Fundamental Immunology PDF
Preview Fundamental Immunology
un amenta mmuno ogy un amenta mmuno ogy BJITOR William E. Paul, MD I 0 ~rs Kluwer Uppincott WIWams lie Wllldns .... .N. ..,_O ';Ph.•_...__. • .. .._. ...__... ..&..... Acquisitions Editor: Julie Goolsby Product Manager. Leanne Vandetty Senior Manufacturing Manager: Benjamin Rivera Marketing Manager: Kimberly Schonberger Design Coordinator: Teresa Mallon Production Service: Absolute Service, Inc. e 2013 by LIPPINCOTT WILLIAMS & WILKINS, a WOLTERS KLUWER business Two Commerce Square 2001 Market Street Philadelphia, PA 19103 USA LWW.com 6th Edition, e 2008 by LIPPINCOTT WILLIAMS & WILKINS, a WOLTERS KLUWER busineas 5th Edition, e 2003 by Lippincott Williams & Wilkins 4th Edition,@ 1999 by Lippincott-Raven Publishers All rights reserved. This book is protected by copyright. No part of this book may be reproduced in any form by any means, including photocopying, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials appearing in this book prepared by individu als as part of their official duties as U.S. government employees are not covered by the above mentioned copyright. Printed in China Library of Congress Cataloging-in-Publication Data Fundamental immunology I editor, William E. Paul.-7th ed. p.;cm. Includes bibliographical references and index. ISBN 978-1-4511-1783-7 (alk. paper)-ISBN 1-4511-1783-3 (alk. paper) I. Paul, William E. [DNLM: 1. Immune System Phenomena. QW 540] 616.07'9-dc23 2012035820 Care has been taken to confirm the accuracy of the information presented and to describe gener ally accepted practices. However, the authors, editors, and publisher are not responsible for errors or omissions or for any consequences from application of the information in this book and make no warranty, expressed or implied, with respect to the currency, completeness, or accuracy of the contents of the publication. Application of the information in a particular situation remains the professional responsibility of the practitioner. The authors, editors, and publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accordance with current recommendations and practice at the time ofp ublication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new or infrequently employed drug. Some drugs and medical devices presented in the publication have Food and Drug Administration (FDA) clearance for limited use in restricted research settings. It is the responsibil ity of the health care provider to ascertain the FDA status of each drug or device planned for use in their clinical practice. To purchase additional copies of this book, call our customer service department at (800) 638-3030 or fux orders to (301) 223-2320. International customers should call (301) 223-2300. Visit Lippincott Williams & Wilkins on the Internet: at LWW.com. Lippincott Williams & Wilkins customer service representatives are available from 8:30am to 6 pm, EST. 10 9 8 7 6 5 4 3 2 1 For Charlotte, Gloria, Lucy, Jenna, Silvie, and Jake-and for Julien .......- .I'IID .J>_t.. . -.._"_""C ens .... 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Flajnik, PhD La Jolla Institute for Allergy and Immunology Professor La Jolla, California Department of Microbiology and Immunology University of Maryland Baltimore Shane Crotty, PhD Baltimore, Maryland Associate Professor Division of Vaccine Discovery Sebastian Fugmann, PhD La Jolla Institute for Allergy and Immunology Investigator La Jolla, California Laboratory of Molecular Biology and Immunology National Institute on Aging/NIH Angel Davey, PhD Baltimore, Maryland Postdoctoral Fellow Laboratory of Immunogenetics Christopher C. Goodnow, BVSc, BScVet, PhD NIH,NIAID Professor &. NHMRC Australia Fellow Rockville, Maryland Department of Immunology John Curtin School of Medical Research Mark M. Davis, PhD The Australian National University Investigator, HHMI Canberra, Australian Capital Territory Department of Microbiology and Immunology Stanford University Siamon Gordon, FRS. MB. ChB. PhD Stanford, California Emeritus Professor Sir William Dunn School of Pathology Ennio De Gregorio, PhD University of Oxford Head Oxford, United Kingdom Department of Immunology Novartis Vaccines and Diagnostics Steven Greenberg, MD Siena, Italy Senior Principal Scientist Respiratory and Immunology Department Charles A. Dinarello, MD Merck Research Laboratories Professor of Medicine and Immunology Kenilworth, New Jersey University of Colorado Denver Adjunct Associate Professor Aurora, Colorado Department of Medicine Professor of Experimental Medicine Columbia University College of Physicians and Surgeons Department of Medicine New York, New York Radboud University Nijmegen, The Netherlands Neil S. Greenspan, MD, PhD Professor Anca Dorhoi Department of Pathology Department of Immunology Case Western Reserve University Max Planck Institute for Infection Biology Director, Histocompatibility and Immunogenetics Berlin, Germany Laboratory University Hospitals Case Medical Center Ugo D'Oro, MD, PhD Cleveland, Ohio Unit Head Department of Immunology Function Ted H. Hansen, PhD Novartis Vaccines and Diagnostics Professor Siena, Italy Department of Pathology Washington University School of Medicine Louis Du Pasquier. PhD St. Louis, Missouri Professor Department of Zoology and Evolutionary Biology Richard R. Hardy, PhD University of Basel Professor Basel, Switzerland Fox Chase Cancer Center Philadelphia, Pennsylvania Hildegund C.J. Ertl, MD Caspar Wistar Professor in Vaccine Research Dirk Homann Professor and Program Leader, Immunology Program Department of Anesthesiology Director, The Wistar Institute Vaccine Center Barbara Davis Center for Childhood Diabetes The Wistar Institute Aurora, Colorado Philadelphia, Pennsylvania University of Colorado, Denver
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