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VOLUMEONEHUNDRED ANDNINETYTHREE P ROGRESS IN MOLECULAR BIOLOGY AND TRANSLATIONAL SCIENCE G Protein-Coupled Receptors - Part A This page intentionally left blank VOLUMEONEHUNDRED ANDNINETYTHREE P ROGRESS IN MOLECULAR BIOLOGY AND TRANSLATIONAL SCIENCE G Protein-Coupled Receptors - Part A Edited by ARUN K. SHUKLA Department of Biological Sciences and Bioengineering Indian Institute of technology, Kanpur, India AcademicPressisanimprintofElsevier 50HampshireStreet,5thFloor,Cambridge,MA02139,UnitedStates 525BStreet,Suite1650,SanDiego,CA92101,UnitedStates TheBoulevard,LangfordLane,Kidlington,OxfordOX51GB,UnitedKingdom 125LondonWall,LondonEC2Y5AS,UnitedKingdom Firstedition2022 Copyright©2022ElsevierInc.Allrightsreserved. Nopartofthispublicationmaybereproducedortransmittedinanyformorbyanymeans,electronic ormechanical,includingphotocopying,recording,oranyinformationstorageandretrievalsystem, withoutpermissioninwritingfromthepublisher.Detailsonhowtoseekpermission,further informationaboutthePublisher’spermissionspoliciesandourarrangementswithorganizationssuch astheCopyrightClearanceCenterandtheCopyrightLicensingAgency,canbefoundatourwebsite: www.elsevier.com/permissions. Thisbookandtheindividualcontributionscontainedinitareprotectedundercopyrightbythe Publisher(otherthanasmaybenotedherein). Notices Knowledgeandbestpracticeinthisfieldareconstantlychanging.Asnewresearchandexperience broadenourunderstanding,changesinresearchmethods,professionalpractices,ormedical treatmentmaybecomenecessary. Practitionersandresearchersmustalwaysrelyontheirownexperienceandknowledgeinevaluating andusinganyinformation,methods,compounds,orexperimentsdescribedherein.Inusingsuch informationormethodstheyshouldbemindfuloftheirownsafetyandthesafetyofothers,including partiesforwhomtheyhaveaprofessionalresponsibility. Tothefullestextentofthelaw,neitherthePublishernortheauthors,contributors,oreditors,assume anyliabilityforanyinjuryand/ordamagetopersonsorpropertyasamatterofproductsliability, negligenceorotherwise,orfromanyuseoroperationofanymethods,products,instructions,orideas containedinthematerialherein. ISBN:978-0-323-99431-6 ISSN:1877-1173 ForinformationonallAcademicPresspublications visitourwebsiteathttps://www.elsevier.com/books-and-journals Publisher:ZoeKruze AcquisitionsEditor:LeticiaLima DevelopmentalEditor:JhonMichaelPeñano ProductionProjectManager: SudharshiniRenganathan CoverDesigner:MattLimbert TypesetbySTRAIVE,India Contents Contributors ix Preface xiii 1. Computational andexperimentalapproaches to probe GPCR activation andsignaling 1 PaulinaDragan, Alessandro Atzei,Swapnil Ganesh Sanmukh,and DorotaLatek 1. Introduction 2 2. ExperimentalmethodstostudyGPCRactivationandsignaltransduction 12 3. ComputationalmethodstostudyGPCRactivation 17 4. ComputationalmethodstostudyGPCRsignaltransduction 24 5. ViralHijackingofGPCRSignaling 28 References 29 2. Adrenergic receptors in breast cancer 37 CeciliaP(cid:1)erez Piñero,Ezequiel MarianoRivero, LucíaGargiulo, MaríaSolRodríguez, CarlosDavidBruque, Ariana Bruzzone,and IsabelAlicia Lu€thy 1. Breastcancer 38 2. Stress 43 3. Adrenergicreceptors 43 4. β -Adrenergicreceptorsinthenormalbreastandbreastcancer 48 2 5. Beta-blockers 52 6. α -Adrenergicreceptorsinbreastcancer 55 2 7. Conclusions 58 References 60 3. Tools for adapting to a complex habitat:G-proteincoupled receptors in Trichoderma 65 MonikaSchmoll andWolfgang Hinterdobler 1. Introduction 66 2. ActivationofGPCRs 67 3. DownstreamtargetsofGPCRreceptors 69 4. RegulationmechanismsofGPCRs 73 5. GPCRsinTrichoderma 79 References 87 v vi Contents 4. TargetingGproteincoupledreceptorsforalleviatingneuropathic pain 99 Poonam Kumari, AnubhavYadav,Monika Patel,and PremN. Yadav 1. Introduction 100 2. Generaletiologyofneuropathicpain 101 3. Opioidreceptorsinneuropathicpain 102 4. Modulationofmesolimbiccircuitrybyopioids 104 5. Cannabinoidreceptors 106 6. Chemokinesreceptors 107 7. Adenosinereceptors 109 8. Conclusionandfutureprospective 111 Acknowledgments 113 Conflictofinterest 113 References 113 5. Crosstalk between neurons and glia through G-protein coupled receptors: Insightsfrom Caenorhabditis elegans 119 PratimaPandey,Gazaldeep Kaur, andKavita Babu 1. Introduction 120 2. Neuron-glialinteractionsthroughneurotransmitterGPCRs 122 3. Conclusion 136 Acknowledgments 137 References 137 6. Cardiovascular GPCR regulation by regulator of Gprotein signaling proteins 145 Anastasios Lymperopoulos, Malka S.Suster, and JordanaI. Borges 1. Introduction 146 2. CardiacGPCRsandRGSproteins 149 3. VascularcardiacGPCRsandRGSproteins 156 4. Platelet/othercardiovascularGPCRsandRGSproteins 157 5. Conclusionsandfutureperspectives 159 References 161 7. The interaction, mechanism andfunction ofGPR158-RGS7 cross-talk 167 ShradhaV.Darira and LaurieP.Sutton Contents vii 8. Taste GPCRs andtheirligands 177 NitzanDubovski, Fabrizio Fierro, EitanMargulis, YaronBen Shoshan-Galeczki, Lior Peri,and MashaY.Niv 1. Introduction 178 2. Currentlyknownligands 179 3. Functionalcell-basedassaysfordiscoveryoftasteGPCRligands 180 4. Facilitatingligandsdiscoverythroughcomputationalmethods 181 5. Futuredirections 185 6. Concludingremarks 187 Acknowledgments 188 References 188 9. Palmitoylation andG-protein coupled receptors 195 GeorgesChalhoub and Peter J. McCormick 1. Introduction 195 2. S-palmitoylation 196 3. Conclusion 206 References 206 Index 213 This page intentionally left blank Contributors AlessandroAtzei FacultyofChemistry,UniversityofWarsaw,Warsaw,Poland KavitaBabu IndianInstituteofScience,Bangalore,Karnataka,India YaronBenShoshan-Galeczki TheInstituteofBiochemistry,FoodScienceandNutrition,RobertH.SmithFacultyof Agriculture,FoodandEnvironment,TheHebrewUniversityofJerusalem,Rehovot,Israel JordanaI.Borges LaboratoryfortheStudyofNeurohormonalControloftheCirculation,Departmentof PharmaceuticalSciences,NovaSoutheasternUniversityCollegeofPharmacy,Fort Lauderdale,FL,UnitedStates CarlosDavidBruque Gen(cid:1)eticaMolecularHumanayBioinforma´tica,UnidaddeConocimientoTraslacional HospitalariaPatago´nica,HospitaldeAltaComplejidadSAMIC-ElCalafate,ElCalafate, Argentina ArianaBruzzone InstitutodeInvestigacionesBioqu´ımicasBah´ıaBlancaINIBIBB–CONICET,BuenosAires, Argentina GeorgesChalhoub DepartmentofEndocrinology,QueenMaryUniversityofLondon,London, UnitedKingdom ShradhaV.Darira DepartmentofBiologicalSciences,UniversityofMarylandBaltimoreCounty,Baltimore, MD,UnitedStates PaulinaDragan FacultyofChemistry,UniversityofWarsaw,Warsaw,Poland NitzanDubovski TheInstituteofBiochemistry,FoodScienceandNutrition,RobertH.SmithFacultyof Agriculture,FoodandEnvironment,TheHebrewUniversityofJerusalem,Rehovot,Israel FabrizioFierro TheInstituteofBiochemistry,FoodScienceandNutrition,RobertH.SmithFacultyof Agriculture,FoodandEnvironment,TheHebrewUniversityofJerusalem,Rehovot,Israel Luc´ıaGargiulo InstitutodeBiolog´ıayMedicinaExperimental,IBYME-CONICET,BuenosAires, Argentina WolfgangHinterdobler MyPilzGmbH,Vienna,Austria ix