Future Aspects in Contraception: Proceedings of an International Symposium held in Heidelberg, 5–8 September 1984 Part 2 Female Contraception PDF
Preview Future Aspects in Contraception: Proceedings of an International Symposium held in Heidelberg, 5–8 September 1984 Part 2 Female Contraception
Future Aspects in Contraception Part 2 Female Contraception Future Aspects in Contraception Part 1 Male Contraception Part 2 Female Contraception Future Aspects in Contraception Proceedings of an International Symposium held in Heidelberg, 5-8 September 1 984 Part 2 Female Contraception Edited by B. Runnebaum, T. Rabe and L. Kiesel MTP PRESS LIMITED .... 1985 a member of the KLUWER ACADEMIC PUBLISHERS GROUP " BOSTON / THE HAGUE / DORDRECHT / LANCASTER Published in the UK and Europe by MTP Press Limited Falcon House Lancaster, England British Library Cataloguing in Publication Data Future aspects in contraception: proceedings of an international symposium held in Heidelberg, September 5-8, 1984. 1. Contraception I. Runnebaum, B. II. Rabe, T. III. Kiesel, L. 613.9'4 RG136 Published in the USA by MTP Press A division of Kluwer Boston Inc. 190 Old Derby Street Higham, MA 02043, USA Library of Congress Cataloging in Publication Data Main entry under title: Future aspects in contraception. Includes bibliographies and index. Contents: pt. 1. Male contraception-pt. 2. Female contraception. 1. Contraception-Addresses, essays, lectures. I. Runnebaum, B. (Benno), 1933- II. Rabe, T. III. Kiesel, L. [DNLM: 1. Contraception-trends. WP 630 F996] RG136.F87 1985 613.9'432 85-11622 ISBN-13: 978-94-010-8678-3 e-ISBN-13: 978-94-009-4916-4 001: 10.1007/978-94-009-4916-4 Copyright © 1985 MTP Press Limited Softcover reprint of the hardcover 1s t edition 1985 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without prior permission from the publishers. Contents of Part 2 Principal contributors to Parts 1 and 2 1 Natural family planning J. G. Schenker and S. Mor-Yosef 2 Barrier methods of contraception 15 P. Senanayake and K. Newman 3 Chemistry. contraceptive activity and toxicology of aryl guanidinobenzoates: inhibitors of sperm acrosin 23 L. J. D. lane veld. J. M. Kaminski. D. P. Waller. R. A. An derson and L. Bauer 4 Measurement of LH in saliva: a new approach to ovulation detection 31 K. K. Loewit, H. -G. Kraft and A. Ortlieb 5 Steroid-induced side-effects of oral contraceptives 49 H. Kopera 6 Efficacy and physiology of a triphasic oral contra- ceptive 63 H. Allen 7 Advantages and disadvantages of low-dose hor- monal contraceptive agents 71 M. Mall-Haefeli, /. Werner-lodrow, M. Birkhauser and P. Huber 8 Emerging routes of delivery for fertility-control agents 83 D. L. Gardner and C. R. Hassler 9 Current status of NORPLANT subdermal implants for contraception 95 S. Roy 10 New aspects in post-coital contraception 107 A. A. Haspels and M. R. Van Santen v vi CONTENTS 11 Biological evaluation of some medicinal plant ex- tracts for contraceptive efficacy in females 115 A. O. Prakash 12 Pharmacokinetic and antigenicity studies with LHRH analogues 129 J. Sandow, G. Jerabek-Sandow, B. Krauss and W. von Rechenberg 13 LHRH nasal spray in contraception 149 S. J. Nil/ius 14 Acute and intermittent LHRH agonist dosing as post-coital and anti-ovulatory contraceptive approaches 161 A. Lemay, N. Faure, F. Labrie and A. T. A. Fazekas 15 LH R H antagonists and contraception 177 M. V. Nekola, M. L. Heiman, S. J. Hocart and D. H. Coy 16 Mechanism of action of gonadotrophin releasing hormone in the pituitary and gonads 189 Z. Naor, J. Molcho, J. Hermon, J. Zer, M. Zilberstein and H. Zakut 17 Morphological changes on the surface of IUDs: are they of clinical significance? 203 L. G. Keith R. Bailey and G. S. Berger 18 The use of non-culture tests for the detection of VD prior to IUD insertion: a view towards the future 229 L. G. Keith and G. S. Berger 19 Experience with GYNE-T Cu-380-A intrauterine con- traceptive device (1981-1984) 235 B. Beric, S. Aleksic, M. Marjanovic and F. Kranc 20 Ten years' experience with continuous use of the butterfly IUD 239 H. G. Massouras 21 The anti progesterone activity of RU 486, a con- tragestive agent in the human 245 E. E. Baulieu, C. Euvrard and E. Sakiz 22 Effects of the anti progesterone RU 486 in early preg- nancy and during the menstrual cycle 249 W. L. Herrmann, A. M. Schindler, R. Wyss and P. Bischof 23 Prostaglandins in contraception 271 M. Bygdeman, M. L. Swahn, V. Lundstrom, N. J. Christensen and K. Green CONTENTS vii 24 Ovarian hormones and cybernins 281 A. Demoulin and P. Franchimont 25 Biochemical aspects of a contraception model based on immunological properties of proteohormones 289 W. E. Merz 26 Variability in antisperm and antiembryonic humoral immune responses 305 D. J. Anderson and J. A. Madrigal 27 Research for the development of an hCG antifertility vaccine 319 V. C. Stevens 28 Present and future aspects of immunological methods in contraception 333 H. Donat 29 Preclinical and clinical aspects of safety in contra- ception 343 K. W. von Eickstedt 30 The politics of contraception 351 P.Senanayake 31 Contraceptive futurology: or 1984 in 1984 361 E. Diczfalusy Subject index 369 Principal contributors to Parts 1 and 2 Nancy J. Alexander Marc Bygdeman Reproductive Biology and Behavior Department of Obstetrics and Gynecology Oregon Regional Primate Research Center Karolinska Hospital 505 North West 185th Ave S-1 0401 Stockholm Beaverton, Oregon 97006 Sweden USA Andre Demoulin Hugh Allen Department of Obstetrics and Gynecology Department of Obstetrics and Gynecology University of Liege University of Western Ontario 81, Bd de la Constitution and B-4020 Liege Suite 201 Belgium 111 Waterloo Street London, Ontario Egon Diczfalusy Canada Reproductive Endocrinology Research Unit Karolinska Institute and Hospital Deborah J. Anderson Box 60500 Division of Immunogenetics S-1 0401 Stockholm Dana-Farber Cancer Institute and Depart- Sweden ment of Pathology Harvard Medical School 44 Binney Street H. Donat Boston, Massachusetts 02115 Department of Obstetrics and Gynecology USA Medical Academy of Magdeburg Gerhart-Hauptmann-Strasse 35 Etienne E. Baulieu 3060 Magdeburg Hormones Laboratory German Democratic Republic INSERM U33 94270 Bicetre Klaus-Wolf von Eickstedt France Department of Pharmacology and Toxico- logy Alain Belanger Bundesgesundheitsamt Berlin Departments of Medicine and Molecular Gebweiler Strasse 1 5 Endocrinology Berlin 33 Le Centre Hospitalier de l'Universite Laval West Germany Quebec G1V 4G2 Canada Norman R. Farnsworth Professor Dr B. Beril: College of Pharmacy and PCRPS Department for Obstetrics and Gynecology The University of Illinois at Chicago Faculty of Medicine Room 310 University of Novi Sad 833 South Wood Street S.v. Mark6vica 15 Box 6998 YU-21 000 Novi Sad Chicago, Illinois 60680 Yugoslavia USA ix x PRINCIPAL CONTRIBUTORS TO PARTS 1 AND 2 David L. Gardner F. Krassnig Polymer Science and Technology Section Department of Dermatology Battelle University of Munich Columbus Laboratories Frauenlobstrasse 9-11 505 King Avenue 0-8000 Munich 2 Columbus, Ohio 43201-2693 West Germany USA H. Kuhl A. A. Haspels U niversitats-Frauenkl i nik Academische Kliniek Abteilung fur Gynakologische Department of Gynecology Endokrinologie Catharijnesingel101 Theodor-Stern-Kai 7 Utrecht 3585 CP 0-6000 Frankfurt am Main The Netherlands West Germany Walter L. Herrmann F. Labrie Hopital Cantonal Universitaire de Geneve Endocrinology of Reproduction Department de Gynecologie et d'Obstetrique St Franc;:ois D'Assise Hospital 32 bis, Bd de la Cluse Department of Molecular Endocrinology CH-1211 Geneva 4 Laval Medical Center Switzerland 10 Rue de I'Espinay Quebec G1 L 3L5 Ilpo Huhtaniemi Canada Department of Clinical Chemistry University of Helsinki Meilahti Hospital Andre Lemay SF-00290 Helsinki Department of Gynecology/Obstetrics Finland Laval University Hopital St-Franc;:ois d'Assise Natwar R. Kalla 10 Rue de I'Espinay Department of Biophysics Quebec G1 L 3L5 Basic Medical Sciences Building Canada Panjab University Chandigarh 160014 Guo-Zhen Liu India Department of Urology Capital Hospital Louis G. Keith Peking Department of Obstetrics and Gynecology China The Medical School Northwestern University Thomas J. Lobi and Biopolymers Research Prentice Women's Hospital and Maternity The Upjohn Company Center Kalamazoo 333 East Superior Street Michigan 49001 Chicago, Illinois 60611 USA USA Ludwig Kiesel K. Loewit Institute for Medical Biology and Genetics Division of Gynaecological Endocrinology University of Innsbruck Department of Obstetrics and Gynaecology Schopfstrasse 41 University of Heidelberg A-6020 Innsbruck 0-6900 Heidelberg 1 Austria West Germany Hans Kopera Marianne Mall-Haefeli Department of Experimental and Clinical Social-Medical Department Pharmacology University Clinic of Obstetrics and Gyne- University of Graz cology U niversitatsplatz 4 Schanzenstrasse 46 A-8010 Graz CH-4031 Basel Austria Switzerland PRINCIPAL CONTRIBUTORS TO PARTS 1 AND 2 xi H. G. Massouras Anand O. Prakash Obstetrician/Gynaecologist School of Studies in Zoology 3 Marasli St Jiwaji University Athens 106 76 Vidya Vihar Greece Gwalior-474011 India Stephen A. Matlin Department of Chemistry T. Rabe The City University Division of Gynaecological Endocrinology Northampton Square Department of Obstetrics and Gynaecology London EC1V OHB University of Heidelberg UK D-6900 Heidelberg 1 West Germany Wolfgang E. Merz Department of Biochemistry II University of Heidelberg Subir Roy 1m Neuenheimer Feld 328 Department of Obstetrics and Gynecology D-6900 Heidelberg 1 University of Southern California School of West Germany Medicine 1240 North Mission Road Marcella Motta Los Angeles Department of Endocrinology California 90033 University of Milan USA Via Andrea del Sarto 21 1-20129 Milan B. Runnebaum Italy Division of Gynaecological Endocrinology Zvi Naor Department of Obstetrics and Gynaecology Department of Hormone Research University of Heidelberg The Weizmann Institute of Science D-6900 Heidelberg 1 West Germany P.O. Box 26 Rehovot 76 100 Israel J. Sandow Hoechst AG Mary V. Nekola Pharmacology H 821 Department of Medicine Postfach 80 03 20 Tulane Medical School D-6230 Frankfurt am Main 80 1430 Tulane Avenue West Germany New Orleans, Louisiana 70112 USA Joseph G. Schenker F. Neumann Department of Obstetrics and Gynecology Hauptdepartment Endokrinpharmakologie Hadassah University Medical School Schering AG P.O. Box 12000 Mullerstrasse 170-178 91120 Jerusalem Postfach 65 03 11 Israel 1000 Berlin 65 West Germany Wolf-Bernhard Schill Dermatologische Klinik und Poliklinik der S. J. Nillius Universitiit Section for Reproductive Endocrinology Frauenlobstrasse 9-11 Department of Obstetrics and Gynaecology D-8000 Munich 2 Academic Hospital West Germany S-751 85 Uppsala Sweden P. Senanayake Willem A. A. van Os International Planned Parenthood Federa- St Elisabeth's Grote Gasthuis tion Boerhaavelaan 22, Postbus 417 18-20 Lower Regent Street 2000 AK Haarlem London SW1 Y 4PW The Netherlands UK
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