Growth, Cancer, and the Cell Cycle: The Molecular, Cellular, and Developmental Biology PDF
Preview Growth, Cancer, and the Cell Cycle: The Molecular, Cellular, and Developmental Biology
Growth, Cancer, and the Cell Cycle The Molecular, Cellular, and Developmental Biology Experimental Biology and Medicine Growth, Cancer and the Cell Cycle, edited by Philip Skehan and Susan J. Friedman, 1984 Ir Genes: Past, Present, and Future, edited by Carl W. Pierce, Susan E. Cullen, Judith A. Kapp, Benjamin D. Schwartz, and Donald C. Shreffler, 1983 Methods in Protein Sequence Analysis, edited by Marshall Elzinga, 1982 Inflammatory Diseases and Copper, edited by John R. J. Sorenson, 1982 Membrane Fluidity: Biophysical Techniques and Cellular Regulation, edited by Morris Kates and Amis Kuksis, 1980 GROWTH, CANCER, AND THE CELL CYCLE The Molecular, Cellular, and Developmental Biology Edited by PHILIP SKEHAN and SUSAN J. FRIEDMAN The University of Calgary Calgary, Alberta, Canada Humana Press . Clifton, New Jersey DEDICATION This book is dedicated to the memory of Jacob Duerksen, a friend, colleague, and fellow member of The International Cell Cycle Society who contributed much to the organization of this conference. His un timely death greatly saddened those of us who knew him. Library of Congress Cataloging in Publication Data International Cell Cycle Conference (10th: 1984 : Banff National Park) Growth, cancer, and the cell cycle. (Experimental biology and medicine) Includes index. 1. Cells-Growth-Congresses 2. Cell proliferation Congresses. 3. Cell cycle-Congresses. 4. Cancer cells Growth-Congresses. I. Skehan, Philip. II. Friedman, Susan J. Ill. Title. IV. Series. [DNLM: 1. Cell Cycle. 2. Cell Transformation. Neoplastic. QZ 202 G884] QH6051525 1984 599'031 84-22468 lSBN-l3: 978-1-4612-9599-0 e-lSBN-l3: 978-1-4612-5178-1 DOl: 10.1007/978-1-4612-5178-1 © 1984 The Humana Press Inc. Softcover reprint of the hardcover 1st edition 1984 Crescent Manor PO Box 2148 Clifton, NJ 07015 All rights reserved No part of this book may be reproduced. stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise without written permission from the Publisher. PREFACE Cell growth, one of the most fundamental of biological processes, has long been among the least understood. On April 24-28, 1984 sci entists convened from around the world in Canada's Banff National Park for The International Cell Cycle Society's 10th Conference. Their purpose was to evaluate recent developments in the field of cell prolif eration and to explore the interrelationship between cell growth, de velopment, and differentiation, and proliferative diseases such as can cer. Growth, Cancer, and the Cell Cycle collects those conference papers that present the most recent advances in this field. The first section of the book is Gene Expression and Development During Growth. It examines the structure and function of chromatin, DNA unwinding proteins, and nonhistone nuclear proteins, then ex plores transcriptional, translational, and post-translational regulation during the cell cycle and the interrelationship and coordinate regula tion of cell growth, differentiation, and gene expression. The second section, Growth Activation and Dormancy, focuses upon the events that occur during the transition between active cell growth and proliferative quiescence. The role of DNA strand breaks, protein kinase activity, growth regulatory factors, and the cytoskeleton are examined. Section three discusses The Topology of the Cell Cycle. It reviews genetic approaches for determining the sequence of events and cau sality relationships that comprise and coordinate the many separate processes involved in cell cycle progression and describes the use of multipara meter flow cytometry to characterize the mammalian cell cy cle and intracellular metabolic and transitional growth states. The final section of the book, Neoplastic Transformation, explores the role of tumor cell heterogeneity in circulatory metastasis and of ac tivator RNA in cellular phenotype transformation, presents the latest advances in the establishment of normal and neoplastic gastrointesti nal cell lines, describes new methods for cancer diagnosis and of cell cycle deconvolution by image analysis, and critically evaluates the concept that cancer is a disease of abnormal cell growth. Philip Skehan Susan J. Friedman v CONTENTS Preface ......................................................... v Acknowledgments .............................................. xiv List of Contributors ............................................... x I. GENE EXPRESSION AND DEVELOPMENT DURING GROWTH Structures Inherent to Chromatin Active in Transcription and Replication . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. ......... 3 A. T. Annunziato. R. D. Smith. S. K. Hanks. and R. L. Seale Chromatin Changes in Skeletal Muscle Cells During the Fusion to Myotubes ............................................... 27 O. Torok and H. Altmann A Eucaryotic Protein with Helix Destabilizing Activity and its Homology to LDH ......................................... 41 Gordhan L. Patel. Sesha Reddigari. Kenneth R. Williams. Edward Baptist. Peter E. Thompson and Sangram S. Sisodia Role of Nonhistone Protein Phosphorylation in the Regulation of Mitosis in Mammalian Cells. . . . . . . . . . . . . . . . 51 Ramesh C. Adlakha. Chintamin G. Sahasrabuddhe. David A. Wright. Helene Bigo. and Potu N. Rao Nonhistone Proteins, Free Radical Defenses and Acceleration of Spherulation in Physarum.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 71 C. Nations. R. G. Allen. and J. McCarthy Coordinate and Non-Coordinate Regulation of Histone mRNAs During Myoblast Growth and Differentiation. . . . . . . . . . . . . . . . . . .. 79 R. Curtis Bird. Fred A. Jacobs. and Bruce H. Sells The Receptor Binding of Insulin and Poly(ADP-Ribosel Synthesis During the Cell Cycle . . . . . . . . . . . . . . . . . . . . .. ....... 87 H. Altmann. O. Torok. P. Kovacs. and G. Csaba A Novel Method of Translation in Fibroin .......................... 99 G. C. Candelas. N. Ortiz. A. Ortiz. T. M. Candelas. and O. M. Rodnguez Tubulin and Actin Gene Expression DUring the Cell Cycle ........... 107 S. Zimmerman. A. M. Zimmerman. J. Thomas. and I. Ginzburg vii viii Contents II. GROWTH ACTIVATION AND DORMANCY Regulation of Nuclear and Mitochondrial RNA Production After Serum Stimulation of Quiescent Mouse Cells. . . . . . . . . . . . . . . . .. 117 Dylan R. Edwards and David T. Denhardt A Decrease in the Steady Level of DNA Strand Breaks as a Factor in the Regulation of Lymphocyte Proliferation ............ 125 W. L. Greer and J. G. Kaplan 70 K Dalton Protein Synthesis and Heat Sensitivity of Chromatin Structure: Dependence on Cell Cycle. . . . . . . . . . . . . . . 135 Roeland van Wijk and Wlel Geilenkirchen Involvement of Protein Kinases in Mitotic-Specific Events ............ 143 Margaret S. Halleck, Katherine Lumley-Sapanskl, Jon A. Reed, and Robert A. Schlegel Protein Kinase Activity in Lymphocytes; Effects of Concanavalin A and A Phorbol Ester ...................................... 151 Anand P. Iyer, Sharon A. Pishak, Marion J. Sniezek, and Andrea M. Mastro Effect of Gossypol on DNA Synthesis in Mammalian Cells. . . . . . . . . .. 159 Potu N. Rao, Larry Rosenberg, and Ramesh C. Adlakha Growth Activation in Adult Rat Hepatocytes ....................... 169 N. L. R. Bucher, W. E. Russell, and J. A. McGowan Isolation and Characterization of a Growth Regulatory Factor from 3T3 Cells. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 177 John L. Wang and Yen-Mlng Hsu Changes in AdheSion, Nuclear Anchorage, and Cytoskeleton During Giant Cell Formation ................................ 187 Susan J. Friedman, Catharine Dewar, James Thomas, and Philip Skehan III. TOPOLOGY OF THE CELL CYCLE The Gl Cell Cycle Interval in Yeasts .............................. 205 R. A. Singer and G. C. Johnston Coordination of Growth With Cell Division in Yeasts ............... 213 G. C. Johnston and R. A. Singer Changed Division Response Mutants Function as Allosuppressors ............................................ 221 Paul G. Young and Peter A. Fantes Molecular and Cell Biology of Cell Cycle Progression Revealed by Mammalian Cells Temperature-Sensitive in DNA Synthesis ................................................. 229 Rose Sheinin Metabolic and Kinetic Compartments of the Cell Cycle Distinguished by Multiparameter Flow Cytometry .............. 249 Zbigniew Darzynkiewlcz Contents ix IV. NEOPLASTIC TRANSFORMATION Cancer Cell Heterogeneity in Resistance to Mechanical Trauma in the Microcirculation as Part of Metastasis. . . . . . . . . . . . . . . . . . . . 281 Helena Gabor Expression of an "Activator" RNA Hybridizable to the SV40 Promotor Correlates with the Transformed Phenotype of Mouse and Human Cells .................................... 289 Margarida Krause. Jolanta Kurz. and Uik Sohn Gastrointestinal Cells: Growth Factors, Transformation, and Malignancy. . ............................................. 297 M. P. Moyer. P. Dixon. D. Escobar. and J. B. Aust A New Technique for Diagnosing Cancer by Inspecting Blood Serum ................................................... 307 A. Kovacs. A. Vertesy. L. Szali. S. Adami. L. Urbancsek. Z. Simon. G. Nemeth. and J. M. Takacs Cytokinetics of Heteroploid Tumor Subpopulations by Combined Autoradiographic Imaging and Feulgen Densitometry . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 315 Robert J. Sklarew Cell Growth, Tissue Neogenesis, and Neoplastic Transformation ............................................ 323 Philip Skehan Index ........................................................ 347 CONTRIBUTORS S. ADAMI Cancer Research Group, Pilisborosjeno, Hungary J. B. AUST . The University of Texas Health Science Center at San Antonio, San Antonio, Texas RAMESH C. ADLAKHA Department of Chemotherapy Re- search, The University of Texas M. D. Anderson Hospital and Tumor Institute, Houston, Texas R. G. ALLEN Department of Biology, Southern Methodist Uni- versity, Dallas, Texas H. ALTMANN Institute of Biology, Research Center Seibersdorf, Austria A. T. ANNUNZIATO Department of Basic and Clinical Re- search, Scripps Clinic and Research Foundation, La Jolla, California EDWARD BAPTIST . Department of Zoology, University of Georgia, Athens, Georgia HELENA BIGO Department of Genetics, The University of Texas M. D. Anderson Hospital and Tumor Institute, Houston, Texas R. CURTIS BIRD Department of Molecular Biology and Ge- netics, College of Biological Science, University of Guelph, Guelph, Ontario, Canada N. L. R. BUCHER Department of Pathology, Boston Univer- sity School of Medicine, Boston, Massachusetts G. C. CANDELAS Department of Biology, University of Puerto Rico, Rio Piedras, Puerto Rico T. M. CANDELAS Department of Biology, University of Puerto Rico, Rio Piedras, Puerto Rico G. CSABA Department of Biology, Semmelweis University School of Medicine, Budapest, Hungary ZBIGNIEW DARZYNKIEWICZ Memorial Sloan-Kettering Can- cer Center, New York, New York DAVID T. DENHARDT . Cancer Research Laboratory, Univer sity of Western Ontario, London, Ontario, Canada CATHARINE L. DEWAR . Oncology Research Group and De partment of Pharmacology, The University of Calgary, Calgary, Alberta, Canada x Contributors xi P. DIXON The University of Texas Health Science Center at San Antonio, San Antonio, Texas DYLAN R. EDWARDS Cancer Research Laboratory, Univer- sity of Western Ontario. London, Ontario, Canada D. ESCOBAR . The University of Texas Health Science Center at San Antonio, San Antonio, Texas PETER A. FANTES Department of Zoology, University of Edinburgh, Edinburgh, Scotland SUSAN J. FRIEDMAN Oncology Research Group and Depart- ment of Phamacology, The University of Calgary, Calgary, Alberta, Canada HELENA GABOR Children's Hospital of Northern California, Oakland, California. WIEL GEILENKIRCHEN Department of Zoology, State Uni- versity, Utrecht, The Netherlands I. GINZBURG Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel W. L. GREER Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada MARGARET S. HALLECK . Molecular and Cell Biology Pro gram, The Pennsylvania State University. University Park. Pennsylvania S. K. HANKS Department of Basic and Clinical Research, Scripps Clinic and Research Foundation. La Jolla, California YEN-MING HSU Department of Biochemistry. Michigan State University, East LanSing, Michigan ANAND P. IYER Microbiology Program, The Pennsylvania State University, University Park, Pennsylvania. FRED A. JACOBS Department of Molecular Biology and Ge- netics. College of Biological Science, University of Guelph. Guelph, Ontario, Canada G. C. JOHNSTON Department of Microbiology, Dalhousie University, Halifax, Nova Scotia, Canada J. G. KAPLAN Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada A. KovAcs Cancer Research Group, Pilisborosjeno, Hungary P. KOVACS Department of Biology, Semmelweis University School of Medicine, Budapest, Hungary MARGARIDA KRAUSE Department of Biology, University of New Brunswick, Fredericton, New Brunswick, Canada
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