Fundamentals and Data in Radiobiology, Radiation Biophysics, Dosimetry and Medical Radiological Protection

353 Pages·2012·4.3 MB·English

by  A. Kaul, J. H. Bernhardt, H. -M. Kramer (auth.), A. Kaul (eds.)

New
Series
Numerical Data
and Functional Relationships
in Science and Technology
GROUP VIII VOLUME 7
Advanced Materials Medical
and Technologies
Radiological
Physics
SUBVOLUME A
Fundamentals and Data in Radiobiology,
Radiation Biophysics, Dosimetry and
Medical Radiological Protection
123
Landolt-Börnstein
Numerical Data and Functional Relationships in Science and Technology
New Series

Group VIII: Advanced Materials and Technologies
Volume 7

Medical Radiological Physics

Subvolume A
Fundamentals and Data in Radiobiology, Radiation Biophysics,
Dosimetry and Medical Radiological Protection

A. Almén, J.H. Bernhardt, L. Johansson, K.-U. Kasch, A. Kaul,
H.-M. Kramer, S. Mattsson, B.M. Moores, D. Noßke, H.-J. Selbach,
F.-E. Stieve, J. Valentin, S. Vatnitsky

Edited by A. Kaul
ISSN 1619-4802 (Advanced Materials and Technologies)

ISBN 978-3-642-23683-9 Springer Berlin Heidelberg New York

Library of Congress Cataloging in Publication Data
Zahlenwerte und Funktionen aus Naturwissenschaften und Technik, Neue Serie
Vol. VIII/7A: Editor: A. Kaul
At head of title: Landolt-Börnstein. Added t.p.: Numerical data and functional relationships in science and technology.
Tables chiefly in English.
Intended to supersede the Physikalisch-chemische Tabellen by H. Landolt and R. Börnstein of which the 6th ed. began publication in 1950 under title:
Zahlenwerte und Funktionen aus Physik, Chemie, Astronomie, Geophysik und Technik.
Vols. published after v. 1 of group I have imprint: Berlin, New York, Springer-Verlag
Includes bibliographies.
1. Physics--Tables. 2. Chemistry--Tables. 3. Engineering--Tables.
I. Börnstein, R. (Richard), 1852-1913. II. Landolt, H. (Hans), 1831-1910.
III. Physikalisch-chemische Tabellen. IV. Title: Numerical data and functional relationships in science and technology.
QC61.23 502'.12 62-53136

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Editor
A. Kaul
Okerstraße 13
38300 Wolfenbüttel, Germany
e-mail: [email protected]
formerly
Bundesamt für Strahlenschutz
Willy-Brandt-Straße 5
38226 Salzgitter, Germany
and
Physikalisch-Technische Bundesanstalt
Bundesallee 100
38116 Braunschweig, Germany
Authors

A. Almén K.-U. Kasch
Department of Medical Physics and Department of Mathematics,
Biomedical Engineering Physics & Chemistry
Sahlgrenska University Hospital Beuth-Hochschule für Technik Berlin
413 45 Gothenburg, Sweden University of Applied Sciences
e-mail: [email protected] Luxemburger Straße 10
Chapter 5 13353 Berlin, Germany
e-mail: [email protected]
J.H. Bernhardt
Chapter 2, Glossary
Neureutherstraße 19
80799 München, Germany A. Kaul
e-mail: [email protected] Okerstraße 13
formerly 38300 Wolfenbüttel, Germany
Bundesamt für Strahlenschutz e-mail: [email protected]
Ingolstädter Landstraße 1 formerly
85764 Oberschleißheim, Germany Bundesamt für Strahlenschutz
Chapters 1, 2, 5, Glossary Willy-Brandt-Straße 5
38226 Salzgitter, Germany
L. Johansson
and
Radiation Physics
Physikalisch-Technische Bundesanstalt
Department of Radiation Sciences
Bundesallee 100
Umeå University Hospital
38116 Braunschweig, Germany
901 85 Umeå, Sweden
Chapters 1, 2, Glossary
e-mail: [email protected]
Chapter 4
VI Authors
H.-M. Kramer H.-J. Selbach
Ernst-Waldvogel-Straße 13 Physikalisch-Technische Bundesanstalt
38116 Braunschweig, Germany Dosimetry of Brachytherapy
e-mail: [email protected] Bundesallee 100
formerly 38116 Braunschweig, Germany
Physikalisch-Technische Bundesanstalt e-mail: [email protected]
Bundesallee 100 Chapter 3
38116 Braunschweig, Germany
F.-E. Stieve
Chapters 1, 3, Glossary
Lindenschmidstraße 45
S. Mattsson 81371 München, Germany
Medical Radiation Physics Malmö formerly
Lund University Bundesamt für Strahlenschutz
Skåne University Hospital Malmö Ingolstädter Landstraße 1
205 02 Malmö, Sweden 85764 Oberschleißheim, Germany
e-mail: [email protected] e-mail: [email protected]
Chapter 4 Chapter 3
B.M. Moores J. Valentin
Integrated Radiological Sevices Ltd Swedish Radiation Safety Authority (SSM)
Unit 188, Century Building Solna Strandväg 96
Tower-Street-Brunswick Business Park 171 16 Stockholm, Sweden
Liverpool UK-L3 4BJ, UK e-mail: [email protected]
e-mail: [email protected] Chapters 1, 5, Glossary
Chapter 3
S. Vatnitsky
D. Noßke Medical Physics
Bundesamt für Strahlenschutz EBG MedAustron
Fachbereich Strahlenschutz und Gesundheit Victor Kaplan-Strasse 2
Ingolstädter Landstraße 1 2700 Wiener Neustadt, Austria
85764 Oberschleißheim, Germany e-mail: [email protected]
e-mail: [email protected] Chapter 3
Chapters 1, 4, Glossary

Landolt-Börnstein
Springer Internet
Tiergartenstr. 17 http://www.springermaterials.com
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Preface
Group VIII of the New Series of Landolt-Börnstein was started a few years ago as the most recent Group
of the 125 years tradition of publication numerical data and functional relationships in science and
technology. It is dedicated to Advanced Materials and Technologies, and covers volumes on “Laser
Physics and Applications”, “Materials”, “Energy Technologies” and “Physical Properties of Liquid
Crystals”. In 2005, Volume 4 of Group VIII was edited on “Radiological Protection” against biological
effects of ionizing radiations and radioisotopes. Apart from fundamental physical and biological
mechanisms of ionizing radiations, Volume 4 covers sources of exposures, dosimetry, shielding against
electromagnetic and in particulate ionizing radiations, and measuring techniques.
Soon after discovery of ionizing radiations, and of the phenomenon radioactivity in 1895/1896,
physicians together with physicists realized the importance of these radiations both as a diagnostic tool
for investigating morphological structures of organs and tissues in the human body and physiological
malfunctions, as well as for treatment of uncontrolled growth of cell clusters, frequently of malignant
nature such as cancer. From these early times a new medical discipline has developed in the area medical
diagnosis and treatment, i.e. radiological imaging and radiooncology, as the two fundamental columns of
medical radiology.
After the early decennia of medical radiology the so-called non-ionizing radiations have become
growing importance in medical diagnosis and therapy. They cover ultrasound, optical radiation and lasers,
electromagnetic fields as well as time-varying electric and magnetic fields. The domain of these non-
ionizing radiations is in imaging, i.e. the emphasis of radiological diagnostics, although optical radiations
such as lasers and ultrasonic radiation are also applied medically for therapeutic purposes.
Therefore, it was a consequent step by Springer as the Publisher of the Landolt-Börnstein New Series
to publish a further volume in Group VIII dedicated to another radiological subject, namely to “Medical
Radiological Physics”, as the important scientific basis of diagnostics and therapy in medical radiology.
Both the efficacy and efficiency of the above mentioned fundamental columns of medical radiology
substantially depend on the kinds of radiations and energies selected for solving a specific diagnostic
problem or for treatment of a tumour, as well as on the fundamental biological and biophysical effects of
the various kinds of radiations and energies absorbed. Consequently, Volume VIII/7 was subdivided into
two subvolumes, i.e. Subvolume 7A with a fundamental scientific discussion of kinds of radiations,
biological and biophysical effects, assessment of dose to tissues, and protection of patients, clinical staff
and members of the public. Subvolume 7B will be dedicated to radiological imaging, radiotherapy and
treatment planning.
Subvolume VIII/7A is entitled “Fundamentals and Data in Radiobiology, Radiation Biophysics,
Dosimetry and Medical Radiological Protection”, Subvolume VIII/7B will cover the tasks of medical
physics in radiological diagnostics and therapy, i.e. X-ray imaging, X-ray computed tomography, nuclear
medical imaging, magnetic resonance imaging, ultrasound imaging, in clinical radiotherapy, other
locoregional therapies and in treatment planning.
Subvolume VIII/7A starts after an introductory chapter as guide for the reader through contents and
data of the volume with four chapters, dedicated to “Radiation and Biological Effects”, “Dosimetry in
Diagnostic Radiology and Radiotherapy”, “Dosimetry in Nuclear Medicine Diagnosis and Therapy”, and
“Medical Radiological Protection”. Finally, radiological quantities, units and terms are explained in a
Glossary, and reference is given in an Index of their location in the Chapters and relevant Sections.
Subvolume VIII/7A “Fundamentals and Data in Radiobiology, Radiation Biophysics, Dosimetry and
Radiological Protection” is written by numerous internationally renowned experts, qualified in the above
VIII Preface
scientific disciplines. Compared to most volumes in the Landolt-Börnstein Series published in the past,
the present publication in the Group Advanced Materials and Technologies is not only a compilation of
numerical data and functional relationships for practical purposes: As already in Volumes VIII/1 “Laser
Physics and Applications” and VIII/4 “Radiological Protection”, Subvolume VIII/7A is a rather
comprehensive text together with basic data, intended to be submitted to the reader on both fundamentals
and corresponding data on medical radiological physics, i.e. concepts and scientific bases of medical
radiology, hence radiobiology and radiation biophysics, physical dosimetry and instrumentation, medical
radiological protection of patients, personnel and the general public, and medical imaging and
radiotherapy.
Volume VIII/7 Subvolume A of “Medical Radiological Physics” addresses to:
- Those already working as physicians or physicists and engineers in medical radiology for getting
information on most recent developments in fundamentals of this discipline, i.e. radiobiology,
radiation biophysics, dosimetry, medical radiological protection and instrumentation;
- Medical physicists and engineers, participating in post-graduate education programmes in
medical radiological physics, in order to become qualified experts in medical physics;
- Physicists and engineers to be qualified for future employment as health physicists or engineers
in so-called competent national authorities for health protection;
- Young physicists and physicians as newcomers in the fields of dosimetry, instrumentation,
radiological imaging, radiotherapy, and medical radiological protection of patients, clinical staff
and members of the public.
Ultimately, the quality of the project fundamentals and data in medical physics, diagnostic radiology and
radiooncology, Subvolume A of Volume VIII of the Landolt-Börnstein New Series on radiobiology,
radiation physics and biophysics, dosimetry and radiological protection, is closely related to the quality of
contributions received from the participants in the present multi-authored publication. The contributors
have done an outstanding job in writing comprehensive treatises on very specialized subjects of various
scientific disciplines. Particularly, thanks are due to the co-ordinators of the individual Chapters,
Drs. J. Bernhardt, H.-M. Kramer, D. Noßke and J. Valentin, as well as to the Development Editor Dr. W.
Finger and the Editorial Office of the Landolt-Börnstein New Series of Springer, Heidelberg, for the
permanent and very active engagement in realizing the edition of the present Volume VIII, Subvolume A.
Finally, I may thank my wife Rosemarie for her valuable support in the technical preparation of the
manuscripts for submission of the material to the Publisher.

Wolfenbüttel, January 2012 Alexander Kaul
Contents
1 Introduction and Guide for the Reader
Contents and Data of Chapters 2-5
(A. KAUL, J.H. BERNHARDT, H.-M. KRAMER, D. NOßKE, J. VALENTIN) ............ 1-1
1.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1-1
1.2 CHAPTER 2: Radiations and Biological Effects: Ionizing and Non-Ionizing
Radiations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1-1
1.2.1 Ionizing Radiation: Physical Properties (SECT. 2.2.1) ........................... 1-2
1.2.2 Ionizing Radiation: Biological Effects (SECT. 2.3.1)............................ 1-3
1.2.2.1 Deterministic Effects (SECT. 2.3.1.2) ....................................... 1-3
1.2.2.2 Stochastic Effects (SECT. 2.3.1.3) .......................................... 1-3
1.2.2.3 Effective Dose (SECT. 2.3.1.4) ............................................. 1-4
1.2.3 Non-Ionizing Radiations: Physical Properties (SECT. 2.2.2) ...................... 1-4
1.2.3.1 Diagnostic Ultrasound (SECT. 2.2.2.2) ...................................... 1-4
1.2.3.2 Static and Slowly Varying Electric and Magnetic Fields (SECT. 2.2.2.3) ............ 1-4
1.2.3.3 Time Varying Electric and Magnetic Fields of Frequencies Less Than 100 kHz and
Above (SECTS. 2.2.2.4 and 2.2.2.5) ......................................... 1-5
1.2.3.4 Optical Radiations Including Lasers (SECT. 2.2.2.6) ............................ 1-5
1.2.4 Non-Ionizing Radiations: Biological Effects (SECT. 2.3.2) ....................... 1-5
1.2.4.1 Diagnostic Ultrasound (SECT. 2.3.2.2) ...................................... 1-5
1.2.4.2 Static and Slowly Varying Electric and Magnetic Fields (SECT. 2.3.2.3) ............ 1-6
1.2.4.3 Time Varying Electric and Magnetic Fields of Frequencies Less Than 100 kHz
(SECT. 2.3.2.4) ......................................................... 1-6
1.2.4.4 Electromagnetic Fields of Frequencies Above 100 kHz (SECT. 2.3.2.5) ............ 1-6
1.2.4.5 Optical Radiation and Lasers (SECT. 2.3.2.6) ................................. 1-7
1.3 CHAPTER 3: Dosimetry in Diagnostic Radiology and Radiotherapy ............ 1-7
1.3.1 Diagnostic Radiology ................................................... 1-7
1.3.2 Radiation Therapy ...................................................... 1-8
1.3.3 Dose Measurement in Diagnostic Radiology and Radiation Therapy
(SECTS. 3.3 and 3.4) ..................................................... 1-8
1.3.3.1 Dosimetric Quantities in Diagnostic Radiology (SECT. 3.3.2) .................... 1-8
1.3.3.3 Dosimetric Equipment for Diagnostic Radiology (SECT. 3.3.4) ................... 1-9
1.3.3.4 Dose Measurements in Diagnostic Radiology (SECT. 3.3.5) ...................... 1-9
1.3.3.5 Dosimetric Quantity and Equipment for Measurement in Radiotherapy (SECT. 3.4.3) . 1-9
1.3.3.6 Dosimetry for Teletherapy (SECT. 3.4.4) ..................................... 1-10
1.3.3.6.1 Photons and Electrons (SECT. 3.4.4.1) ....................................... 1-10
1.3.3.6.2 Non-Reference Conditions (SECT. 3.4.4.2) ................................... 1-10
1.3.3.6.3 Protons and Heavier Ions (SECT. 3.4.4.4) .................................... 1-10
1.3.3.6.4 Uncertainties (SECT. 3.4.4.5) .............................................. 1-11
1.3.3.7 Dosimetry for Brachytherapy (SECT. 3.4.5) .................................. 1-11
X Contents
1.4 CHAPTER 4: Dosimetry in Nuclear Medicine Diagnosis and Therapy ........... 1-12
1.4.1 Dosimetric and Biokinetic Models (SECT. 4.2) ................................ 1-12
1.4.2 Biokinetic Data and Physical Properties of Radionuclides (SECTS. 4.3 and 4.4) ...... 1-13
1.4.3 Dose Coefficients and Diagnostic Reference Activities (SECT. 4.5) ................ 1-14
1.4.4 Dosimetry in Nuclear Medical Therapy (SECT. 4.6) ............................ 1-14
1.4.5 Necessity of Patient-Specific Dose Planning in Radionuclide Therapy (SECT. 4.7) .... 1-15
1.4.6 Dose to the Embryo and Fetus During Pregnancy (SECT. 4.8) .................... 1-15
1.4.7 Doses to Infants From Breastfeeding (SECT. 4.9) .............................. 1-15
1.5 CHAPTER 5: Medical Radiological Protection ............................... 1-16
1.5.1 The Concept of Medical Radiological Protection (SECT. 5.2) ..................... 1-16
1.5.2 The System of Applied Medical Radiological Protection (SECT. 5.3) .............. 1-17
1.5.3 Medical Radiological Protection in Magnetic Resonance Imaging and Diagnostic
Ultrasound (SECT. 5.4) ................................................... 1-17
1.6 Glossary and Index of Terms ............................................ 1-17

2 Radiation and Biological Effects
(J.H. BERNHARDT, K.-U. KASCH, A. KAUL) .................................. 2-1
2.1 Introduction (J.H. BERNHARDT, K.-U. KASCH, A. KAUL) ....................... 2-1
2.2 Kinds of Radiation ..................................................... 2-3
2.2.1 Ionizing Radiation (K.-U. KASCH) ........................................ 2-3
2.2.1.1 Photons ............................................................... 2-3
2.2.1.1.1 Coherent scattering ..................................................... 2-4
2.2.1.1.2 Photoelectric effect ..................................................... 2-4
2.2.1.1.3 Compton effect (incoherent scattering) ...................................... 2-5
2.2.1.1.4 Pair production ......................................................... 2-8
2.2.1.1.5 Photonuclear reaction ................................................... 2-8
2.2.1.1.6 Attenuation law, energy transfer and energy deposition ......................... 2-9
2.2.1.1.7 Relative predominance of individual effects .................................. 2-11
2.2.1.1.8 Photon production ...................................................... 2-12
2.2.1.2 Charged particles ....................................................... 2-14
2.2.1.2.1 Stopping power ........................................................ 2-15
2.2.1.2.1.1 Collisional losses ....................................................... 2-15
2.2.1.2.1.2 Radiative losses ........................................................ 2-17
2.2.1.2.2 Radiative versus collisional losses .......................................... 2-18
2.2.1.2.3 Scattering of charged particles ............................................. 2-18
2.2.1.2.4 Range of heavy charged particles .......................................... 2-19
2.2.1.2.5 Range of electrons ...................................................... 2-20
2.2.1.2.6 Production of charged particles ............................................ 2-21
2.2.1.3 Absorbed dose D and linear energy transfer (LET)............................. 2-21
2.2.1.4 Photons versus charged particles in medical applications ........................ 2-22
2.2.1.5 Neutrons and π-mesons .................................................. 2-23
2.2.1.6 Interaction modeling in radiation therapy treatment planning .................... 2-24
2.2.1.7 Summary ............................................................. 2-25
2.2.1.8 References for 2.2.1 ..................................................... 2-26
2.2.2 Non-Ionizing Radiations (J.H. BERNHARDT) ................................ 2-28
2.2.2.1 Introduction ........................................................... 2-28
2.2.2.2 Ultrasound ............................................................ 2-30
2.2.2.2.1 Introduction ........................................................... 2-30
2.2.2.2.2 Physical Characteristics .................................................. 2-31
2.2.2.2.3 Pulsed mode of operation ................................................ 2-33
Contents XI
2.2.2.2.4 Medical Applications .................................................... 2-35
2.2.2.2.5 Acoustic parameters used to describe ultrasound exposure ...................... 2-36
2.2.2.2.6 Mechanisms of interaction ................................................ 2-37
2.2.2.2.6.1 Introduction ........................................................... 2-37
2.2.2.2.6.2 Thermal mechanism ..................................................... 2-38
2.2.2.2.6.3 Non-thermal mechanisms ................................................ 2-38
2.2.2.2.7 Summary ............................................................. 2-39
2.2.2.3 Static and slowly varying electric and magnetic fields .......................... 2-39
2.2.2.3.1 Physical characteristics .................................................. 2-39
2.2.2.3.2 Natural and anthropogenic sources ......................................... 2-40
2.2.2.3.3 Interaction mechanisms .................................................. 2-41
2.2.2.3.4 Summary ............................................................. 2-42
2.2.2.4 Time-varying electric and magnetic fields of frequencies less than 100 kHz ......... 2-43
2.2.2.4.1 Introduction ........................................................... 2-43
2.2.2.4.2 Natural and anthropogenic sources ......................................... 2-43
2.2.2.4.3 Interaction mechanisms .................................................. 2-44
2.2.2.4.4 Summary ............................................................. 2-47
2.2.2.5 Electromagnetic fields of frequencies above 100 kHz .......................... 2-48
2.2.2.5.1 Physical characteristics .................................................. 2-48
2.2.2.5.2 Sources of concern ...................................................... 2-50
2.2.2.5.2.1 Technical applications ................................................... 2-50
2.2.2.5.2.2 Medical applications .................................................... 2-50
2.2.2.5.2.3 Magnetic Resonance Imaging ............................................. 2-51
2.2.2.5.2.4 RF ablation, surgery ..................................................... 2-51
2.2.2.5.3 Biophysical interaction mechanisms ........................................ 2-52
2.2.2.5.4 Summary ............................................................. 2-54
2.2.2.6 Optical Radiation and Lasers .............................................. 2-54
2.2.2.6.1 Introduction ........................................................... 2-54
2.2.2.6.2 Radiometric terms and units .............................................. 2-55
2.2.2.6.3 Optical Radiation Sources ................................................ 2-56
2.2.2.6.4 Mechanisms of interaction ................................................ 2-58
2.2.2.6.5 Summary ............................................................. 2-59
2.2.2.7 References for 2.2.2 ..................................................... 2-59
2.3 Biological Effects ...................................................... 2-63
2.3.1 Biological Effects of Ionizing Radiations (A. KAUL) .......................... 2-63
2.3.1.1 Introduction ........................................................... 2-63
2.3.1.2 Deterministic effects .................................................... 2-64
2.3.1.2.1 Dose response relationships for radiation damage ............................. 2-64
2.3.1.2.2 Whole body irradiation .................................................. 2-64
2.3.1.2.3 Partial body irradiation: Tolerance dose ..................................... 2-64
2.3.1.2.4 Irradiation in utero ...................................................... 2-65
2.3.1.3 Stochastic effects ....................................................... 2-65
2.3.1.3.1 Cancer induction and development ......................................... 2-65
2.3.1.3.2 Risk of cancer ......................................................... 2-66
2.3.1.3.3 Dose-response relationships, risk estimation and the radiological concept of limiting
the risk ............................................................... 2-66
2.3.1.3.4 Risk of heritable effects .................................................. 2-67
2.3.1.3.5 Induction of diseases other than cancer ...................................... 2-67
2.3.1.4 The biological concept of the effective dose .................................. 2-67
2.3.1.5 Summary ............................................................. 2-68
2.3.1.6 References for 2.3.1 ..................................................... 2-68