Guide to Neuropsychiatric Therapeutics PDF
Preview Guide to Neuropsychiatric Therapeutics
Guide to Neuropsychiatric Therapeutics Guide to Neuropsychiatric Therapeutics C. Edward Coffey, , MD FANPA KathleenandEarlWardChairofPsychiatry, VicePresident,BehavioralHealthServices, HenryFordHealthSystem; ProfessorofPsychiatryandofNeurology, WayneStateUniversity,HenryFordCampus, Detroit,Michigan Thomas W. McAllister, , MD FANPA ProfessorofPsychiatry,Director,Neuropsychiatry, Dartmouth-HitchcockMedicalCenter, Lebanon,NewHampshire Jonathan M. Silver, , MD FANPA ClinicalProfessorofPsychiatry,NewYork UniversitySchoolofMedicine,NewYork,NewYork AcquisitionsEditor:CharlesW.Mitchell ManagingEditor:LisaKairis ProjectManager:BridgettDougherty AssociateDirectorofMarketing:AdamGlazer DesignCoordinator:DougSmock ProductionServices:LaserwordsPrivateLimited,Chennai,India Printer:R.R.Donnelley,Crawfordsville 2007byLIPPINCOTTWILLIAMS&WILKINS,aWoltersKluwerbusiness 530WalnutStreet Philadelphia,PA19106USA LWW.com Allrightsreserved.Thisbookisprotectedbycopyright.Nopartofthisbookmaybereproducedinany formorbyanymeans,includingphotocopying,orutilizedbyanyinformationstorageandretrieval systemwithoutwrittenpermissionfromthecopyrightowner,exceptforbriefquotationsembodiedin criticalarticlesandreviews.Materialsappearinginthisbookpreparedbyindividualsaspartoftheir officialdutiesasU.S.governmentemployeesarenotcoveredbytheabove-mentionedcopyright. PrintedintheUSA LibraryofCongressCataloging-in-PublicationData Guidetoneuropsychiatrictherapeutics/[editedby]C.EdwardCoffey, ThomasW.McAllister,JonathanSilver. p.;cm. Includesbibliographicalreferencesandindex. ISBN13:978-0-7817-9935-5 ISBN10:0-7817-9935-X 1.Neuropsychiatry.2.Neurobehavioraldisorders. I.Coffey,C. Edward,1952- . II.McAllister,ThomasW. III.Silver, JonathanM., 1953- . [DNLM: 1.NeurologicManifestations. 2.MentalDisorders—physio- pathology. 3.MentalDisorders—therapy. 4.NervousSystemDiseases —physiopathology. 5.NervousSystemDiseases—therapy. 6.Neuro- psychology—methods. WL340G9462007] RC341.G8522007 616.89—dc22 2006028360 Carehasbeentakentoconfirmtheaccuracyoftheinformationpresentedandtodescribegenerally acceptedpractices.However,theauthors,editors,andpublisherarenotresponsibleforerrorsor omissionsorforanyconsequencesfromapplicationoftheinformationinthisbookandmakeno warranty,expressedorimplied,withrespecttothecurrency,completeness,oraccuracyofthecontents ofthepublication.Applicationofthisinformationinaparticularsituationremainstheprofessional responsibilityofthepractitioner. Theauthors,editors,andpublisherhaveexertedeveryefforttoensurethatdrugselectionanddosage setforthinthistextareinaccordancewithcurrentrecommendationsandpracticeatthetimeof publication.However,inviewofongoingresearch,changesingovernmentregulations,andtheconstant flowofinformationrelatingtodrugtherapyanddrugreactions,thereaderisurgedtocheckthepackage insertforeachdrugforanychangeinindicationsanddosageandforaddedwarningsandprecautions. Thisisparticularlyimportantwhentherecommendedagentisaneworinfrequentlyemployeddrug. SomedrugsandmedicaldevicespresentedinthispublicationhaveFoodandDrugAdministration (FDA)clearanceforlimiteduseinrestrictedresearchsettings.Itistheresponsibilityofthehealthcare providertoascertaintheFDAstatusofeachdrugordeviceplannedforuseintheirclinicalpractice. Topurchaseadditionalcopiesofthisbook,callourcustomerservicedepartmentat(800)638-3030or faxordersto(301)223-2320.Internationalcustomersshouldcall(301)223-2300. VisitLippincottWilliams&WilkinsontheInternet:atLWW.com.LippincottWilliams&Wilkins customerservicerepresentativesareavailablefrom8:30amto6pm,EST. 10 9 8 7 6 5 4 3 2 1 To our patients, whose lives we are dedicated to improving through excellence in the science and art of health care and healing Contents Contributors ix Preface xiii 1 ApathyandRelatedDisordersofDiminishedMotivation 1 JamesD.Duffy 2 Delirium 14 WalterKnysz,III,C.EdwardCoffey 3 CognitiveImpairment 24 DavidB.Arciniegas,ThomasW.McAllister,DanielI.Kaufer 4 GlobalCognitiveImpairment:TheDementias 79 StevenA.Rogers,PoH.Lu,JeffreyL.Cummings 5 DisturbancesofMood,Affect,andEmotion 109 C.EdwardCoffey 6 Anxiety 138 RobertG.Robinson,JessG.Fiedorowicz 7 PsychosisinNeuropsychiatricDisorders 170 LauraA.Flashman,ThomasW.McAllister 8 NonepilepticSeizures 216 KarenE.Anderson 9 ParkinsonianMovementDisorders 226 EdwardC.Lauterbach 10 HyperkineticMovementDisorders 243 EdwardC.Lauterbach vii viii Contents 11 ChangesinPersonality 267 JohnJ.Campbell,III 12 Pain 286 KevinJ.Black 13 SleepDisorders 301 SheldonBenjamin 14 UnexplainedNeuropsychiatricSymptoms 335 FredOvsiew,JonathanM.Silver 15 IntellectualDisabilitiesofDevelopmentalOnset 348 AlyaReeve 16 AgitationandAggression 371 JonathanM.Silver,StuartC.Yudofsky,KarenE.Anderson 17 ForensicNeuropsychiatry 388 JamesR.Merikangas 18 RationalApproachtoBrainImagingandElectrophysiology 402 RobinA.Hurley,NashN.Boutros,KatherineH.Taber Index 429 Contributors KarenE.Anderson,MD NashN.Boutros,MD AssistantProfessorofPsychiatry Professor,DepartmentofPsychiatry andNeurology,DivisionofPsychiatry andBehavioralNeurosciences andNeurosciences,University andNeurology,WayneStateUniversity, ofMarylandMedicalCenter, SchoolofMedicine, Baltimore,Maryland Detroit,Michigan DavidB.Arciniegas,MD Director,NeurobehavioralDisorders Program,AssociateProfessorofPsychiatry C.EdwardCoffey,MD andNeurology,UniversityofColorado KathleenandEarlWardChair SchoolofMedicine,Denver,Colorado; ofPsychiatry,VicePresident,Behavioral Co-MedicalDirector,BrainInjury HealthServices,HenryFordHealth RehabilitationUnit,HealthONESpalding System;ProfessorofPsychiatryand RehabilitationHospital, ofNeurology,WayneStateUniversity, Aurora,Colorado HenryFordCampus, Detroit,Michigan SheldonBenjamin,MD Professor,DepartmentofPsychiatryand Neurology,UniversityofMassachusetts MedicalSchool;DirectorofPsychiatric JohnJ.Campbell,MD EducationandTraining,Director MedicalDirectorofHospitalPsychiatric ofNeuropsychiatry,Department Services,MaineMedicalCenter;Clinical ofPsychiatry,UMassMemorial AssociateProfessorofPsychiatry, Healthcare,Inc., UniversityofVermont Worcester,Massachusetts CollegeofMedicine, Portland,Maine KevinJ.Black,MD AssociateProfessor,Department ofPsychiatry,Neurology,Radiology, andNeurobiology,WashingtonUniversity JeffreyL.Cummings,MD SchoolofMedicine;Attending ProfessorofNeurologyandPsychiatry, Psychiatrist,DepartmentofPsychiatry, DepartmentofNeurology,University Barnes-JewishHospital, ofCalifornia,LosAngeles, St.Louis,Missouri LosAngeles,California ix x Contributors JamesD.Duffy,MD,FANPA WalterKnysz,III,MD ProfessorofPsychiatryinPublicHealth, Director,Consultation-LiaisonPsychiatry, WeillMedicalCollegeofCornell AssistantDirector,BrainStimulation University;Director,Institute Service,DepartmentofBehavioralHealth, forPalliativeMedicine, HenryFordHealthSystem, TheMethodistHospital, Detroit,Michigan Houston,Texas EdwardC.Lauterbach,MD,FANPA, JessG.Fiedorowicz,MD DFAPA FellowAssociate,Department Chief,DivisionofAdultandGeriatric ofPsychiatry,TheUniversityofIowa; Psychiatry,DepartmentofPsychiatry FellowAssociate,Department andBehavioralSciences,Mercer ofPsychiatry,TheUniversityofIowa UniversitySchoolofMedicine;Medical HospitalsandClinics, Staff,DepartmentofPsychiatry,The IowaCity,Iowa MedicalCenterofCentralGeorgia, Macon,Georgia LauraA.Flashman,PhD,ABPP-Cn AssociateProfessor,Department PoH.Lu,PsyD ofPsychiatry,DartmouthMedicalSchool, AssistantClinicalProfessor,Department Dartmouth-HitchcockMedicalCenter, ofNeurology,UniversityofCalifornia Lebanon,NewHampshire;Co-Director, atLosAngeles, NeuropsychologyProgram, LosAngeles,California Dartmouth-HitchcockMedicalCenter andNewHampshireHospital, Concord,NewHampshire ThomasW.McAllister,MD,FANPA ProfessorofPsychiatry, Director,Neuropsychiatry RobinA.Hurley,MD,FANPA Dartmouth-HitchcockMedicalCenter, AssociateChiefofStaff,MentalHealth& Lebanon,NewHampshire BehavioralSciences;Co-Directorfor Education,VeteransIntegratedService Network6MentalIllnessResearch, JamesR.Merikangas,MD,FACP, Education,andClinicalCenter,Salisbury FANPA VeteransAffairsMedicalCenter, ClinicalProfessorofPsychiatry Salisbury,NorthCarolina;Associate andBehavioralNeuroscience,Department Professor,DepartmentofPsychiatry ofPsychiatry,GeorgeWashington andRadiology,WakeForestUniversity University,Washington,DC;Attending SchoolofMedicine,Winston-Salem,North inPsychiatryandNeurology,Department Carolina;ClinicalAssociateProfessor, ofPsychiatry,SuburbanHospital, DepartmentofPsychiatry, Bethesda,Maryland BaylorCollegeofMedicine, Houston,Texas FredOvsiew,MD Professor,DepartmentofPsychiatry, DanielI.Kaufer,MD UniversityofChicago;MedicalDirector, AssociateProfessor,Director,Memory AdultInpatientPsychiatry;Chief,Clinical andCognitiveDisorders,Department Neuropsychiatry,Department ofNeurology,TheUniversityofNorth ofPsychiatry,Universityof CarolinaatChapelHill, ChicagoHospitals, ChapelHill,NorthCarolina Chicago,Illinois
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