GABA Outside the CNS PDF
Preview GABA Outside the CNS
Sandor L. Erda (Ed.) GABA eNS Outside the With 73 Figures Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest Sandor L.Erdo, Ph.D. Department of Anatomy University of Gottingen Kreuzbergring 36 W-3400 Gottingen, FRG Proceedings of the International Symposium on Peripheral GABAergic Mechanisms, Rome, July 19 - 21, 1990 ISBN-13: 978-3-642-76917-7 e-ISBN-13: 978-3-642-76915-3 DOl: 10.1007/978-3-642-76915-3 Library of Congress Cataloging-in-Publication Data. International Symposium on Peripheral GABAergic Me chanisms (1990: Rome, Italy). GABA outside the CNS 1 Sandor L. Erda (ed.). p. em. "Proceedings ofthe In ternational Symposium on Peripheral GABAergic Mechanisms, Rome, July 19-21, 1990" -T.p. verso. Includes bibliographical references and index. ISBN-13: 978-3-642-76917-7 1. GABA-Physiological effect-Congresses. 2. GABA-Receptors-Congresses. 3. Nerves, Peripheral-Congtesses. 1. Erda, Sandor L. II. Title. QP364.7.1595 1990 599'.019245-dc20 91-38963 CIP This work is subject to copyright. All rights are reserved, whether the whole or part of the material is con cerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, repro duction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its cur rent version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. © Springer-Verlag Berlin Heidelberg 1992 Softcover reprint of the hardcover 1st edition 1992 The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and appli cation contained in this book. In every individual case the user must check such information by consulting the relevant literature. 1YPesetting: Camera ready by author 25/3130-5 4 3 2 1 0 - Printed on acid-free paper Acknowledgements I am grateful for financial support from the following pharmaceutical and chemical companies: Schering-Plough Ltd., Bloomfield, NJ, USA; Ciba-Geigy, AG Basel, Switzerland; Bayer AG, Frankfurt, Germany; and Research Biochemicals Inc., Natick, MA, USA. Without their generous help it would have been impossible to hold this symposium. The excellent secretarial assistance of Louise Muller is ~reatly appreciated. Preface The first comprehensive review of the possible role of y-aminobutyric acid (GABA) outside the mammalian brain appeared 5 years ago!. Since that time, a large body of new evidence has accumulated to suggest that GABA may have a functional significance outside the central nervous system. The recent important findings obtained using biochemical, pharmacological, histochemical, physiological and other approaches made it necessary to update, summarize, and resynthesize the knowledge of peripheral GABA ergic mechanisms. These were the major goals of the International Sym posium on Peripheral GABAergic Mechanisms held in Rome in July 1990. Although this was a satellite symposium of the European Society for Neurochemistry meeting, the participants, and thus the contributors to this book, were also invited from overseas, from countries such as Australia, Canada, Japan and the United States. The meeting thus took on an in ternational, or even intercontinental, character. This book will provide the reader with state-of-the-art knowledge of the role of GABA in the mammalian periphery. Moreover, my hope is that the volume will serve not only as a comprehensive source of timely informa tion for the GABA specialist, but also as thought-provoking reading for other life scientists with an interest in the biochemistry, physiology, pharmacology, or even morphology of the neuronal and nonneuronal tissues of mammals. Now read on ... The Editor, 1991 I Erda SL, Bowery NG (eds) (1986) GABAergic Mechanisms in the Mammalian Periphery. Raven, New York. Contents GADA in the Peripheral Nervous System The Role of GABA in the Peripheral NelVous System C. Tanaka and K. Taniyama .........•................... 3 GABAergic Neurons in the Myenteric Plexus K.R. Jessen . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 GABA and Gut Motility D.I.B. Kerr and J. Ong ................................. 29 The GABAergic InnelVation of Paravertebral Sympathetic Ganglia 1.R. Wolff, P. Kasa, E. DoM, A Piirducz, and F. 106 ........... 45 L-Glutamate Decarboxylase Immunoreactivity in the Sympathoadrenal System O. HappaUi, T. Karhula, H. Paivarinta, S. Soinila, J.-Y. Wu, and M. Ahonen ............................... 65 GABAergic Action on Cholinergic Axon Terminals in the Superior Cervical Ganglion P. Kasa, E. DoM, and J.R. Wolff ......................... 83 GADA in Non-Neural Tissues Non-Neuronal GABA Systems: An Overview S.L. Erda .......................................... 97 GABA and Endocrine Cells of the Gastro-entero-pancreatic System: A Review P. Gilon and C. Remacle .............................. 111 GABA and Diamine Oxidase Activity in the Gastrointestinal Mucosa: Possible links W.A. Fogel and S.L. Erda ............................. 133 GABA and the liver: The First 40 Years G.Y. Minuk ....................................... 143 VIII Contents GABA-Immunoreactive Structures in Rat Kidney E. Dob6, A Parducz, J.R. Wolff, and S.L. Erda .............. 155 GABAergic Mechanisms in Bovine Adrenal Chromaffin Cells: Their Role in the Regulation of Catecholamine Secretion M.J. Oset-Gasque, E. Castro, and M.P. Gonzalez ............. 167 The GABAergic System in Human Female Genital Organs A Laszl6, G.L. Nadasy, E. Monos, B. Zsolnai, and S.L. Erda .... 183 Neurotransmitter Amino Acids as Modulators of Biological Processes of Spermatozoa H.K. Boldizsar, L. Wekerle, E. V~n, P. Sarl6s, and J. Barna ...... 199 Pharmacology and GADA Receptors GABA Receptors Inside and Outside the Brain N.G. Bowery ....................................... 215 Autoradiographic Localization of Peripheral GABA Receptors A W.L. Collier, M. Carlesimo, P. Napoleone, and F. Amenta ....... 233 The GABAs Receptor Profile of a Series of Phosphinic Acids: Agonist and Antagonist Activity in a Range of Peripheral Tissues J.M. Hills and W. Howson ..... 249 0 •••••• 0 •••• 0 •• 0000. 0 ••• GABAergic Mechanisms and Cardiovascular Function K. Taniyama, N. Saito, S. Matsuyama, K. Takeda, and C. Tanaka .. 261 GABAergic Mechanisms in the Pulmonary System R.W. Chapman, JoA. Hey, D.C. Bolser, C.A. Rizzo, R.W. Egan, and W. Kreutner ................. 269 0 ••• 0 •••••• 0 ••••••• GABAergic Mechanisms and Modulation of the Anaphylactic Response L. Zilletti, M. Ciuffi, S. Franchi-Micheli, and G. Gentilini ...... 277 0 Subject Index . 295 0 •••• 0 0 ••• 0 0 0 •• 0 ••• 0 ••••••• 0 0 ••• 0 ••• 0 list of Contributors M. Ahonen Department of Anatomy and Neurobiological Research Unit, University of Helsinki, Helsinki, Finland F. Amenta Dipartimento Di Scienze Neurologiche, Universita "La Sapienza", Via A. Borelli 50, 1-00161 Rome, Italy J. Barna Research Centre for Animal HuSbandry, H-2053 Herceghalom, Hungary H.K. Boldizsar Department of Physiology and Biochemistry, University of Veterinary Science, P. O. Box 2, H-14oo Budapest, Hungary D.C. Bolser Department of Allergy and Immunology, Schering-Plough Research 60 Orange Street, Bloomfield, NJ 07003, USA N.G. Bowery Department of PharmaCOlogy, School of Pharmacy, University of London, 29/39 Brunswick Square, London WC1N lAX, UK M. Broekman Smith Kline Beecham Pharmaceuticals, The Fry the, Welwyn, AL6 9AR, UK E. Castro Instituto de Bioquimica, Centro mixto c.S.I.C.-U.C.M., Facultad de Farmacia, Ciudad Universitaria, E-28040 Madrid, Spain M. Carlesimo Dipartimento Di Scienze Neurologiche, Universita "La Sapienza", Via A. Borelli 50, 1-00161 Rome, Italy R.W. Chapman Department of Allergy and Immunology, Schering-Plough Research, 60 Orange Street, Bloomfield, NJ 07003, USA X List of Contri butors M. Ciuffi Department of Preclinical and Qinical Pharmacology, "Mario Aiazzi Mancini", University of Florence, Viale G.B. Morgagni 65, 1-50134 Florence, Italy W.L. Collier Dipartimento Di Scienze Neurologiche, Universita "La Sapienza", Via A. Borelli 50, 1-00161 Rome, Italy E. Dob6 Central Research Laboratory, Albert-Szentgyorgyi University, H-6720 Szeged, Hungary R.W. Egan Department of Allergy and Immunology, SChering-Plough Research, 60 Orange Street, Bloomfield, NJ 07003, USA S.L. Erdo Department of Anatomy, Georg-August-University, Kreuzbergring 36, W-3400 Gottingen, FRG W.A. Fogel Department of Biogenic Amines, Polish Academy of Sciences, Tylna 3, P.O. Box 225, PL-90-950 Lodz 1, Poland S. Franchi-Micheli Department of Preclinical and Clinical Pharmacology, "Mario Aiazzi Mancini", University of Florence, Viale G.B. Morgagni 65, 1-50134 Florence, Italy G. Gentilini Department of Preclinical and Clinical Phramacology, "Mario Aiazzi Mancini", University of Florence, Viale G.B. Morgagni 65, 1-50134 Florence, Italy P. Gilon Laboratory de Biologie Cellulaire, Batiment Claude Bernard, Place Croix du Sud 5, B-1348 Louvain-Ia-Neuve, Belgium Present address: Laboratoire de Diabetologie et Nutrition, Tour Claude Bernard, UCL 54.74, Avenue Hippocrate 54, B-1200 Brussels, Belgium List of Contributors XI M.P. Gonzalez Instituto de Bioquimica, Centro mixto C.S.I.C.-U.C.M., Facultad de Farmacia, Ciudad Universitaria, E-28040 Madrid, Spain O. Happala Department of Anatomy and Neurobiological Research Unit, University of Helsinki, Helsinki, Finland J.A Hey Department of Allergy and Immunology, Schering-Plough Research, 60 Orange Street, Bloomfield, NJ 07003, USA J.M. Hills SmithKline Beecham Pharmaceuticals, The Fry the, Welwyn, AL6 9AR, UK W. Howson Smith Kline Beecham Pharmaceuticals, The Fry the, Welwyn, AL6 9AR, UK K. Jessen Department of Anatomy, University College London, Gower Street, London WCIE6BT, UK F. J06 Institute of Biphysics, Biological Research Centre, Hungarian Academy of Sciences, Sz~ged, Hungary T. Karhula Department of Anatomy and Neurobiological Research Unit, University of Helsinki, Helsinki, Finland P. Kasa Central Research Laboratory, Albert-Szentgyorgyi University, H-6720 Szeged, Hungary D.I.B. Kerr Department of Anaesthesia and Intensive Care, The University of Adelaide, South Australia 5000, Australia W. Kreutner Department of Allergy and Immunology, Schering-Plough Research, 60 Orange Street, Bloomfield, NJ 07003, USA
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