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CONTENTS OF VOLUME 101 NO. 1, JULY 1991 This Month in GASTROENTEROLOGY 122 Epidemiology of Inflammatory Bowel Disease Among U.S. Military Veterans ALIMENTARY TRACT A. SONNENBERG AND I.H. WASSERMAN Basophil-Bound and Serum Immunoglobulin E Directed Sensitivity of the Gastric Mucosa to Acid and Duodenal Against Helicobacter pylori in Patients With Chronic Contents in Patients With Nonulcer Dyspepsia Gastritis A.A. GEORGE, M. TSUCHIYOSE, AND C.P. DOOLEY A. ACETI, D. CELESTINO, M. CAFERRO, V. CASALE, F. CITARDA, Phospholipid— and Neutral Lipid—Containing Organelles of E.M. Conti, A. Grassi, A. GRILLI, A. PENNICA, F. SCIARRETTA, Rat Gastroduodenal Mucous Cells O. LerRI, F. AMEGLIO, AND A. SEBASTIANI Y.-C.J. KAO AND L.M. LICHTENBERGER Pharmacokinetics of Oral and Intravenous Omeprazole in Acute Intestinal Injury Induced by Acetic Acid and Casein: Patients With the Zollinger—Ellison Syndrome Prevention by Intraluminal Misoprostol R. VINAYEK, M. AMANTEA, P.N. MATON, H. FRUCHT, M.J.S. MILLER, X.-J. ZHANG, X. GU, AND D.A. CLARK J.D. GARDNER, AND R.T. JENSEN T-Lymphocyte Modulation of Intestinal Muscle Function in Long-Term Prognosis After Partial Gastrectomy for Benign the Trichinella-Infected Rat Conditions D.L. VERMILLION, P.B. ERNST, AND S.M. COLLINS A.C. TERSMETTE, G.J.A. OFFERHAUS, F.M. GIARDIELLO, R. BRAND, Use of Azathioprine or 6-Mercaptopurine in the Treatment K.W.F. TERSMETTE, G.N.J. TYTGAT, AND J.P. VANDENBROUCKE of Crohn’s Disease Genetic Characterization of the APC Locus Involved in J.J. O'BRIEN, T.M. BAYLESS, AND J.A. BAYLESS Familial Adenomatous Polyposis Localization of Endothelinlike Immunoreactivity and S. OLSCHWANG, B. WEIFFENBACH, P. LAURENT-PUIG, T. MELOT, Endothelin Binding Sites in Human Colon A. VASSAL, K. FALLS, R.J. SALMON, R. PARC, L. STRONG, H. INAGAKI, A.E. BisHop, C. Escric, J. WHARTON, Y. NAKAMURA, L. HERRERA, AND G. THOMAS T.G. ALLEN-MERSH, AND J.M. POLAK Induction of Heat Shock Proteins and Their Implication in The Mechanism of Action of Peppermint Oil on Protection Against Ethanol-Induced Damage in Cultured Gastrointestinal Smooth Muscle Guinea Pig Gastric Mucosal Cells K. NAKAMURA, K. ROKUTAN, N. MARUI, A. AOIKE, AND K. KAWAI J.M. HILLs AND P.I. AARONSON Gastric Acid Secretion and Parietal Cell Mass: Effect of Sex Positive Serum Antibody and Negative Tissue Staining for Hormones Helicobacter pylori in Subjects With Atrophic Body K.A. ADENIYI Gastritis W.E. KARNES, JR., I.M. SAMLOFF, M. SIURALA, M. KEKKI, Proliferation of Endocrine Cells in the Rat Stomach Caused P. SIPPONEN, S.W.R. KIM, AND J.H. WALSH by Drug-Induced Achlorhydria R. EISSELE, B. Ro&kopr, H. Koop, G. ADLER, AND R. ARNOLD Reproducibility of Measurements of Trace Gas Concentrations in Expired Air A Novel Enzyme Immunoassay for Serodiagnosis of A. STROCCHI, C. ELLIS, AND M.D. Levitt Helicobacter pylori Infection T. SucryaMa, K. IMAI, H. YOSHIDA, Y. TAKAYAMA, T. YABANA, LIVER, PANCREAS, AND BILIARY TRACT K. YOKOTA, K. OGUMA, AND A. YACHI The Effect of Elemental Diet on Intestinal Permeability and Increased Paracellular Permeability in Intrahepatic Inflammation in Crohn’s Disease Cholestasis Induced by Carmustine (BCNU) in Rats K. TEAHON, P. SMETHURST, M. PEARSON, A.J. LEVI, H. KRELL, H. FROMM, AND R.E. LARSON AND I. BJARNASON Cost-Effectiveness of Extracorporeal Shock-Wave Lamina Propria Lymphocytes Are Derived From Circulating Lithotripsy Versus Cholecystectomy for Symptomatic Cells That Lack the Leu-8 Lymph Node Homing Receptor Gallstones M. BERG, Y. MURAKAWA, D. CAMERINI, AND S.P. JAMES E.B. Bass, E.P. STEINBERG, H.A. Pitt, G.P. SABA, K.D. LILLEMOE, D.R. KAFONEK, T.R. GADACZ, T.A. GORDON, AND G.F. ANDERSON Effect of Enteric Pacing on Intestinal Motility and Hormone Secretion in Dogs With Short Bowel Distribution of the VLA Family of Integrins in Normal and S.B. REISER, V. SCHUSDZIARRA, E. BOLLSCHWEILER, Pathological Human Liver Tissue A.H. HOLSCHER, AND J.R. SIEWERT R. VOLPES, J.J. VAN DEN OORD, AND V.J. DESMET Scintigraphic Measurement of Regional Gut Transit in The Bentiromide Test Using Plasma p-Aminobenzoic Acid Idiopathic Constipation for Diagnosing Pancreatic Insufficiency in Young Children T. STIVLAND, M. CAMILLERI, M. VASSALLO, M. PROANO, D. RATH, D. LauFER, G. CLEGHORN, G. FORSTNER, L. ELLIS, G. KOREN, M. Brown, G. THOMFORDE, J. PEMBERTON, AND S. PHILLIPS AND P. DURIE Lipase and Pepsin Activity in the Gastric Mucosa of Infants, Factors Affecting the Measurement of Cholesterol Children, and Adults Nucleation in Human Gallbladder and Duodenal Bile J. DrPALMA, C. KirK, M. HAMOsH, A.R. COLON, S.B. BENJAMIN, J.W. Marks, P. BROOMFIELD, G.G. BONORRIS, AND P. HAMOSH AND L.J. SCHOENFIELD iv CONTENTS GASTROENTEROLOGY Vol. 101, No. 6 220 Secretagogue Response of Azaserine-Induced Rat Pancreatic How Enterocytes Stick and What They Stick To Acinar Tumors in Vivo Superficial Esophageal Carcinoma: Will Early Detection K.-H. HERZIG, W. CREUTZFELDT, AND U.R. FOLSCH Help? Impaired Hepatic Handling and Processing of Evidence for a Direct Hepatoprotective Action of Lysophosphatidylcholine in Rats With Liver Cirrhosis Ursodeoxycholic Acid in Primary Human Hepatocytes M. ANGELICO, D. ALVARO, A. CANTAFORA, R. MASELLA, E. Gaunio, C. GANpDIN, S.G. CorRADINI, F. ARIOSTO, O. RIGGIO, Toward a Treatment for Anorexia and Cachexia in Patients AND L. CAPOCACCIA With Cancer CASE REPORTS BOOK REVIEWS Growth in Adulthood After Liver Transplantation for CORRESPONDENCE Glycogen Storage Disease Type | B.S. KIRSCHNER, A.L. BAKER, AND F.K. THORP 24-Hour Intragastric Acidity and Plasma Gastrin After Development of Sustained Achlorhydria in a Patient With Omeprazole Treatment and After Proximal Gastric the Zollinger—Ellison Syndrome Treated With Omeprazole Vagotomy in Ducdenal Ulcer Patients J.L. GRIFFITH, O.W. CUMMINGS, AND B.I. HIRSCHOWITZ Persisting Benzodiazepine Metabolites Responsible for the Cytomegalovirus Infection of the Appendix in a Patient Reaction to the Benzodiazepine Antagonist Flumazenil in With the Acquired Immunodeficiency Syndrome Patients With Hepatic Encephalopathy S. VALERDIZ-CASASOLA AND F.J. PARDO-MINDAN Treatment of Cholesterol Gallstone Patients With Ursodeoxycholic Acid for the Treatment of Home Parenteral Ursodeoxycholic Acid Nutrition—Associated Cholestasis ‘Abstract Creep’ in GASTROENTEROLOGY K.D. LINDOR AND J. BURNES Pancreatic Exocrine Secretion in Acute Experimental Pancreatitis CLINICAL CHALLENGES Efficacy of Dextran-70 As a Substitute for Albumin Exacerbation of Ulcerative Colitis D.J. HERMENS AND P.B. MINER, JR. Calcium Carbonate Solubility in Human Common Duct Bile: Calcium Carbonate Precipitation in Gallstones SFLECTED SUMMARIES Acute Necrotizing Esophagitis: Another Case Treatment of Bleeding Arteriovenous Malformations With Oral Contraceptives: Safe Sex? NOTICES NO. 2, AUGUST 1991 This Month in GASTROENTEROLOGY Effects of Vibrio cholerae Recombinant Strains on Rabbit Ileum In Vivo C.D. Linn, R.H. Davis, R.L. GUERRANT, J.B. KAPER, ALIMENTARY TRACT AND J.R. MATHIAS The Parietal Cell Autoantibodies Recognized in Neonatal Effect of Neuropeptide Y on Jejunal Water and Ion Thymectomy-Induced Murine Gastritis Are the a and B Transport in Humans Subunits of the Gastric Proton Pump U. HOLZER-PETSCHE, W. PETRITSCH, T. HINTERLEITNER, A. EHERER, C.M. JONES, J.M. CALLAGHAN, P.A. GLEESON, Y. Mor!, G. SPERK, AND G.J. KREJS T. MASUDA, AND B.-H. TOH Mechanism of Short-Chain Fatty Acid Uptake by Apical Microvascular Permeability Increases Early in the Course Membrane Vesicles of Rat Distal Colon of Acid-Induced Esophageal Injury N. MASCOLO, V.M. RAJENDRAN, AND H.J. BINDER F.G. ZyLSTRA, T.T. HYNNA-LIEPERT, P.K. DINDA, I.T. BECK, Developmental Characteristics of the Kitten Antrum AND W.G. PATERSON A.C. HILLEMEIER, K.N. BITAR, AND P. BIANCANI Establishment and Characterization of a Human Carcinoid Abnormal Esophageal Motility in Nude Mice and Effect of Various Agents on Tumor B.T. Massey, W.J. Dopps, W.J. HoGAN, J.G. BRASSEUR, Grewth AND J.F. HELM B.M. Evers, C.M. TOWNSEND, JR., J.R. Upp, E. ALLEN, S.C. HURLBUT, S.W. Kim, S. RAJARAMAN, P. SINGH, J.C. REUBI, Regional Esophageal Distribution and Clearance of AND J.C. THOMPSON Refluxed Gastric Acid R. SHAKER, W.J. Dopps, J.F. HELM, M.K. KERN, AND W.J. HOGAN Postiranslational Cleavage of Rat Intestinal Lactase Occurs at the Luminal Side of the Brush Border Membrane Intestinal Absorption of Fructose in the Rat K.-Y. YEH, M. YEH, P.-C. PAN, AND P.R. HOLT T. FUujISAWA, J. RIBY, AND N. KRETCHMER December 1991 Long-Term Survival Analysis in Hereditary 497 Comparison of 1 or 3 MU of Interferon Alfa-2b and Placebo Hemochromatosis in Patients With Chronic Non-A, Non-B Hepatitis P.C. ADAMS, M. SPEECHLEY, AND A.E. KERTESZ X. CAUSSE, H. GODINOT, M. CHEVALLIER, P. CHOSSEGROS, F. ZOuLIM, D. OuZAN, J.-P. HEYRAUD, T. FONTANGES, Variation of Muscle Tone in the Human Colon J. ALBRECHT, C. MESCHIEVITZ, AND C. TREPO C.J. STEADMAN, S.F. PHILLIPS, M. CAMILLERI, A.C. HADDAD, AND R.B. HANSON Role of Cholecystokinin in the Regulation of Gastric Premicellar Taurocholate Enhances Ferrous Iron Uptake Emptying and Pancreatic Enzyme Secretion in Humans From All Regions of Rat Small Intestine M. FRIED, U. ERLACHER, W. SCHWIZER, C. LOCHNER, J. KOERFER, C. BEGLINGER, J.B. JANSEN, C.B. LAMERS, F. HARDER, A.J. SANYAL, M.L. SHIFFMAN, J.I. HIRSCH, AND E.W. MOORE A. BISCHOF-DELALOYE, G.A. STALDER, AND L. ROVATI T-Lymphocyte Dysfunctions Occurring Together With Apical Gut Epithelial Cell Autoantibodies Intraductal Mucin-Hypersecreting Neoplasms of the J.M. MarTiN-VILLA, J.R. REGUEIRO, D. DE JUAN, P. PEREZ-ACIEGO, Pancreas M. PEREZ BLAS, J. MANZANARES, G. VARELA, F. RICKAERT, M. CREMER, J. DEVIERE, L. TAVARES, AND A. ARNAIZ-VILLENA J.P. LAMBILLIOTTE, S. SCHRODER, D. WuRBS, AND G. KLOPPEL Ion Transport Abnormalities in Rectal Suction Biapsies CASE REPORTS From Children With Cystic Fibrosis H.J. VEEZE, M. SINAASAPPEL, J. BIJMAN, J. BOUQUET, Intestinal and Hepatic Apolipoprotein B Gene Expression in AND H.R. DE JONGE Abetalipoproteinemia Aspirin Induces Morphological Transformation to the D.D. BLAck, R.V. Hay, P.L. ROHWER-NUTTER, H. ELLINAS, Secretory State in Isolated Rabbit Parietal Cells J.K. STEPHENS, H. SHERMAN, B.-B. TENG, P.F. WHITINGTON, U.K. MurTuy AND R.A. LEVINE AND N.O. DAVIDSON Circadian Rhythm of Cellular Proliferation in the Human Rhabdomyolysis and Cutaneous Necrosis Following Rectal Mucosa Intravenous Vasopressin Infusion K.N. Bucul, J.G. Moore, W.J.M. HRUSHESKY, R.B. SOTHERN, D. MorENO-SANCHEZ, B. Casis, A. MARTIN, P. ORTIZ, AND N.H. RUBIN G. CASTELLANO, M.T. MUNOZ, F. VANACLOCHA, AND J.A. SOLIS-HERRUZO Sensory Neurons Signal for an Increase in Rat Gastric Mucosal Blood Flow in the Face of Pending Acid Injury Idiopathic Myointimal Hyperplasia of Mesenteric Veins P. Houzer, E.H. LIVINGSTON, AND P.H. GUTH R.M. GENTA AND R.C. HAGGITT Presence of Atrial Natriuretic Factor Prohormone in Enterochromaffin Cells of the Human Large Intestine BRIEF REPORTS A.L. GERBES, W. NATHRATH, M. CANTIN, AND H. DENECKE Metabolism of Trinitrobenzene Sulfonic Acid by the Rat Increased Na*-H* Exchange in Jejunal Brush Border Colon Produces Reactive Oxygen Species Membrane Vesicles of Spontaneously Hypertensive Rats M.B. GRISHAM, C. VOLKMER, P. TsO, AND T. YAMADA S. ACRA AND F.K. GHISHAN Helicobacter pylori Infection Induces Antibodies Cross- SPECIAL REPORTS AND REVIEWS Reacting With Human Gastric Mucosa Reports From the NIH DDDN R. NEGRINI, L. LISATO, I. ZANELLA, L. CAVAZZINI, S. GULLINI, F.A. HAMILTON AND J.H. HOOFNAGLE V. VILLANACCI, C. Potgsi, A. ALBERTINI, AND S. GHIELMI LIVER, PANCREAS, AND BILIARY TRACT SELECTED SUMMARIES Activation of Mast Cells by Bile Acids Antibiotic Prophylaxis for Prevention of Spontaneous R.G. Quist, H.-T. TON-Nu, J. LILLIENAU, A.F. HOFMANN, Bacterial Peritonitis? AND K.E. BARRETT Nitroglycerin in the Treatment of Portal Hypertension Cell Type—Dependent Effect of Phospholipid and Endoscopic Management of Gastric Outlet Obstruction Cholesterol on Bile Salt Cytotoxicity A.L.M. VELARDI, A.K. GROEN, R.P.J.O. ELFERINK, At Long Last—The Histamine H,-Receptor Gene Is Cloned R. VAN DER MEER, G. PALASCIANO, AND G.N.J. TYTGAT NSAID-Induced Gastroduodenal Injury: What's the Score? Pancreatic Lesions in the von Hippel-Lindau Syndrome H.P.H. NEUMANN, E. DINKEL, H. BRAMBS, B. WIMMER, BOOK REVIEWS H. FRIEDBURG, B. VOLK, G. SIGMUND, P. RIEGLER, K. HAAG, P. SCHOLLMEYER, AND O.D. WIESTLER TRAINING AND EDUCATION IN The Stomach in Liver Cirrhosis GASTROENTEROLOGY S. VIGNERI, R. TERMINI, A. PIRAINO, A. SCIALABBA, G. PISCIOTTA, List of Available Training Programs AND N. FONTANA Bile Evacuation Induced by Hypothalamic Stimulation in CORRESPONDENCE Dogs N. FURUKAWA AND H. OKADA Ethanol Stimulates Pepsinogen Release From Isolated Guinea Pig Chief Cells Comparative Evaluation of Chenodeoxycholic and Ursodeoxycholic Acids in Obese Patients Hemodynamic Events in a Prospective Randomized Trial of G. MAZZELLA, F. BAZZOLI, D. FEsTI, M. RONCHI, R. ALDINI, Propranolol Versus Placebo ir the Prevention of a First A. Roba, B. GRIGOLO, P. SIMONI, N. VILLANOVA, AND E. RODA Variceal Hemorrhage vi CONTENTS GASTROENTEROLOGY Vol. 101, No. 6 592 The Possible Role of Phospholipase in Gallstone 594 Fasting and Postprandial Residual Gallbladder Volumes Pathogenesis 593 Host Response to Mycobacterial Infection in the Alcoholic 595 CORRECTION Rat 594 Tumor Necrosis Factor a in the Pathophysiology of Necrotizing Enterocolitis 596 NOTICES NO. 3, SEPTEMBER 1991 597 This Month in GASTROENTEROLOGY Isolation, Characterization, and Attachment of Rabbit Distal Colon Epithelial Cells R.V. BENYA, L.N. SCHMIDT, J. SAHI, T.J. LAYDEN, AND M.C. RAO ALIMENTARY TRACT Mechanism for the Gastrokinetic Aciion of Domperidone 599 The Cephalic and Gastric Phases of Gastric Secretion T. TAKAHASHI, S. KUROSAWA, J.W. WILEY, AND C. OWYANG During H,-Antagonist Treatment H.S. MERKI, C.H. WILDER-SMITH, R.P. WALT, AND F. HALTER Cancer Incidence Following Subtotal Gastrectomy G.N. STEMMERMANN, A.M.Y. NOMURA, AND P.-H. CHYOU 607 Effect of Intrathoracic Pressure on Plasma Arginine Vasopressin Levels Rat Enterocyte Injury by Oxygen-Dependent Processes J.A. SOLIS-HERRUZO, D. MORENO, A. GONZALEZ, L. LARRODERA, S.S. BAKER AND C.L. CAMPBELL G. CASTELLANO, J. GUTIERREZ, AND A. GOZALO Fecal Carriage of Streptococcus bovis and Colorectal 618 Expression of Sucrase-Isomaltase and Dipeptidylpeptidase Adenomas IV in Human Small Intestine and Colon R. Dusrow, S. EDBERG, E. WIkFors, D. CALLAN, F. TRONCALE, J.P. GoRVEL, A. FERRERO, L. CHAMBRAUD, A. RIGAL, J. BONICEL, R. VENDER, M. BRAND, AND R. YAPP AND S. MAROUX Antitumor Effect of Synthetic Derivatives of Lipid A in an 626 Intestinal Obstruction During Shigellosis: Incidence, Experimental Model of Colon Cancer in the Rat Clinical Features, Risk Factors, and Outcome J.-F. JEANNIN, N. ONtIER, P. LAGADEC, N. VON JENEY, P. STUTZ, M.L. BENNISH, A.K. AZAD, AND D. YOUSEFZADEH AND E. LIEHL 635 Sulindac Causes Regression of Rectal Polyps in Familial Neural and Hormonal Mechanisms Mediate the Adenomatous Polyposis Enterogastric Reflex: A Study in Intestinal Transplants in D. LABAYLE, D. FISCHER, P. VIELH, F. DROUHIN, A. PARIENTE, C. BortEs, O. DUHAMEL, M. TROUSSET, AND P. ATTALI Rats S.L. OrLoFF, N.W. BUNNETT, H. WONG, J.H. WALSH, 640 Radioautographic Localization of Epidermal Growth Factor AND H.T. DEBAS Receptors in Human Fetal Gut D. MENARD AND P. POTHIER Classic and Vigorous Achalasia: A Comparison of Manometric, Radiographic, and Clinical Findings 650 Observations on a Proposed Measure of Genotoxicity in Rat S.P. GOLDENBERG, M. BURRELL, G.G. FETTE, C. Vos, Gastric Mucosa AND M. TRAUBE S. HOLT, Z. ZHAO-HUA, AND R.E. POWERS Apolipoprotein Synthesis in Normal and 657 Hypertrophic Smooth Muscle in the Partially Obstructed Abetalipoproteinemic Intestinal Mucosa Opossum Esophagus R.M. GLICKMAN, J.N. GLICKMAN, A. MAGUN, AND M. BRIN J.L. CONKLIN, C. Du, K. SCHULZE-DELRIEU, AND S. SHIRAZI Nonsalicylate Nonsteroidal Antiinflammatory Drugs 664 Trichinella spiralis Infection Alters Small Bowel Motor Augment Prestimulated Acid Secretion in Rabbit Parietal Activity in the Fed State Cells V.E. COWLES AND S.K. SARNA R.A. LEVINE, J. NANDI, AND R.L. KING 670 I histochemical Characterization, Distribution, and Ultrastructure of Lymphocytes Bearing T-Cell Receptor y/5 in Inflammatory Bowel Disease LIVER, PANCREAS, AND BILIARY TRACT K. FUKUSHIMA, T. MAsuDA, H. OHTANI, I. SASAKI, Y. FUNAYAMA, Detection and Partial Sequencing of Hepatitis C Virus RNA S. MATSUNO, AND H. NAGURA in the Liver 679 Quality of Life After Proctocolectomy K. Hosopa, O. Yokosuka, M. Omata, N. KATO, AND M. OHTO L.W. KOHLER, J.H. PEMBERTON, A.R. ZINSMEISTER, The Effects of Benzodiazepine-Receptor Antagonists and AND K.A. KELLY Partial Inverse Agonists on Acute Hepatic Encephalopathy 685 Acute Abdomen as the First Presentation of in the Rat Pseud b Colitis D.K. BOSMAN, C.A.C.G. VAN DEN Buys, J.G. DE HAAN, G. TRIADAFILOPOULOS AND A.E. HALLSTONE M.A.W. MAAS, AND R.A.F.M. CHAMULEAU December 1991 Elevation of Serum Interleukin-6 Concentration Precedes CLINICAL CHALLENGES Acute-Phase Response and Reflects Severity in Acute Pancreatitis 848 Hypoproteinemia, Anemia, and Failure to Thrive in an Infant H.-G. LEsER, V. Gross, C. SCHEIBENBOGEN, A. HEINISCH, R. SALM, M. LauSEN, K. RUCKAUER, R. ANDREESEN, E.H. FARTHMANN, J.E. BINES AND E.J. ISRAEL AND J. SCHOLMERICH Acalculous Biliary Pain: Cholecystectomy Alleviates EDITORIALS Symptoms in Patients With Abnormal Cholescintigraphy Lessons From Experimental Cholelithiasis: Gallbladder and L. YAP, A.G. WYCHERLEY, A.D. MORPHETT, AND J. TOOULI Mucosa, Nonsteroidal Antiinflammatory Drugs, and Noninvasive Measurement of Liver Regeneration With Gallstones Positron Emission Tomography and [2-"'C]Thymidine S.P. LEE T. VANDER BorGHT, L. LAMBOTTE, S. PAUWELS, D. LABAR, C. BECKERS, AND C. DIVE The Effects of Chronic Endoscopic Variceal Sclerotherapy SELECTED SUMMARIES on Portal Pressure in Cirrhotics One More Reason for Weight Loss in Patients With AIDS J. KORULA AND P. RALLS Chronic Dietary Iron Overload in Rats Results in Impaired Hepatitis B and Human I daft. iency Virus: Double Trouble Calcium Sequestration by Hepatic Mitochondria and Microsomes Acute and Chronic Giant Cell Hepatitis: A Paramyxovirus R.S. BRITTON, R. O’NEILL, B.R. BACON Infection? Inhibition of Prostaglandin Synthesis Fails to Prevent Peliosis Hepatis: Old Disease, New Cause Gallbladder Mucin Hypersecretion in the Cholesterol-Fed Prairie Dog A Biopsychosocial Model for Functional Dyspepsia D.P. O’LEARY, W.W. LAMortE, T.E. ScoTT, M.L. BOOKER, BOOK REVIEWS AND J. STEVENSON Microanalysis of Bile Acid Composition in Intrahepatic Calculi and Its Etiological Significance CORRESPONDENCE J. SHopa, N. TANAKA, Y. MATSUZAKI, A. HonpA, T. OsuGa, Vegetable Peroxidase Is Denatured by Gastric Acid S. SHIGEMATSU, AND H. MIYAZAKI Estimation of Risk of Transmission of Non-A, Non-B CASE REPORTS Hepatitis by Needlestick Injury Clonorchis-Associated Cholangiocarcinoma: A Report of 872 Free Radical Scavengers and Inflammatory Bowel Disease Two Cases With Unusual Manifestations F.V. ONA AND J.N.T. DyToc 872 Role of Parenteral Nutrition in Crohn’s Colitis 874 Treatment of Intestinal Cryptosporidiosis With Zidovudine BRIEF REPORTS and SMS 201-995, a Somatostatin Analog Interferon-Induced Chronic Active Hepatitis? 874 Somatostatin and Acute Variceal Hemorrhage M.O. SILVA, K.R. REDDY, L.J. JEFFERS, M. HILL, AND E.R. SCHIFF 875 Prevalence of Columnar-Lined (Barrett’s) Esophagus SPECIAL REPORTS AND REVIEWS 876 Asthmatics’ Gastroesophageal Reflux With or Without 843 A Reappraisal of the Magnitude and Implications of the Bronchodilator Therapy Intestinal Unstirred Layer A. STROCCHI AND M.D. LEvITT NOTICES NO. 4, OCTOBER 1991 879 This Month in GASTROENTEROLOGY 889 The Effect of Histamine H,-Receptor Blockade on Bismuth Absorption From Three Ulcer-Healing Compounds C.U. NWoKOLo, E.J. PREWETT, A.M. SAWYERR, M. HUDSON, AND R.E. POUNDER ALIMENTARY TRACT Electrolyte Transport in Piglets Infected With Transmissible Gastroenteritis Virus 881 Comparison of Enteral Nutrition and Drug Treatment in F.R. HOMAIDAN, A. TORRES, M. DONOWITZ, AND G.W.G. SHARP Active Crohn’s Disease H. Locus, H.J. STEINHARDT, B. KLAUS-WENTZ, M. ZEITZ, Comparative Evaluation of Acid- and Bile-Induced H. VOGELSANG, H. SOMMER, W.E. FLEIG, P. BAUER, Damage to Pedicied Jejunal or Colonic Segments in the Rat J. SCHIRRMEISTER, AND H. MALCHOW G.B. RATTO, P. ROMANO, AND D. ZACCHEO CONTENTS GASTROENTEROLOGY Vol. 101, No. 6 Mechanism of Inhibitory Action of Prostaglandins on the Reversal of Protein-Bound Vitamin B,, Malabsorption With Growth of Human Gastric Carcinoma Cell Line KATO III Antibiotics in Atrophic Gastritis A. NAKAMURA, T. YAMATANI, T. FUJITA, AND T. CHIBA P.M. SUTER, B.B. GOLNER, B.R. GOLDIN, F.D. Morrow, AND R.M. RUSSELL Comparative Evaluation of Carcinoembryonic Antigen, Short-Chain Glucose Polymer and Secretory Component, and Mucins in Index and Anthracene-9-carboxylic Acid Inhibit Water and Metachronous Adenomas of the Colorectum Electrolyte Secretion Induced by Dibutyryl Cyclic AMP in G. GRIFFIOEN, F.T. BOSMAN, H.W. VERSPAGET, K.F.M. SIER, the Small Intestine I. BIEMOND, AND C.B.H.W. LAMERS G.H. RABBANI, R.-B. Lu, K. HORVATH, AND E. LEBENTHAL Epidemiology of Colonic Symptoms and the Irritable Bowel Syndrome LIVER, PANCREAS, AND BILIARY TRACT N.J. TALLEY, A.R. ZINSMEISTER, C. VAN DYKE, Light and Electron Microscopy of Neuropeptide Y- AND L.J. MELTON III Containing Nerves in Human Liver, Gallbladder, Action of Beer and Its Ingredients on Gastric Acid and Pancreas Secretion and Release of Gastrin in Humans W.-G. DING, M. Fujimura, A. Mort, I. TOOYAMA, M.V. SINGER, S. TEYSSEN, AND V.E. EYSSELEIN AND H. KIMURA Omeprazole Treatment Does Not Affect the Metabolism of Ornipressin in the Treatment of Functional Renal Failure Caffeine in Decompensated Liver Cirrhosis T. ANDERSSON, R. BERGSTRAND, C. CEDERBERG, S. ERIKSSON, K. LENZ, H. HORTNAGL, W. DRUML, H. REITHER, R. SCHMID, P.-O. LAGERSTROM, AND I. SKANBERG B. SCHNEEWEISS, A. LAGGNER, G. GRIMM, AND A.L. GERBES Complications of Endoscopic Sphincterotomy Tolerance During 5 Months of Dosing With Ranitidine, 150 mg Nightly: A Placebo-Controlled, Double-Blind Study S. SHERMAN, T.A. RUFFOLO, R.H. HAWES, AND G.A. LEHMAN C.U. NWOoKOLO, E.J. PREWETT, A.M. SAWYERR, M. HUDSON, Defective Fc Receptor—Mediated Clearance in Patients S. LIM, AND R.E. POUNDER With Primary Biliary Cirrhosis K. NILSSON EKDAHL, L. LOOF, A. NYBERG, U.R. NILSSON, Role of Capsaicin-Sensitive Afferent Neurons in Alkaline AND B. NILSSON Secretory Response to Luminal Acid in the Rat Duodenum K. TAKEUCHI, J. MATSUMOTO, K. UESHIMA, AND S. OKABE Azathioprine Treatment Increases Hepatocyte Turnover N. ARBER, G. ZAJICEK, J. NORDENBERG, AND Y. SIDI Reverse-Perfused Sleeve: An Improved Device for Prophylactic Sclerotherapy in High-Risk Cirrhotics Measurement of Sphincteric Function of the Crural Selected by Endosvopic Criteria Diaphragm B. SIvRI AND R.K. MITTAL R. DE FRANCHIS, M. PRIMIGNANI, P.G. ARCIDIACONO, P.M. RIZZI, P. VITAGLIANO, M.C. VAZZOLER, R. ARCIDIACONO, A. ROSSI, Opioids Inhibit Neuromuscular Transmission in Circular A. ZAMBELLI, F. COSENTINO, G. CALETTI, S. BRUNATI, Muscle of Human and Baboon Jejunum G. BATTAGLIA, AND G. GERUNDA A.J. BAUER, M.G. SARR, AND J.H. SZURSZEWSKI An Na‘*-Dependent and an Na*-Independent System for Glutamine Transport in Rat Liver Basolateral Membrane Effect of Age on Gastric Acid Secretion and Serum Gastrin Vesicles Concentrations in Healthy Men and Women H.M. Sap, D. HOLLANDER, AND S. KHORCHID M. GOLDSCHMIEDT, C.C. BARNETT, B.E. SCHWARZ, W.E. KARNES, J.S. REDFERN, AND M. FELDMAN Glucocorticoids Stimulate Ornithine Decarboxylase Gene Expression in Pancreatic AR42J Cells Enterogastric Reflux After Various Types of Antiulcer S. ROSEWICZ AND C.D. LOGSDON Gastric Surgery: Quantitation by °"Tc-HIDA Scintigraphy E. Xynos, J.S. VASSILAKIS, A. FOUNTOS, G. PECHLIVANIDES, Aspirin Does Not Inhibit Cholesterol Cholelithiasis in Two AND N. KARKAVITSAS Established Animal Models B.I. COHEN, E.H. MosBacu, N. AYYAD, M. YOSHII, The Origin of Symptoms on the Brain-Gut Axis in AND C.K. MCSHERRY Functional Dyspepsia F. MEARIN, M. CuCALA, F. AZPIROZ, AND J.-R. MALAGELADA BRIEF REPORTS Electroencephalogram Patterns During Sleep Reflux in Hepatitis C Virus Antibodies in Acute Icteric and Chronic Infants Non-A, Non-B Hepatitis J.M. SONDHEIMER AND E. HODDES J.G. McHuTCcHISON, G. Kuo, M. HOUGHTON, Q.-L. CHOO, In Vivo Evidence of Altered Chloride but Not Potassium AND A.G. REDEKER Secretion in Cystic Fibrosis Rectal Mucosa J.L. GOLDSTEIN, A.B. SHAPIRO, M.C. RAO, AND T.J. LAYDEN CLINICAL CHALLENGES Increased Activation of Isolated Intestinal Lamina Propria Fecal Incontinence in a 39-Year-Old Man Mononuclear Cells in Inflammatory Bowel Disease R.J. MAY S. SCHREIBER, R.P. MACDERMOTT, A. RAEDLER, R. PINNAU, M.J. BERTOVICH, AND G.S. NASH EDITORIALS Effects of Diazepam and Ro 15-1788 on Duodenal Enterai Feeding Versus Drug Therapy in Crohn’s Disease: Bicarbonate Secretion in the Rat A Continuing Story B. SAFSTEN, G. JEDSTEDT, AND G. FLEMSTROM J.W. SINGLETON December 1991 SELECTED SUMMARIES BOOK REVIEWS Treatment of Severe Postgastrectomy Dumping With a Long-Acting Somatostatin Analog: Is Effective Management CORRESPONDENCE Finally Available? Concentration in Pancreatic Juice of Lithostathine Sulfasalazine vs. Steroids in Crohn’s Disease: David vs. Pathogenesis and Treatment of Rotavirus Diarrhea Goliath? Prevalence of Spontaneous Hepatofugal Portal Flow in Recurrent Hepatitis B in Liver Transplant Recipients—No Liver Cirrhosis Easy Answers Enteric Neuronal Autoantibodies in Pseudoobstruction Sporadic vs. Posttransfusion Hepatitis C: Why the With Small-Cell Lung Carcinoma Differences? Hyperplastic Polyps and Risk of Adenomas Bidirectional Communication Between Mast Cells and Nerves Controls Intestinal Secretion NOTICES NO. 5, NOVEMBER 1991 This Month in GASTROENTEROLOGY 1229 Prostaglandins and the Colonic Epithelium R.A. GOODLAD, N. MANoDIR, S. LEVIN, J.L. ALLEN, AND N.A. WRIGHT ALIMENTARY TRACT Morphometry and Cell Proliferation in Endoscopic A Critical Analysis, With Appropriate Controls, of Gastric Biopsies: Evaluation of a Technique Acid and Pepsin Secretion in Clinical Esophagitis R.A. GOoDLaD, S. Levi, C.Y. LEE, N. MANDIR, H. HopGson, B.I. HIRSCHOWITZ AND N.A. WRIGHT Primary B-Cell Gastric Lymphoma: A Clinicopathological The Role of Vasopressin in the Pathogenesis of Ethanol- Study of 145 Patients Induced Gastric Hemorrhagic Erosions in Rats S.B. CoGuiatti, U. ScHmip, U. SCHUMACHER, F.. ECKERT, F. LAsz.0, G. KARACSONY, E. SzaB0, J. LANG, L. BALASPIRI, M.-L. HANSMANN, J. HEDDERICH, H. TAKAHASHI, AND K. LENNERT AND F.A. LASZLO Value of Transrectal Ultrasonography in Crohn’s Disease M.J. VAN OUTRYVE, P.A. PELCKMANS, P.P. MICHIELSEN, Central and Peripheral Control of Postprandial Pyloric AND Y.M. VAN MAERCKE Motility by Endogenous Opiates and Cholecystokinin in Dogs y-Aminobutyric Acid Localization and Function as Y. LOPEZ, J. FIORAMONTI, AND L. BUENO Modulator of Cholinergic Neurotransmission in Rat Antral Mucosal/Submucosal Fragments Peptidergic Innervation of the Human Esophageal Smooth R.F. Harty, M.G. BouarskI, G.S. BOCHNA, T.A. CARR, Muscle P.E. EAGAN, M. RINGs, D.C. LAssITER, M.P. Pour, C. SINGARAM, A. SENGUPTA, D.J. SUGARBAKER, AND R.K. GOYAL D.F. SCHAFER, AND R.S. MARKIN Changes in the Structure and Regeneration Mode of the Histological Maturity of Healed Duodenal Ulcers and Rat Small Intestinal Mucosa Following Benzalkonium Ulcer Recurrence After Treatment With Colloidal Bismuth Chloride Treatment Subcitrate or Cimetidine G.E. HOLLE S. PAN, C.-H. Liao, G.-S. LIEN, AND S.-H. CHEN Different Fibers Have Different Regional Effects on Portal Colopathy: Prospective Study of Colonoscopy in Luminal Contents of Rat Colon Patients With Portal Hypertension A. MCINTYRE, G.P. YOUNG, T. TARANTO, P.R. GIBSON, R.A. KOZAREK, V.A. BOTOMAN, J.E. BREDFELDT, J.M. ROACH, AND P.B. WARD D.J. PATTERSON, AND T.J. BALL Inversion of the Slow-Wave Frequency Gradient in Distribution of Aneuploid Cell Pepulations in Ulcerative Symptomatic Patients With Roux-en-Y Anastomoses Colitis With Dysplasia or Cancer G. VANTRAPPEN, G. COREMANS, J. JANSSENS, A. MANTIDES, D.S. LEVINE, P.S. RABINOVITCH, R.C. Haceitt, P.L. BLOUNT, AND F. VANDEN BORRE P.J. DEAN, C.E. RUBIN, AND B.J. REID Calcitonin Gene-Related Peptide and Substance P Colonic Motility and Transit in Health and Ulcerative Decrease in the Rabbit Colon During Colitis Colitis V.E. EYSSELEIN, M. REINSHAGEN, F. COMINELLI, C. STERNINI, S.N. Reppy, G. BAZZOCCHI, S. CHAN, K. AKASHI, W. Davis, A. PATEL, C.C. NAST, D. BERNSTEIN, K. ANDERSON, J. VILLANUEVA-MEYER, G. YANNI, I. MENA, AND W.J. SNAPE, JR. H. KHAN, AND W.J. SNAPE, JR. Effect of Eating on Colonic Motility and Transit in Patients Mechanisms of Acid Injury to Rabbit Esophageal With Functional Diarrhea Epithelium G. Bazzoccul, J. ELLIS, J. VILLANUEVA-MEYER, S.N. REDDY, N.A. TOBEY AND R.C. ORLANDO I. MENA, AND W.J. SNAPE, JR. x CONTENTS GASTROENTEROLOGY Vol. 101, No. 6 1307 Quality of Life of Patients With Ulcerative Colitis CASE REPORTS Preoperatively and Postoperatively 1417 Postinfantile Giant Cell Hepatitis in Association With R.S. McLeEop, D.N. CHURCHILL, A.M. Lock, S. VANDERBURGH, Hypereosinophilia AND Z. COHEN A. KUMAR AND G.Y. MINUK Perendoscopic Manometry of the Distal Ileum and Idiopathic Neonatal Iron-Storage Disease Ileocecal Junction in Humans J.A. BARNARD III AND E. MANCI E. CoRAZZIARI, F. BARBERANI, M. TOSONI, S. BOSCHETTO, AND A. TORSOLI BRIEF REPORTS Delayed Gastrointestinal Transit Times in Anorexia Nervosa and Bulimia Nervosa Cholecystokinin-Mediated Ileal Electrolyte Transport in N. KAMAL, T. CHAMI, A. ANDERSEN, F.A. ROSELL, the Guinea Pig M.M. SCHUSTER, AND W.E. WHITEHEAD J.F. KAcHur, S.-X. WANG, G.W. GULLIKSON, AND T.S. GAGINELLA LIVER, PANCREAS, AND BILIARY TRACT CLINICAL CHALLENGES Ultrasonic Tissue Characterization of Chronic Liver Disease Using Cepstral Analysis Recurrent Gastrointestinal Bleeding Associated With K. Suzuki, N. HAYASHI, Y. SASAKI, M. Kono, Y. IMAI, Myelofibrosis and Diffuse Intestinal Telangiectasias H. FUSAMOTO, AND T. KAMADA S.D. FREEDMAN, R.E. Drews, D.J. GLOTZER, D. KIM, Treatment of Primary Biliary Cirrhosis With Low-Dose H. GARDNER, AND S.J. GALLI Weekly Methotrexate M.M. KAPLAN AND T.A. KNOX EDITORIALS Effect of Phospholipase C on Cholesterol Solubilization in Methotrexate Therapy of Primary Biliary Cirrhosis: Model Bile Promising but Worrisome N.R. PATTINSON AND K.E. WILLIS J.H. HOOFNAGLE AND N.V. BERGASA Effectiveness of a Purified Human Hemoglobin as a Blood Substitute in the Perfused Rat Liver SELECTED SUMMARIES H.F. STARNES, JR., A. TEWARI, K. FLOKAS, J.C. KOSEK, Pregnancy in Liver Transplant Patients—And Vice Versa D. BRown, A.L. VAN-KESSEL, AND C.E. MONDON Abnormal Sympathetic and Renal Response to Sodium The p53 Gene and Hepatocellular Carcinoma Restriction in Compensated Cirrhosis Transforming Growth Factors in Human Chronic Hepatitis M.-A. SIMON, J. Dizz, AND J. PRIETO and Cirrhosis: Correlations With Fibrogenesis and Hepatic Lipase/Amylase Ratio Regeneration V.V. GUMASTE, P.B. DAVE, D. WEISSMAN, AND J. MESSER Somatostatin Therapy for AIDS Diarrhea: Muddy Waters HLA DRwé8 and Coinplement C4 Deficiency as Risk Factors H, Antagonists by Continuous Infusion: IV or IG? in Primary Biliary Cirrhosis M.P. MANNS, A. BREMM, P.M. SCHNEIDER, A. NOTGHI, BOOK REVIEWS G. GERKEN, M. PRAGER-EBERLE, B. STRADMANN-BELLINGHAUSEN, K.-H. MEYER ZUM BUSCHENFELDE, AND C. RITTNER CORRESPONDENCE Risk Factors for Septicemia Following Endoscopic Biliary Stenting Functional Bowel Disease: The Role of Fructose and S. MorrteE, J. DEVIERE, J.-M. DUMONCEAU, E. SERRUYS, Sorbitol J.-P. THys, AND M. CREMER Role of Fructose-Sorbitol Malabsorption in the Irritable A Shift in Balance Between Profibrinolytic and Bowel Syndrome Antifibrinolytic Factors Causes Enhanced Fibrinolysis in Cirrhosis Fructose Malabsorption and the Irritable Bowel Syndrome F.W.G. LEEBEEK, C. KLuFT, E.A.R. KNOT, M.P.M. DE Maat, Helicobacter pylori Infection and Inflammation of the AND J.H.P. WILSON Gastric Corpus Lithotripsy of Gallstones by Means of a Quality-Switched Postparacentesis Plasma Expansion Prevents Giant-Pulse Neodymium: Yttrium-Aluminum-Garnet Laser Asymptomatic Laboratory Abnormalities, but Does It Have J. HocHBERGER, E. GRUBER, P. WirTZ, U. DURR, A. KOLB, Any Impact on Morbidity or Mortality? U. ZANGER, E.G. HAHN, AND C. ELL Cancer Risk in Left-Sided Colitis Portal and Biliary Phases of Enterohepatic Circulation of Corrinoids in Humans Stress Ulcer Prophylaxis S. EL KHOLTY, J.-L. GUEANT, L. BRESSLER, M. DJALALI, The Use of 6-Mercaptopurine in Adolescents With Crohn’s P. BoISSEL, P. GERARD, AND J.-P. NICOLAS Disease Significance of Computed Tomography for Shock-Wave Therapy of Radiolucent Gallbladder Stones 1460 CORRECTIONS C. ELL, H.T. SCHNEIDER, J. BENNINGER, S. THEOBALDY, N. FRIEDEL, W. RODL, P. WiRTZ, AND E.G. HAHN 1461 NOTICES December 1991 NO. 6, DECEMBER 1991 1463 This Month in GASTROENTEROLOGY 1564 Cisapride in Children With Chronic Intestinal Pseudoobstruction AMERICAN GASTROENTEROLOGICAL ASSOCIATION C. Di LORENZO, S.N. REDDY, J. VILLANUEVA-MEYER, I. MENA, S. MARTIN, AND P.E. HYMAN 1465 Presidential Address Colonic Motility in Innervated and Extrinsically D.H. ALPERS Denervated Loops in Dogs 1468 Presentation of the Julius Friedenwald Medal to Cyrus E. C. SHIBATA, I. SASAKI, S. MATSUNO, A. MIZUMOTO, AND Z. ITOH Rubin, M.D. Dual Effect of Trimebutine on Contractility of the Guinea W.M. WEINSTEIN Pig Ileum via the Opioid Receptors K. TANIYAMA, I. SANO, S. NAKAYAMA, S. MATSUYAMA, ALIMENTARY TRACT K. TAKEDA, C. YOSHIHARA, AND C. TANAKA Galanin Inhibition of Vasoactive Intestinal Polypeptide Flow-Cytometric DNA Content Analysis of Esophageal Release and Circular Muscle Motility in the Isolated Squamous Cell Carcinomas Perfused Canine Ileum M. ROBASZKIEWICZ, B.J. REID, A. VOLANT, J.M. CAUVIN, J.-A.E.T. FOX-THRELKELD, T.J. MCDONALD, S. CIpRis, P.S. RABINOVITCH, AND H. GOUEROU Z. WOSKOWSKA, AND E.E. DANIEL Loss of Interleukin-2—Producing Intestinal CD4+ T Cells in The Minor Components of the Rat Asialoglycoprotein Inflammatory Bowel Disease Receptor Are Apically Located in Neonatal Enterocytes K. KusuGAMI, T. MATSUURA, G.A. WEST, K.R. YOUNGMAN, C. Hu, E.Y. LEE, J.E. HEwirt, J.U. BAENZiGER, J.-Z. Mu, D. RACHMILEWITZ, AND C. FIOCCHI K. DESCHRYVER-KECSKEMETI, AND D.H. ALPERS Sensorial and Intestinointestinal Reflex Pathways in the Gastrointestinal Motor Effects of Erythromycin in Humans Human Jejunum S.K. SARNA, K.H. SOERGEL, T.R. KOCH, J.E. STONE, C.M. Woop, J.-M. ROUILLON, F. AZPIROZ, AND J.-R. MALAGELADA R.P. RYAN, R.C. ARNDORFER, J.H. CAVANAUGH, H.N. NELLANS, Modification of the Effects of Blood on Amino Acid AND M.B. LEE Metabolism by Intravenous Isoleucine Colonic Fermentation to Short-Chain Fatty Acids Is N.E.P. DEUTZ, P.L.M. RENVEN, M.C.F. Bost, C.L.H. VAN BERLO, Decreased in Antibiotic-Associated Diarrhea AND P.B. SOETERS M.R. CLAUSEN, H. BONNEN, M. TVEDE, AND P.B. MORTENSEN Enhanced Perception of Physiological Intestinal Motility Differential Effect on Neuropeptide Release of Different in the Irritable Bowel Syndrome Concentrations of Hydrogen Ions on Afferent and Intrinsic J.E. KELLow, G.M. ECKERSLEY, AND M.P. JONES Neurons of the Rat Stomach P. GEPPETTI, M. TRAMONTANA, S. EVANGELISTA, D. RENZI, LIVER, PANCREAS, AND BILIARY TRACT C.A. MaccI, B.M. Fusco, AND E. DEL BIANCO Gas in Gallstones: Quantitative Determinations and High Incidence of Esophageal Motor Disorders in Possible Effects on Fragmentation by Shock Waves Consecutive Patients With Globus Sensation N. VAKIL AND E.C. EVERBACH G. Moser, G.V. VACARIU-GRANSER, C. SCHNEIDER, T.-A. ABATZI, P. POKIESER, G. STACHER-JANOTTA, G. GAUPMANN, U. WEBER, The Antiinflammatory Effect of Dopamine ia Alcoholic T. WENZEL, M. RODEN, AND G. STACHER Hemorrhagic Pancreatitis in Cats N.D. KARANjIA, A.L. WIDDISON, F.J. LUTRIN, Y.-B. CHANG, Imbalance of Plasminogen Activators and Their Inhibitors AND H.A. REBER in Human Colorectal Neoplasia C.F.M. SIER, H.W. VERSPAGET, G. GRIFFIOEN, J.H. VERHEIJEN, A Prospective Controlled Study of the Risk of Bacteremia P.H.A. Quax, G. DOONEWAARD, P.A.F. DE BRUIN, in Emergency Sclerotherapy of Esophageal Varices AND C.B.H.W. LAMERS H. Ho, M.J. ZUCKERMAN, AND C. WASSEM Activation and Signaling Status of Human Lamina Propria Patterns of Hepatitis Delta Virus Reinfection and Disease T Lymphocytes in Liver Transplantation L. Qiao, G. SCHURMANN, M. BETZLER, AND S.C. MEUER A. OTTOBRELLI, A. MARZANO, A. SMEDILE, S. RECCHIA, Colonic Motor Response to a Meal in Acute Colitis M. SALIzZONI, C. CoRNu, M.E. Lamy, J.B. OTTE, B. DE HEMPTINNE, A. GEUBEL, M. GRENDELE, M. COLLEDAN, A.K. SETHI AND S.K. SARNA D. GALMARINI, G. MARINUCCI, C. Dr GIACOMO, S. AGNES, Antral Gastrin Cell Hyperfunction in Children F. BONINO, AND M. RIZZETTO B. ANNIBALE, M. BONAMICO, G. RINDI, L. VILLANI, E. FERRANTE, Spontaneous Bacterial Peritonitis in Patients With A. VANIA, E. SOLCIA, AND G. DELLE FAVE Hepatitis B—Related Cirrhosis and Hepatocellular Regulation of Rat Antral Gastrin and Somatostatin Gene Carcinoma Expression During Starvation and After Refeeding S.-S. WANG, Y.-T. Tsal, S.-D. LEE, H.-T. CHEN, C.-W. Lu, V. Wu, K. Summ, A. TARI, M. SUMII, AND J.H. WALSH F.-Y. LEE, J.-S. JENG, Y.-C. Liu, AND K.-J. Lo Radial and Longitudinal Asymmetry of Human Pharyngeal Regional Orientation of Actin Filaments in the Pressures During Swaliowing Pericanalicular Cytoplasm of Rat Hepatocytes V.W. SEARS, JR., J.A. CASTELL, AND D.O. CASTELL M. IsHu, H. WASHIOKA, A. TONOSAKI, AND T. TOYOTA CONTENTS GASTROENTEROLOGY Vol. 101, No. 6 1673 Acute Infusions of Bile Salts Increase Biliary Excretion of EDITORIALS Iron in Iron-Loaded Rats Liver Transplantation: A Model for the Transmission of P. Levy, M. DuMOoNnT, P. BrissoT, A. LETREUT, A. FAVIER, Hepatitis Delta Virus Y. DEUGNIER, AND S. ERLINGER W.S. MASON AND J.M. TAYLOR Differential Inhibition of Individual Human Liver Cytochromes P-450 by Cimetidine SELECTED SUMMARIES R.G. KNODELL, D.G. BRowneE, G.P. Gwozpbz, W.R. BRIAN, Laparoscopic Treatment of Duodenal Ulcer: A Plea for AND F.P. GUENGERICH Clinical Triais Experimental Evaluation of an Endoscopic Balloon for Manometry of Esophageal Varices Alcohol Abuse and Liver Disease: True, True, but Not Necessarily Related P. GERTSCH, A.M. WHEATLEY, R. MAIBACH, G.J. MADDERN, AND J.-N. VAUTHEY Sphincter of Oddi Manomeiry in Patients With Possible Occult Microlithiasis in ‘Idiopathic’ Acute Pancreatitis: Sphincter of Oddi Dysfunction Prevention of Relapses by Cholecystectomy or Palliation of Advanced Esophageal Cancer: A (Laser) Light Ursodeoxycholic Acid Therapy at the End of the Tunnel E. Ros, S. NAVARRO, C. BRU, A. GARCIA-PUGES, Is Exercise Good for Gastrointestinal Function? AND R. VALDERRAMA Glucagon Hinders the Effects of Somatostatin on Portal BOOK REVIEWS Hypertension M.P. Pizcueta, J.C. GARCIA-PAGAN, M. FERNANDEZ, CORRESPONDENCE R. CASAMITJANA, J. BOSCH, AND J. RODES Extracorporeal Shock-Wave Lithotripsy for the Intraacinar Profiles of Alcohol Dehydrogenase and Management of Bile Duct Stones: Is It Always a Safe Aldehyde Dehydr >genase Activities in Human Liver Procedure? I.P. MALY AND D. SASSE Microvillus Inclusion Disease Antibodies to Hepatitis C Virus in Low-Risk Blood Donors: Implications for Counseling Positive Donors Hyperplastic Polyps Do Not Predict Adenomatous Polyps H.H. Hsu, M. GONZALEZ, S.K.H. FOUNG, S.M. FEINSTONE, A Role for NMR in Alcoholism? AND H.B. GREENBERG Whither Biliary Sludge—Do You Exist? CASE REPORTS Helicobacter pylori in Autoimmune Gastritis Successful Orthotopic Liver Transplantation in a Patient Propranolol for Prophylactic Treatment of a First Variceal With Refractory Biliary Candidiasis Hemorrhage : K.B. Noack, D.R. Osmon, K.P. BATTS, M. WILHELM, Intestinal Lymphangiectasia: Lack of Efficacy of R.A.F. KROM, AND K.D. LINDOR Antiplasmin Therapy? Acute Biliary-Vascular Fistula Following Needle Aspiration of the Liver 1761 CORRECTIONS M.S. VERHILLE AND S.J. MUNOZ 1762 NOTICES Severe M Ind ed Liver Cell Necrosis G. BABANY, J. BERNUAU, A. CAILLEUX, J.-F. CADRANEL, 1763 SPECIAL NOTICE C. DEGOTT, S. ERLINGER, AND J.-P. BENHAMOU 1768 AUTHOR INDEX TO VOLUME 101 Severe Cholestatic Jaundice Associated With Piroxicam K.S. Hepps, G.M. MALIHA, R. ESTRADA, AND R.W. GOODGAME 1781 SUBJECT INDEX TO VOLUME 101

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CONTENTS OF VOLUME 101 NO. 1, JULY 1991 This Month in GASTROENTEROLOGY 122 Epidemiology of Inflammatory Bowel Disease Among U.S. Military Veterans ALIMENTARY TRACT A. SONNENBERG AND I.H. WASSERMAN Basophil-Bound and Serum Immunoglobulin E Directed Sensitivity of the Gastric Mucosa to Acid and Duodenal Against Helicobacter pylori in Patients With Chronic Contents in Patients With Nonulcer Dyspepsia Gastritis A.A. GEORGE, M. TSUCHIYOSE, AND C.P. DOOLEY A. ACETI, D. CELESTINO, M. CAFERRO, V. CASALE, F. CITARDA, Phospholipid— and Neutral Lipid—Containing Organelles of E.M. Conti, A. Grassi, A. GRILLI, A. PENNICA, F. SCIARRETTA, Rat Gastroduodenal Mucous Cells O. LerRI, F. AMEGLIO, AND A. SEBASTIANI Y.-C.J. KAO AND L.M. LICHTENBERGER Pharmacokinetics of Oral and Intravenous Omeprazole in Acute Intestinal Injury Induced by Acetic Acid and Casein: Patients With the Zollinger—Ellison Syndrome Prevention by Intraluminal Misoprostol R. VINAYEK, M. AMANTEA, P.N. MATON, H. FRUCHT, M.J.S. MILLER, X.-J. ZHANG, X. GU, AND D.A. CLARK J.D. GARDNER, AND R.T. JENSEN T-Lymphocyte Modulation of Intestinal Muscle Function in Long-Term Prognosis After Partial Gastrectomy for Benign the Trichinella-Infected Rat Conditions D.L. VERMILLION, P.B. ERNST, AND S.M. COLLINS A.C. TERSMETTE, G.J.A. OFFERHAUS, F.M. GIARDIELLO, R. BRAND, Use of Azathioprine or 6-Mercaptopurine in the Treatment K.W.F. TERSMETTE, G.N.J. TYTGAT, AND J.P. VANDENBROUCKE of Crohn’s Disease Genetic Characterization of the APC Locus Involved in J.J. O'BRIEN, T.M. BAYLESS, AND J.A. BAYLESS Familial Adenomatous Polyposis Localization of Endothelinlike Immunoreactivity and S. OLSCHWANG, B. WEIFFENBACH, P. LAURENT-PUIG, T. MELOT, Endothelin Binding Sites in Human Colon A. VASSAL, K. FALLS, R.J. SALMON, R. PARC, L. STRONG, H. INAGAKI, A.E. BisHop, C. Escric, J. WHARTON, Y. NAKAMURA, L. HERRERA, AND G. THOMAS T.G. ALLEN-MERSH, AND J.M. POLAK Induction of Heat Shock Proteins and Their Implication in The Mechanism of Action of Peppermint Oil on Protection Against Ethanol-Induced Damage in Cultured Gastrointestinal Smooth Muscle Guinea Pig Gastric Mucosal Cells K. NAKAMURA, K. ROKUTAN, N. MARUI, A. AOIKE, AND K. KAWAI J.M. HILLs AND P.I. AARONSON Gastric Acid Secretion and Parietal Cell Mass: Effect of Sex Positive Serum Antibody and Negative Tissue Staining for Hormones Helicobacter pylori in Subjects With Atrophic Body K.A. ADENIYI Gastritis W.E. KARNES, JR., I.M. SAMLOFF, M. SIURALA, M. KEKKI, Proliferation of Endocrine Cells in the Rat Stomach Caused P. SIPPONEN, S.W.R. KIM, AND J.H. WALSH by Drug-Induced Achlorhydria R. EISSELE, B. Ro&kopr, H. Koop, G. ADLER, AND R. ARNOLD Reproducibility of Measurements of Trace Gas Concentrations in Expired Air A Novel Enzyme Immunoassay for Serodiagnosis of A. STROCCHI, C. ELLIS, AND M.D. Levitt Helicobacter pylori Infection T. SucryaMa, K. IMAI, H. YOSHIDA, Y. TAKAYAMA, T. YABANA, LIVER, PANCREAS, AND BILIARY TRACT K. YOKOTA, K. OGUMA, AND A. YACHI The Effect of Elemental Diet on Intestinal Permeability and Increased Paracellular Permeability in Intrahepatic Inflammation in Crohn’s Disease Cholestasis Induced by Carmustine (BCNU) in Rats K. TEAHON, P. SMETHURST, M. PEARSON, A.J. LEVI, H. KRELL, H. FROMM, AND R.E. LARSON AND I. BJARNASON Cost-Effectiveness of Extracorporeal Shock-Wave Lamina Propria Lymphocytes Are Derived From Circulating Lithotripsy Versus Cholecystectomy for Symptomatic Cells That Lack the Leu-8 Lymph Node Homing Receptor Gallstones M. BERG, Y. MURAKAWA, D. CAMERINI, AND S.P. JAMES E.B. Bass, E.P. STEINBERG, H.A. Pitt, G.P. SABA, K.D. LILLEMOE, D.R. KAFONEK, T.R. GADACZ, T.A. GORDON, AND G.F. ANDERSON Effect of Enteric Pacing on Intestinal Motility and Hormone Secretion in Dogs With Short Bowel Distribution of the VLA Family of Integrins in Normal and S.B. REISER, V. SCHUSDZIARRA, E. BOLLSCHWEILER, Pathological Human Liver Tissue A.H. HOLSCHER, AND J.R. SIEWERT R. VOLPES, J.J. VAN DEN OORD, AND V.J. DESMET Scintigraphic Measurement of Regional Gut Transit in The Bentiromide Test Using Plasma p-Aminobenzoic Acid Idiopathic Constipation for Diagnosing Pancreatic Insufficiency in Young Children T. STIVLAND, M. CAMILLERI, M. VASSALLO, M. PROANO, D. RATH, D. LauFER, G. CLEGHORN, G. FORSTNER, L. ELLIS, G. KOREN, M. Brown, G. THOMFORDE, J. PEMBERTON, AND S. PHILLIPS AND P. DURIE Lipase and Pepsin Activity in the Gastric Mucosa of Infants, Factors Affecting the Measurement of Cholesterol Children, and Adults Nucleation in Human Gallbladder and Duodenal Bile J. DrPALMA, C. KirK, M. HAMOsH, A.R. COLON, S.B. BENJAMIN, J.W. Marks, P. BROOMFIELD, G.G. BONORRIS, AND P. HAMOSH AND L.J. SCHOENFIELD iv CONTENTS GASTROENTEROLOGY Vol. 101, No. 6 220 Secretagogue Response of Azaserine-Induced Rat Pancreatic How Enterocytes Stick and What They Stick To Acinar Tumors in Vivo Superficial Esophageal Carcinoma: Will Early Detection K.-H. HERZIG, W. CREUTZFELDT, AND U.R. FOLSCH Help? Impaired Hepatic Handling and Processing of Evidence for a Direct Hepatoprotective Action of Lysophosphatidylcholine in Rats With Liver Cirrhosis Ursodeoxycholic Acid in Primary Human Hepatocytes M. ANGELICO, D. ALVARO, A. CANTAFORA, R. MASELLA, E. Gaunio, C. GANpDIN, S.G. CorRADINI, F. ARIOSTO, O. RIGGIO, Toward a Treatment for Anorexia and Cachexia in Patients AND L. CAPOCACCIA With Cancer CASE REPORTS BOOK REVIEWS Growth in Adulthood After Liver Transplantation for CORRESPONDENCE Glycogen Storage Disease Type | B.S. KIRSCHNER, A.L. BAKER, AND F.K. THORP 24-Hour Intragastric Acidity and Plasma Gastrin After Development of Sustained Achlorhydria in a Patient With Omeprazole Treatment and After Proximal Gastric the Zollinger—Ellison Syndrome Treated With Omeprazole Vagotomy in Ducdenal Ulcer Patients J.L. GRIFFITH, O.W. CUMMINGS, AND B.I. HIRSCHOWITZ Persisting Benzodiazepine Metabolites Responsible for the Cytomegalovirus Infection of the Appendix in a Patient Reaction to the Benzodiazepine Antagonist Flumazenil in With the Acquired Immunodeficiency Syndrome Patients With Hepatic Encephalopathy S. VALERDIZ-CASASOLA AND F.J. PARDO-MINDAN Treatment of Cholesterol Gallstone Patients With Ursodeoxycholic Acid for the Treatment of Home Parenteral Ursodeoxycholic Acid Nutrition—Associated Cholestasis ‘Abstract Creep’ in GASTROENTEROLOGY K.D. LINDOR AND J. BURNES Pancreatic Exocrine Secretion in Acute Experimental Pancreatitis CLINICAL CHALLENGES Efficacy of Dextran-70 As a Substitute for Albumin Exacerbation of Ulcerative Colitis D.J. HERMENS AND P.B. MINER, JR. Calcium Carbonate Solubility in Human Common Duct Bile: Calcium Carbonate Precipitation in Gallstones SFLECTED SUMMARIES Acute Necrotizing Esophagitis: Another Case Treatment of Bleeding Arteriovenous Malformations With Oral Contraceptives: Safe Sex? NOTICES NO. 2, AUGUST 1991 This Month in GASTROENTEROLOGY Effects of Vibrio cholerae Recombinant Strains on Rabbit Ileum In Vivo C.D. Linn, R.H. Davis, R.L. GUERRANT, J.B. KAPER, ALIMENTARY TRACT AND J.R. MATHIAS The Parietal Cell Autoantibodies Recognized in Neonatal Effect of Neuropeptide Y on Jejunal Water and Ion Thymectomy-Induced Murine Gastritis Are the a and B Transport in Humans Subunits of the Gastric Proton Pump U. HOLZER-PETSCHE, W. PETRITSCH, T. HINTERLEITNER, A. EHERER, C.M. JONES, J.M. CALLAGHAN, P.A. GLEESON, Y. Mor!, G. SPERK, AND G.J. KREJS T. MASUDA, AND B.-H. TOH Mechanism of Short-Chain Fatty Acid Uptake by Apical Microvascular Permeability Increases Early in the Course Membrane Vesicles of Rat Distal Colon of Acid-Induced Esophageal Injury N. MASCOLO, V.M. RAJENDRAN, AND H.J. BINDER F.G. ZyLSTRA, T.T. HYNNA-LIEPERT, P.K. DINDA, I.T. BECK, Developmental Characteristics of the Kitten Antrum AND W.G. PATERSON A.C. HILLEMEIER, K.N. BITAR, AND P. BIANCANI Establishment and Characterization of a Human Carcinoid Abnormal Esophageal Motility in Nude Mice and Effect of Various Agents on Tumor B.T. Massey, W.J. Dopps, W.J. HoGAN, J.G. BRASSEUR, Grewth AND J.F. HELM B.M. Evers, C.M. TOWNSEND, JR., J.R. Upp, E. ALLEN, S.C. HURLBUT, S.W. Kim, S. RAJARAMAN, P. SINGH, J.C. REUBI, Regional Esophageal Distribution and Clearance of AND J.C. THOMPSON Refluxed Gastric Acid R. SHAKER, W.J. Dopps, J.F. HELM, M.K. KERN, AND W.J. HOGAN Postiranslational Cleavage of Rat Intestinal Lactase Occurs at the Luminal Side of the Brush Border Membrane Intestinal Absorption of Fructose in the Rat K.-Y. YEH, M. YEH, P.-C. PAN, AND P.R. HOLT T. FUujISAWA, J. RIBY, AND N. KRETCHMER December 1991 Long-Term Survival Analysis in Hereditary 497 Comparison of 1 or 3 MU of Interferon Alfa-2b and Placebo Hemochromatosis in Patients With Chronic Non-A, Non-B Hepatitis P.C. ADAMS, M. SPEECHLEY, AND A.E. KERTESZ X. CAUSSE, H. GODINOT, M. CHEVALLIER, P. CHOSSEGROS, F. ZOuLIM, D. OuZAN, J.-P. HEYRAUD, T. FONTANGES, Variation of Muscle Tone in the Human Colon J. ALBRECHT, C. MESCHIEVITZ, AND C. TREPO C.J. STEADMAN, S.F. PHILLIPS, M. CAMILLERI, A.C. HADDAD, AND R.B. HANSON Role of Cholecystokinin in the Regulation of Gastric Premicellar Taurocholate Enhances Ferrous Iron Uptake Emptying and Pancreatic Enzyme Secretion in Humans From All Regions of Rat Small Intestine M. FRIED, U. ERLACHER, W. SCHWIZER, C. LOCHNER, J. KOERFER, C. BEGLINGER, J.B. JANSEN, C.B. LAMERS, F. HARDER, A.J. SANYAL, M.L. SHIFFMAN, J.I. HIRSCH, AND E.W. MOORE A. BISCHOF-DELALOYE, G.A. STALDER, AND L. ROVATI T-Lymphocyte Dysfunctions Occurring Together With Apical Gut Epithelial Cell Autoantibodies Intraductal Mucin-Hypersecreting Neoplasms of the J.M. MarTiN-VILLA, J.R. REGUEIRO, D. DE JUAN, P. PEREZ-ACIEGO, Pancreas M. PEREZ BLAS, J. MANZANARES, G. VARELA, F. RICKAERT, M. CREMER, J. DEVIERE, L. TAVARES, AND A. ARNAIZ-VILLENA J.P. LAMBILLIOTTE, S. SCHRODER, D. WuRBS, AND G. KLOPPEL Ion Transport Abnormalities in Rectal Suction Biapsies CASE REPORTS From Children With Cystic Fibrosis H.J. VEEZE, M. SINAASAPPEL, J. BIJMAN, J. BOUQUET, Intestinal and Hepatic Apolipoprotein B Gene Expression in AND H.R. DE JONGE Abetalipoproteinemia Aspirin Induces Morphological Transformation to the D.D. BLAck, R.V. Hay, P.L. ROHWER-NUTTER, H. ELLINAS, Secretory State in Isolated Rabbit Parietal Cells J.K. STEPHENS, H. SHERMAN, B.-B. TENG, P.F. WHITINGTON, U.K. MurTuy AND R.A. LEVINE AND N.O. DAVIDSON Circadian Rhythm of Cellular Proliferation in the Human Rhabdomyolysis and Cutaneous Necrosis Following Rectal Mucosa Intravenous Vasopressin Infusion K.N. Bucul, J.G. Moore, W.J.M. HRUSHESKY, R.B. SOTHERN, D. MorENO-SANCHEZ, B. Casis, A. MARTIN, P. ORTIZ, AND N.H. RUBIN G. CASTELLANO, M.T. MUNOZ, F. VANACLOCHA, AND J.A. SOLIS-HERRUZO Sensory Neurons Signal for an Increase in Rat Gastric Mucosal Blood Flow in the Face of Pending Acid Injury Idiopathic Myointimal Hyperplasia of Mesenteric Veins P. Houzer, E.H. LIVINGSTON, AND P.H. GUTH R.M. GENTA AND R.C. HAGGITT Presence of Atrial Natriuretic Factor Prohormone in Enterochromaffin Cells of the Human Large Intestine BRIEF REPORTS A.L. GERBES, W. NATHRATH, M. CANTIN, AND H. DENECKE Metabolism of Trinitrobenzene Sulfonic Acid by the Rat Increased Na*-H* Exchange in Jejunal Brush Border Colon Produces Reactive Oxygen Species Membrane Vesicles of Spontaneously Hypertensive Rats M.B. GRISHAM, C. VOLKMER, P. TsO, AND T. YAMADA S. ACRA AND F.K. GHISHAN Helicobacter pylori Infection Induces Antibodies Cross- SPECIAL REPORTS AND REVIEWS Reacting With Human Gastric Mucosa Reports From the NIH DDDN R. NEGRINI, L. LISATO, I. ZANELLA, L. CAVAZZINI, S. GULLINI, F.A. HAMILTON AND J.H. HOOFNAGLE V. VILLANACCI, C. Potgsi, A. ALBERTINI, AND S. GHIELMI LIVER, PANCREAS, AND BILIARY TRACT SELECTED SUMMARIES Activation of Mast Cells by Bile Acids Antibiotic Prophylaxis for Prevention of Spontaneous R.G. Quist, H.-T. TON-Nu, J. LILLIENAU, A.F. HOFMANN, Bacterial Peritonitis? AND K.E. BARRETT Nitroglycerin in the Treatment of Portal Hypertension Cell Type—Dependent Effect of Phospholipid and Endoscopic Management of Gastric Outlet Obstruction Cholesterol on Bile Salt Cytotoxicity A.L.M. VELARDI, A.K. GROEN, R.P.J.O. ELFERINK, At Long Last—The Histamine H,-Receptor Gene Is Cloned R. VAN DER MEER, G. PALASCIANO, AND G.N.J. TYTGAT NSAID-Induced Gastroduodenal Injury: What's the Score? Pancreatic Lesions in the von Hippel-Lindau Syndrome H.P.H. NEUMANN, E. DINKEL, H. BRAMBS, B. WIMMER, BOOK REVIEWS H. FRIEDBURG, B. VOLK, G. SIGMUND, P. RIEGLER, K. HAAG, P. SCHOLLMEYER, AND O.D. WIESTLER TRAINING AND EDUCATION IN The Stomach in Liver Cirrhosis GASTROENTEROLOGY S. VIGNERI, R. TERMINI, A. PIRAINO, A. SCIALABBA, G. PISCIOTTA, List of Available Training Programs AND N. FONTANA Bile Evacuation Induced by Hypothalamic Stimulation in CORRESPONDENCE Dogs N. FURUKAWA AND H. OKADA Ethanol Stimulates Pepsinogen Release From Isolated Guinea Pig Chief Cells Comparative Evaluation of Chenodeoxycholic and Ursodeoxycholic Acids in Obese Patients Hemodynamic Events in a Prospective Randomized Trial of G. MAZZELLA, F. BAZZOLI, D. FEsTI, M. RONCHI, R. ALDINI, Propranolol Versus Placebo ir the Prevention of a First A. Roba, B. GRIGOLO, P. SIMONI, N. VILLANOVA, AND E. RODA Variceal Hemorrhage vi CONTENTS GASTROENTEROLOGY Vol. 101, No. 6 592 The Possible Role of Phospholipase in Gallstone 594 Fasting and Postprandial Residual Gallbladder Volumes Pathogenesis 593 Host Response to Mycobacterial Infection in the Alcoholic 595 CORRECTION Rat 594 Tumor Necrosis Factor a in the Pathophysiology of Necrotizing Enterocolitis 596 NOTICES NO. 3, SEPTEMBER 1991 597 This Month in GASTROENTEROLOGY Isolation, Characterization, and Attachment of Rabbit Distal Colon Epithelial Cells R.V. BENYA, L.N. SCHMIDT, J. SAHI, T.J. LAYDEN, AND M.C. RAO ALIMENTARY TRACT Mechanism for the Gastrokinetic Aciion of Domperidone 599 The Cephalic and Gastric Phases of Gastric Secretion T. TAKAHASHI, S. KUROSAWA, J.W. WILEY, AND C. OWYANG During H,-Antagonist Treatment H.S. MERKI, C.H. WILDER-SMITH, R.P. WALT, AND F. HALTER Cancer Incidence Following Subtotal Gastrectomy G.N. STEMMERMANN, A.M.Y. NOMURA, AND P.-H. CHYOU 607 Effect of Intrathoracic Pressure on Plasma Arginine Vasopressin Levels Rat Enterocyte Injury by Oxygen-Dependent Processes J.A. SOLIS-HERRUZO, D. MORENO, A. GONZALEZ, L. LARRODERA, S.S. BAKER AND C.L. CAMPBELL G. CASTELLANO, J. GUTIERREZ, AND A. GOZALO Fecal Carriage of Streptococcus bovis and Colorectal 618 Expression of Sucrase-Isomaltase and Dipeptidylpeptidase Adenomas IV in Human Small Intestine and Colon R. Dusrow, S. EDBERG, E. WIkFors, D. CALLAN, F. TRONCALE, J.P. GoRVEL, A. FERRERO, L. CHAMBRAUD, A. RIGAL, J. BONICEL, R. VENDER, M. BRAND, AND R. YAPP AND S. MAROUX Antitumor Effect of Synthetic Derivatives of Lipid A in an 626 Intestinal Obstruction During Shigellosis: Incidence, Experimental Model of Colon Cancer in the Rat Clinical Features, Risk Factors, and Outcome J.-F. JEANNIN, N. ONtIER, P. LAGADEC, N. VON JENEY, P. STUTZ, M.L. BENNISH, A.K. AZAD, AND D. YOUSEFZADEH AND E. LIEHL 635 Sulindac Causes Regression of Rectal Polyps in Familial Neural and Hormonal Mechanisms Mediate the Adenomatous Polyposis Enterogastric Reflex: A Study in Intestinal Transplants in D. LABAYLE, D. FISCHER, P. VIELH, F. DROUHIN, A. PARIENTE, C. BortEs, O. DUHAMEL, M. TROUSSET, AND P. ATTALI Rats S.L. OrLoFF, N.W. BUNNETT, H. WONG, J.H. WALSH, 640 Radioautographic Localization of Epidermal Growth Factor AND H.T. DEBAS Receptors in Human Fetal Gut D. MENARD AND P. POTHIER Classic and Vigorous Achalasia: A Comparison of Manometric, Radiographic, and Clinical Findings 650 Observations on a Proposed Measure of Genotoxicity in Rat S.P. GOLDENBERG, M. BURRELL, G.G. FETTE, C. Vos, Gastric Mucosa AND M. TRAUBE S. HOLT, Z. ZHAO-HUA, AND R.E. POWERS Apolipoprotein Synthesis in Normal and 657 Hypertrophic Smooth Muscle in the Partially Obstructed Abetalipoproteinemic Intestinal Mucosa Opossum Esophagus R.M. GLICKMAN, J.N. GLICKMAN, A. MAGUN, AND M. BRIN J.L. CONKLIN, C. Du, K. SCHULZE-DELRIEU, AND S. SHIRAZI Nonsalicylate Nonsteroidal Antiinflammatory Drugs 664 Trichinella spiralis Infection Alters Small Bowel Motor Augment Prestimulated Acid Secretion in Rabbit Parietal Activity in the Fed State Cells V.E. COWLES AND S.K. SARNA R.A. LEVINE, J. NANDI, AND R.L. KING 670 I histochemical Characterization, Distribution, and Ultrastructure of Lymphocytes Bearing T-Cell Receptor y/5 in Inflammatory Bowel Disease LIVER, PANCREAS, AND BILIARY TRACT K. FUKUSHIMA, T. MAsuDA, H. OHTANI, I. SASAKI, Y. FUNAYAMA, Detection and Partial Sequencing of Hepatitis C Virus RNA S. MATSUNO, AND H. NAGURA in the Liver 679 Quality of Life After Proctocolectomy K. Hosopa, O. Yokosuka, M. Omata, N. KATO, AND M. OHTO L.W. KOHLER, J.H. PEMBERTON, A.R. ZINSMEISTER, The Effects of Benzodiazepine-Receptor Antagonists and AND K.A. KELLY Partial Inverse Agonists on Acute Hepatic Encephalopathy 685 Acute Abdomen as the First Presentation of in the Rat Pseud b Colitis D.K. BOSMAN, C.A.C.G. VAN DEN Buys, J.G. DE HAAN, G. TRIADAFILOPOULOS AND A.E. HALLSTONE M.A.W. MAAS, AND R.A.F.M. CHAMULEAU December 1991 Elevation of Serum Interleukin-6 Concentration Precedes CLINICAL CHALLENGES Acute-Phase Response and Reflects Severity in Acute Pancreatitis 848 Hypoproteinemia, Anemia, and Failure to Thrive in an Infant H.-G. LEsER, V. Gross, C. SCHEIBENBOGEN, A. HEINISCH, R. SALM, M. LauSEN, K. RUCKAUER, R. ANDREESEN, E.H. FARTHMANN, J.E. BINES AND E.J. ISRAEL AND J. SCHOLMERICH Acalculous Biliary Pain: Cholecystectomy Alleviates EDITORIALS Symptoms in Patients With Abnormal Cholescintigraphy Lessons From Experimental Cholelithiasis: Gallbladder and L. YAP, A.G. WYCHERLEY, A.D. MORPHETT, AND J. TOOULI Mucosa, Nonsteroidal Antiinflammatory Drugs, and Noninvasive Measurement of Liver Regeneration With Gallstones Positron Emission Tomography and [2-"'C]Thymidine S.P. LEE T. VANDER BorGHT, L. LAMBOTTE, S. PAUWELS, D. LABAR, C. BECKERS, AND C. DIVE The Effects of Chronic Endoscopic Variceal Sclerotherapy SELECTED SUMMARIES on Portal Pressure in Cirrhotics One More Reason for Weight Loss in Patients With AIDS J. KORULA AND P. RALLS Chronic Dietary Iron Overload in Rats Results in Impaired Hepatitis B and Human I daft. iency Virus: Double Trouble Calcium Sequestration by Hepatic Mitochondria and Microsomes Acute and Chronic Giant Cell Hepatitis: A Paramyxovirus R.S. BRITTON, R. O’NEILL, B.R. BACON Infection? Inhibition of Prostaglandin Synthesis Fails to Prevent Peliosis Hepatis: Old Disease, New Cause Gallbladder Mucin Hypersecretion in the Cholesterol-Fed Prairie Dog A Biopsychosocial Model for Functional Dyspepsia D.P. O’LEARY, W.W. LAMortE, T.E. ScoTT, M.L. BOOKER, BOOK REVIEWS AND J. STEVENSON Microanalysis of Bile Acid Composition in Intrahepatic Calculi and Its Etiological Significance CORRESPONDENCE J. SHopa, N. TANAKA, Y. MATSUZAKI, A. HonpA, T. OsuGa, Vegetable Peroxidase Is Denatured by Gastric Acid S. SHIGEMATSU, AND H. MIYAZAKI Estimation of Risk of Transmission of Non-A, Non-B CASE REPORTS Hepatitis by Needlestick Injury Clonorchis-Associated Cholangiocarcinoma: A Report of 872 Free Radical Scavengers and Inflammatory Bowel Disease Two Cases With Unusual Manifestations F.V. ONA AND J.N.T. DyToc 872 Role of Parenteral Nutrition in Crohn’s Colitis 874 Treatment of Intestinal Cryptosporidiosis With Zidovudine BRIEF REPORTS and SMS 201-995, a Somatostatin Analog Interferon-Induced Chronic Active Hepatitis? 874 Somatostatin and Acute Variceal Hemorrhage M.O. SILVA, K.R. REDDY, L.J. JEFFERS, M. HILL, AND E.R. SCHIFF 875 Prevalence of Columnar-Lined (Barrett’s) Esophagus SPECIAL REPORTS AND REVIEWS 876 Asthmatics’ Gastroesophageal Reflux With or Without 843 A Reappraisal of the Magnitude and Implications of the Bronchodilator Therapy Intestinal Unstirred Layer A. STROCCHI AND M.D. LEvITT NOTICES NO. 4, OCTOBER 1991 879 This Month in GASTROENTEROLOGY 889 The Effect of Histamine H,-Receptor Blockade on Bismuth Absorption From Three Ulcer-Healing Compounds C.U. NWoKOLo, E.J. PREWETT, A.M. SAWYERR, M. HUDSON, AND R.E. POUNDER ALIMENTARY TRACT Electrolyte Transport in Piglets Infected With Transmissible Gastroenteritis Virus 881 Comparison of Enteral Nutrition and Drug Treatment in F.R. HOMAIDAN, A. TORRES, M. DONOWITZ, AND G.W.G. SHARP Active Crohn’s Disease H. Locus, H.J. STEINHARDT, B. KLAUS-WENTZ, M. ZEITZ, Comparative Evaluation of Acid- and Bile-Induced H. VOGELSANG, H. SOMMER, W.E. FLEIG, P. BAUER, Damage to Pedicied Jejunal or Colonic Segments in the Rat J. SCHIRRMEISTER, AND H. MALCHOW G.B. RATTO, P. ROMANO, AND D. ZACCHEO CONTENTS GASTROENTEROLOGY Vol. 101, No. 6 Mechanism of Inhibitory Action of Prostaglandins on the Reversal of Protein-Bound Vitamin B,, Malabsorption With Growth of Human Gastric Carcinoma Cell Line KATO III Antibiotics in Atrophic Gastritis A. NAKAMURA, T. YAMATANI, T. FUJITA, AND T. CHIBA P.M. SUTER, B.B. GOLNER, B.R. GOLDIN, F.D. Morrow, AND R.M. RUSSELL Comparative Evaluation of Carcinoembryonic Antigen, Short-Chain Glucose Polymer and Secretory Component, and Mucins in Index and Anthracene-9-carboxylic Acid Inhibit Water and Metachronous Adenomas of the Colorectum Electrolyte Secretion Induced by Dibutyryl Cyclic AMP in G. GRIFFIOEN, F.T. BOSMAN, H.W. VERSPAGET, K.F.M. SIER, the Small Intestine I. BIEMOND, AND C.B.H.W. LAMERS G.H. RABBANI, R.-B. Lu, K. HORVATH, AND E. LEBENTHAL Epidemiology of Colonic Symptoms and the Irritable Bowel Syndrome LIVER, PANCREAS, AND BILIARY TRACT N.J. TALLEY, A.R. ZINSMEISTER, C. VAN DYKE, Light and Electron Microscopy of Neuropeptide Y- AND L.J. MELTON III Containing Nerves in Human Liver, Gallbladder, Action of Beer and Its Ingredients on Gastric Acid and Pancreas Secretion and Release of Gastrin in Humans W.-G. DING, M. Fujimura, A. Mort, I. TOOYAMA, M.V. SINGER, S. TEYSSEN, AND V.E. EYSSELEIN AND H. KIMURA Omeprazole Treatment Does Not Affect the Metabolism of Ornipressin in the Treatment of Functional Renal Failure Caffeine in Decompensated Liver Cirrhosis T. ANDERSSON, R. BERGSTRAND, C. CEDERBERG, S. ERIKSSON, K. LENZ, H. HORTNAGL, W. DRUML, H. REITHER, R. SCHMID, P.-O. LAGERSTROM, AND I. SKANBERG B. SCHNEEWEISS, A. LAGGNER, G. GRIMM, AND A.L. GERBES Complications of Endoscopic Sphincterotomy Tolerance During 5 Months of Dosing With Ranitidine, 150 mg Nightly: A Placebo-Controlled, Double-Blind Study S. SHERMAN, T.A. RUFFOLO, R.H. HAWES, AND G.A. LEHMAN C.U. NWOoKOLO, E.J. PREWETT, A.M. SAWYERR, M. HUDSON, Defective Fc Receptor—Mediated Clearance in Patients S. LIM, AND R.E. POUNDER With Primary Biliary Cirrhosis K. NILSSON EKDAHL, L. LOOF, A. NYBERG, U.R. NILSSON, Role of Capsaicin-Sensitive Afferent Neurons in Alkaline AND B. NILSSON Secretory Response to Luminal Acid in the Rat Duodenum K. TAKEUCHI, J. MATSUMOTO, K. UESHIMA, AND S. OKABE Azathioprine Treatment Increases Hepatocyte Turnover N. ARBER, G. ZAJICEK, J. NORDENBERG, AND Y. SIDI Reverse-Perfused Sleeve: An Improved Device for Prophylactic Sclerotherapy in High-Risk Cirrhotics Measurement of Sphincteric Function of the Crural Selected by Endosvopic Criteria Diaphragm B. SIvRI AND R.K. MITTAL R. DE FRANCHIS, M. PRIMIGNANI, P.G. ARCIDIACONO, P.M. RIZZI, P. VITAGLIANO, M.C. VAZZOLER, R. ARCIDIACONO, A. ROSSI, Opioids Inhibit Neuromuscular Transmission in Circular A. ZAMBELLI, F. COSENTINO, G. CALETTI, S. BRUNATI, Muscle of Human and Baboon Jejunum G. BATTAGLIA, AND G. GERUNDA A.J. BAUER, M.G. SARR, AND J.H. SZURSZEWSKI An Na‘*-Dependent and an Na*-Independent System for Glutamine Transport in Rat Liver Basolateral Membrane Effect of Age on Gastric Acid Secretion and Serum Gastrin Vesicles Concentrations in Healthy Men and Women H.M. Sap, D. HOLLANDER, AND S. KHORCHID M. GOLDSCHMIEDT, C.C. BARNETT, B.E. SCHWARZ, W.E. KARNES, J.S. REDFERN, AND M. FELDMAN Glucocorticoids Stimulate Ornithine Decarboxylase Gene Expression in Pancreatic AR42J Cells Enterogastric Reflux After Various Types of Antiulcer S. ROSEWICZ AND C.D. LOGSDON Gastric Surgery: Quantitation by °"Tc-HIDA Scintigraphy E. Xynos, J.S. VASSILAKIS, A. FOUNTOS, G. PECHLIVANIDES, Aspirin Does Not Inhibit Cholesterol Cholelithiasis in Two AND N. KARKAVITSAS Established Animal Models B.I. COHEN, E.H. MosBacu, N. AYYAD, M. YOSHII, The Origin of Symptoms on the Brain-Gut Axis in AND C.K. MCSHERRY Functional Dyspepsia F. MEARIN, M. CuCALA, F. AZPIROZ, AND J.-R. MALAGELADA BRIEF REPORTS Electroencephalogram Patterns During Sleep Reflux in Hepatitis C Virus Antibodies in Acute Icteric and Chronic Infants Non-A, Non-B Hepatitis J.M. SONDHEIMER AND E. HODDES J.G. McHuTCcHISON, G. Kuo, M. HOUGHTON, Q.-L. CHOO, In Vivo Evidence of Altered Chloride but Not Potassium AND A.G. REDEKER Secretion in Cystic Fibrosis Rectal Mucosa J.L. GOLDSTEIN, A.B. SHAPIRO, M.C. RAO, AND T.J. LAYDEN CLINICAL CHALLENGES Increased Activation of Isolated Intestinal Lamina Propria Fecal Incontinence in a 39-Year-Old Man Mononuclear Cells in Inflammatory Bowel Disease R.J. MAY S. SCHREIBER, R.P. MACDERMOTT, A. RAEDLER, R. PINNAU, M.J. BERTOVICH, AND G.S. NASH EDITORIALS Effects of Diazepam and Ro 15-1788 on Duodenal Enterai Feeding Versus Drug Therapy in Crohn’s Disease: Bicarbonate Secretion in the Rat A Continuing Story B. SAFSTEN, G. JEDSTEDT, AND G. FLEMSTROM J.W. SINGLETON December 1991 SELECTED SUMMARIES BOOK REVIEWS Treatment of Severe Postgastrectomy Dumping With a Long-Acting Somatostatin Analog: Is Effective Management CORRESPONDENCE Finally Available? Concentration in Pancreatic Juice of Lithostathine Sulfasalazine vs. Steroids in Crohn’s Disease: David vs. Pathogenesis and Treatment of Rotavirus Diarrhea Goliath? Prevalence of Spontaneous Hepatofugal Portal Flow in Recurrent Hepatitis B in Liver Transplant Recipients—No Liver Cirrhosis Easy Answers Enteric Neuronal Autoantibodies in Pseudoobstruction Sporadic vs. Posttransfusion Hepatitis C: Why the With Small-Cell Lung Carcinoma Differences? Hyperplastic Polyps and Risk of Adenomas Bidirectional Communication Between Mast Cells and Nerves Controls Intestinal Secretion NOTICES NO. 5, NOVEMBER 1991 This Month in GASTROENTEROLOGY 1229 Prostaglandins and the Colonic Epithelium R.A. GOODLAD, N. MANoDIR, S. LEVIN, J.L. ALLEN, AND N.A. WRIGHT ALIMENTARY TRACT Morphometry and Cell Proliferation in Endoscopic A Critical Analysis, With Appropriate Controls, of Gastric Biopsies: Evaluation of a Technique Acid and Pepsin Secretion in Clinical Esophagitis R.A. GOoDLaD, S. Levi, C.Y. LEE, N. MANDIR, H. HopGson, B.I. HIRSCHOWITZ AND N.A. WRIGHT Primary B-Cell Gastric Lymphoma: A Clinicopathological The Role of Vasopressin in the Pathogenesis of Ethanol- Study of 145 Patients Induced Gastric Hemorrhagic Erosions in Rats S.B. CoGuiatti, U. ScHmip, U. SCHUMACHER, F.. ECKERT, F. LAsz.0, G. KARACSONY, E. SzaB0, J. LANG, L. BALASPIRI, M.-L. HANSMANN, J. HEDDERICH, H. TAKAHASHI, AND K. LENNERT AND F.A. LASZLO Value of Transrectal Ultrasonography in Crohn’s Disease M.J. VAN OUTRYVE, P.A. PELCKMANS, P.P. MICHIELSEN, Central and Peripheral Control of Postprandial Pyloric AND Y.M. VAN MAERCKE Motility by Endogenous Opiates and Cholecystokinin in Dogs y-Aminobutyric Acid Localization and Function as Y. LOPEZ, J. FIORAMONTI, AND L. BUENO Modulator of Cholinergic Neurotransmission in Rat Antral Mucosal/Submucosal Fragments Peptidergic Innervation of the Human Esophageal Smooth R.F. Harty, M.G. BouarskI, G.S. BOCHNA, T.A. CARR, Muscle P.E. EAGAN, M. RINGs, D.C. LAssITER, M.P. Pour, C. SINGARAM, A. SENGUPTA, D.J. SUGARBAKER, AND R.K. GOYAL D.F. SCHAFER, AND R.S. MARKIN Changes in the Structure and Regeneration Mode of the Histological Maturity of Healed Duodenal Ulcers and Rat Small Intestinal Mucosa Following Benzalkonium Ulcer Recurrence After Treatment With Colloidal Bismuth Chloride Treatment Subcitrate or Cimetidine G.E. HOLLE S. PAN, C.-H. Liao, G.-S. LIEN, AND S.-H. CHEN Different Fibers Have Different Regional Effects on Portal Colopathy: Prospective Study of Colonoscopy in Luminal Contents of Rat Colon Patients With Portal Hypertension A. MCINTYRE, G.P. YOUNG, T. TARANTO, P.R. GIBSON, R.A. KOZAREK, V.A. BOTOMAN, J.E. BREDFELDT, J.M. ROACH, AND P.B. WARD D.J. PATTERSON, AND T.J. BALL Inversion of the Slow-Wave Frequency Gradient in Distribution of Aneuploid Cell Pepulations in Ulcerative Symptomatic Patients With Roux-en-Y Anastomoses Colitis With Dysplasia or Cancer G. VANTRAPPEN, G. COREMANS, J. JANSSENS, A. MANTIDES, D.S. LEVINE, P.S. RABINOVITCH, R.C. Haceitt, P.L. BLOUNT, AND F. VANDEN BORRE P.J. DEAN, C.E. RUBIN, AND B.J. REID Calcitonin Gene-Related Peptide and Substance P Colonic Motility and Transit in Health and Ulcerative Decrease in the Rabbit Colon During Colitis Colitis V.E. EYSSELEIN, M. REINSHAGEN, F. COMINELLI, C. STERNINI, S.N. Reppy, G. BAZZOCCHI, S. CHAN, K. AKASHI, W. Davis, A. PATEL, C.C. NAST, D. BERNSTEIN, K. ANDERSON, J. VILLANUEVA-MEYER, G. YANNI, I. MENA, AND W.J. SNAPE, JR. H. KHAN, AND W.J. SNAPE, JR. Effect of Eating on Colonic Motility and Transit in Patients Mechanisms of Acid Injury to Rabbit Esophageal With Functional Diarrhea Epithelium G. Bazzoccul, J. ELLIS, J. VILLANUEVA-MEYER, S.N. REDDY, N.A. TOBEY AND R.C. ORLANDO I. MENA, AND W.J. SNAPE, JR. x CONTENTS GASTROENTEROLOGY Vol. 101, No. 6 1307 Quality of Life of Patients With Ulcerative Colitis CASE REPORTS Preoperatively and Postoperatively 1417 Postinfantile Giant Cell Hepatitis in Association With R.S. McLeEop, D.N. CHURCHILL, A.M. Lock, S. VANDERBURGH, Hypereosinophilia AND Z. COHEN A. KUMAR AND G.Y. MINUK Perendoscopic Manometry of the Distal Ileum and Idiopathic Neonatal Iron-Storage Disease Ileocecal Junction in Humans J.A. BARNARD III AND E. MANCI E. CoRAZZIARI, F. BARBERANI, M. TOSONI, S. BOSCHETTO, AND A. TORSOLI BRIEF REPORTS Delayed Gastrointestinal Transit Times in Anorexia Nervosa and Bulimia Nervosa Cholecystokinin-Mediated Ileal Electrolyte Transport in N. KAMAL, T. CHAMI, A. ANDERSEN, F.A. ROSELL, the Guinea Pig M.M. SCHUSTER, AND W.E. WHITEHEAD J.F. KAcHur, S.-X. WANG, G.W. GULLIKSON, AND T.S. GAGINELLA LIVER, PANCREAS, AND BILIARY TRACT CLINICAL CHALLENGES Ultrasonic Tissue Characterization of Chronic Liver Disease Using Cepstral Analysis Recurrent Gastrointestinal Bleeding Associated With K. Suzuki, N. HAYASHI, Y. SASAKI, M. Kono, Y. IMAI, Myelofibrosis and Diffuse Intestinal Telangiectasias H. FUSAMOTO, AND T. KAMADA S.D. FREEDMAN, R.E. Drews, D.J. GLOTZER, D. KIM, Treatment of Primary Biliary Cirrhosis With Low-Dose H. GARDNER, AND S.J. GALLI Weekly Methotrexate M.M. KAPLAN AND T.A. KNOX EDITORIALS Effect of Phospholipase C on Cholesterol Solubilization in Methotrexate Therapy of Primary Biliary Cirrhosis: Model Bile Promising but Worrisome N.R. PATTINSON AND K.E. WILLIS J.H. HOOFNAGLE AND N.V. BERGASA Effectiveness of a Purified Human Hemoglobin as a Blood Substitute in the Perfused Rat Liver SELECTED SUMMARIES H.F. STARNES, JR., A. TEWARI, K. FLOKAS, J.C. KOSEK, Pregnancy in Liver Transplant Patients—And Vice Versa D. BRown, A.L. VAN-KESSEL, AND C.E. MONDON Abnormal Sympathetic and Renal Response to Sodium The p53 Gene and Hepatocellular Carcinoma Restriction in Compensated Cirrhosis Transforming Growth Factors in Human Chronic Hepatitis M.-A. SIMON, J. Dizz, AND J. PRIETO and Cirrhosis: Correlations With Fibrogenesis and Hepatic Lipase/Amylase Ratio Regeneration V.V. GUMASTE, P.B. DAVE, D. WEISSMAN, AND J. MESSER Somatostatin Therapy for AIDS Diarrhea: Muddy Waters HLA DRwé8 and Coinplement C4 Deficiency as Risk Factors H, Antagonists by Continuous Infusion: IV or IG? in Primary Biliary Cirrhosis M.P. MANNS, A. BREMM, P.M. SCHNEIDER, A. NOTGHI, BOOK REVIEWS G. GERKEN, M. PRAGER-EBERLE, B. STRADMANN-BELLINGHAUSEN, K.-H. MEYER ZUM BUSCHENFELDE, AND C. RITTNER CORRESPONDENCE Risk Factors for Septicemia Following Endoscopic Biliary Stenting Functional Bowel Disease: The Role of Fructose and S. MorrteE, J. DEVIERE, J.-M. DUMONCEAU, E. SERRUYS, Sorbitol J.-P. THys, AND M. CREMER Role of Fructose-Sorbitol Malabsorption in the Irritable A Shift in Balance Between Profibrinolytic and Bowel Syndrome Antifibrinolytic Factors Causes Enhanced Fibrinolysis in Cirrhosis Fructose Malabsorption and the Irritable Bowel Syndrome F.W.G. LEEBEEK, C. KLuFT, E.A.R. KNOT, M.P.M. DE Maat, Helicobacter pylori Infection and Inflammation of the AND J.H.P. WILSON Gastric Corpus Lithotripsy of Gallstones by Means of a Quality-Switched Postparacentesis Plasma Expansion Prevents Giant-Pulse Neodymium: Yttrium-Aluminum-Garnet Laser Asymptomatic Laboratory Abnormalities, but Does It Have J. HocHBERGER, E. GRUBER, P. WirTZ, U. DURR, A. KOLB, Any Impact on Morbidity or Mortality? U. ZANGER, E.G. HAHN, AND C. ELL Cancer Risk in Left-Sided Colitis Portal and Biliary Phases of Enterohepatic Circulation of Corrinoids in Humans Stress Ulcer Prophylaxis S. EL KHOLTY, J.-L. GUEANT, L. BRESSLER, M. DJALALI, The Use of 6-Mercaptopurine in Adolescents With Crohn’s P. BoISSEL, P. GERARD, AND J.-P. NICOLAS Disease Significance of Computed Tomography for Shock-Wave Therapy of Radiolucent Gallbladder Stones 1460 CORRECTIONS C. ELL, H.T. SCHNEIDER, J. BENNINGER, S. THEOBALDY, N. FRIEDEL, W. RODL, P. WiRTZ, AND E.G. HAHN 1461 NOTICES December 1991 NO. 6, DECEMBER 1991 1463 This Month in GASTROENTEROLOGY 1564 Cisapride in Children With Chronic Intestinal Pseudoobstruction AMERICAN GASTROENTEROLOGICAL ASSOCIATION C. Di LORENZO, S.N. REDDY, J. VILLANUEVA-MEYER, I. MENA, S. MARTIN, AND P.E. HYMAN 1465 Presidential Address Colonic Motility in Innervated and Extrinsically D.H. ALPERS Denervated Loops in Dogs 1468 Presentation of the Julius Friedenwald Medal to Cyrus E. C. SHIBATA, I. SASAKI, S. MATSUNO, A. MIZUMOTO, AND Z. ITOH Rubin, M.D. Dual Effect of Trimebutine on Contractility of the Guinea W.M. WEINSTEIN Pig Ileum via the Opioid Receptors K. TANIYAMA, I. SANO, S. NAKAYAMA, S. MATSUYAMA, ALIMENTARY TRACT K. TAKEDA, C. YOSHIHARA, AND C. TANAKA Galanin Inhibition of Vasoactive Intestinal Polypeptide Flow-Cytometric DNA Content Analysis of Esophageal Release and Circular Muscle Motility in the Isolated Squamous Cell Carcinomas Perfused Canine Ileum M. ROBASZKIEWICZ, B.J. REID, A. VOLANT, J.M. CAUVIN, J.-A.E.T. FOX-THRELKELD, T.J. MCDONALD, S. CIpRis, P.S. RABINOVITCH, AND H. GOUEROU Z. WOSKOWSKA, AND E.E. DANIEL Loss of Interleukin-2—Producing Intestinal CD4+ T Cells in The Minor Components of the Rat Asialoglycoprotein Inflammatory Bowel Disease Receptor Are Apically Located in Neonatal Enterocytes K. KusuGAMI, T. MATSUURA, G.A. WEST, K.R. YOUNGMAN, C. Hu, E.Y. LEE, J.E. HEwirt, J.U. BAENZiGER, J.-Z. Mu, D. RACHMILEWITZ, AND C. FIOCCHI K. DESCHRYVER-KECSKEMETI, AND D.H. ALPERS Sensorial and Intestinointestinal Reflex Pathways in the Gastrointestinal Motor Effects of Erythromycin in Humans Human Jejunum S.K. SARNA, K.H. SOERGEL, T.R. KOCH, J.E. STONE, C.M. Woop, J.-M. ROUILLON, F. AZPIROZ, AND J.-R. MALAGELADA R.P. RYAN, R.C. ARNDORFER, J.H. CAVANAUGH, H.N. NELLANS, Modification of the Effects of Blood on Amino Acid AND M.B. LEE Metabolism by Intravenous Isoleucine Colonic Fermentation to Short-Chain Fatty Acids Is N.E.P. DEUTZ, P.L.M. RENVEN, M.C.F. Bost, C.L.H. VAN BERLO, Decreased in Antibiotic-Associated Diarrhea AND P.B. SOETERS M.R. CLAUSEN, H. BONNEN, M. TVEDE, AND P.B. MORTENSEN Enhanced Perception of Physiological Intestinal Motility Differential Effect on Neuropeptide Release of Different in the Irritable Bowel Syndrome Concentrations of Hydrogen Ions on Afferent and Intrinsic J.E. KELLow, G.M. ECKERSLEY, AND M.P. JONES Neurons of the Rat Stomach P. GEPPETTI, M. TRAMONTANA, S. EVANGELISTA, D. RENZI, LIVER, PANCREAS, AND BILIARY TRACT C.A. MaccI, B.M. Fusco, AND E. DEL BIANCO Gas in Gallstones: Quantitative Determinations and High Incidence of Esophageal Motor Disorders in Possible Effects on Fragmentation by Shock Waves Consecutive Patients With Globus Sensation N. VAKIL AND E.C. EVERBACH G. Moser, G.V. VACARIU-GRANSER, C. SCHNEIDER, T.-A. ABATZI, P. POKIESER, G. STACHER-JANOTTA, G. GAUPMANN, U. WEBER, The Antiinflammatory Effect of Dopamine ia Alcoholic T. WENZEL, M. RODEN, AND G. STACHER Hemorrhagic Pancreatitis in Cats N.D. KARANjIA, A.L. WIDDISON, F.J. LUTRIN, Y.-B. CHANG, Imbalance of Plasminogen Activators and Their Inhibitors AND H.A. REBER in Human Colorectal Neoplasia C.F.M. SIER, H.W. VERSPAGET, G. GRIFFIOEN, J.H. VERHEIJEN, A Prospective Controlled Study of the Risk of Bacteremia P.H.A. Quax, G. DOONEWAARD, P.A.F. DE BRUIN, in Emergency Sclerotherapy of Esophageal Varices AND C.B.H.W. LAMERS H. Ho, M.J. ZUCKERMAN, AND C. WASSEM Activation and Signaling Status of Human Lamina Propria Patterns of Hepatitis Delta Virus Reinfection and Disease T Lymphocytes in Liver Transplantation L. Qiao, G. SCHURMANN, M. BETZLER, AND S.C. MEUER A. OTTOBRELLI, A. MARZANO, A. SMEDILE, S. RECCHIA, Colonic Motor Response to a Meal in Acute Colitis M. SALIzZONI, C. CoRNu, M.E. Lamy, J.B. OTTE, B. DE HEMPTINNE, A. GEUBEL, M. GRENDELE, M. COLLEDAN, A.K. SETHI AND S.K. SARNA D. GALMARINI, G. MARINUCCI, C. Dr GIACOMO, S. AGNES, Antral Gastrin Cell Hyperfunction in Children F. BONINO, AND M. RIZZETTO B. ANNIBALE, M. BONAMICO, G. RINDI, L. VILLANI, E. FERRANTE, Spontaneous Bacterial Peritonitis in Patients With A. VANIA, E. SOLCIA, AND G. DELLE FAVE Hepatitis B—Related Cirrhosis and Hepatocellular Regulation of Rat Antral Gastrin and Somatostatin Gene Carcinoma Expression During Starvation and After Refeeding S.-S. WANG, Y.-T. Tsal, S.-D. LEE, H.-T. CHEN, C.-W. Lu, V. Wu, K. Summ, A. TARI, M. SUMII, AND J.H. WALSH F.-Y. LEE, J.-S. JENG, Y.-C. Liu, AND K.-J. Lo Radial and Longitudinal Asymmetry of Human Pharyngeal Regional Orientation of Actin Filaments in the Pressures During Swaliowing Pericanalicular Cytoplasm of Rat Hepatocytes V.W. SEARS, JR., J.A. CASTELL, AND D.O. CASTELL M. IsHu, H. WASHIOKA, A. TONOSAKI, AND T. TOYOTA CONTENTS GASTROENTEROLOGY Vol. 101, No. 6 1673 Acute Infusions of Bile Salts Increase Biliary Excretion of EDITORIALS Iron in Iron-Loaded Rats Liver Transplantation: A Model for the Transmission of P. Levy, M. DuMOoNnT, P. BrissoT, A. LETREUT, A. FAVIER, Hepatitis Delta Virus Y. DEUGNIER, AND S. ERLINGER W.S. MASON AND J.M. TAYLOR Differential Inhibition of Individual Human Liver Cytochromes P-450 by Cimetidine SELECTED SUMMARIES R.G. KNODELL, D.G. BRowneE, G.P. Gwozpbz, W.R. BRIAN, Laparoscopic Treatment of Duodenal Ulcer: A Plea for AND F.P. GUENGERICH Clinical Triais Experimental Evaluation of an Endoscopic Balloon for Manometry of Esophageal Varices Alcohol Abuse and Liver Disease: True, True, but Not Necessarily Related P. GERTSCH, A.M. WHEATLEY, R. MAIBACH, G.J. MADDERN, AND J.-N. VAUTHEY Sphincter of Oddi Manomeiry in Patients With Possible Occult Microlithiasis in ‘Idiopathic’ Acute Pancreatitis: Sphincter of Oddi Dysfunction Prevention of Relapses by Cholecystectomy or Palliation of Advanced Esophageal Cancer: A (Laser) Light Ursodeoxycholic Acid Therapy at the End of the Tunnel E. Ros, S. NAVARRO, C. BRU, A. GARCIA-PUGES, Is Exercise Good for Gastrointestinal Function? AND R. VALDERRAMA Glucagon Hinders the Effects of Somatostatin on Portal BOOK REVIEWS Hypertension M.P. Pizcueta, J.C. GARCIA-PAGAN, M. FERNANDEZ, CORRESPONDENCE R. CASAMITJANA, J. BOSCH, AND J. RODES Extracorporeal Shock-Wave Lithotripsy for the Intraacinar Profiles of Alcohol Dehydrogenase and Management of Bile Duct Stones: Is It Always a Safe Aldehyde Dehydr >genase Activities in Human Liver Procedure? I.P. MALY AND D. SASSE Microvillus Inclusion Disease Antibodies to Hepatitis C Virus in Low-Risk Blood Donors: Implications for Counseling Positive Donors Hyperplastic Polyps Do Not Predict Adenomatous Polyps H.H. Hsu, M. GONZALEZ, S.K.H. FOUNG, S.M. FEINSTONE, A Role for NMR in Alcoholism? AND H.B. GREENBERG Whither Biliary Sludge—Do You Exist? CASE REPORTS Helicobacter pylori in Autoimmune Gastritis Successful Orthotopic Liver Transplantation in a Patient Propranolol for Prophylactic Treatment of a First Variceal With Refractory Biliary Candidiasis Hemorrhage : K.B. Noack, D.R. Osmon, K.P. BATTS, M. WILHELM, Intestinal Lymphangiectasia: Lack of Efficacy of R.A.F. KROM, AND K.D. LINDOR Antiplasmin Therapy? Acute Biliary-Vascular Fistula Following Needle Aspiration of the Liver 1761 CORRECTIONS M.S. VERHILLE AND S.J. MUNOZ 1762 NOTICES Severe M Ind ed Liver Cell Necrosis G. BABANY, J. BERNUAU, A. CAILLEUX, J.-F. CADRANEL, 1763 SPECIAL NOTICE C. DEGOTT, S. ERLINGER, AND J.-P. BENHAMOU 1768 AUTHOR INDEX TO VOLUME 101 Severe Cholestatic Jaundice Associated With Piroxicam K.S. Hepps, G.M. MALIHA, R. ESTRADA, AND R.W. GOODGAME 1781 SUBJECT INDEX TO VOLUME 101

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