Glycolic Acid Peels (Basic and Clinical Dermatology)

256 Pages·2002·3.37 MB·English

by  Moy Luftman Kakita

Glycolic
Acid
Peels
edited by
Ronald Moy
Debra Luftman
Lenore S. Kakita
University of California, Los Angeles
Los Angeles, California
Marcel Dekker, Inc. New York Basel
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Series Introduction
Over the past decade, there has been a vast explosion in new information
relating to the art and science of dermatology as well as fundamental cutaneous
biology. Furthermore, this information is no longer of interest only to the small
but growing specialty of dermatology. Scientists from a wide variety of disci-
plines have come to recognize both the importance of skin in fundamental bio-
logical processes and the broad implications of understanding the pathogenesis
of skin disease. As a result, there is now a multidisciplinary and worldwide
interestintheprogressofdermatology.
With these factors in mind, we have undertaken to develop this series of
books specifically oriented to dermatology. The scope of theseriesispurposely
broad, with books ranging from pure basic science to practical, applied clinical
dermatology. Thus, while there is something for everyone, all volumes in the
series will ultimately prove to be valuable additions to the dermatologist’s
library.
The latest addition to the series by Larry E. Millikan is both timely and
pertinent. The authors are well known authorities in the fields of cutaneous
microbiology and clinical skin infections. We trust that this volume will be of
broadinteresttoscientistsandcliniciansalike.
AlanR.Shalita
SUNYHealthScienceCenter
Brooklyn,NewYork
iii
BASICANDCLINICALDERMATOLOGY
SeriesEditors
ALANR.SHALITA,M.D.
DistinguishedTeachingProfessorandChairman
DepartmentofDermatology
StateUniversityofNewYork
HealthScienceCenteratBrooklyn
Brooklyn,NewYork
DAVIDA.NORRIS,M.D.
DirectorofResearch
ProfessorofDermatology
TheUniversityofColorado
HealthSciencesCenter
Denver,Colorado
1. Cutaneous Investigation in Health and Disease: Noninvasive Methods and
Instrumentation,editedbyJean-LucLévêque
2. IrritantContactDermatitis,editedbyEdwardM.JacksonandRonaldGoldner
3. Fundamentals ofDermatology:AStudyGuide,FranklinS.GlickmanandAlanR.
Shalita
4. AgingSkin:PropertiesandFunctionalChanges,editedbyJean-LucLévêqueand
PierreG.Agache
5. Retinoids: Progress in Research and Clinical Applications, edited by Maria A.
LivreaandLesterPacker
6. ClinicalPhotomedicine,editedbyHenryW.LimandNicholasA.Soter
7. Cutaneous Antifungal Agents: Selected Compounds in Clinical Practice and
Development,editedbyJohnW.RipponandRobertA.Fromtling
8. OxidativeStressinDermatology,editedbyJürgenFuchsandLesterPacker
9. Connective Tissue Diseases of the Skin, edited by Charles M. Lapière and
ThomasKrieg
10. Epidermal Growth Factors and Cytokines, edited by Thomas A. Luger and
ThomasSchwarz
11. Skin Changes and Diseases in Pregnancy, edited by Marwali Harahap and
RobertC.Wallach
12. Fungal Disease: Biology, Immunology, and Diagnosis, edited by Paul H. Jacobs
andLexieNall
13. Immunomodulatory and Cytotoxic Agents in Dermatology, edited by Charles J.
McDonald
14. Cutaneous Infection and Therapy, edited by Raza Aly, Karl R. Beutner, and
HowardI.Maibach
15. Tissue Augmentation in Clinical Practice: Procedures and Techniques, edited by
ArnoldWilliamKlein
16. Psoriasis:ThirdEdition,RevisedandExpanded,editedbyHenryH.Roenigk,Jr.,
andHowardI.Maibach
17. SurgicalTechniquesforCutaneousScarRevision,editedbyMarwaliHarahap
18. DrugTherapyinDermatology,editedbyLarryE.Millikan
19. ScarlessWoundHealing,editedbyHariG.GargandMichaelT.Longaker
20. CosmeticSurgery:AnInterdisciplinaryApproach,editedbyRhodaS.Narins
21. TopicalAbsorptionofDermatologicalProducts,editedbyRobertL.Bronaughand
HowardI.Maibach
22. GlycolicAcidPeels,editedbyRonaldMoy,DebraLuftman,andLenoreS. Kakita
23. InnovativeTechniquesinSkinSurgery,editedbyMarwaliHarahap
ADDITIONALVOLUMESINPREPARATION
SafeLiposuction,editedbyRhodaS.Narins
Series Introduction
Over the past decade, there has been a vast explosion in new
information relating to the art and science of dermatology as
well as fundamental cutaneous biology. Furthermore, this
information is no longer of interest only to the small but grow-
ing specialty of dermatology. Scientists from a wide variety of
disciplines have come to recognize both the importance of skin
in fundamental biological processes and the broad implica-
tions of understanding the pathogenesis of skin disease. As a
result, there is now a multidisciplinary and worldwide inter-
est in the progress of dermatology.
With these factors in mind, we have undertaken to
develop this series of books specifically oriented to dermatol-
ogy. The scope of the series is purposely broad, with books
ranging from pure basic science to practical, applied clinical
dermatology. Thus, while there is something for everyone, all
iii
iv Series Introduction
volumes in the series will ultimately prove to be valuable
additions to the dermatologist’s library.
The latest addition to the series, edited by Drs. Ronald
Moy, Debra Luftman, and Lenore S. Kakita, is both timely
and pertinent. The authors are well known authorities in the
fields of chemical peels and facial rejuvenation. We trust that
this volume will be of broad interest to scientists and clini-
cians alike.
Alan R. Shalita
SUNY Health Science Center
Brooklyn, New York
Preface
Over the past several years we have witnessed an overwhelm-
ing plethora of glycolic acid products marketed for facial reju-
venation. Glycolic acids are currently being used by dermatol-
ogists as superficial chemical peel agents for the treatment
of photodamaged and aged skin, dyschromias, rosacea, and
acne. More recently they have proved to be safe and effective
for ethnic skin types. These products are widely prescribed to
patients in various formulations as part of their daily recom-
mended skin care regimen and without a doubt have been a
valuable addition to the dermatologist’s armamentarium.
Through aggressive marketing the annual sales of cosmetics
containing glycolic acid are estimated to be in the range of bil-
lions of dollars.
Until recently, little research was available to substanti-
ate many of the claimed benefits of the short- and long-term
v
vi Preface
use of glycolic acid products. An increasing number of scientific
studies have recently been published validating their thera-
peutic efficacy. These studies not only have demonstrated the
clinical and histological improvement of the signs of photoag-
ing achieved by the application of glycolic acid but have eluci-
dated its role as a stimulant of fibroblast collagen production.
Furthermore, glycolic acid has been shown to have both a pho-
toprotective effect as well as anti-inflammatory capabilities.
New applications in the use of glycolic acid have recently been
formulated.
This book presents the most recent data available re-
garding the clinical and histological effects of glycolic acid. We
believe that readers will benefit from this collection of studies
and that the book will enhance their understanding of glycolic
acid and its role in clinical practice.
Ronald Moy
Debra Luftman
Lenore S. Kakita