Genetics and Biochemistry of Antibiotic Production

681 Pages·1994·40.59 MB·English

by  Colin Stuttard and L. Vining (Auth.)

BIOTECHNOLOGY
JULIAN E. DA VIES, Editor
Pasteur Institute
Paris, France
Editorial Board
L. Bogorad Harvard University, Cambridge, USA
J. Brenchley Pennsylvania State University, University Park, USA
P. Broda University of Manchester Institute of Science and Tech-
nology, Manchester, United Kingdom
A.L. Demain Massachusetts Institute of Technology, Cambridge, USA
D.E. Eveleigh Rutgers University, New Brunswick, USA
D.H. Gelfand Cetus Corporation, Emeryville, California, USA
D.A. Hop wood John Innes Institute, Norwich, United Kingdom
S.-D. Kung University of Maryland, College Park, USA
J.-F. Martin University of Leon, Leon, Spain
C. Nash Schering-Plough Research Institute, Kenilworth, New
Jersey, USA
T. Noguchi Suntory, Ltd., Tokyo, Japan
W. Reznikoff University of Wisconsin, Madison, USA
R.L. Rodriguez University of California, Davis, USA
A.H. Rose University of Bath, Bath, United Kingdom
P. Valenzuela Chiron, Inc., Emeryville, California, USA
D. Wang Massachusetts Institute of Technology, Cambridge, USA
BIOTECHNOLOGY SERIES
1. R. Saliwanchik Legal Protection for Microbiological and
Genetic Engineering Inventions
2. L. Vining (editor) Biochemistry and Genetic Regulation of
Commercially Important Antibiotics
3. K. Herrmann and Amino Acids: Biosynthesis and Genetic
R. Somerville Regulation
(editors)
4. D. Wise (editor) Organic Chemicals from Biomass
5. A. Laskin (editor) Enzymes and Immobilized Cells in
Biotechnology
6. A. Demain and Biology of Industrial Microorganisms
N. Solomon (editors)
7. Z. Van6k and Overproduction of Microbial Metabolites:
Z. HoStälek (editors) Strain Improvement and Process Control
Strategies
8. W. Reznikoff Maximizing Gene Expression
and L. Gold (editors)
9. W. Thilly (editor) Mammalian Cell Technology
10. R. Rodriguez Vectors: A Survey of Molecular Cloning
and D. Denhardt Vectors and Their Uses
(editors)
11. S.-D. Kung and Plant Biotechnology
C. Arntzen (editors)
12. D. Wise (editor) Applied Biosensors
13. P. Barr, A. Brake, Yeast Genetic Engineering
and P: Valenzuela
(editors)
IV Biotechnology Series
14. S. Narang (editor) Protein Engineering: Approaches to the
Manipulation of Protein Folding
15. L. Ginzburg (editor) Assessing Ecological Risks of Biotechnology
16. N. First and Transgenic Animals
F. Haseltine (editors)
17. C. Ho and Animal Cell Bioreactors
D. Wang (editors)
18. I. Goldberg and Biology of Methylotrophs
J.S. Rokem (editors)
19. J. Goldstein (editor) Biotechnology of Blood
20. R. Ellis (editor) Vaccines: New Approaches to Immunological
Problems
21. D. Finkelstein and Biotechnology of Filamentous Fungi
C. Ball (editors)
22. R. Doi and Biology of Bacilli: Applications to Industry
M. McGloughlin
(editors)
23. J. Bennett and Aspergillus: Biology and Industrial
M. Klich (editors) Applications
24. J. Davies and Milestones in Biotechnology: Classic Papers on
W. Reznikoff (editors) Genetic Engineering
25. D. Woods (editor) The Clostridia and Biotechnology
26. V. Gullo (editor) The Discovery of Natural Products with
Therapeutic Potential
27 . K. Sibley (editor) The Law and Strategy of Biotechnology
Patents
28.. L. Vining and Genetics and Biochemistry of
C. Stuttard (editors) Antibiotic Production
Genetics and Biochemistry of
Antibiotic Production
Edited by
Leo C. Vining and Colin Stuttard
Dalhousie University
Halifax, Nova Scotia, Canada
Butterworth-Heinemann
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Copyright © 1995 by Butterworth-Heinemann.
^L A member of the Reed Elsevier group
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CONTRIBUTORS
Vladislav BShal
Institute of Microbiology, Czech Academy of Science
Videftskä 1083, 14220 Prague, Czech Republic
Tel. [phone]; Fax [phone]
Teruhiko Beppu
Department of Agricultural Chemistry, University of Tokyo
Bunkyo-ku, Tokyo 113, Japan
Tel. [phone] ext. 5123; Fax [phone]
Mervyn J. Bibb
Department of Genetics, John Innes Centre
Norwich Research Park, Colney, Norwich NR4 7UH, UK
Tel. [phone]; Fax [phone]
Ashley W. Birch
Organisch-Chemisches Institut, Universität Zürich
Winterthurerstrasse 190, CH-8057, Zurich, Switzerland
Tel. [phone]; Fax [phone]
David Cane
Chemistry Department, Box H, Brown University
324 Brook Street, Providence, RI 02912, USA
Tel. [phone]; Fax [phone]
Keith F. Chater
Department of Genetics, John Innes Institute
Colney Lane, Norwich NR4 7UH, UK
Tel. [phone]; Fax [phone]
JuiShen Chiao
Institute of Plant Physiology, Academia Sinica
300 Fonglin Road, Shanghai 20032, China
Tel. [phone]; Fax [phone]
Vll
viii Contributors
Bruce Clare
Department of Crop Protection, The University of Adelaide
Waite Campus, Glen Osmond, South Australia 5064
Tel. [phone]; Fax [phone]
Julian Davies
Department of Microbiology, University of British Columbia
300-6174 University Blvd., Vancouver, BC, V6T 1Z3 Canada
Tel. [phone]; Fax [phone]
Arnold L. Demain
Department of Biology, Massachusetts Institute of Technology
77 Massachusettes Ave., Cambridge, MA 02139, USA
Tel. [phone]; Fax [phone]
Stefano Donadio
Corporate Molecular Biology, Abbott Laboratories
Department 47N, Building 9A, One Abbott Park Rd.
Abbott Park, IL 60064-3500, USA
Tel. [phone]; Fax [phone]
Janice L. Doull
Department of Biology, Mount St. Vincent University
Halifax, N.S., B3M 2J6 Canada
Tel. [phone]; Fax [phone]
Jeffrey Fayerman
Eli Lilly and Company
Automated Culture Selection and Preservation
Indianapolis, IN 46285-3317, USA
Tel. [phone]; Fax [phone]
Heinz G. Floss
Department of Chemistry BG-10, University of Washington
Seattle, WA 98195, USA
Tel. [phone]
Michael J. Gasson
AFRC Institute of Food Research, Norwich Laboratory
Norwich Research Park, Colney, Norwich NR4 7UA, UK
Tel. [phone]; Fax [phone]
Contributors ix
WeiLing Gu
Institute of Plant Physiology, Academia Sinica
300 Fonglin Road, Shanghai 20032, China
Tel. [phone]; Fax [phone]
Concepcion Hernändez-Chico
Unidad de Gen&ica Molecular, Hospital Ramon y Cajal
Carretera Colmenar Km 9,1, 28034 Madrid
Tel. [phone]; Fax [phone]
David A. Hop wood
Department of Genetics, John Innes Centre
Norwich Research Park, Colney, Norwich NR4 7UH, UK
Tel. [phone]; Fax [phone]
Sueharu Horinouchi
Department of Agricultural Chemistry, University of Tokyo
Bunkyo-ku, Tokyo 113, Japan
Tel. [phone] ext. 5147; Fax [phone]
Kunimoto Hotta
Department of Antibiotics, National Institute of Health
2-10-35 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan
Tel. [phone]; Fax [phone]
Iain S. Hunter
Robertson Institute of Biotechnology
Genetics Department, University of Glasgow
Church Street, Glasgow, Gil 5JS, UK
Tel. [phone]; Fax [phone]
C. Richard Hutchinson
Dept of Medicinal Chemistry & Bacteriology
School of Pharmacy, University of Wisconsin
425 North Charter St., Madison WI 53706, USA
Tel. [phone]; Fax [phone]
Kiyoshi Isono
Department of Marine Science
School of Marine Science and Technology, Tokai University
3-20-1 Orido, Shimizu 424, Japan
Tel.[phone]; Fax [phone]
x Contributors
Susan Jensen
Department of Microbiology, University of Alberta
Edmonton, Alta, T6G 2E9 Canada
Tel. [phone]; Fax [phone]
ZhiKun Jin
Institute of Plant Physiology, Academia Sinica
300 Fonglin Road, Shanghai 20032, China
Tel. [phone]; Fax [phone]
Leonard Katz
Corporate Molecular Biology, Abbott Laboratories
Department 93D, Building 9A, One Abbott Park Rd.
Abbott Park, IL 60064-3500, USA
Tel. [phone]; Fax [phone]
Ullrich Keller
Institut für Biochemie & Molekulare Biologie
Technische Universität Berlin
Franklinstrasse 29, D-1000, Berlin 10, Germany
Tel. [phone]; Fax [phone]
Roberto Kolter
Department of Microbiology & Molecular Genetics
Harvard Medical School
200 Longwood Ave., Boston, MA 02115, USA
Tel. [phone]; Fax [phone]
Douglas MacNeil
Department of Molecular Pharmacology & Biochemistry
Bldg 80Y-235, Merck, Sharp and Dohme Research Laboratories
PO Box 2000, Rahway NJ 07065, USA
Tel. [phone]; Fax [phone]
BaiGen Mei
Institute of Plant Physiology, Academia Sinica
J00 Fonglin Road, Shanghai 20032, China
rel. 4042090-16; Fax [phone]
iose Luis San Millän
Unidad de Gen&ica Molecular, Hospital Ramon y Cajal
üarretera Colmenar Km 9,1, 28034 Madrid, Spain
rel. 1-336-8541; Fax [phone]
Contributors xi
Felipe Moreno
Unidad de Genitica Molecular, Hospital Ramon y Cajal
Carretera Colmenar Km 9,1, 28034 Madrid, Spain
Tel. [phone]; Fax [phone]
Wolfgang Piepersberg
Fachbereich Mikrobiologie, Bergische Universität-GH Wuppertal
Gauss-strasse 20, D5600 Wuppertal 1, Germany
Tel. [phone]; Fax [phone]
John A. Robinson
Organisch-Chemisches Institut, Universität Zürich
Winterthurerstrasse 190, CH-8057, Zurich, Switzerland
Tel. [phone]; Fax [phone]
Haruo Seto
Institute of Applied Microbiology, University of Tokyo
Bunkyo-ku, Tokyo 113, Japan
Fax [phone]
William R. Strohl
Department of Microbiology, Ohio State University
484 West 12th Ave., Columbus, OH 43210-1292, USA
Tel. [phone]; Fax [phone]
Colin Stuttard
Department of Microbiology and Immunology, Dalhousie University,
Halifax, N.S., B3H 4H7 Canada
Tel. [phone]; Fax [phone]
Charles J. Thompson
Department of Microbiology, BIOZENTRUM der Universität Basel
Klingelbergstrasse 70, CH-4056 Basel, Switzerland
Tel. [phone]; Fax [phone]
Leo C. Vining
Department of Biology, Dalhousie University
Halifax, N.S., B3H 4J1 Canada
Tel. [phone]; Fax [phone]