Functional Biomaterials: Drug Delivery and Biomedical Applications PDF
Preview Functional Biomaterials: Drug Delivery and Biomedical Applications
Sougata Jana Subrata Jana Editors Functional Biomaterials Drug Delivery and Biomedical Applications Functional Biomaterials (cid:129) Sougata Jana Subrata Jana Editors Functional Biomaterials Drug Delivery and Biomedical Applications Editors SougataJana SubrataJana DepartmentofHealthandFamilyWelfare DepartmentofChemistry DirectorateofHealthServices IndiraGandhiNationalTribalUniversity Kolkata,WestBengal,India Amarkantak,India ISBN978-981-16-7151-7 ISBN978-981-16-7152-4 (eBook) https://doi.org/10.1007/978-981-16-7152-4 ©TheEditor(s)(ifapplicable)andTheAuthor(s),underexclusivelicensetoSpringerNatureSingapore PteLtd.2022 Thisworkissubjecttocopyright.AllrightsaresolelyandexclusivelylicensedbythePublisher,whether thewholeorpartofthematerialisconcerned,specificallytherightsoftranslation,reprinting,reuseof illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similarordissimilarmethodologynowknownorhereafterdeveloped. Theuseofgeneraldescriptivenames,registerednames,trademarks,servicemarks,etc.inthispublication doesnotimply,evenintheabsenceofaspecificstatement,thatsuchnamesareexemptfromtherelevant protectivelawsandregulationsandthereforefreeforgeneraluse. The publisher, the authors, and the editorsare safeto assume that the adviceand informationin this bookarebelievedtobetrueandaccurateatthedateofpublication.Neitherthepublishernortheauthorsor theeditorsgiveawarranty,expressedorimplied,withrespecttothematerialcontainedhereinorforany errorsoromissionsthatmayhavebeenmade.Thepublisherremainsneutralwithregardtojurisdictional claimsinpublishedmapsandinstitutionalaffiliations. ThisSpringerimprintispublishedbytheregisteredcompanySpringerNatureSingaporePteLtd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore Contents FunctionalBiomaterials:DrugDeliveryandBiomedical ApplicationsPolymericMicelleinDrugDeliveryApplications. . . . . . . . 1 SajminaKhatun,SabeerabiBonala,SunilVenkannaPogu, andAravindKumarRengan pH-ResponsiveBiomaterialsinDrugDelivery. . . . . . . . . . . . . . . . . . . . 37 KanchanBhartiandBrahmeshwarMishra Stimuli-ResponsiveHydrogelsinDrugDelivery. . . . . . . . . . . . . . . . . . . 75 RogelioRodríguez-Rodríguez,HugoEspinosa-Andrews, andZairaYunuenGarcía-Carvajal PolysaccharideBasedBiomaterialsforDermalApplications. . . . . . . . . 105 KhaledE.Abuelella,HendAbd-Allah,SaraM.Soliman, andMonaM.A.Abdel-Mottaleb BiomaterialsinGeneDelivery. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 129 MuhammadUsamaSaeed,NazimHussain,andMuhammadBilal PolymericNanoparticlesforTheranosticTreatmentofCancer. . . . . . . 149 CamilaFabianodeFreitas,AndréLuizTessaro,andDiogoSilvaPellosi SmartTheranosticBiomaterialsforAdvancedHealthcare Application. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 187 SushmithaNehru,TamilmuruganRajavel,andRanjitaMisra SilkFibroin-BasedBiomaterialsinBiomedicalApplications. . . . . . . . . . 203 PrasannaKumarByram,LopamudraDas,KrishnaChaitanyaSunka, GauravKulkarni,SantanuDhara,andNishantChakravorty Biomaterial-BasedNanofibersScaffoldsinTissueEngineering Application. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 245 ArbindPrasad v vi Contents BiomedicalApplicationsofInorganicBiomaterials. . . .. . . . . . . . . . . .. 265 AzeemIntisar,NazimHussain,AroojRamzan,TehzeebSawaira, ArpitaRoy,andMuhammadBilal SynthesisBiomaterialsinBiomedicalApplications. . . . . . . . . . . . . . . . . 285 ShadiSadatNasiri,ZahedAhmadi,andFaramarzAfshar-Taromi 3D-PrintedBiomaterialsinBiomedicalApplication. . . . . . . . . . . . . . . . 319 DineshRokaya,SuchadaKongkiatkamon,ArtakHeboyan,VanVietDam, PokpongAmornvit,ZohaibKhurshid,ViritponSrimaneepong, andMuhammadSohailZafar MetallicBiomaterialsinBiomedicalApplications. . . . . . . . . . . . . . . . . . 341 AmaraLakshmiLasita,SakshiPabrekar,NileshS.Wagh, andJayaLakkakula CeramicBiomaterialsinAdvancedBiomedicalApplications. . . . . . . . . 371 V.Lalzawmliana,PrasenjitMukherjee,SubhasisRoy,MangalRoy, andSamitK.Nandi HybridBiomaterialsinDrugDeliveryandBiomedicalApplications. . . 409 IkaDewiAna GraphenePolymerCompositesforBiomedicalApplications. . . . . . . . . 435 ChinnuSabuandK.Pramod ApplicationsofIonicLiquidsinPharmaceuticalSciences. . . . . . . . . . . . 471 SorayaS.Santos,NicolasKeppeler,JeanineGiarolla,ElizabethI.Ferreira, andOmarA.ElSeoud MetallicBiomaterialsforMedicalandDentalProstheticApplications. . . 503 DineshRokaya,SmritiBohara,ViritponSrimaneepong, SuchadaKongkiatkamon,ZohaibKhurshid,ArtakHeboyan, MuhammadSohailZafar,andJanakSapkota About the Editors Sougata Jana has completed his Ph.D. in pharmaceutical technology from Maulana Abul Kalam Azad University of Technology (MAKAUT), West Bengal (FormerlyKnownasWBUT),India.Hehasspent14yearsinpharmacy,including teaching, research, and health services. Sougata has published 30 research and review articles in different national and international peer-reviewed journals. He hasalsoedited10booksandpublishedmorethan45bookchaptersineditedbooks byElsevier,Springer,WileyVCH,CRCPress,andTaylor&FrancisGroup.Heisa reviewer for peer-reviewed international journals. Sougata is a life member of the AssociationofPharmaceuticalTeachersofIndia(APTI)andholdsanassociateship withtheInstitutionofChemists(AIC),India.Hesuccessfullyguided17postgraduate studentsintheirresearchprojects.Sougataisworkingondrugdeliveryscienceand technology,includingmodificationofsyntheticandnaturalbiopolymers,micropar- ticles, nanoparticles, andsemisolids andinterpenetratingnetwork(IPN)systemfor controlleddrugdelivery. Subrata Jana is an Associate Professor in the Department of Chemistry, Indira Gandhi National Tribal University (Central University), Amarkantak, Madhya Pradesh,India.Hiscurrentresearchfocusesonthedesignandsynthesisofartificial receptorsfortherecognitionofanions,cations,andbiomoleculesalongwithbiode- gradablepolymeric-basedcarriersystemsforthedeliveryofdrugmolecules.Sofar, hehaspublishedaround40researchpapersinpeer-reviewedinternational journals and contributed more than 20 book chapters in edited books published by interna- tionally renowned publishers. He is currently serving as executive editor of Mekal Insights, the official research journal of IGNTU. He also served as a reviewer for internationaljournals. SubratahasobtainedhisPh.D.inorganicchemistryfromtheIndianInstituteof EngineeringScienceandTechnology(IIEST),Shibpur,India.Thenheworkedwith vii viii AbouttheEditors Professor (Dr.) Fraser Hof at the University of Victoria, Canada, and Dr. Kenneth J. Woycechowsky at the University of Utah, USA, as a postdoc. Overall, he has extensively studied the supramolecular behavior of the host–guest interaction and synthesisofdifferentheterocyclicmoieties. Functional Biomaterials: Drug Delivery and Biomedical Applications Polymeric Micelle in Drug Delivery Applications SajminaKhatun,SabeerabiBonala,SunilVenkannaPogu, andAravindKumarRengan Abstract One of the extensively studied subjects in nano-biotheranostic is devel- oping a suitable drug delivery system with well-defined structures and functions. Polymeric micelles are an emerging therapeutic approach in drug delivery and targeting selective cells/tissues. The amphiphilic block co-polymer self-assembled inanaqueoushydrodynamicenvironmenttodevelopasupramolecularstructureof polymeric micelles yielding the hydrophobic core and hydrophilic shell. Simple, easysynthesismethod,absenceoforganicsolvent,abilitytocarryandenhancethe solubility of the hydrophobic drug, and improved blood circulation make the polymeric micelles an attractive drug carrier in several disease therapies such as cancer, viral, gastrointestinal, ocular, and so on. The polymeric micelles have also gainedimportanceasmultipletarget-specific,controlleddrugreleasecarriersdueto theireasysurfacemodificationandspecificstimuli-responsiveproperty.Thisarticle instigates a brief introduction to polymeric micelles. Several types of polymeric micelles, depending on the material used and the intermolecular forces stabilizing the amphiphilic conformation in aqueous media, are discussed. Polymeric/copoly- mericmaterialsareusedforthesynthesisofpolymericmicelles,andtwoimportant synthesis methods, direct and indirect dissolution and several characterization methods, are also reviewed. The targeting approach of polymeric micelles by active/passive mechanism and drug release in response to several stimuli like pH, thermal,reduction,andlightresponsehasbeenelaborated.Thisarticlealsoexplores the application of polymeric micelles in the delivery of anticancer drugs, genes, immunotherapeutics, ocular drugs, and oral drugs to improve therapeutic efficacy andovercomemajorhindrancesassociatedwithconventionaltherapy. Keywords Polymericmicelles·Blockcopolymers·Self-assembly·Target-specific drugrelease·Stimuliresponsiveness S.Khatun·S.Bonala·S.V.Pogu·A.K.Rengan(*) DepartmentofBiomedicalEngineering,IndianInstituteofTechnologyHyderabad,Kandi, Sangareddy,Telengana,India e-mail:[email protected];[email protected]; [email protected];[email protected] ©TheAuthor(s),underexclusivelicensetoSpringerNatureSingaporePteLtd.2022 1 S.Jana,S.Jana(eds.),FunctionalBiomaterials, https://doi.org/10.1007/978-981-16-7152-4_1 2 S.Khatunetal. 1 Introduction Polymeric micelles (PMs) are a globular suspension of macromolecular structures with10–100nmsize.Thesearecommonlyproducedfromtheautomaticassembly of monomeric amphiphilic blocks with hydrophobic and hydrophilic units in an aqueous environment (Yokoyama et al. 1990; Jones and Leroux 1999; Torchilin 2007). The formation of PMs occurs randomly when the amphiphilic monomer concentration reaches above the critical micelle concentration (CMC). The CMC triggers the formation of a core (hydrophobic)-shell (hydrophilic) supramolecular configuration of a micelle (Yokoyama et al. 1990; Torchilin 2001) and has been presented in schematic Fig. 1. The PMs can accommodate polar units at shell surfaces, non-polar moieties inside core, and intermediately polar molecules along with surfactant molecules (Jhaveri and Torchilin 2014; Bodratti and Alexandridis 2018).Commonly,micellecopolymershavinglowCMCdisplayenhancedstability atlowamountsofamphiphileinahydrodynamicenvironment.LowerCMCbecause ofincreasedhydrophobicityimprovescore-shellformationandstabilityofamicelle inanaqueousmedium(Yokoyamaetal.1990;JhaveriandTorchilin2014;Bodratti andAlexandridis2018). Unique properties of PMs such as safety, low CMCs, high molecular weight, higher stability, slow dissociation, regulated drug delivery, and extended retention propertymakethemsuperiorcomparedtosurfactantmicelles(Mahmudetal.2007; Ahmad et al. 2014). The mesoscopic and/or nanoscale size range of PMs helps in improving the enhanced permeability and retention (EPR) effect of cargo drugs significantly (Batrakova et al. 2010; Mora-Huertas et al. 2010). The core-nano chamber of PMs can carry hydrophobic drugs. The shell acts as a safeguard of the drug from unwanted reactions and degradations in an aqueous physiological envi- ronment. Micelles of core-shell-forming polymer materials have been designed to synthesize PMs with an extended half-life in circulation. PMs coupled with other polymericmaterialslikepolyethyleneglycol(PEG)havebeenengineeredinthepast to develop “stealth” attributes, thus immune escape, active targeting, and reduced intakebymacrophagesofthereticuloendothelial(RES)system(Kultheetal.2012; Fig. 1 Schematic presentation of core-shell structure of polymeric micelles at/above critical micellarconcentration(CMC)
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