Genitourinary Cancer: Basic and Clinical Aspects

314 Pages·1987·14.925 MB·English

by  Charles B. Brendler (auth.), Timothy L. Ratliff Ph.D., William J. Catalona M.D. (eds.)

Genitourinary Cancer
Cancer Treatment and Research
WILLIAM L MCGUIRE, series editor
Livingston RB (ed): Lung Cancer I. 1981. ISBN 90-247-2394-9.
Bennett Humphrey G, Dehner LP, Grindey GB, Acton RT (eds): Pediatric Oncology I. 1981.
ISBN 90-247-2408-2.
DeCosse JJ, Sherlock P (eds): Gastrointestinal Cancer I. 1981. ISBN 90-247-2461-9.
Bennett JM (ed): Lymphomas I, including Hodgkin's Disease. 1981. ISBN 90-247-2479-1.
Bloomfield CD (ed): Adult Leukemias I. 1982. ISBN 90-247-2478-3.
Paulson DF (ed): Genitourinary Cancer I. 1982. ISBN 90-247-2480-5.
Muggia FM (ed): Cancer Chemotherapy I. ISBN 90-247-2713-8.
Bennett Humphrey G, Grindey GB (eds): Pancreatic Tumors in Children. 1982. ISBN 90-247-2702-2.
Costanzi JJ (ed): Malignant Melanoma I. 1983. ISBN 90-247-2706-5.
Griffiths CT, Fuller AF (eds): Gynecologic Oncology. 1983. ISBN 0-89838-555-5.
Greco AF (ed): Biology and Management of Lung Cancer. 1983. ISBN 0-89838-554-7.
Walker MD (ed): Oncology of the Nervous System. 1983. ISBN 0-89838-567-9.
Higby DJ (ed): Supportive Care in Cancer Therapy. 1983. ISBN 0-89838-569-5.
Herberman RB (ed): Basic and Clinical Tumor Immunology. 1983. ISBN 0-89838-579-2.
Baker LH (ed): Soft Tissue Sarcomas. 1983. ISBN 0-89838-584-9.
Bennett JM (ed): Controversies in the Management of Lymphomas. 1983. ISBN 0-89838-586-5.
Bennett Humphrey G, Grindey GB (eds): Adrenal and Endocrine Tumors in Children. 1983.
ISBN 0-89838-590-3.
DeCosse JJ, Sherlock P (eds): Clinical Management of Gastrointestinal Cancer. 1984.
ISBN 0-89838-601-2.
Catalona W J, Ratliff TL (eds): Urologic Oncology. 1984. ISBN 0-89838-628-4.
Santen RJ, Manni A (eds): Diagnosis and Management of Endocrine-related Tumors. 1984.
ISBN 0-89838-636-5.
Costanzi JJ (ed): Clinical Management of Malignant Melanoma. 1984.
ISBN 0-89838-656-X.
Wolf GT (ed): Head and Neck Oncology. 1984. ISBN 0-89838-657-8.
Alberts DS, Surwit EA (eds): Ovarian Cancer. 1985. ISBN 0-89838-676-4.
Muggia FM (ed): Experimental and Clinical Progress in Cancer Chemotherapy. 1985.
ISBN 0-89838-679-9.
Higby DJ (ed): The Cancer Patient and Supportive Care. 1985. ISBN 0-89838-690-X.
Bloomfield CD (ed): Chronic and Acute Leukemias in Adults. 1985. ISBN 0-89838-702-7.
Herberman RB (ed): Cancer Immunology: Innovative Approaches to Therapy. 1986.
ISBN 0-89838-757-4.
Hansen HH (ed): Lung Cancer: Basic and Clinical Aspects. 1986.
ISBN 0-89838-763-9.
Pinedo HM, Verweij J (eds): Clinical Management of Soft Tissue Sarcomas. 1986.
ISBN 0-89838-808-2.
Higby DJ (ed): Issues in Supportive Care of Cancer Patients. 1986. ISBN 0-89838-816-3.
Surwit EA, Alberts DS (eds): Cervix Cancer. 1987. ISBN 0-89838-822-8.
Jacobs C (ed): Cancers of the Head and Neck. 1987. ISBN 0-89838-825-2.
MacDonald JS (ed): Gastrointestinal Oncology. 1987. ISBN 0-89838-829-5.
Ratliff TL, Catalona WJ (eds): Genitourinary Cancer. 1987. ISBN 0-89838-830-9.
Genitourinary Cancer
Basic and Clinical Aspects
edited by
TIMOTHY L. RATLIFF, Ph.D.
Washington University School of Medicine
The Jewish Hospital of St. Louis
216 South Kingshighway Boulevard
P.O. Box 14109, St. Louis, MO 63178
U.S.A.
and
WILLIAM J. CATALONA, M.D.
Washington University School of Medicine
The Jewish Hospital of St. Louis
St. Louis, MO 63178
U.S.A.
II,
1987 MARTINUS NIJHOFF PUBLISHERS ...
a member of the KLUWER ACADEMIC PUBLISHERS GROUP
BOSTON / DORDRECHT / LANCASTER •
Distributors
for the United States and Canada: Kluwer Academic Publishers, P.O. Box 358,
Accord Station, Hingham, MA 02018-0358, USA
for the UK and Ireland: Kluwer Academic Publishers, MTP Press Limited,
Falcon House, Queen Square, Lancaster LAI lRN, UK
for all other countries: Kluwer Academic Publishers Group, Distribution Center,
P.O. Box 322, 3300 AH Dordrecht, The Netherlands
Library of Congress Cataloging in Publication Data
Genitourinary cancer.
(Cancer treatment and research)
Includes index.
1. Genito-urinary organs--Cancer. I. Ratliff,
Timothy L. II. Catalona, William J. III. Series.
[ONLM: 1. Urogenital Neoplasms. Wi CA693 /
WJ 160 G33032]
RC280.G4G473 1986 616.99'46 86-18143
ISBN 13: 978-1-4612-9210-4 e-ISBNI3: 978-1-4613-2033-3
001: 10.1007/978-1-4613-2033-3
Copyright
© 1987 by Martinus Nijhoff Publishers, Boston.
Softcover reprint of the hardcover I st edition 1987
All rights reserved. No part of this publication may be reproduc~d, stored in a
retrieval system, or transmitted in any form or by any means, mechanical,
photocopying, recording, or otherwise, without the prior written permission of
the publishers,
Martinus Nijhoff Publishers, P.O. Box 358, Accord Station, Hingham, MA
02018-0358, USA.
Contents
Foreword to the series. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. VII
Preface......................................................... IX
List of Contributors ............................................. XI
1. Isoenzymes in Prostate Cancer ... , ............................ .
CHARLESB.BRENDLER
Editorial Comment.. . . . .. . ..... . .. . ... . . .. .. .. . .. . . . . . ... .. . . 19
LELAND W.K. CHUNG
2. Potency-Sparing Modification of Radical Retropubic Prostatecto-
my.. ........ ... ... ...... ............. ....................... 21
WILLIAM J. CATALONA
Editorial Comment ........................................... 32
RICHARD D. WILLIAMS
3. Ureteroscopic Resection of Upper Tract Urothelial Tumors 35
HARRY W. HERR AND JEFFRY L. HUFFMAN
Editorial Comment ........................................... 42
EDWARD S. LYON
4. Growth Factors in Urology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43
STEPHEN C. JACOBS AND MICHAEL T. STORY
Editorial Comment ........................................... 71
WARREN D.W. HESTON, MUHAMMED A. BULBUL AND WILLIAM R. FAIR
5. Methods of Detecting Prostatic Tumors ........................ 77
DOV KADMON
Editorial Comment ........................................... 94
MARTIN I. RESNICK
VI
6. Oncogenes and Genitourinary Neoplasia ........................ 101
ALEXANDER KIRSCHENBAUM AND MICHAEL J. DROLLER
Editorial Comment. ... . . . .. .. . . . .. . . . . . . .. . . . .. . . . .. .. . .. . . . . 120
DONALD S. COFFEY
7. Monoclonal Antibodies and Urologic Oncology: Antigenic Ex-
pression of Genitourinary Tumors ............................. 123
LAURENCE H. KLOTZ AND NEIL H. BANDER
Editorial Comment. .. . . . . . . .. . .. .. . .. . . . .. . .. . .. . . . . . .. . . . ... 154
THOMAS R. HAKALA
8. LHRH Agonists and Antiandrogens in Prostate Cancer. . .. . .. . . . . 157
FERNAND LABRIE, ANDRE DUPONT AND ALAIN BELANGER
Editorial Comment. . .. . . . .. . .. . .. .. . . . . .. . . . . . . .. . . . . . .. . . . .. 201
JOSEPH A. SMITH, JR.
9. BCG Immunotherapy for Superficial Bladder Cancer 205
DONALD L. LAMM
Editorial Comment ........................................... 223
ALVARO MORALES
10. Expectant Management of Stage A Nonseminomatous Testicular
Tumors...................................................... 225
ARTHUR I. SAGALOWSKY
Editorial Comment ................... . . . . . . . . . . . . . . . . . . . . . . . . 238
ROBERT R. BAHNSON
11. The Role of Flow Cytometry in Urologic Oncology. . . . . . . . . . . . . .. 241
KENNETH R. STONE
Editorial Comment ........................................... 272
JEFFRY L. HUFFMAN
12. Approaches to the Treatment of Renal Cell Cacinoma . .. .. . .. .. .. 279
HOWARD N. WINFIELD AND TIMOTHY L. RATLIFF
Editorial Comment ....... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 297
JEAN B. deKERNION
Subject Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 299
Cancer Treatment and Research
Foreword
Where do you begin to look for a recent, authoritative article on the diagnosis
or management of a particular malignancy? The few general oncology textbooks
are generally out of date. Single papers in specialized journals are informative but
seldom comprehensive; these are more often preliminary reports on a very limited
number of patients. Certain general journals frequently publish good indepth
reviews of cancer topics, and published symposium lectures are often the best
overviews available. Unfortunately, these reviews and supplements appear spo
radically, and the reader can never be sure when a topic of special interest will
be covered.
Cancer Treatment and Research is a series of authoritative volumes which aim
to meet this need. It is an attempt to establish a critical mass of oncology literature
covering virtually all oncology topics, revised frequently to keep the coverage up to
date, easily available on a single library shelf or by a single personal subscription.
We have approached the problem in the following fashion. First, by dividing
the oncology literature into specific subdivisions such as lung cancer, genitourina
ry cancer, pediatric oncology, etc. Second, by asking eminent authorities in each
of these areas to edit a volume on the specific topic on an annual or biannual
basis. Each topic and tumor type is covered in a volume appearing frequently and
predictably, discussing current diagnosis, staging, markers, all forms of treatment
modalities, basic biology, and more.
In Cancer Treatment and Research, we have an outstanding group of editors,
each having made a major commitment to bring to this new series the very best
literature in his of her field. Martinus Nijhoff Publishers has made an equally
major commitment to the rapid publication of high quality books, and world
wide distribution.
Where can you go find quickly a recent authoritative article on any major
oncology problem? We hope that Cancer Treatment and Research provides an
answer.
WILLIAM L. MCGUIRE
Series Editor
Preface
The preface to our earlier work in this series (Urologic Oncology, Catalona and
Ratliff, editors, Martinus Nijhoff Publishing, 1984) began as follows:
The study of genitourinary tumors is an area of recent rapid growth both in
the understandign of disease processes and in the development of new
diagnostic and therapeutic modalities. During rapid growth phases within any
field, it is desirable to reflect on the current 'state of the art' . It is difficult even
for experts in reputed areas of advancement to distinguish true advances from
false leads, but it is far more difficult yet for those whose expertise lies in other
areas to evaluate important advances. Thus, an objective assessment of evolv
ing areas of investigation in the form of a comprehensive review is of consider
able value.
In this volume, wa have attempted to provide the reader with an overview of
some of the current areas of investigation in urologic oncology by experts in
each area. There often is a tendency for invited papers in books of this nature
to lack important critical peer review and therefore, suffer from a lack of
objectivity. We have attempted to diminish this problem by the selection of two
experts to discuss each subject. We believe that this format has improved the
overal quality of the book for two reasons: 1) the knowledge of each contribu
tor that his or her work would be reviewed by a peer encourages more rigorous
scholarship, and 2) the fact that contributions by two experts, including the
individual insights of each, provides a better perspective for the reader.
This volume, entitled Genitourinary Cancer: Basic and Clinical Aspects, is an
extention of our earlier work. The topics discussed are distinct but naturally
complimentary.
The review articles in this book are provided to aid investigators in their
attempts to stay abreast of advancements in the field. To provide as critical an
evaluation as possible, we have maintained the format of our previous volume
in which the insights of two experts are presented for each topic.
x
We gratefully acknowledge the efforts of each contributor. The strength and
utility ofthis volume lies within the individual contributions. Also, we particularly
wish to acknowledge the secretarial assistance of Christine Floyd and Kimberly
Merritt whose efforts made the completion of this volume possible.
List of contributors
BAHNSON, Robert R., M.D., Assistant Professor, Division ofU rology, Washing
ton University School of Medicine, 4960 Audubon Avenue, St. Louis, Missouri
63110 USA.
BANDER, Neil H., M.D., Assistant Professor Surgery/Urology, New York
Hospital-Cornell Medical Center, 525 East 68th Street, New York, NY 10021
USA.
BRENDLER, Charles B., M.D., Associate Professor, Johns Hopkins Hospital,
Department of Urology, Marburg 145, 600 N. Wolfe St., Baltimore, Maryland
21205.
BULBUL, M., M.D., Urologic Oncology Research, Memorial Sloan-Kettering
Cancer Center, 1275 York Avenue, New York NY 100021 USA.
CATALONA, William J., M.D., Professor of Surgery, Division of Urology,
Washington University School of Medicine, 4960 Audubon Avenue and The
Jewish Hospital of St. Louis, 216 S. Kingshighway, St. Louis, Missouri 63110
USA.
CHUNG, Leland W.K., Ph.D., Associate Professor of Pharmacology Depart
ment of Urology, University of Texas System Cancer Center, M.D. Anderson
Hospital and Cancer Center, Houston, Texas 77030 USA.
COFFEY, Donald, Ph.D., Professor of Urology, Oncology, Pharmacology and
Experimental Therapeutics; Director of Research Laboratories of the Depart
ment of Urology, John Hopkins Hospital, Brady Urologic Institute, Baltimore,
MD, 21205 USA.
deKERNION, Jean B., M.D., Professor of Surgery/Urology, Director for Clini
cal Programs, University of California - Los Angeles Jonsson Cancer Center,
University of California - Los Angeles Medical Center, 10833 Le Conte
Avenue, 66-128CHS, Los Angeles, CA 90024 USA.
DROLLER, Michael J., M.D., Professor and Chairman, Department of Urol
ogy, The Mount Sinai Medical Center, One Gustave L. Levy Place, New York,
NY 10029 USA.