Table Of Content

Advances in Experimental Medicine and Biology 1339 Panayiotis Vlamos Editor GeNeDis 2020 Genetics and Neurodegenerative Diseases Advances in Experimental Medicine and Biology Volume 1339 Series Editors Wim E. Crusio, CNRS and University of Bordeaux UMR 5287, Institut de Neurosciences Cognitives et Intégratives d’Aquitaine, Pessac Cedex, France John D. Lambris, University of Pennsylvania, Philadelphia, PA, USA Heinfried H. Radeke, Clinic of the Goethe University Frankfurt Main, Institute of Pharmacology & Toxicology, Frankfurt am Main, Germany Nima Rezaei, Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran More information about this series at http://www.springer.com/series/5584 Panayiotis Vlamos Editor GeNeDis 2020 Genetics and Neurodegenerative Diseases Editor Panayiotis Vlamos Department of Informatics Ionian University Corfu, Greece ISSN 0065-2598 ISSN 2214-8019 (electronic) Advances in Experimental Medicine and Biology ISBN 978-3-030-78786-8 ISBN 978-3-030-78787-5 (eBook) https://doi.org/10.1007/978-3-030-78787-5 © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2021 This work is subject to copyright. All rights are solely and exclusively licensed by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland To my son, Michail, who is always motivating me. Preface The 4th World Congress on Genetics, Geriatrics and Neurodegenerative Diseases Research (GeNeDis 2020) focuses on the latest major challenges in scientific research, the new drug targets, the development of novel biomarkers, the new imaging techniques, the novel protocols for early diagnosis of neurodegenerative diseases, and several other scientific advances, with the aim of better and safe health aging. The relation between genetics and their effect on several diseases are lengthily examined in this volume. This volume focuses on the sessions from the conference on Genetics and Neurodegenerative Diseases. vii Acknowledgment I would like to thank Konstantina Skolariki for the help she provided during the editorial process. The original version of this book was inadvertently published without the “Acknowledgments and Dedication” sections in the front matter. These sections have been included in the book. ix Contents Attitudes and Smoking Prevalence Among Undergraduate Students in Central Greece . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Dimitrios Papagiannis, Foteini Malli, Ioanna V. Papathanasiou, Panagiotis Routis, Evangelos Fradelos, Lamprini Kontopoulou, Georgios Rachiotis, and Konstantinos I. Gourgoulianis Care of Patients with Alzheimer’s Disease . . . . . . . . . . . . . . . . . . . . . . 9 Eleni Athanasiadou, Areti Tsaloglidou, Konstantinos Koukourikos, Ioanna V. Papathanasiou, Christos H. Iliadis, Aikaterini Frantzana, Evangelos Fradelos, and Lambrini Kourkouta Regulation of Antioxidant Enzyme Levels in Rat Brain . . . . . . . . . . . 21 Sandhyarani Guggilla, Middela Karthik, and Boini Shylendra NIRS-Based Assessment of Cerebral Oxygenation During High- Definition Anodal Transcranial Direct Current Stimulation in Patients with Posttraumatic Encephalopathy . . . . . . . . . . . . . . . . . . . 27 Alex O. Trofimov, Darya I. Agarkova, Arthem A. Kopylov, Anton Dubrovin, Kseniia A. Trofimova, Anatoly Sheludyakov, Dmitry Martynov, Peter N. Cheremuhin, and Denis E. Bragin Cerebral Critical Closing Pressure in Concomitant Traumatic Brain Injury and Intracranial Hematomas . . . . . . . . . . . . 33 Kseniia A. Trofimova, Darya I. Agarkova, Alex O. Trofimov, Andrew Y. Abashkin, and Denis E. Bragin The Role of Inflammatory Biomarkers as a Diagnostic Tool for Possible Late-Life Cognitive Decline and Dementias . . . . . . 39 Marianna Katsoulaki, Alexandros Kastrinis, Xenia Konstantoudaki, and Maria Tsekoura The Development of Antisense RNA Treatments Using Engineered Protein Substrates . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47 Michael Harney Biomarker-Driven Analysis Using High-Throughput Approaches in Neuroinflammation and Neurodegenerative Diseases . . . . . . . . . . . 51 Marios G. Krokidis xi xii Contents Sensitive and Stereospecific High- Performance Liquid Chromatographic Method for Flurbiprofen in Human Plasma . . . . . 59 Sandhyarani Guggilla, Middela Karthik, and Boini Shylendra Genotypic and Clinical Analysis of a Thalassemia Major Cohort: An Observational Study . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 65 Tsartsalis A, George I. Lambrou, Athanasia Samartzi, Eugenia Vlachou, Ioannis Papassotiriou, Styliani A. Geronikolou, Christina Kanaka-Gantenbein, George P. Chrousos, and Antonis Kattamis Design and Validation of a New Diagnostic Tool for the Differentiation of Pathological Voices in Parkinsonian Patients . . . . 77 Eleana E. I. Almaloglou, Geronikolou S, George Chrousos, and Kotropoulos K Effects of an 8-Week Stress Management Program in Women with Breast Cancer: A Randomized Controlled Trial . . . . . . . . . . . . . 85 Theodora Seliniotaki, Flora Bacopoulou, Dimitrios Vlachakis, Artemios Artemiadis, Katerina Kampoli, George Chrousos, Christina Darviri, and Anna Koumarianou The Rosenberg Self-Esteem Scale: Translation and Validation in the Greek Language in Adolescents . . . . . . . . . . . . . . . . . . . . . . . . . 97 Alexandra Kourakou, Xanthi Tigani, Flora Bacopoulou, Dimitrios Vlachakis, Eleni Papakonstantinou, Sofia Simidala, Electra Ktena, Sofia Katsaouni, George Chrousos, and Christina Darviri Stress System Activation Analysis in Greek Female Adolescents: A Bioimpedance Study . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 105 Geronikolou S, Flora Bacopoulou, Dario Boschiero, and George P. Chrousos Kisspeptin and the Genetic Obesity Interactome . . . . . . . . . . . . . . . . 111 Geronikolou S, Athanassia Pavlopoulou, George I. Lambrou, John Koutelekos, Dennis Cokkinos, Konstantinos Albanopoulos, and George P. Chrousos The Importance of Diagnostic and Prognostic Biomarker Identification and Classification Towards Understanding ALS Pathogenesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 119 Katerina Kadena and Panayiotis Vlamos Entropy in Cardiac Autonomic Nervous System of Adolescents with General Learning Disabilities or Dyslexia . . . . . . . . . . . . . . . . . . 121 Geronikolou S, Flora Bacopoulou, Stavros Chryssanthopoulos, John Koutelekos, George I. Lambrou, and Dennis Cokkinos Ebola Virus Disease and Current Therapeutic Strategies: A Review . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 131 Kalliopi Io Diakou, Thanasis Mitsis, Katerina Pierouli, Eleni Papakonstantinou, Erik Bongcam-Rudloff, Misaki Wayengera, and Dimitrios Vlachakis Contents xiii Hyperbaric Oxygen Therapy Effect on “Kinesia Paradoxa” Brain Circuits . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 139 Eirini Banou Early and Very Early GRIM19 and MCL1 Expression Are Correlated to Late Acquired Prednisolone Effects in a T-Cell Acute Leukemia Cell Line . . . . . . . . . . . . . . . . . . . . . . . . . . 147 Lambrou G, Maria Adamaki, Kyriaki Hatziagapiou, Styliani A. Geronikolou, Athanasios N. Tsartsalis, and Spiros Vlahopoulos Phospholipid Fatty Acid Profile of Spirulina platensis . . . . . . . . . . . . . 161 Lavanya Sara, Swathi Konda, B. Nikitha, and Naveena Palupanuri Chronic Systemic Inflammation Measured by Bioimpedance Technology Before and After Sleeve Gastrectomy: A Feasibility Study . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 169 Geronikolou S, Dennis Cokkinos, Dario Boschiero, George P. Chrousos, and Konstantinos Albanopoulos Synthesis and Biological Evaluation of Substituted Thiophene Derivatives . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 179 Naveena Palupanuri, Swathi Konda, Lavanya Sara, and B. Nikitha Force Spectroscopy in Mechanical Protein Domains Unfolding. . . . . 187 Dionysios G. Cheirdaris Genetic Pathways Involved in the Pathogenesis of Parkinson’s Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 195 Konstantina Skolariki, Marios Diamantopoulos, and Panayiotis Vlamos Urticaria from the Neurodermatological Perspective: A Temporal Analysis of Urticaria and Cognition . . . . . . . . . . . . . . . . . 209 Tagka A, George I. Lambrou, Aikaterini Kyritsi, Styliani A. Geronikolou, Electra Nikolaidou, Alexandra Katsarou, Argyro Chatziioannou, Alexandros Stratigos, and Dimitris Rigopoulos Novel Low-Noise CMOS Bioamplifier for the Characterization of Neurodegenerative Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 221 A. K. Gnanasekar, M. Deivakani, Neeraja Bathala, E. Fantin Irudaya Raj, and V. Ramakrishna The Kentucky Inventory of Mindfulness Skills in Greek Undergraduate and Postgraduate Students . . . . . . . . . . . . . . . . . . . . . 227 Evgenia E. Psarraki, Flora Bacopoulou, Dimitrios Vlachakis, George P. Chrousos, Maria Michou, Panagiotis Pelekasis, Niki Stavrianou, and Christina Darviri Synthesis, In Silico Studies, and Biological Evaluation of 1,3,4-Oxadiazino Indole Derivatives . . . . . . . . . . . . . . . . . . . . . . . . . 239 K. Pavani and K. Swathi