Gastric Cancer: Principles and Practice

331 Pages·2015·9.824 MB·English

by  Vivian E. Strong (eds.)

Gastric Cancer
Vivian E. Strong, M.D., F.A.C.S.
Editor
Gastric Cancer
Principles and Practice
2123
Editor
Vivian E. Strong, M.D., F.A.C.S.
Gastric and Mixed Tumor Service
Memorial Sloan-Kettering Cancer Center
New York, New York
USA
ISBN 978-3-319-15825-9 ISBN 978-3-319-15826-6 (eBook)
DOI 10.1007/978-3-319-15826-6
Library of Congress Control Number: 2015933643
Springer Cham Heidelberg New York Dordrecht London
© Springer International Publishing Switzerland 2015
This work is subject to copyright. All rights are reserved by the Publisher, whether the whole
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The publisher, the authors and the editors are safe to assume that the advice and information in
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Printed on acid-free paper
Springer is part of Springer Science+Business Media (www.springer.com)
This book is dedicated to those who strive for improvement
in the field of gastric cancer; the science, the technique and
the clinical care of our patients. With deference to those who
paved the way before us and with hope for the discoveries yet
to come.
Preface
Gastric cancer has been declared by the World Health Organization (WHO)
to be a Global Public Health Concern, with nearly 1 million new cases world-
wide per year. Although the incidence is highest in Eastern parts of the world,
South America and Eastern Europe; rates are also increasing in western coun-
tries such as the USA. Not only proximal gastric cancers are increasing in
incidence but also distal gastric cancers in the young age group of 25–39.
In the last 15 years, our progress and understanding of this cancer have
exploded. Revolutionary progress has been made in both the understanding
of gastric cancer as a heterogenous disease with many subtypes, as well as in
our multidisciplinary strategies to treating gastric cancer—from minimally
invasive techniques to novel chemotherapeutic agents. We have a far better
understanding and with improved molecular characterization, these differ-
ences are becoming more apparent and hopefully will lead to better targeted
approaches to the treatment of various forms of gastric cancer.
In this volume, there is the amalgamated knowledge of the foremost
experts and leaders in the field of gastric cancer from around the world. Each
author is a respected and recognized authority in his or her field that has
been especially handpicked for the topics presented. Currently, there is no
textbook entirely devoted to the pathophysiology, management, and treat-
ment of gastric cancer. This textbook is designed to provide a comprehensive
and current overview of the important issues specific to the field of gastric
cancer. Care of these patients and clinical conditions can be quite complex,
and materials have been collected from the most current, evidence-based
resources, providing an overview of all aspects of gastric carcinoma, from
the historical perspectives and epidemiology to the surgical approaches and
oncologic treatments, to the most innovative, molecular advances that will
further launch our understanding of this complex disease forward.
vii
viii Preface
On behalf of all the authors and myself, we sincerely hope this text will
serve as a valuable and useful guide of better understanding and treatment
strategies for those who are interested in providing the very best approaches
to the care of our patients with gastric cancer.
Editor:
Vivian E. Strong, MD, FACS
Associate Attending Surgeon
Gastric and Mixed Tumor Service
Memorial Sloan Kettering Cancer Center
New York, NY 10021
and
Associate Professor of Surgery
Weill Medical College of Cornell University
Contents
Part I Historical Perspective and Gastric Pathophysiology
1 The Historical Perspective of Gastric Cancer ............................... 3
Michael A. Rogy and Marius A. Bünger
2 Epidemiology of Gastric Cancer ..................................................... 23
Massimo Rugge, Matteo Fassan and David Y. Graham
3 Molecular Mechanisms in Gastric Carcinogenesis ....................... 35
Jonathan Cools-Lartigue, Laura Baker and Lorenzo E. Ferri
4 Pathology of Gastric Cancer ........................................................... 57
Laura H. Tang and Luke V. Selby
5 Role of HER2 in Gastric Cancers ................................................... 77
Elizabeth Won and Yelena Y. Janjigian
6 Pathophysiology of Hereditary Diffuse Gastric Cancer ............... 91
Sharon Pattison and Alex Boussioutas
7 Western Perspective and Epidemiology of Gastric Cancer ......... 111
Giovanni de Manzoni, Daniele Marrelli, Giuseppe Verlato,
Paolo Morgagni and Franco Roviello
Part II Diagnostic Techniques for Gastric Cancer
8 Diagnosis, Staging, and Workup of Gastric Cancer ..................... 127
Arvind Sabesan and Joseph J. Bennett
9 Endoscopy and Endoscopic Ultrasound
Examination of the Stomach ........................................................... 143
Mark A. Schattner and John Chi To Wong
10 The Role of Staging Laparoscopy and Peritoneal
Cytology in Gastric Cancer ............................................................. 155
James P. De Andrade, James J. Mezhir and Vivian E. Strong
ix
x Contents
Part III Gastric Resection and Postoperative Management
11 Endoscopic Resection for Gastric Cancer ..................................... 163
Yoshihiro Komatsu and Blair Anderson Jobe
12 Methods of Reconstruction—BI, BII, Roux-en-Y,
Jejunal Interposition, Proximal Gastrectomy
and Pouch Reconstruction ............................................................. 175
Daniel E. Stange and Jürgen Weitz
13 Lymphadenectomy—D1, D2, and D3 ............................................ 185
Johan L. Dikken and Henk H. Hartgrink
14 Open Methods of Resection and Reconstruction for
Subtotal and Total Gastrectomy .................................................... 199
Brian Badgwell and Paul F. Mansfield
15 Laparoscopic Methods of Resection and
Reconstruction for Subtotal and Total
Gastrectomy with D2 Lymphadenectomy...................................... 211
Han-Kwang Yang and Do Joong Park
16 Robotic Methods of Resection and Reconstruction
for Subtotal and Total Gastrectomy with
D2 Lymphadenectomy .................................................................... 229
Taeil Son and Woo Jin Hyung
17 Managing Early and Late Postoperative Complications
Following Gastric Surgery ............................................................. 239
Brian Badgwell, Ryan Day and Thomas Aloia
18 Hereditary Diffuse Gastric Cancer ............................................... 251
George Poultsides and Jeffrey A. Norton
19 Surveillance After Gastric Resection............................................. 255
Domenico D’Ugo, Alberto Biondi, Andrea Tufo,
Gianluca Baiocchi and Roberto Persiani
20 Surgical Trials for Gastric Cancer ................................................ 271
Daniel Reim, Alexander Novotny and Christoph Schuhmacher
Part IV Neoadjuvant and Adjuvant Treatments for
Gastric Cancer and Targeted Therapy
21 Neoadjuvant and Adjuvant Treatment—Strategies
and Clinical Trials—Western Perspective .................................... 297
Geoffrey Y. Ku and David H. Ilson
Contents xi
22 Adjuvant and Neoadjuvant Treatment: Standard
Treatment and Clinical Trials in the East ...................................... 303
Mitsuru Sasako
23 Radiation Treatment for Gastric Cancer ....................................... 307
Carla Hajj and Karyn A. Goodman
24 Targeted Therapy and Novel Agents for the
Treatment of Gastric Cancer: A View Toward the Future ........... 317
Georgios D. Lianos, Alberto Mangano, Stefano Rausei,
Aikaterini Lianou, Zoi Anastasiadi, Gianlorenzo Dionigi
and Dimitrios H. Roukos
Index ........................................................................................................ 331