Table Of Content

CONTENTS INTRODUCTORY REMARKS Romani, M., Casciano, L., Querzola, F., De Ambrosis, A. and Bernardi, G. ..................... 1-2 Siniscalco, M. 153-160 ‘From the double helix to , the huma:i n genome: 40 years of Analysis of a viral integration event in a CG-rich region at molecular genetics’ the 1p36 human chromosomal site Ehrlich, S.D., Bierne, H., d’Alencon, E., Vilette, D., Petranovic, M., Noirot, P. and Michel, B. 161-166 OPENING SESSION Mechanisms of illegitimate recombination Jacob, F. Zachau, H.G. 167-173 Genetics and the twentieth century The immunoglobulin «x locus — or — what has been learned Perutz, M.F. a et from looking closely at one-tenth of a percent of the human Before the double helix genome Crick, F. aiid fas Skalka, A.M. 175-182 Looking backwards a birthdz 1y card for the double helix Retroviral DNA integration: lessons for transposon shuffling Judson, H.F. 19-23 Singer, M.F., Krek, V., McMillan, J.P., Swergold, G.D. and Frederick Sanger, Erwin Chargaff, and the metamorphosis of Thayer, R.E. 183-188 specificity LINE-1: a human transposable element Klein, G. 189-196 Multistep evolution of B-cell-derived tumors in humans GENOME ORGANIZATION AND EVOLUTION and rodents Orgel, L.E. Genome organization and evolution de Duve,C . ..... The RN. A world: before and after? GENETICS Of DEVELOPMENT AND TRANSGENIC Cech, T.R. i 33—36 ORGANISMS The efficiency and versatility of catalytic RN A implications Zatloukal, K., Schmidt, W., Cotten, M., Wagner, E., Stingl, G. for an RNA world and Birnstiel, M.L. 199-207 Eigen, M. damsel ane wea 37-47 Somatic gene therapy for cancer: the utility of transferrinfec- The origin of genetic informata tion: viruses as models tion in generating ‘tumor vaccines’ Arber, W. - 49-56 Littauer, U.Z. 209-214 E volution of prokarir yotic genomes Reflections on RNA INTIS cccncccsnadcdaiacadatiedssiiliek 57-66 Gehring, W.J. 215-221 The isochore organization of the ‘human genome and its Exploring the homeobox evolutionary history — a review Chambon, P. 223-228 Cohen, S.N. 67—76 The molecular and genetic dissection of the retinoid signal- Bacterial plasmids: their extre 1ordinaa ry ‘contribution to molec- ling pathway ular genetics Grigorian, M.S., Tulchinsky, E.M., Zain, S., Ebralidze, A.K 2) Es a eee he a 77-79 Krameroy, D.A., Kriajevska, M.V., Georgiev, G.P. and The denaturation of DNA Lukanidin, E.M. 229-238 The mts] gene and control of tumor metastasis Saedler, H. and Huijser, P. 239-243 GENOME FUNCTIONS Molecular biology of flower development in intirrhinum Klug, A. m 83-92 majus (snapdragon) Protein designs for ‘the specific rr ecognition of DNA Schell, J., Konez, C., Spena, A., Palme, K. and Tocchini-Valentini, G.P., Baldi, M.1., Gandini-Attardi, D. and Walden, R. 245-249 Mattoccia, E. 93-—97 Genes involved in the control of growth and differentiation Cleavage site recognition by the tRNA splicing endo- in plants ribonuclease Starlinger, P. 251-255 Rich, A. ieciliaitainadenielicnttacatnsion 99-109 What do we still need to know about transposable element 1? DNA “ogy A many forms Mirzabekov, ee 111-118 Cc ecm agst ructure: mapping proteins associated with geno- mic DNA using crosslinking + eee ia 119-124 GENOME PROJECTS Chromatin structure and the expression of globin-encoding Dulbecco, R. 259-260 genes The human genome project and cancer Falaschi, A., Giacca, M., Zentilin, L., Norio, P., Diviacco, S.., Berg, P. 261-264 Dimitrova, D., Kumar, S., Tuteja, R., Biamonti, G., Reverse genetics: directed modification of DNA for func- Perini, G., Weighardt, F., Brito, J. and Riva, S..... 125-135 tional analysis Searching for replication origins in mammalian DNA Matsubara, K. and Okubo, K. 265-274 GRrre, WU, came Gp IG nse ccsesneccnsccsanes 137-144 cDNA analyses in the human genome project On the ancient nature of introns Weissenbach, J. 275-278 A second generation linkage map of the human genome based on highly informative microsatellite loci GENOME DYNAMICS Szybalski, W. 279-290 Campbell, A.M. ........... From the double-helix to novel approaches to the sequencing Genetic recombination in the molecular era of large genomes 336 ETHICAL AND LEGAL ISSUES Pa III ssencstsceancscussneilocaiowiesnniaanatenh bgshonsnenaidiaeiee 309-315 iad hacaicansemnntninicnniosiioedianinonein 293 294 Looking forward Co-Chairman’s Remarks SRIee eRe n one eens a ww. 317-318 Zinder, N.D. ........ 295 298 ‘From the double helix to the human genome: 40 years of Patenting cDNA 1993: efforts and happenings molecular genetics’ Sgaramella, V. 299 302 Participants in the Symposium — Photographs and Curriculae Lawyers’ delights and geneticists’ nightmares: at forty, the double helix shows some wrinkles CLOSING SESSION Contents Vol. 135 ..... Gros, F. 308 Jim Watson: the double helix, messenger RNA and the Human Genome Project — a personal view Author Index, Vol. 135 (1993 ) ae aa7 Ys l