, Pennsylvania Oncology Adam Bass, MD Aarhus University Hospital Associate Professor of Medicine Ranjit S. Bindra, MD, PhD Aarhus, Denmark Dana-Farber Cancer Institute Associate Professor Harvard Medical School Therapeutic Radiology K. Kian Ang, MD, PhD† Boston, Massachusetts Yale Medical School Professor and Gilbert H. Fletcher Endowed New Haven, Connecticut Chair Brian C. Baumann, MD Department of Radiation Oncology Assistant Professor Michael W. Bishop, MD University of Texas MD Anderson Cancer Department of Radiation Oncology Assistant Member Center Washington University School of Medicine Department of Oncology Houston, Texas in St. Louis St. Jude Children’s Research Hospital St. Louis, Missouri Memphis, Tennessee Lilyana Angelov, MD, FAANS, FRCS(C) The Kerscher Family Chair for Spine Tumor Beth M. Beadle MD, PhD Rachel Blitzblau, MD, PhD Excellence Associate Professor Associate Professor Head, Section of Spine Tumors Department of Radiation Oncology Department of Radiation Oncology Professor, Department of Neurological Stanford University Duke University Medical Center Surgery Stanford, California Durham, North Carolina Cleveland Clinic Lerner College of Medicine at Case Western Reserve University Staci Beamer, MD Jeffrey A. Bogart, MD Rose Ella Burkhart Brain Tumor and Neuro- Assistant Professor Professor and Chair Oncology Center Division of Cardiovascular and Thoracic Department of Radiation Oncology Department of Neurosurgery Surgery SUNY Upstate Medical University Neurological Institute and Taussig Cancer Mayo Clinic College of Medicine and Science Syracuse, New York Institute Phoenix, Arizona Cleveland Clinic James A. Bonner, MD Cleveland, Ohio Chairman and Merle M. Salter Professor Department of Radiation Oncology The University of Alabama at Birmingham Birmingham, Alabama †Deceased vii viii CONTRIBUTORS J. Daniel Bourland, PhD, MSPH Bruce A. Chabner, MD Stephen G. Chun, MD Professor Clinical Director, Emeritus Assistant Professor Radiation Oncology, Biomedical Massachusetts General Hospital Cancer Department of Radiation Oncology Engineering, and Physics Center The University of Texas MD Anderson Wake Forest School of Medicine Massachusetts General Hospital Cancer Center Winston-Salem, North Carolina Professor of Medicine Houston, Texas Harvard Medical School Joseph A. Bovi, MD Boston, Massachusetts Christine H. Chung, MD Department of Radiation Oncology Chair, Department of Head and Neck– Medical College of Wisconsin Michael D. Chan, MD Endocrine Oncology Froedtert Memorial Lutheran Hospital Associate Professor and Vice Chairman Moffitt Cancer Center Milwaukee, Wisconsin Department of Radiation Oncology Tampa, Florida Wake Forest School of Medicine Andrew G. Brandmaier, MD, PhD Winston-Salem, North Carolina Peter W. M. Chung, MBChB, MRCP, Assistant Professor FRCR, FRCPC Department of Radiation Oncology Samuel T. Chao, MD Radiation Oncologist Weill Cornell Medical College Associate Professor Princess Margaret Cancer Centre New York, New York Department of Radiation Oncology Associate Professor Rose Ella Burkhardt Brain Tumor and Department of Radiation Oncology John Breneman, MD Neuro-Oncology Center University of Toronto Professor Cleveland Clinic Toronto, Ontario, Canada Department of Radiation Oncology Cleveland, Ohio University of Cincinnati Jeffrey M. Clarke, MD Cincinnati Children’s Hospital Medical Anne-Marie Charpentier, MD, FRCPC Assistant Professor Center Radiation Oncologist Department of Medicine Cincinnati, Ohio Centre Hospitalier de l’Université de Division of Medical Oncology Montréal Duke University School of Medicine Juan P. Brito, MD Clinical Assistant Professor Durham, North Carolina Assistant Professor of Medicine Université de Montréal Division of Endocrinology, Diabetes, Montréal, Quebec, Canada Louis S. Constine, MD, FASTRO, FACR Metabolism, and Nutrition The Philip Rubin Professor of Radiation Mayo Clinic College of Medicine and Aadel A. Chaudhuri, MD Oncology and Pediatrics Science, Mayo Clinic Assistant Professor Vice Chair, Department of Radiation Rochester, Minnesota Department of Radiation Oncology Oncology Washington University School of Medicine James P. Wilmot Cancer Center Michael D. Brundage, MD, MSc, FRCPC in St. Louis University of Rochester Medical Center Professor St. Louis, Missouri The Judy DiMarzo Cancer Survivorship Oncology and Public Health Sciences Program Queen’s University Nathan I. Cherny, MBBS, FRACP, FRCP James P. Wilmot Cancer Institute Radiation Oncologist Norman Levan Chair of Humanistic University of Rochester Medical Center Cancer Centre of Southeastern Ontario Medicine Rochester, New York Kingston, Ontario, Canada Cancer Pain and Palliative Medicine Service Shaare Zedek Medical Center Benjamin W. Corn, MD Matthew R. Callstrom, MD, PhD Jerusalem, Israel Chairman Professor of Radiology Department of Radiation Medicine Mayo Clinic College of Medicine and Fumiko Chino, MD Shaare Zedek Medical Center Science, Mayo Clinic Assistant Professor Jerusalem, Israel; Rochester, Minnesota Department of Radiation Oncology Professor Memorial Sloan Kettering Cancer Center Tel Aviv University School of Medicine Felipe A. Calvo, MD, PhD New York, New York Tel Aviv, Israel Professor and Chairman Department of Oncology John P. Christodouleas, MD, MPH Allan Covens, MD, FRCSC Clinica Universidad de Navarra Attending Physician Professor Madrid, Spain Department of Radiation Oncology Department of Obstetrics and Gynecology University of Pennsylvania Division of Gynecologic Oncology George M. Cannon, MD Philadelphia, Pennsylvania Sunnybrook Health Sciences Centre Adjunct Assistant Professor University of Toronto Radiation Oncology Toronto, Ontario, Canada University of Utah Salt Lake City, Utah Downloaded for [email protected] upr07 ([email protected]) at Autonomous University of Guadalajara from ClinicalKey.com by Elsevier on April 23, 2020. For personal use only. No other uses without permission. Copyright ©2020. Elsevier Inc. All rights reserved. CONTRIBUTORS ix Christopher H. Crane, MD Ryan W. Day, MD Hugues Duffau, MD, PhD Department of Radiation Oncology Instructor of Surgery Professor and Chairman Memorial Sloan Kettering Cancer Center Mayo Clinic Montpellier University Medical Center New York, New York Scottsdale, Arizona; Institute for Neurosciences of Montpellier Senior Fellow Hôpital Gui de Chauliac Carien L. Creutzberg, MD, PhD Department of Surgical Oncology Montpellier, France Professor University of Texas MD Anderson Cancer Department of Radiation Oncology Center Thierry Duprez, MD Leiden University Medical Center Houston, Texas Medical Imaging and Radiology Leiden, Netherlands Universite Catholique de Louvain Amanda J. Deisher, PhD Head of Neurology/Head and Neck Section Juanita M. Crook, MD, FRCP Instructor Cliniques Universitaires Saint-Luc Professor Department of Radiation Oncology Brussels, Belgium Department of Radiation Oncology Mayo Clinic College of Medicine and University of British Columbia Science, Mayo Clinic Peter T. Dziegielewski, MD, FRCS(C) Radiation Oncologist Rochester, Minnesota Associate Professor Center for the Southern Interior Chief, Division of Head and Neck Oncologic British Columbia Cancer Agency Thomas F. DeLaney, MD Surgery Kelowna, British Columbia, Canada Andres Soriano Professor of Radiation Microvascular Reconstructive Surgery Oncology Kenneth W. Grader Professor Brian G. Czito, MD Harvard Medical School University of Florida College of Medicine Professor Associate Medical Director Gainesville, Florida Department of Radiation Oncology Francis H. Burr Proton Therapy Center Duke Cancer Institute Massachusetts General Hospital Charles Eberhart, MD, PhD Duke University Boston, Massachusetts Professor Durham, North Carolina Pathology, Ophthalmology, and Oncology Phillip M. Devlin, BPhil, MTS, EdM, MD, Johns Hopkins University School of Bouthaina S. Dabaja, MD FACR, FASTRO, FFRRSCI (Hon) Medicine Professor Chief, Division of Brachytherapy Baltimore, Maryland Section Chief, Hematology Dana-Farber/Brigham and Women’s Cancer Department of Radiation Oncology Center David W. Eisele, MD, FACS University of Texas MD Anderson Cancer Associate Professor of Radiation Oncology Andelot Professor and Director Center Harvard Medical School Department of Otolaryngology–Head and Houston, Texas Institute Physician Neck Surgery Dana-Farber Cancer Institute Johns Hopkins University School of Thomas B. Daniels, MD Boston, Massachusetts Medicine Department of Radiation Oncology Baltimore, Maryland Mayo Clinic Arizona James J. Dignam, PhD Assistant Professor of Radiation Oncology Professor Suzanne B. Evans, MD, MPH Mayo Clinic College of Medicine and Science Department of Public Health Sciences Associate Professor, Therapeutic Radiology Phoenix, Arizona University of Chicago Associate Director, Residency Program Chicago, Illinois Yale University School of Medicine Marc David, MD Statistics and Data Management Center New Haven, Connecticut Assistant Professor NRG Oncology Department of Radiation Oncology Michael Farris, MD McGill University Health Centre Don S. Dizon, MD Assistant Professor Montreal, Quebec, Canada Associate Professor Department of Radiation Oncology Warren Alpert Medical School of Brown Wake Forest Baptist Health Laura A. Dawson, MD University Winston-Salem, North Carolina Professor Head of Women’s Cancers at Lifespan Department of Radiation Oncology Cancer Institute Mary Feng, MD Princess Margaret Cancer Centre Director of Medical Oncology Professor University of Toronto Rhode Island Hospital Department of Radiation Oncology Toronto, Ontario, Canada Providence, Rhode Island University of California, San Francisco San Francisco, California Jeffrey S. Dome, MD, PhD Chief Rui P. Fernandes, MD, DMD, FACS, Hematology and Oncology FRCS(Ed) Children’s National Health System Associate Professor Washington, DC OMS, Neurosurgery, Orthopedics, Surgery University of Florida College of Medicine Jacksonville, Florida Downloaded for [email protected] upr07 ([email protected]) at Autonomous University of Guadalajara from ClinicalKey.com by Elsevier on April 23, 2020. For personal use only. No other uses without permission. Copyright ©2020. Elsevier Inc. All rights reserved. x CONTRIBUTORS Gini F. Fleming, MD Adam S. Garden, MD Dennis E. Hallahan, MD Professor Professor Elizabeth H. and James S. McDonnell Department of Medicine Department of Radiation Oncology Distinguished Professor of Medicine University of Chicago Medical Center University of Texas MD Anderson Cancer Chair, Department of Radiation Oncology Chicago, Illinois Center Washington University School of Medicine Houston, Texas in St. Louis John C. Flickinger, MD Barnes Jewish Hospital Professor Lilian T. Gien, MD St. Louis, Missouri Department of Radiation Oncology Associate Professor University of Pittsburgh Division of Gynecologic Oncology Christopher L. Hallemeier, MD Radiation Oncologist Odette Cancer Center Associate Professor Department of Radiation Oncology Sunnybrook Health Sciences Centre Department of Radiation Oncology UPMC Presbyterian-Shadyside Toronto, Ontario, Canada Mayo Clinic College of Medicine and Pittsburgh, Pennsylvania Science, Mayo Clinic Mary K. Gospodarowicz, MD, FRCPC, Rochester, Minnesota Robert L. Foote, MD, FACR, FASTRO FRCR (Hon) Hitachi Professor of Radiation Oncology Professor and Chair Michele Y. Halyard, MD Research Department of Radiation Oncology Professor Department of Radiation Oncology University of Toronto Department of Radiation Oncology Mayo Clinic College of Medicine and Princess Margaret Hospital Mayo Clinic College of Medicine and Science, Mayo Clinic Toronto, Ontario, Canada Science, Mayo Clinic Rochester, Minnesota Phoenix, Arizona Cai Grau, MD, DMSc Silvia C. Formenti, MD Professor Marc Hamoir, MD Sandra and Edward Meyer Professor of Department of Oncology and Danish Centre Head and Neck Surgery Cancer Research for Particle Therapy Chairman of the Executive Board of the Chairman, Department of Radiation Aarhus University Hospital Cancer Center Oncology Aarhus, Denmark Saint-Luc University Hospital Cancer Center Associate Director, Meyer Cancer Institute Brussels, Belgium Weill Cornell Medical College Vincent Grégoire, MD, PhD, FRCR Radiation Oncologist in Chief Radiation Oncology Department Timothy P. Hanna, MD, MSc, PhD, New York Presbyterian Hospital Centre Léon Bérard FRCPC New York, New York Lyon, France Clinician Scientist Cancer Care and Epidemiology Benedick A. Fraass, PhD, FAAPM, Chul S. Ha, MD Cancer Research Institute at Queen’s FASTRO, FACR Professor University Vice Chair for Research, Professor and Department of Radiation Oncology Radiation Oncologist Director of Medical Physics University of Texas Health Science Center at Cancer Centre of Southeastern Ontario Department of Radiation Oncology San Antonio Kingston General Hospital Cedars-Sinai Medical Center San Antonio, Texas Kingston, Ontario, Canada Health Sciences Professor Department of Radiation Oncology Michael G. Haddock, MD Paul M. Harari, MD University of California, Los Angeles Professor of Radiation Oncology Jack Fowler Professor and Chairman Los Angeles, California; Mayo Clinic College of Medicine and Human Oncology Professor Emeritus Science, Mayo Clinic University of Wisconsin School of Medicine Department of Radiation Oncology Rochester, Minnesota and Public Health University of Michigan Madison, Wisconsin Ann Arbor, Michigan Ezra Hahn, MD, FRCPC Radiation Oncologist Joseph M. Herman, MD, MSc, MSHCM Carolyn R. Freeman, MBBS, FRCPC, Department of Radiation Oncology Professor FASTRO Princess Margaret Cancer Centre Department of Radiation Oncology Professor of Oncology and Pediatrics Sunnybrook Health Sciences Centre of the The University of Texas MD Anderson Mike Rosenbloom Chair of Radiation University of Toronto Cancer Center Oncology Toronto, Ontario, Canada Houston, Texas McGill University Montreal, Quebec, Canada Matthew D. Hall, MD, MBA Michael G. Herman, PhD Radiation Oncology Professor Miami Cancer Institute Department of Radiation Oncology Baptist Health South Florida Mayo Clinic College of Medicine and Miami, Florida Science, Mayo Clinic Rochester, Minnesota Downloaded for [email protected] upr07 ([email protected]) at Autonomous University of Guadalajara from ClinicalKey.com by Elsevier on April 23, 2020. For personal use only. No other uses without permission. Copyright ©2020. Elsevier Inc. All rights reserved. CONTRIBUTORS xi Caroline L. Holloway, MD, FRCPC Patricia A. Hudgins, MD Brian D. Kavanagh, MD Clinical Assistant Professor Professor Professor and Chair Department of Radiation Oncology Department of Radiology and Imaging Department of Radiation Oncology BC Cancer Agency, Vancouver Island Centre Sciences University of Colorado School of Medicine Victoria, British Columbia, Canada Emory University School of Medicine University of Colorado Comprehensive Atlanta, Georgia Cancer Center Bradford S. Hoppe, MD, MPH Aurora, Colorado Associate Professor Christine A. Iacobuzio-Donahue, MD, Department of Radiation Oncology PhD Kara M. Kelly, MD Mayo Clinic College of Medicine and Director, David M. Rubenstein Center for Waldemar J. Kaminski Endowed Chair of Science, Mayo Clinic Pancreatic Cancer Research Pediatrics Jacksonville, Florida Department of Radiation Oncology Department of Pediatric Oncology Memorial Sloan Kettering Cancer Center Roswell Park Cancer Institute Michael R. Horsman, PhD, DMSc New York, New York Division Chief, Pediatric Hematology/ Professor Oncology and Research Professor Department of Experimental Clinical Andrei Iagaru, MD Department of Pediatrics Oncology Assistant Professor University of Buffalo School of Medicine Aarhus University Hospital Department of Radiology and Biomedical Sciences Aarhus, Denmark Division of Nuclear Medicine and Molecular Buffalo, New York Imaging Janet K. Horton, MD Stanford University Amir H. Khandani, MD Adjunct Associate Professor Stanford, California Associate Professor of Radiology Duke University Medical Center Chief, Division of Nuclear Medicine Durham, North Carolina Nicole M. Iñiguez-Ariza, MD Department of Radiology Division of Endocrinology, Diabetes, University of North Carolina at Chapel Hill Julie Howle, MBBS, MS, FRACS, FACS Metabolism, and Nutrition Chapel Hill, North Carolina Surgical Oncologist Mayo Clinic College of Medicine and Westmead Private Hospital Science, Mayo Clinic Deepak Khuntia, MD Westmead, New South Wales, Australia; Rochester, Minnesota; Vice President, Medical Affairs Clinical Senior Lecturer Department of Endocrinology and Oncology Systems Department of Surgery Metabolism Varian Medical Systems, Inc. The University of Sydney Instituto Nacional de Ciencias Médicas y Palo Alto, California; Sydney, New South Wales, Australia Nutrición Salvador Zubirán Radiation Oncologist Mexico City, Mexico Valley Medical Oncology Consultants Brian A. Hrycushko, PhD Pleasanton, California Assistant Professor Jedediah E. Johnson, PhD Department of Radiation Oncology Assistant Professor Ana Ponce Kiess, MD, PhD UT Southwestern Medical Center Department of Radiation Oncology Assistant Professor Dallas, Texas Mayo Clinic College of Medicine and Departments of Radiation Oncology and Science, Mayo Clinic Molecular Radiation Sciences David Hsu, MD, PhD Rochester, Minnesota Johns Hopkins University School of William Dalton Family Assistant Professor Medicine Division of Medical Oncology Joseph G. Jurcic, MD Baltimore, Maryland Department of Internal Medicine Professor of Medicine Duke Cancer Institute Director, Hematologic Malignancies Section Joseph K. Kim, MD Duke University Department of Medicine Resident Physician Durham, North Carolina Columbia University Irving Medical Center Department of Radiation Oncology Attending Physician New York University Chen Hu, PhD New York-Presbyterian Hospital/Columbia New York, New York Assistant Professor of Oncology University Irving Medical Center Division of Biostatistics and Bioinformatics New York, New York Susan J. Knox, MD, PhD Sidney Kimmel Comprehensive Cancer Associate Professor Center John A. Kalapurakal, MD, FACR, Department of Radiation Oncology Johns Hopkins University FASTRO Stanford University Baltimore, Maryland Professor Stanford, California Statistics and Data Management Center Department of Radiation Oncology NRG Oncology Northwestern University Wui-Jin Koh, MD Chicago, Illinois Senior Vice President and Chief Medical Officer National Comprehensive Cancer Network (NCCN) Philadelphia, Pennsylvania Downloaded for [email protected] upr07 ([email protected]) at Autonomous University of Guadalajara from ClinicalKey.com by Elsevier on April 23, 2020. For personal use only. No other uses without permission. Copyright ©2020. Elsevier Inc. All rights reserved.
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