Gastric Cardiac Cancer PDF
Preview Gastric Cardiac Cancer
Gastric Cardiac Cancer Qin Huang Editor 123 Gastric Cardiac Cancer Qin Huang Editor Gastric Cardiac Cancer Editor Qin Huang Harvard Medical School/Brigham and Women’s Hospital Veterans Affairs Boston Healthcare System West Roxbury Massachusetts USA ISBN 978-3-319-79113-5 ISBN 978-3-319-79114-2 (eBook) https://doi.org/10.1007/978-3-319-79114-2 Library of Congress Control Number: 2018943619 © Springer International Publishing AG, part of Springer Nature 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by the registered company Springer International Publishing AG part of Springer Nature. The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland Preface This book is intended to be used by physicians, patients, and translational research scientists as an easy-to-use practical guide when dealing with gastric cardiac cancer. Gastric cardiac cancer arises in cardiac mucosa located primarily in the proximal stomach and occasionally invading into the distal esophagus. In recent years, this poorly understood cancer has been the focus of intense investigation on mecha- nisms of pathogenesis, genomic profile, classification, diagnosis, prognosis, stag- ing, and clinical management. As such, a growing body of high-quality evidence has been accumulated for better clinical management. It is time for a specialized, con- cise reference on this cancer for clinicians and patients alike. Because of uncertainty in tumorigenesis mechanisms, there are no universally accepted clinical practice guidelines on gastric cardiac cancer. The best clinical management strategy, we believe, is a multidisciplinary approach, including a team of healthcare subspecialists in gastroenterology, pathology, radiology, abdominal surgery, thoracic surgery, medical oncology, radiation oncology, and palliative care. The pertinent essential information on gastric cardiac cancer in these medical fields is included in this book. The manner of presentation of the information in this book will, we hope, help the reader to quickly master the essential characteristics of this cancer as described and illustrated with numerous endoscopic, gross, and micro- scopic photographs, and drawings. We hope this book will facilitate efficient com- munication and the decision-making process by the multidisciplinary team for appropriate patient triage and treatment. A plain, simple language, without medical jargon, is utilized throughout the book so that patients and their family members and friends may find the materials presented understandable and useful when they face the challenge of this potentially fatal cancer. v vi Preface We believe that with joint efforts from clinical healthcare professionals, patients and their family members, and translational research scientists, gastric cardiac cancer could be cured in the future. We would appreciate feedback from our read- ers regarding the usefulness of this book in their clinical practice and research on this cancer. The views expressed in the book do not necessarily represent the views of the Veterans Affairs or the United States Government. West Roxbury, MA, USA Qin Huang Acknowledgment Special thanks are given to Raj K. Goyal, M.D., M.B.B.S, of Harvard Medical School and Veterans Affairs Boston Healthcare System; Robert D. Odze, M.D., F.R.C.P.C., of Harvard Medical School and Brigham and Women’s Hospital; and Gregory Y. Lauwers, M.D., previously at Harvard Medical School and Massachusetts General Hospital in Boston, USA, for their strong support and guidance over the past 13 years to our clinicopathologic investigation on gastric cardiac cancer. This book could not have been written without generous support and assistance of physicians working at the Veterans Affairs Boston Healthcare System and Harvard Medical School in Boston, USA; the Nanjing Drum Tower Hospital in Nanjing; and the Changzhou Second Hospital in Changzhou, P. R. China. vii Contents 1 The Esophagogastric Junction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Qin Huang 2 Cardiac Mucosa . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 Qin Huang 3 Epidemiology and Risk Factors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39 Qin Huang and Edward Lew 4 Natural History . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51 Qin Huang and Lily Huang 5 Clinical Molecular Pathology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55 Xiangshan Fan and Qin Huang 6 Pathology of Early Gastric Cardiac Cancer . . . . . . . . . . . . . . . . . . . . . 73 Qin Huang 7 Pathology of Advanced Gastric Cardiac Carcinoma Cancer . . . . . . . 119 Qin Huang 8 Gastric Lymphoma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 147 Hongbo Yu and Xiangshan Fan 9 Diagnosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 161 Chenggong Yu, Guifang Xu, Qin Huang, Tingshan Lin, and Edward Lew 10 Prognosis and Staging . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 183 Qin Huang and Jason S. Gold 11 Endoscopic Resection of Early Gastric Cardiac Cancer . . . . . . . . . . . 201 Guifang Xu, Rui Li, Dongtao Shi, Qin Huang, and Hiroshi Mashimo 12 Pathologic Evaluation of Endoscopic Resection Specimens . . . . . . . . 227 Qi Sun and Qin Huang ix x Contents 13 Surgical Therapy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 243 Jun Qian, Yu Gong, Qin Huang, A. Travis Manasco, Liming Tang, and Jason S. Gold 14 Chemical Therapy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 263 Kequn Xu, Yang Yang, Qin Huang, Hua Jiang, and Valia Boosalis 15 Radiotherapy and Chemoradiotherapy . . . . . . . . . . . . . . . . . . . . . . . . 283 Xingchu Ni and Kun (Kim) Huang 16 Palliative Care . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 299 Qian Geng, Xiaolin Pu, Kun Yan, Qin Huang, and Ellen Hui Zhan Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 317 Contributors Valia Boosalis Department of Hematology, VA Boston Healthcare System, Jamaica Plain, MA, USA Xiangshan Fan Department of Pathology, The Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu, People’s Republic of China Qian Geng Department of Oncology, the Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, People’s Republic of China Jason S. Gold Brigham and Women’s Hospital/Harvard Medical School, Boston, MA, USA VA Boston Healthcare System, Boston, MA, USA Yu Gong Department of Gastrointestinal Surgery, Affiliated Changzhou No 2 Peoples Hospital Nanjing Medical University, Changzhou, Jiangsu, People’s Republic of China Kun (Kim) Huang Department of Radiation Oncology, Harvard Medical School, Boston University School of Medicine, VA Boston Healthcare System, Jamaica Plain, MA, USA Lily Huang Beth Israel Deaconess Medical Center, Boston, MA, USA Qin Huang Pathology and Laboratory Medicine, Veterans Affairs Boston Healthcare System, West Roxbury, MA, USA Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA Hua Jiang Department of Oncology, Affiliated Changzhou Second Hospital of Nanjing Medical University, Changzhou, People’s Republic of China xi
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