Glycans in Cancer I

178 Pages·2017·32.68 MB·English

www.glyco24.org
Program and Abstract Book
GLYCO XXIV

TABLE OF CONTENT
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ELCOME ADDRESS ····································································································· 4
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YMPOSIUM COMMITTEES ··························································································· 5
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CIENTIFIC PROGRAMME ····························································································· 7
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OSTER PROGRAM ····································································································· 24
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BSTRACT ····················································································································· 37
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OSTER SESSION·········································································································· 47
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UTHOR INDEX ··········································································································· 147
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ALL INFORMATION ································································································ 158
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MPORTANT INFORMATION ···················································································· 160
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RESENTATION INSTRUCTION ··············································································· 163
WELCOME ADDRESS
Dear Sweet Friends,
Welcome to GLYCO XXIV, the 24th International Symposium on Glycoco-
njugates, an official biannual international symposium of International
Glycoconjugate Organization (IGO).
Despite exaggerated News about precarious states, I respect you all who
visited the Republic of Korea, which is in fact one of the safest countries in
the world. Public peace in Korea is alwayswell maintained that it is safe to
walk around even at night. In fact Korea is much safer than Europe.
Especially Jeju Island is known as “Island of no three kinds”.
This reputation came from the fact that beggars, thieves and locked gates
were hard to be found in Jeju Island. In other words, you are in the safest place in Korea. Juju Island
therefore is the most suitable place for us, the sweet glycoscientists.
This symposium consists of 2 award lectures, 10 plenary lectures, 26 sessions with 31 key note speakers,
and 2 poster sessions. It is expected to bring an opportunity for revival to the field of glycoscience in the
Republic of Korea and Asia region.
In 1995, Professor William Lennarz, Dr. Yoshitaka Nagai, Dr. Naoyuki Taniguchi, Dr. Akemi Suzuki and
other glycobiologist from Japan introduced the field of glycobiology for the first time in Korean Society of
Molecular Biology Annual Meeting. After symposium Dr. Nagai mentioned that glycobiology in Korea was
not even born yet.
22 years from then, however, glycobiology in Korea has grown well and about 150 Korean glycoscientists
participate in this symposium. This could not be possible without help of countries like Japan and the
United States ofAmerica that are advanced in the field of glycobiology. Korean glycoscientists always
appreciate dedication of Dr. Naoyuki Taniguchi, Dr. Akemi Suzuki, and Professor Jürgen Roth who helped
to develop Korean glycoscience.
Sugar is sweet and sticky. Likewise, I hope that we as carbohydrate researchers can make sweet
friendship through active academic exchange in such a beautiful place, JeJu.
Jin Won Cho
Organizer of GLYCOXXIV
President Elect of IGO
4 24th International Symposium on Glycoconjugates
SYMPOSIUM COMMITTEES
Organizer
Jin Won Cho (Yonsei University)
Local Organising Committee
Jong Shin Yoo (KBSI) Eok-Soo Oh (Ewha Womans University)
Boyoun Park (Yonsei University) In Kown Chung (Yonsei University)
Hyun Joo An (Chungnam National University) Yong Il Park (The Catholic University of Korea)
Seonghun Kim (KRIBB) Moonjae Cho (Jeju National University)
Jin-Hong Kim (Seoul National University) Jaehan Kim (Chungnam National University)
Doo-Byoung Oh (KRIBB) Hyun-soo Cho (Yonsei University)
Jeong Gu Kang (KRIBB) Eugene C. Yi (Seoul National University)
Jeong-Heun Ko (KRIBB) Daesik Lim (KAIST)
Yong-Sam Kim (KRIBB) Inn-Oc Han (Inha University)
Yong-Ho Lee (Yonsei University College of Medicine) Jae Kyung Sohng (SunMoon University)
Kyun Oh Lee (Gyeongsang National University) Kisung Ko (Chung-Ang University)
Hyun Ah Kang (Chung-Ang University) Injae Shin (Yonsei University)
Glyco24 Scientific Advisory Board
Jin Won Cho (Korea), Chairman Iain Wilson (Austria)
Gordan Lauc (Croatia) Els van Damme (Belgium)
Nicolai Bovin (Russia) Jaroslav Katrlik (Slovakia)
Naoyuki Taniguchi (Japan) Jukka Finne (Finland)
Akira Kobata (Japan) Ken Kitajima (Japan)
Anne Dell (United Kingdom) Yehiel Zick (Israel)
Jianxin Gu (China) Michaela Wimmerová (Czech Republic)
Ken Kitajima (Japan) Kay-Hooi Khoo (Taiwan)
Hakon Leffler (Sweden) Hyun Joo An (Korea)
Sandro Sonnino (Italy) Guosong Chen (China)
Celso Reis (Portugal) Karen Colley (USA)
Hans Vliegenthart (The Netherlands) Christine Szymanski (USA)
IGO President
Gordan Lauc (Croatia)
24th International Symposium on Glycoconjugates 5
IGO Immediate Past President
Jianxin Gu (China)
IGO President Elect
Jin Won Cho (Korea)
IGO Past Presidents
Eugene A Davidson (USA) Guido Tettamanti (Italy)
Paul A Gleeson (Australia) Iain Wilson (Austria)
Gerald Hart (USA) Hans Vliegenthart (The Netherlands)
Akira Kobata (Japan) Tamio Yamakawa (Japan)
Jerzy Koscielak (Poland) M.C. Glick† (USA)
Jürgen Roth (Switzerland) R.W. Jeanloz† (USA)
Harry Schachter (Canada) B. Lindberg† (Sweden)
Roland Schauer (Germany) J. Montreuil† (France)
Avadhesha Surolia (India) N. Sharon† (Israel)
IGO NATIONAL REPRESENTATIVES
Pedro Bonay (Spain) Haojie Lu (China)
Nicolai Bovin (Russia) Jean-Claude Michalski (France)
Inka Brockhausen (Canada) Paulo A. S.Mourão (Brasil)
Jin Won Cho (Korea, President elect IGO for 2017-2019) Andrei Petrescu (Romania)
Henrik Clausen (Denmark) Celso Albuquerque Reis (Portugal)
José Luis Daniotti (Argentina) Werner Reutter (Germany)
Anne Dell (UK) Sandro Sonnino (Italy, Secretary of IGO)
Jukka Finne (Finland) Avadhesha Surolia (India)
Paul Gleeson (Australia) Maciej Ugorski (Poland)
Gerald Hart (USA) Els Van Damme (Belgium)
Thierry Hennet (Switzerland, Treasurer of IGO) Johannes F.G. Vliegenthart (The Netherlands)
Jaroslav Katrlík (Slovakia) Iain B. H. Wilson (Austria)
Ken Kitajima (Japan) Michaela Wimmerová (Czech Republic)
Ute Krengel (Norway) Albert M. Wu (Taiwan)
Gordan Lauc (Croatia, President of IGO for 2015-2017) Yehiel Zick (Israel)
Hakon Leffler (Sweden)
Secretary
Jihye Won
6 24th International Symposium on Glycoconjugates
SCIENTIFIC PROGRAMME
Sunday, August 27, 2017
HALLA HALL
17:30-17:45 Opening Ceremony
17:45-18:20 IGO-Award Lecture▸Pauline M Rudd: Glycosylation, Complexity and the Emergence of
Functional Glycoproteins (11)
18:20-18:55 IGO-Young Scientist Award Lecture▸Yoann Rombouts: Glycosylation of Anti-Citrullinated
Protein Antibodies in Rheumatoid Arthritis: A Bitter Sweet Symphony (12)
OCEANVIEW
19:10 Welcome Reception (5F, Ocean View)
Monday, August 28, 2017
Plenary Lecture
09:00-10:00 HALLA HALL
Chairs: In Kwon Chung
09:00-09:30 Plenary Lecture 1▸Injae Shin: Glycan Microarray Story from Fabrication to Applica-
tions (1)
Chairs: Hyun Ah Kang
09:30-10:00 Plenary Lecture 2▸Anne Imberty: Lectins from Bacteria and Fungi: Therapeutical
Targets and Research (2)
10:00-10:30 Coffee Break
24th International Symposium on Glycoconjugates 7
Session 1 - Glycans in Development/Signaling
10:30-12:00 HALLA HALL A
Chairs: Koichi Furukawa, Robert Haltiwanger
10:30-11:00 Keynote Lecture▸Robert Haltiwanger: Deletion of B3glct Disrupts Craniofacial, Skeletal,
and Cardiac Development in Mice (13)
11:00-11:10 Selected from Poster▸Elena Chiricozzi: The Neurotrophic Properties of GM1 Oligo-
saccharide: A New Promising Story (124)
11:10-11:40 Keynote Lecture▸Koichi Furukawa: Regulation of Cell Signaling by Ganglioside GD3/
GD2 in Gliomas (14)
11:40-12:00 Dipak Banerjee: Tunicamycin: A Dual Action Glycotherapy to treat Breast Cancer (15)
Session 2 - Glycans in Metabolism/Glycogene expression and regulation
10:30-12:00 HALLA HALL B
Chairs: Naoyuki Taniguchi, Tadashi Suzuki
10:30-11:00 Keynote Lecture▸Tadashi Suzuki: ENGase as a Potential Drug Target for NGLY1-
Deficiency (16)
11:00-11:10 Pingping Li: Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin
Resistance (18)
11:10-11:40 Keynote Lecture▸Naoyuki Taniguchi: Expression of N-glycan Branching Enzymes and
Their Products in Disease Implication (17)
11:40-11:50 Vlatka Zoldos: MGAT3 Gene Promoter Methylation Correlates with IgG Glycosylation in
Inflammatory Bowel Disease (19)
11:50-12:00 Aleksandar Vojta: Modulation of Glyco-Gene Expression using CRISPR/Cas9-Based
Molecular Tools for Epigenetic Editing (20)
12:00-13:30 Lunch Break (Halla Hall)
Chair: Jin-Hong Kim
Lunch on Seminar▸Yoshihiko Takinami (Bruker Daltonics): Glycan Analysis by Bruker
Mass Spectrometers : from MALDI, ESI to ion mobility
8 24th International Symposium on Glycoconjugates
Session 3 - ACGG Guest Session I
13:30-15:00 HALLA HALL A
Chairs: Yong Il Park, Hyun Joo An
13:30-14:00 Keynote Lecture▸Hyun Joo An: A Stepwise Approach using MS Platform for Glycosy-
lation CQAs (21)
14:00-14:30 Keynote Lecture▸Kay-Hooi Khoo: Dissecting the Site-Specific Nand O-Glycosylation of
the Ectodomains of Receptor Protein Tyrosine Phosphatase Functionally Implicated in
Extracellular Matrix Binding and Intracellular Signaling (22)
14:30-14:40 Ju-Zheng Sheng: Uncovering the Catalytic Mode of Heparan Sulfate N-Deacetylase/
N-sulfotransferase-4 (23)
14:40-14:50 Atit Silsirivanit: Serum GalNAc-Associated Glycan as a Biomarker for Diagnosis and
Prognosis of Cholangiocarcinoma (24)
14:50-15:00 Jisun Lee: Galactofuco-Oligosaccharides derived from Undaria galactofucan Induce
Apoptotic Death of Human Prostate Cancer Cells in vitro and in vivo (25)
Session 4 - Glycotechnology I
13:30-15:00 HALLA HALL B
Chairs: Gordan Lauc, Hans Wandall
13:30-14:00 Keynote Lecture▸Hans Wandall: Glycan Function in Simple Cells and Simplified
Tissues (26)
14:00-14:30 Keynote Lecture▸Gordan Lauc: Inter-Individual Differences in the IgG Glycome; What
Did We Learn from Analyzing 40,000 IgG Glycomes (27)
14:30-14:40 Selected from Poster▸Alexander Chinarev: Two-Component Supramers Strongly Inhibi-
ting Influenza Virus-to-Cell Adhesion in vivo (131)
14:40-14:50 Selected from Poster▸Maria Adamopoulou: Genetically Engineered Tissue to Screen
for Glycan Function in Tissue Formation (132)
14:50-15:00 Selected from Poster▸Feng Liu: Luteolin Reduces Mucin-Type OGlycosylation through
on-Target Inhibition of ppGalNAc-Ts (133)
24th International Symposium on Glycoconjugates 9
Session 5 - ACGG Guest Session II
15:00-16:30 HALLA HALL A
Chairs: Kay-Hooi Khoo, Guosong Chen
15:00-15:30 Keynote Lecture▸Guosong Chen: Carbohydrate-based Macromolecular Self-assemblies
and their Immunological Functions (28)
15:30-15:45 Kuo-I Lin: Essential roles of O-GlcNAcylation in B cell activation (29)
15:45-16:00 Yasuhiko Kizuka: Glyco-chemical biology using fucose analogs (30)
16:00-16:15 Takashi Sato: Wisteria floribunda agglutinin, a unique lectin, as a probe for serum
biomarker research (31)
16:15-16:30 Frederic Bard: Golgi, O-glycosylation and cancer development (32)
Session 6 - Glycotechnology II
15:00-16:30 HALLA HALL B
Chairs: Doo-Byoung Oh, Herta Steinkellner
15:00-15:30 Keynote Lecture▸Herta Steinkellner: Plant based glycan engineering for the production
of therapeutic proteins (33)
15:30-15:45 Rachel Chen: An efficient and versatile whole-cell biocatalyst based on respiring
Escherichia coli culture: useful for the synthesis of fucosylated oligosaccharides (34)
15:45-16:00 Xiaochen Jia: Novel LPMO enzymes identification, characterization, structural study
and application on polysaccharides degradation (35)
16:00-16:15 Kohji Itoh: “Neo-glycoenzymes” produced by utilizing transglycosylation activity of
endoglycosidases and synthetic Nglycans and its application to development of
glycobiologics for lysosomal storage diseases (36)
16:15-16:25 Selected from Poster▸Seunghyup Jeong: Intact glycopeptide analysis of targeted
serum haptoglobin for biomarker discovery in gastric cancer (130)
16:30-17:00 Coffee Break
10 24th International Symposium on Glycoconjugates