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General Pharmacology 1994: Vol 25 Table of Contents PDF

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CONTENTS OF VOLUME 25 Vol. 25, No. 1 Minireview Stefano Manzini Antagonists of NK, tachykinin receptors as a potential new class of antibronchospastic agents General Papers Stefano Camanni and Paolo Nencini Physiological and environmental aspects of drinking stimulated by chronic exposure to amphetamine in rats Naoki Agata, Yoshimitsu Kato, 15 Differential effects of hypoxia on electrical and mechanical Hikaru Tanaka and Koki Shigenobu activities of isolated ventricular muscles from fetal and adult guinea-pigs T. B. Ng, W. Y. Chan and H. W. Yeung 19 Changes in ovulatory and steroidogenic responses in mice after administration of the ribosome inactivating proteins momorcochin, luffaculin and luffins P. M. Hopkins, F. R. Ellis and 23 The effects of benzamil on in vitro contracture responses of P. J. Halsall human skeletal muscle to halothane Maryse Vasseur, Thierry Jean, 31 Effects of repeated treatments with an extract of Ginkgo Francis V. DeFeudis and Katy Drieu biloba (EGb 761), bilobalide and ginkgolide B on the electri- cal activity of pancreatic f cells of normal or alloxan-diabetic mice: an ex vivo study with intracellular microelectrodes Hiroyasu Satoh 47 Regulation of the action potential configuration by taurine in guinea-pig ventricular muscles Akihiko Takeuchi, Katsuhiko Harada, 53 Effect of KRN2391 on canine ventricular arrhythmia models Atushi Miwa, Yasuhiro Jinno, Soichiro Kaneta, Takashi Yokoyama and Nobuyuki Ogawa Masayuki Fukazawa and Atsushi Namiki 61 Reduced endothelium-dependent vasodilation by acetyl- choline and bradykinin in isolated nitroglycerin-tolerant blood vessels Katsuo Kamata, Mariko Noguchi 69 Hypotensive effects of lithospermic acid B isolated from the and Masahiro Nagai extract of Salviae miltiorrhizae Radix in the rat T. B. Ng, W. K. Liu, S. F. Sze and 75 Action of «-momorcharin, a ribosome inactivating protein, H. W. Yeung on cultured tumor cell lines Anthony de Luca, Natalie V. Korszniak 79 Opiate agonist and antagonist action on guinea-pig isolated and Ian M. Coupar ileum Zdzislaw Szreder, Tetsuro Hori 85 Thermoregulatory effect of intracerebral injections of neuro- and Yasuo Kaizuka peptide Y in rats at different environmental temperatures M. Koutsoviti-Papadopoulou, 93 Effect of erythromycin on different parts of the rabbit G. Kounenis and V. Elezoglou intestine: comparison with motilin Antonella Saija, Pietro Princi, 97 Protective effect of glutathione on kainic acid-induced Antonina Pisani, Maria Lanza, neuropathological changes in the rat brain Mario Scalese, Ehsan Aramnejad, Roberto Ceserani and Giovanni Costa Francisco J. Ruiz, Andrés C. Inglés, 103 Indomethacin does not modify the role of nitric oxide on Tomas Quesada, Miguel G. Salom and blood pressure regulation of SHR Luis F. Carbonell Ill Contents Enver Hasanoglu, Nilgiin Altan, 107 The relationship between erythrocyte superoxide dismutase Siikrii Sindel, C. Gznur Ongun, activity and plasma levels of some trace elements (Al, Cu, Zn) Musa Bali and Engin Altintas of dialysis patients Yoshiaki Akimoto, Yoshiko Mochizuki, 111 Amoxicillin concentration in pus from abscess caused by Akio Uda, Hiroaki Omata, odontogenic infection Jun Shibutani, Hitoshi Nishimura, Masamichi Komiya, Kenju Kaneko and Akira Fujii M. A. Noguera, S. Chulia 115 The effect of EDTA on contractile responses of guinea-pig and M. P. D’Océn trachea in calcium-free medium and on the recovery of the contractile responses in calcium-containing solution Yoshiki Iwabuchi and Taizo Masuhara 123 Sialogogic activities of SNI-2011 compared with those of pilocarpine and McN-A-343 in rat salivary glands: identification of a potential therapeutic agent for treatment of Sjérgen’s syndrome N. T. Panagopoulos and N. A. Matsokis 131 Pharmacologic characterization of [*H]dopamine and (’H]spiperone binding in mouse cerebellum M. R. Zarrindast and Sh. Nikfar 139 Different influences of adenosine receptor agonists and antagonists on morphine antinociception in mice Fiona M. Reekie and 143 Some effects of purines on neurones of guinea-pig superior Geoffrey Burnstock cervical ganglia Hemendra N. Bhargava, 149 Effects of naltrexone pellet implantation on morphine George A. Matwyshyn, Phillip M. Gerk, tolerance and physical dependence in the rat Pamela S. Bozek, Melissa D. Bailey, Karen H. Ko, Robert J. Simko _and Sanjay N. Thorat Hikaru Tanaka, Tomoyuki Matsuda, 157 Post-natal decrease in chronotropic sensitivity to Hiroya Kawada and Koki Shigenobu acetylcholine in rat heart F. S. Guimaraes, J. C. de Aguiar, 161 Anxiolytic effect of cannabidiol derivatives in the elevated R. Mechoulam and A. Breuer plus-maze M. J. Moina, B. Bardan, 165 Effects of hydralazine on contractile responses to a,- and M. Campos Toimil, A. F. Alzueta, a,-adrenoceptor agonists in isolated rubbed rat aorta J. Gil-Longo and F. Orallo R. Cabral, M. Gutiérrez, A. I. Fernandez, 173 Progesterone and pregnanolone derivatives relaxing effect on B. Cantabrana and A. Hidalgo smooth muscle Makoto Ukai, Tetsuya Kobayashi 179 Effects of several amnesic drugs on the habituation of and Tsutomu Kameyama exploratory activity in mice as indexed by horizontal and vertical activities M. G. Martinez-Pifiero, M. V. Milanes 187 Modulation by catecholamine of hypothalamus-—pituitary— and M. L. Vargas adrenocortical (HPA) axis activity in morphine-tolerance and withdrawal T. Kimura, P. A. Saunders, H. S. Kim, 193 Interactions of ginsenosides with ligand-bindings of GABA, H. M. Rheu, K. W. Oh and I. K. Ho and GABA, receptors Ladislav Novotny, Eliska Balazova, 201 Effect of arabinosylcytosine derivative cyclocytidine on Pavol Tejec and Viliam Ujhazy hepatal functions in rats and on Zajdela hepatoma Albert S. Cornelius, Michael P. Reilly, 205 The mechanism of chlorpromazine-induced red blood cell Michihiro Suzuki, Toshio Asakura swelling and Kazumi Horiuchi Patricio Saez, Yolanda Borges, 211 a-Adrenergic and 5-HT,-serotonergic effects of some Ernesto Gonzalez and Bruce K. Cassels B-phenylethylamines on isolated rat thoracic aorta IV Contents Letter to the Editor T. W. Stone 217 Further thoughts on “selectivity” and “specificity” Book Reviews 219 Forthcoming Conferences 221 Vol. 25, No. 2 Review Arpad Szallasi 223 The vanilloid (capsaicin) receptor: receptor types and species differences General Papers Christine Leroy, 245 Invitro expression of the 15 kDa subunit of the mediatophore Francgois-Marie Meunier, and functional reconstitution of acetylcholine release Bernard Lesbats and Maurice Israél T. Nasu, H. Murase and H. Shibata 257 Temperature high sensitivity of manganese uptake in ileal longitudinal smooth muscle of guinea-pig B. L. Slomiany, V. L. N. Murty, 261 Activation of arachidonoyl phospholipase A, in prosta- E. Piotrowski, M. Morita, J. Piotrowski glandin-mediated action of sucralfate and A. Slomiany Noriyuki Miyata, Hiroko Yamaura, 267 Role of cyclic GMP in inhibitory effects of CD-349 in isolated Katsuharu Tsuchida, Susumu Otomo blood vessels and Eiji Miyajima J. A. Micol and M. L. Laorden 275 Interaction of U-50,488H and noradrenergic systems on isolated right atria Carlos A. Taira and Maria A. Eneroy« 279 Cardiovascular responses to cholinergic agonists in sinoaortic denervated rats Norio Funayama, 285 A regional difference of the effect of tachykinin on cholinergic Michiko Goroumaru-Shinkai and response evoked by electrical field stimulation in the rabbit Issei Takayanagi airway K. H. Al-zadjali, M. P. Imler and 289 Inhibitory effect of prostaglandins on dopamine release from S. E. Ohia the retina G. N. Balerio, M. E. Otero Losada 297 A possible inhibitory action of baclofen on hippocampus and M. C. Rubio GABAergic neurones R. Radomirov, N. Pencheva, I. Stoyneva 303 Opioid effects of short enkephalin fragments containing the and L. Lazova Gly—Phe sequence on contractile responses of guinea pig ileum M. R. Zarrindast and M. Rezayat 311 Caerulein changes morphine-induced antinociception depending on pretreatment times Ahmad Reza Dehpour, Emad Tajkhorshid The role of calcium and alpha-adrenoceptors in contractile and Nahid Radjaee Behbahani response of chick expansor secundariorum muscle to field stimulation Hiroyasu Satoh 325 Elevation of intracellular Ca** concentration by protein kinase C stimulation in isolated single rabbit sino-atrial node cells R. Gonzalez, M. S. Fernandez-Alfonso, 333 Pressure-induced contraction of the juxtamedullary afferent M. A. Rodriguez-Martinez, E. Fuertes, arterioles in spontaneously hypertensive rats J. Angulo, C. F. Sanchez-Ferrer and J. Marin Contents Aysel Aricioglu, Selvin Aydin, The effect of allopurinol on Na*K*ATPase related lipid Nurten Turkozkan and Osman Durmus peroxidation in ischemic and reperfused rabbit kidney Andrew N. A. Wilson and 345 Adenosine is not the sole vasodilator released on exposure of Kenneth J. Broadley isolated guinea-pig hearts to histamine and isoprenaline Poluru L. Reddy, Veeranna, 355 Effect of morphine tolerance and abstinence on the binding George A. Matwyshyn, Sanjay N. Thorat of [*H] naltrexone to discrete brain regions and spinal cord of and Hemendra N. Bhargava the rat W. Y. Chan, T. B. Ng and H. W. Yeung 363 Differential abilities of the ribosome inactivating proteins luffaculin, luffins and momorcochin to induce abnormalities in developing mouse embryos in vitro A. De Sarro, D. Ammendola 369 Effects of some quinolones on imipenem-induced seizures in and G. De Sarro DBA/2 mice Book Reviews 381 Erratum 383 Forthcoming Conferences 385 Vol. 25, No. 3 Minireviews Jill Coates, Michael J. Sheehan and 387 1,3-Dipropyl-8-cyclopentyl xanthine (DPCPX): a useful tool Peter Strong for pharmacologists and physiologists? F. S. Messiha 395 Developmental toxicity of cesium in the mouse General Papers Guglielmina Froldi, Luisa Pandolfo, 401 Protection of atrial function in hypoxia by high potassium Alessandro Chinellato, Eugenio R»gazzi, concentration Laura Caparrotta and Giuliana Fassina P. Sacerdote, M. Bianchi and 409 Chlorimipramine and nortriptyline but not fluoxetine A. E. Panerai and fluvoxamine inhibit human polymorphonuclear cell chemotaxis in vitro Hiroaki Nishio, Yuri Ikegami, 413 Stimulation of calcium sequestration by mezerein, a protein Tomio Segawa and Yoshihiro Nakata kinase C activator, in saponized rabbit platelets S. M. O. Hourani and D. A. D. Jones 417 Post-junctional excitatory adenosine A, receptors in the rat vas deferens Robert M. Levin, Sheila S. Levin, 421 Effect of partial outlet obstruction of the rabbit urinary Stephen A. Zderic, Masahiko Saito, bladder on ryanodine binding to microsomal membranes Jai-Young Yoon and Alan J. Wein Yuji Ueno, Yasushi Miyauchi and 427 Beraprost sodium protects occlusion/reperfusion injury in the Shintaro Nishio dog by inhibition of neutrophil migration Makoto Ukai, Tetsuya Kobayashi and 433 Characterization of the effects of scopolamine on the Tsutomu Kameyama habituation of exploratory activity: differential effects of oxotremorine and physostigmine Hyangja Gu, Susan B. McKay, 439 Comparison of the effects of antimitotic drugs on «-tubulin Allan M. Burkman and mRNA, microtubules and nicotinic receptor-mediated cate- Dennis B. McKay cholamine secretion in adrenal chromaffin cells in culture A. F. E. Rump, M. Boller, R. Berkels, 447 Comparative effects of the dihydropyridine-type calcium- R. Résen, U. Fricke and W. Klaus agonists (—)-S-Bay K 8644, (+)-Bay-W 5035 and (+)- Bay-T 5006 on human platelet aggregability Vi Contents B. L. Slomiany, J. Piotrowski, 451 Gastric mucosal laminin receptor expression with ulcer A. Czajkowski, F. Yotsumoto, healing by ebrotidine J. Majka and A. Slomiany Hikaru Tanaka, Norikazu Takagi 457 Effects of low sodium, ouabain and amiloride on chick and Koki Shigenobu myocardial contraction Huda S. Ammash, Foaad Y. Essa 461 Inactivation of aminoglycosides against Pseudomonas aerugi- and Victor A. Padron nosa by a nutrition supplementation solution Halina Zaporowska 467 Effect of vanadium on L-ascorbic acid concentration in rat tissues Atsushi Miwa, Yasuhiro Jinno, 471 Pharmacological analysis of the effect of KRN2391 on Takashi Yokoyama, Toshio Izawa coronary vasculature in perfused rat heart and Nobuyuki Ogawa Hikaru Tanaka, Kazuo Noguchi 475 Myocardial action potential prolongation by calcium channel and Koki Shigenobu activation under calcium-free EGTA condition in guinea pigs and rats A. K. Masters, H. Huddart and 481 Actions of abscisic acid and the analogue S$D217595 on A. M. Hetherington calcium mediated activity of rat vas deferens smooth muscle Tomoko Kashiwabara, Yuji Okada, 487 Antihypertensive and vasorelaxant effects on KRN2391 in Nobuyuki Ogawa and spontaneously hypertensive rats Hideaki Fukushima Ayse Bilgihan, Nurten Tiirkézkan, 495 The effect of deferoxamine on brain lipid peroxide levels and Aysel Aricioglu, Siikrii Aykol, Na-K ATPase activity following experimental subarachnoid Cemal Cevik and Murat Géksel hemorrhage M. Victoria Clos, Montserrat Ramoneda 499 Modification of testicular cytochrome P-450 after and Gloria Garcia fenitrothion administration Masayuki Uchida, Takeshi Iwata, 505 Effect of trimebutine maleate on the contractile response of Satoshi Takagi, Yoshiko Sugiyama, the isolated ileum from diabetic rats Kouki Ishitani, Hideo Honda and Yasushi Sakai M. Guillerma Juarranz, Luis G. Guijarro, Ontogeny of vasoactive intestinal peptide receptors in rat Ana M. Bajo, Maria J. Carmena ventral prostate and Juan C. Prieto Ahmad Reza Dehpour, Maryam Jabbary, Possible evidence for involvement of new subtype of P,- Farrokh Shadan and purinoceptors in rat isolated uterus Pedram Ghafourifar Raffaele Acierno, Alfonsina Gattuso, The isolated and perfused working heart of the frog, Rana Maria Carmela Cerra, esculenta: an improved preparation Daniela Pellegrino, Claudio Agnisola and Bruno Tota Isabel Hernandez, Andrés C. Inglés, Cardiovascular effects of angiotensin II and vasopressin in Francisco Ruiz, Tomas Quesada intact awake rats and Luis F. Carbonell Masaharu Ishikawa, Yuji Okada, 533 Pharmacological effects of recombinant human granulocyte Rika Satake-Ishikawa, colony-stimulating factor modified by polyethylene glycol on Makoto Kakitani, Mayumi Kawagishi, anticancer drug-induced neutropenia in mice Shigeru Matsuki, Masaru Kusaka and Katsuhiko Asano I. D. Nelson and H. Huddart 539 Neuromodulation in molluscan smooth muscle: the action of 5-HT, FMRFamide and purine compounds Vil Contents I. Kocié 553 Negative inotropic action of corynanthine in the guinea pig papillary muscle is attenuated by glibenclamide Dilek Lafgi-Erol, V. Melih Altan 559 Increased «,-adrenergic responsiveness of alloxan diabetic rat and Yusuf Oztiirk atria: effects of insulin therapy and thyroidectomy Masayuki Shibasaki, Osamu Inagaki 565 Hemodynamic effects of barnidipine hydrochloride in and Toichi Takenaka conscious squirrel monkeys John P. Batcabe, Randall S. MacGill, 569 Mitomycin C induced alterations in antioxidant enzyme Khalequz Zaman, Sami Ahmad levels in a model insect species, Spodoptera eridania and Ronald S. Pardini C. Pérez Guerrero, M. J. Martin 575 Prevention by Rutin of gastric lesions induced by ethanol in and E. Marhuenda rats: role of endogenous prostaglandins Timothy V. Murphy, 581 Phorbol esters impair endothelium-dependent and Kathryn M. L. Cross, independent relaxation in rat aortic rings Paul M. Dunning and Christopher J. Garland R. A. Ward, C. R. Gardner, A. Pringle, 589 The effects of RU 33965 and RU 34030, two new 3-cyclo- J. Bagust and R. J. Walker propyl carbonyl imidazobenzodiazepines, on GABA, receptor-mediated synaptic transmission in cerebellar slices in the rat K. Grosfils, M. Métioui and J. P. Dehaye Mepacrine inhibits amylase secretion mediated by a guanyl- nucleotide binding protein G. Csaba and A’. Inczefi-Gonda 603 Breastmilk can mediate chemical imprinting. Benzpyrene exposure during lactation reduces the thymic glucocorticoid receptor density of the offspring Book Reviews 607 Forthcoming Conferences Vol. 25, No. 4 Minireview Nobuyuki Ogawa 609 Pharmacological properties of KRN2391, a novel vasodilator of the nitrate-potassium channel opener hybrid type General Papers Matao Sakanashi, Toshihiro Matsuzaki, 617 Inhibitory effect of vapiprost on contractile responses of Katsuhiko Noguchi, Junko Nakasone, isolated dog renal arteries to thromboxane A, analogue, Tatsushi Itomine, Miyoko Uza, U46619 Fujiko Toyama and Makie Higuchi Ehsan Etemadzadeh 623 Cerebral dopamine and noradrenaline in mice withdrawn from repeated morphine treatment and development of tolerance to a test dose of morphine G. Kounenis, 631 Ketamine inhibits the anticholinesterase activity of ranitidine M. Koutsoviti-Papadopoulou and physostigmine and V. Elezoglou G. Pinardi, T. Pelissier, V. Kramer, 635 Effects of CDP-choline on acetylcholine-induced relaxation C. Paeile and H. F. Miranda of the perfused carotid vascular beds of the rat G. Dobreva, Z. Mizhorkova, 639 Some characteristics of the muscularis mucosae of the cat N. Kortezova and M. Papasova lower esophageal sphincter Vill Biss ead Se eel an. Contents Sofia G. Konstantinova, 645 Do indomethacin and cimetidine or Cu(cimetadine), affect Diana R. Radeva-Domuschieva the nature of superoxide dismutase activity in the liver of and Elevter M. Russanov copper-deficient rats? Bin-nan Wu, Chia-rong Yang, 651 A new f-adrenoceptor blocking agent derived from Jwu-maw Yang and Ing-jun Chen dehydrozingerone Bozena Mikoluc and Roza J. Wisniewska 661 The effect of C-terminal fragment of ANF-ANF(24-28)OH on the cardiovascular system in rat Bozena Mikoluc and Roza J. Wisniewska 667 The interaction of ANF and C-terminal fragment ANF (24—28)OH with agonist and antagonist of the B-adrenergic receptor in the cardiovascular system in rats G. Keith Matheson, Diane M. Pfeifer, 675 The effects of azapirones on serotonin,, neurons of the dorsal Michéle B. Weiberg and Carla Michel raphe Norio Funayama, Michiko Shinkai, 685 Effects of ageing on regional differences in the contractile Sachiko Ebisawa, Taichi Abe and responses to acetylcholine and neurokinin A in rabbit airway Issei Takayanagi Yuuki Miyauchi, Kazuhiko Oishi 691 Actin-severing and Ca**t-induced reversal of smooth muscle and Masaatsu K. Uchida contraction that is independent of Ca?* Michio Shimabukuro, Fumio Nagamine, 697 Chronic gliclazide treatment affects basal and post-ischemic Keiji Murakami, Koichi Oshiro and cardiac function in diabetic rats Goro Mimura Yoshiki Iwabuchi and Taizo Masuhara 705 Effects of vasoactive intestinal peptide and its homologues on the substance P-mediated secretion of fluid and protein from the rat submandibular gland Seico Hanada, Jayme A. A. Sertié, 713 Miconazole as inflammatory agent—I. Cellular and Ezequiel Waisbich and Lia S. Sudo pathophysiological effects M. Luisa Gonzalvez, M. Luisa Vargas 719 Lack of involvement of 6-opioid receptor in mediating and M. Victoria Milanés physical dependence at the hypothalamus—pituitary—adreno- cortical (HPA) axis in the rat Yi Gao and John W. Phillis 725 Atropine and cerebral ischemic injury in the Mongolian gerbil Kazuhiko Oishi, Tomoyuki Uekusa, 729 Fc,RI-stimulated Ca’*+-dependent secretion from _ rat Takako Iwasaki, Youichi Fukuda, basophilic leukemia (RBL-2H3) cells permeabilized with Hisao Ikeya, Rika Inoue and Staphylococcal a-toxin: Fec,RI-operated signals are not Masaatsu K. Uchida mimicked by the actions of GTPyS N. Satake, Q. Zhou and S. Shibata 739 Inhibitory effect of sodium nitroprusside on the relaxing action of isoproterenol in isolated rat urinary bladder Fabiana L. A. S. Lebrun, Ivo Lebrun 747 Lack of involvement of the kallikrein—kinin system in the and Fernando M. A. Corréa depressor effect of a-methyldopa in normotensive rats Raquel Molina, Manuel Sanchez, 753 Influences of age and sex on endothelium-dependent vascular Agustin Hidalgo and responses and arterial blood pressure in the rat M. José Garcia de Boto of high Fernando Gabriel Princ, 761 Porphyrinogenesis in rat cerebellum. Effect Adela Ana Juknat and 6-aminolevulinic acid concentration Alcira Maria del Carmen Batlle W. Y. Chan, T. B. Ng, S. H. Rong, 767 Antiproliferative and teratogenic activities of the bishemisuc- H. W. Yeung and S. C. Mok cinates of 7x-hydroxycholesterol and 78-hydroxycholesterol Youji Takeda, Yuichi Hattori, 773 Enhancement of the positive inotropic effect mediated by Haruaki Nakaya and Morio Kanno a,-adrenoceptors in pertussis toxin-treated rabbit papillary muscles IX Contents Osman Durmus, Aysel Aricioglu, 781 The effect of allopurinol on the liver ultrastructure, reduced Turan Giiven, Mehmet Oguz, glutathione and lipid peroxide levels during liver ischemia in Mustafa Yel and Nurten Tiirkézkan guinea pigs Azra Rabbani and Jamshid Davoodi 787 Effects of anthracycline antibiotic, daunomycin on thymus chromatin: the role of chromosomal proteins Cimen Karasu and V. Melih Altan 795 The role of the endothelium on enhanced contractile response of non-insulin-dependent diabetic rat aortae: effects of insulin treatment M. R. Zarrindast, S. M. Mamanpush 803 Morphine inhibits dopaminergic and cholinergic induced and A. Rashidy-Pour ejaculation in rats Letter to the Editors J. F. Chaulet, A. Flechaire, H. Delolme, 809 Inter-subject variability in biological fluid drug levels during G. Fevre, J. L. Brazier and F. Peyron long-term malaria prophylaxis with choroquine/proguanil Book Reviews Forthcoming Conferences Vol. 25, No. 5 Review Seppo Kaakkola, Ariel Gordin and 813 General properties and clinical possibilities of new selective Pekka T. Mannisté inhibitors of catechol O-methyltransferase Minireviews Carmen Valenzuela, Onésima Pérez, 825 Effects of lisinopril on cardiac contractility and ionic currents Eva Delpoén and Juan Tamargo B. L. Slomiany, V. L. N. Murty, 833 Gastroprotective agents in mucosal defense against J. Piotrowski and A. Slomiany Helicobacter pylori Yoshiaki Habara and Tomio Kanno 843 Stimulus-secretion coupling and Ca’** dynamics in pancreatic acinar cells General Papers Gonzalo Romero, Eva Toscano 851 Effect of prenatal exposure to antidepressants on 5-HT- and Joaquin Del Rio stimulated phosphoinositide hydrolysis and 5-HT, receptors in rat brain Hiroshi Teshigawara and 857 The role of leukotriene C, in biphasic release of histamine Yoshiko Moriya from mouse mastocytoma cell line (P-815) Toshiaki Nakatani, 865 Negative chronotropic and inotropic responses to nicotine Toshikatsu Nakashima and in rat right and left atria Hiroyasu Satoh Nilgiin Altan, C. Oznur Ongun, 875 Effect of the sulfonylurea glyburide on glutathione and Esra Elmali, Nedret Kilic, 6z iem Yavuz glutathione peroxidase activity in alloxan-induced diabetic and Banu Cayci rat hepatocytes M. Pestana and P. Soares-da-Silva 879 Outflow of dopamine and noradrenaline originating from L-dopa and L-threo-DOPS in rat renal tissues Felix Vargas, Rosa Montes, 887 Role of nitric oxide in the systemic circulation of conscious J. Mario Sabio and hyper- and hypothyroid rats Joaquin Garcia-Estaii Contents Byung-Ha Chung and Ki-Churl Chang 893 Photo-induced adequate nitric oxide (PIANO)-mediated relaxation in isolated rabbit corpus cavernosum J. Martinez-Orgado, M. Salaices, 899 Role of nitric oxide on the endothelium-dependent vasodila- M. A. Rodriguez-Martinez, tion in newborn piglet cerebral arteries C. F. Sanchez-Ferrer and J. Marin Luis Menendez, Fernando Andrés-Trelles, 903 Gender and test dependence of a type of kappa mediated Agustin Hidalgo and Ana Baamonde stress induced analgesia in mice Celia R. Nogueira, Ubiratan F. Machado, 909 Modulation of insulin secretion and “Ca’* efflux by Rui Curi and Angelo R. Carpinelli dopamine in glucose-stimulated pancreatic islets Milovan K. Krsti¢ and 917 Further evidence that the tachycardiac response to 5- Zvonimir S. KatuSi¢ hydroxytryptamine in rats is not mediated via typical 5-HT, receptors Renato Gaggi, Paola Roncada, 923 Interaction between dihydropyridine calcium antagonists and Anna Maria Gianni and morphine on the brain biogenic amines Rossella Dall’olio C. S. Planeta, R. DeLucia and 931 Effects of fencamfamine withdrawal in rats M. L. Aizenstein Katsuhiko Harada, Atsushi Miwa, 935 Pharmacological analysis of the inhibitory effects of Takashi Yokoyama, Toshio Izawa, KRN2391 on endothelin-l-induced contraction in isolated Nobuyuki Ogawa and Yasuhiro Jinno large coronary artery of the pig Takashi Yokoyama, Yuji Okada, 941 Comparative analysis of vasodilating mechanisms of Yasuhiro Jinno, Hideakira Izumi, Kil769, Ki3315 and KRN2391, pyridinecarboximidamide Toshio Izawa and Nobuyuki Ogawa derivatives, in porcine isolated coronary artery Abdul Manan Mat Jais, Ross McCulloch 947 Fatty acid and amino acid composition in haruan as a and Kevin Croft potential role in wound healing Ahmad Reza Dehpour, Aziz Delfan, 951 Effects of atropine, pirenzepine, clonidine, and morphine on Kazem Mousavizadeh and biphasic response of rat gastric fundus to field stimulation Seid Reza Mortazavi C. Frank, R. Longo and S. Sagratella 957 Pertussis toxin prevents neomycin-induced calcium- dependent electrophysiological effects in rat hippocampal slices Soichiro Kaneta, Tomoko Kashiwabara, 963 Cardiovascular effects of KRN2391, nitroglycerin and Yoshihiro Tanaka, Takashi Yokoyama, cromakalim in dihydroergotamine-treated pithed rats Hideakira Izumi, Toshio Izawa and Nobuyuki Ogawa J. Piotrowski, J. Majka, Inhibition of gastric mucosal mucin receptor by Helicobacter V. L. N. Murty, A. Czajkowski, pylori lipopolysaccharide: effect of sulglycotide A. Slomiany and B. L. Slomiany Christina I. Hadjiivanova and 977 Invitro and in vivo effect of the nootropic agent adafenoxate Stefanka L. Stancheva on the 5-HT, sites in different rat brain structures Stefanka L. Stancheva and 981 Biogenic monoamine uptake by rat brain synaptosomes Liana G. Alova during aging. Effects of nootropic drugs Abrao Elias Abdalla, 989 Action of diclofenac sodium on the reparation process of the Manuel De Jesus Simées, surgically-perforated myometrium of pregnant albino rats: Oswaldo Alves Mora, morphological and morphometrical evaluation Gustavo Rubino De Azevedo Focchi and Luiz Kulay Jr F. Gocer, E. Yaris and M. Tuncer 995 The action of amyl nitrite and isosorbide dinitrate on the contractility of sphincter of Oddi of guinea-pigs XI GP 25/8—O Contents Sheila A. Doggrell 1001 Characterization of the contractile responses to noradrena- line and adrenaline of aorta from normotensive and hypertensive rats Jean R. Rapin, Ioanis Lamproglou, 1009 Demonstration of the “‘anti-stress” activity of an extract of Katy Drieu and Francis V. DeFeudis Ginkgo biloba (EGb 761) using a discrimination learning task C. Kasinathan, M. Rizwan, 1017 Effect of sofalcone on tyrosylprotein sulfotransferase A. Slomiany and B. L. Slomiany Masahiko Saito, 1021 Effect of slow and rapid cystometry on in vitro rat urinary Penelope A. Longhurst, Miles Murphy, bladder DNA synthesis Frederick C. Monson, Alan J. Wein and Robert M. Levin Angela De Sarro, 1027 Anticonvulsant activity of pyrrolo[l’,2’:1,2]imidazo[4,5-b] Giovambattista De Sarro, Alba Chimirri, pyridines, pyrrolo[2’,1’:2,3]imidazo[4,5-c] pyridines and Silvana Grasso, Anna-Maria Monforte pyrrolo[2,1-f]purines in DBA/2 mice and Maria Zappala’ B. L. Slomiany, E. Piotrowski, 1033 Enhancement of gastric mucus phospholipid secretion by an J. Piotrowski, K. A. Zirvi, Y. H. Liau, antiulcer agent, ebrotidine V. L. N. Murty and A. Slomiany Ester J. Filinger 1039 Effect of a reserpine-like agent on the release and metabolism of HINA in cell bodies and terminals Ester J. Filinger 1045 In vitro release of [’H]noradrenaline by tyramine from the superior cervical ganglion and in the nictitating membrane of the cat Erratum 1051 Vol. 25, No. 6 Review Fiona E. Parkinson, Karl A. Rudolphi 1053 Propentofylline: a nucleoside transport inhibitor with neuro- and Bertil B. Fredholm protective effects in cerebral ischemia Minireview Kenji Tasaka and Kazuhiro Kitazumi 1059 The control of endothelin-1 secretion General Papers Nak Doo Kim, Soo Yeon Kang and 1071 Ginsenosides evoke endothelium-dependent vascular relax- Valerie B. Schini ation in rat aorta A. Walcourt-Ambakederemo 1079 5-HT receptors on identified Lymnaea neurones in culture: and W. Winlow pharmacological characterization of 5-HT, receptors Giovanni Anfossi, Paola Massucco, 1093 Effects of forskolin and organic nitrate on aggregation and Elena Mularoni, Franco Cavalot, intracellular cyclic nucleotide content in human platelets Luigi Mattiello and Mariella Trovati Masahiko Saito, Alan J. Wein 1101 Biphasic response of the rabbit detrusor muscle to changing and Robert M. 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