Growth Factors and Alzheimer’s Disease PDF
Preview Growth Factors and Alzheimer’s Disease
RESEARCH AND PERSPECTIVES IN ALZHEIMER'S DISEASE Fondation Ipsen Editor Yves Christen, Fondation Ipsen, Paris (France) Editorial Board Yves Agid, H6pital Pi tie Salpetriere, Paris (France) Albert Aguayo, The Montreal General Hospital, Montreal (Canada) Luigi Amaducci, University of Florence, Florence (Italy) Brian H. Anderton, Institute of Psychiatry, London (GB) Raymond T Bartus, Cortex, Irvine (USA) Anders BjOrklund, University of Lund (Sweden) Floyd Bloom, Scripps Clinic and Research Foundation, La Jolla (USA) Fran{:ois Boller, Inserm U 324, Paris (France) Carl Cotman, University of California, Irvine (USA) Peter Davies, Albert Einstein College of Medicine, New-York (USA) Andre Delacourte, Inserm U 16, Lille (France) Steven Ferris, New York University Medical Center, New-York (USA) Jean-Fran{:ois Fon cin , H6pital Pitie Salpetriere, Paris (France) Fran{:ois Forette, H6pital Broca, Paris (France) Fred Gage, University of California, La Jolla (USA) Carleton D. Gajdusek, National Institute of Health, Bethesda (USA) George G. Glenner, University of California, La Jolla (USA) Dmitry Goldgaber, State University of New York Stone Brook (USA) John Hardy, St Mary's Hospital, Medical School, London (GB) Jean-Jaques Hauw, H6pital Pitie Salpetriere, Paris (France) Robert Katzman, University of California, La Jolla (USA) Claude Kordon, Inserm U 159, Paris (France) Kenneth K. Kosik, Harvard Medical School Center for Neurological Diseases and Brigham and Women's Hospital, Boston (USA) Yvon Lamour, Inserm U 161, Paris (France) Jacques Mallet, CNRS, Gif-sur-Yvette (France) Colin L. Masters, University of Melbourne, Parkville (Australia) Stanley I. Rapoport, National Institute on Aging, Bethesda (USA) Andre Rascol, H6pital Purpan, Toulouse (France) Barry Reisberg, New York University Medical Center, New York (USA) Dennis J Selkoe, Harvard Medical School Center for Neurological Diseases and Brigham and Women's Hospital, Boston (USA) Michael L. Shelanski, Columbia University, New-York (USA) Jean-Louis Signoret, H6pital Pitie Salpetriere, Paris (France) Pierre-Marie Sinet, H6pital Necker, Paris (France) Peter St George Hyslop, Massachussetts General Hospital, Boston (USA) Robert Terry, University of California, La Jolla (USA) Henry Wisniewski, Institute for Basic Research in Development Disabilities, Staten Island (USA) Edouard Zarijian, Centre Hospitalier Universitaire, Caen (France). F. Hefti Ph. Brachet B. Will Y. Christen (Eds.) Growth Factors and Alzheitner's Disease Springer-Verlag Berlin Heidelberg New York London Paris Toyko Hong Kong Barcelona Hefti, Franz, Ph. D. Andrus Gerontology Center University of Southern California Los Angeles, CA 90089 USA Brachet, Philippe, Ph. D. INSERM U 298 Centre Hospitalier Regional et Universitaire F-49033 Angers Cedex Will, Bruno, Ph. D. Departement de Neurophysiologie et de Biologie des Comportements Centre de Neurochimie du C.N.R.S. 12 rue Goethe F-67000 Strasbourg Christen, Yves, Ph.D. Fondation IPSEN pour la Recherche Therapeutique 30, rue Cambro nne F-75737 Paris Cedex ISBN-13: 978-3-642-46724-0 e-ISBN-13: 978-3-642-46722-6 DOl: 10.1007/978-3-642-46722-6 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. Duplication of this pUblication or parts thereof is only permitted under the provi sions of the German Copyright Law of September 9, 1965, in its version of June 24, 1985, and a copyright fee must always be paid. Violations fall under the prosecution act of the German Copyright Law. © Springer-Verlag Berlin Heidelberg 1991 Softcover reprint of the hardcover 1st edition 1991 The use of general descriptive names, trade names, trade marks, etc. in this publication, even if the former are not especially identified, is not to be taken as a sign that such names, as understood by the Trade Marks and Merchandise Marks Act, may accordingly be used free ly hy anyone. Product Liability: The publisher can give no guarantee for information about drug dosage and application thereof contained in this book. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature. 2127/3140/543210 - Printed on acid-free paper Preface This volume contains the proceedings of the sixth Colloque M6decine et Re cherche organized by the Fondation Ipsen pour la Recherche Therapeutique and devoted to Alzheimer's disease. It was held in Strasbourg on April 25, 1990 and dedicated to growth factors and Alzheimer's disease. The proceedings of the previous meetings were published as the present one in the same series: Immunology and Alzheimer's disease (A. Pouplard-Barthelaix, J. Emile, Y Christen eds., 1988), Genetics and Alzheimer's disease (P.-M. Sinet, Y Lamour, Y Christen eds., 1988), Neuronal grafting and Alzheimer's disease (F. Gage, A. Privat, Y Christen eds., 1989), Biological markers and Alzheimer's disease (F. Boller, R. Katzman, A. Rascol, J.-L. Signoret, Y Christen eds., 1989), Imaging, cerebral topography and Alzheimer's disease (S. I. Rapoport, H. Petit, D. Leys, Y Christen eds., 1990). The next meeting of the series entitled Neurophilosophy and Alzheimer's disease was being held in La Jolla (California, USA) on January 11,1991. The proceed ings will be published this year. Yves Christen Fondation Ipsen Acknowledgements. The editors wish to express their gratitude to M. Sensenbren ner (Strasbourg), A. Bjorklund (Lund), R. Terry (La Jolla) for their collaboration as chairmen for the meeting, G. Vincendon, dean of the Facult6 de M6decine de Strasbourg, who made the introductive talk, Mary Lynn Gage for her editorial assistance and Jacqueline Mervaillie for the organization of the meeting. Contents Neurotrophic Factors and Neurodegenerative Diseases F Hefti and B. Knusel ............. . Survival, Regrowth, and Reconnection of Injured Retinal Ganglion Cells A. J Aguayo, M. P. Villegas-Perez, L. McKerracher, M. Vidal-Sanz, D. Carter, apd G. M. Bray ................ . 15 Localizing Expression of the Three Members of the Nerve Growth Factor Family to Neurons in the Brain L. Olson, C. Wetmore, P. Ernfors, T Ebendal, and H. Persson 29 Nerve Growth Factor: Studies Addressing its Expression and Actions in the Central Nervous System F M. Longo and W C. Mobley 39 Nerve Growth Factor Gene Expression in Actively Growing Brain Glia B. Lu, M. Yokoyama, C. F Dreyfus, and I. B. Black ....... . 61 Human Nerve Growth Factor Receptor Expression in the CNS of Transgenic Mice N. Pati!, E. Lacy, and M. V. Chao ........... . 62 Involvement of Protein Kinase C in the Regulation of Nerve Growth Factor Synthesis: A Possible Cause of Impaired Trophic Supply in Alzheimer's Disease? P. Brachet, R. Houlgatte, I. Neveu, D. MacGrogan, and D. Wion 73 Distribution and Characterization of ~-Nerve Growth Factor Receptors in Alzheimer's Disease S. J Allen, J J S. Treanor, S. H. MacGowan, G. K. Wilcock, and D. Dawbarn ..................... . 81 Regulation of Nerve Growth Factor Synthesis in the Central Nervous System by Cytokines and Implications for the Treatment of Alzheimer's Disease D. Lindholm, F Zafra, and H. Thoenen ...... . 98 Nerve Growth Factor Expression and Function in the CNS F H. Gage, M. Tuszynski, K. Yoshida, and G. Higgins 106 VIII Contents Nerve Growth Factor and Behavioral Recovery After Brain Damage in Rats B. Will, V. Pal/age, and F Eclancher 117 Functional Impairments that Develop in Nerve Growth Factor-Sensitive Neuronal Projections in the PNS and CNS of Aged Rats Are Ameliorated by Dietary Interventions 1. Diamond, M. Cameron, and B. Cassells ....... . 131 Morphological and Behavioral Effects of Basic Fibroblast Growth Factor and Heparin on Transplanted Fetal Dopaminergic Neurons and Astrocytes in the Denervated Rat Caudate-Putamen M.1. Dolleman-Van Der Weel, A. Nijssen, 1. De Vente, F C. S. Ramaekers, B. Cordell, F Fuller, and H. W M. Steinbusch 149 Acidic Fibroblast Growth Factor Localization and Basic Fibroblast Growth Factor Binding Sites in the Eye and Optic Nerve B. A. Faucheux, C. Dupuis, P. Delaere, D. Raulais, G. Soubrane, M. Vigny, 1. 1. Hauw, Y Courtois, and 1. C. Jeanny ..... 165 Synthetic Peptide Agonists and Antagonists of Basic Fibroblast Growth Factor: Increasing Cellular Specificity of a Multifunctional Growth Factor P. A. Walicke and C. Harrison 175 ACTH(4 Analog Potentiates Cognitive and Morphological Recovery -10) After Frontal Cortex Lesions in Adult Rats D. G. Stein, S. W Hoffman, and M. 1. Attella 193 Effects of Neurotrophic Factors on the Secretion and Metabolism of the Alzheimer Amyloid Precursor N. K. Robakis, K. Sambamurti, 1. P. Anderson, P. Mehta, and L. M. Refolo ................... . 208 Nerve Growth Factor Induces Differential Splicing of ~-Amyloid Precursor mRNAs in the PC12 Cell Line C. 1. Smith, D. D. Wion, and P. Brachet 216 The Role of Misdirected Plasticity in Plaque Biogenesis and Alzheimer's Disease Pathology C. W Cotman, B. 1. Cummings, and 1. S. Whitson 222 The Neuritic Dystrophy of Alzheimer's Disease: Degeneration or Regeneration? K. S. Kosik 234 Subject Index 241 Contributors Aguayo, A. J Centre for Research in Neurosciences, Montreal General Hospital, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4, Canada Allen, S. J Department of Medicine (Care of the Elderly), University of Bristol, Bristol Royal Infirmary, Bristol BS2 8HW, UK Anderson, J P. Department of Psychiatry and Neurobiology Center, The Mount Sinai School of Medicine of the City University of New York, One Gustave Levy Place, Box 1229, New York, NY 10029, USA Attella, M. J Worcester Foundation for Experimental Biology, 222 Maple Avenue, Shrewsbury, MA 01545, USA Black, I. B. The New York Hospital Cornell Medical Center, Department of Neurology, 515 E 71 St., New York, NY 10021, USA Brachet, P. INSERM U 298, Centre Hospitalier Regional et U niversitaire, 49033 Angers Cedex, France Bray, G. M. Centre for Research in Neuroscience, Montreal General Hospital, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4, Canada Cameron, M. Mc Master University, Faculty of Health Sciences, Department of Biomedical Sciences, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada Carter, D. Centre for Research in Neurosciences, Montreal General Hospital, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4, Canada X Contributors Cassells, B. Mc Master University, Faculty of Health Sciences, Department of Biomedical Sciences, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada Chao, M. V. Department of Cell Biology and Anatomy, Division of Hematology/Oncology, Cornell University Medical College, 1300 York Avenue, New York, NY 10021, USA Cordell, B. California Biotechnology, Inc., 2450 Bayshore Parkway, Mountain View, CA 94043, USA Cotman, C. W Department of Psychobiology, University of California, Irvine, CA 92717, USA Courtois, Y. Unite de Recherches Gerontologiques INSERM (U 118), Affiliee au CNRS, and Centre de Gerontologie de l'Association Claude Bernard, 29 rue Wilhem, 75016 Paris, France Cummings, B. J. Department of Psychobiology, University of California, Irvine, CA 92717, USA Dawbarn, D. Department of Medicine (Care of the Elderly), University of Bristol, Bristol Royal Infirmary, Bristol BS2 8HW, UK Delaere, P. a Laboratoire de Neuropathologie R. Escourolle, Formation Associee I' Asso ciation Claude Bernard, Hopital de la Salpetriere, 47 Boulevard de I'Hopital, 75013 Paris, France Diamond, J. Mc Master University, Faculty of Health Sciences, Department of Biomedical Sciences, 1200 Main Street West. Hamilton, Ontario L8N 3Z5, Canada Dolleman-Van Der Weel, M. J. Department of Pharmacology, Free University, van der Boechorstraat 7, 1081 BT Amsterdam, The Netherlands Dreyfus, C. F. The New York Hospital Cornell Medical Center, Department of Neurology, 515 E 71 St., New York, NY 10021, USA Contributors XI Dupuis, C. Unite de Recherches Gerontologiques INSERM (U 118), Affiliee au CNRS, and Centre de Gerontologie de l' Association Claude Bernard, 29 rue Wilhem, 75016 Paris, France Ebendal, T. Developmental Biology, Biomedical Center, Uppsala University, Uppsala, Sweden Eclancher, F. Departement de Neurophysiologie et Biologie des Comportements, Centre de Neurochimie du CNRS, 5, rue Blaise Pascal, 67084 Strasbourg Cedex, France Ernfors, P. Medical Chemistry II, Laboratory of Molecular Neurobiology, Karolinska Institutet, 10401 Stockholm, Sweden Faucheux, B. A. Unite de Recherches Gerontologiques INSERM (U 118), Affiliee au CNRS, and Centre de Gerontologie de l' Association Claude Bernard, 29 rue Wilhem, 75016 Paris, France Fuller, F. California Biotechnology Inc., 2450 Bayshore Parkway, Mountain View, CA 94043, USA Gage, F. H. Department of Neurosciences, University of California, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0624, USA Harrison, C. Department of Neuroscience, M. 008 University of California, La Jolla, CA 92092, USA Hauw, J. J. a Laboratoire de Neuropathologie R. Escourolle, Formation Associee l'Asso ciation Claude Bernard, Hopital de la Salpetriere, 47 Boulevard de I'Hopital, 75013 Paris, France Hefti, F. Andrus Gerontology Center, University of Southern California, University Park - MC 0191, Los Angeles, CA 90089, USA Higgins, G. A. Gerontology Research Center, Laboratory of Biological Chemistry, 4940 Eastern Avenue, Baltimore, MD 21224, USA
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